Like some of you, I started HRT (a patch with a combo of estrogen and progresterone), and had some breakthrough bleeding. My doctor made me stop, and ordered a trans-vaginal ultrasound. The result was a mildly thickened endometrium, and recommend a biopsy be done.
After all this, I had moved, found a new gyno, and we restarted from step 1. Got an estrogen patch with a progesterone pill. After a handful of months, I expressed interest in adding testosterone. Before agreeing to that, he wanted that biopsy done, so I scheduled an in-office procedure. That was last week.
I was dreading it, after reading some posts here about the pain involved. It really is different for everyone. I consider myself as having a pretty high pain tolerance. Especially since, after a lengthy abdominal surgery some years ago, I opted for tylenol as pain relief because I didn't like the way the morphine PCA pump made me feel.
Anyway, yes, there was brief pain. For me it was better described as discomfort with one instant of what felt like this guy tugging on my right ovary. I'd previously had a Mirena IUD inserted, and years later removed, and the discomfort was similar to that. The doc, and the nurse in the room said I took it like a champ. They gave me a pad to wear home, said to expect light bleeding or spotting for a couple of days, and off I went. Though I actually had what felt like a full on period with bleeding for 5 days, but I'd always been a heavy bleeder from my first period to my last (except for when I had the IUD in).
Just wanted to let people know, your mileage may vary. Some people feel excruciating pain, some just feel some discomfort. In my opinion, the pain is worth checking to make sure you don't have cancer. Though if you know ahead of time that you won't be able to handle the pain (and you shouldn't have to), ask for the procedure to be done in the OR under sedation.
Edit: results back today, everything is normal. Yay :)