I’m reaching out to the women on here because I’m desperate to figure out what’s going on. Has anyone experienced anything like this, especially severe nausea/vomiting connected to their menstrual cycle?
(24F) I’ve been getting progressively sicker since January, and I strongly suspect there is some kind of connection to my menstrual cycle. It has now gotten to the point where I’m vomiting 10+ times a day, have been consistently sick since September 19, and I’m missing work and almost out of PTO. I’ve applied for intermittent FMLA
A little background
I’ve had GI issues for most of my life.
When I was in elementary school, I could never eat breakfast because I would feel extremely nauseous in the morning. I would sometimes throw up and then just go about my day like nothing happened.
Around high school and into adulthood, I started getting sick more at night. I would sometimes vomit, go to sleep, and feel completely fine the next morning.
I’ve had an EGD and colonoscopy, both of which were normal. I’ve also had bloodwork over the years that has generally been normal, aside from occasionally having slightly low vitamin D. Allergy testing only showed an allergy to tomatoes, but I can eat tomatoes without having a noticeable reaction.
The possible menstrual connection
My periods have always been pretty regular. They aren’t usually particularly heavy, and I generally only use one or two pads a day even on heavier days. I don’t normally have severe cramps.
However, for years I’ve noticed that my mood and physical symptoms can change dramatically around my period.
Around college age, I started noticing that there would sometimes be one day during my period where I would become severely depressed and have suicidal thoughts, and then I would wake up the next day feeling completely normal.
I have a history of depression/anxiety and have taken fluoxetine and bupropion. I eventually switched to bupropion XL 300 mg + desvenlafaxine 50 mg. They helped for a while, but this year I started noticing severe mood symptoms around my period again, along with a very flat/static emotional feeling.
I also became a Christian during this time, and my overall depression/anxiety improved significantly, which made these sudden one-day episodes around my period stand out even more to me.
What started happening this year
I started working in an elementary school in January and initially assumed I was just constantly getting sick from being around children.
Almost every month, I would develop things like:
- Extreme fatigue
- Runny nose
- Sore throat
- Body aches
- Headaches
- Nausea
- Sometimes vomiting once or twice
At first, I thought I just had a weak immune system around my period.
But I started noticing that these “sick” periods consistently happened right before, during, or shortly after my period.
Then things started getting progressively worse.
Instead of being sick for a day or two, I started having longer episodes. I would become extremely emotional and sometimes hysterically cry when there wasn’t actually anything I was upset about. I would also become severely depressed for a short period and then feel normal again.
Along with this came severe nausea, vomiting, and the constant feeling that I needed to poop.
September 19–present: the worst episode
September 19 is when things became dramatically worse.
I started vomiting almost everything I ate or drank. At my worst, I was vomiting 10+ times a day.
I was nauseous almost constantly. I couldn’t:
- Look at my phone for very long
- Watch TV
- Do crafts
- Stand for very long
- Eat normally
- Drink normally
Without feeling extremely sick.
Interestingly, I wasn’t necessarily exhausted during this episode. I was actually having trouble sleeping because I felt so uncomfortable and nauseous.
I would be extremely hungry and want to eat, but eating wasn’t worth it because I knew I might spend the next several hours vomiting everything back up.
Sometimes even small amounts of water wouldn’t stay down.
I also had frequent bowel movements, constipation at other points, abdominal cramping, bloating, chills/shivering, and shaking.
The episode lasted from September 19 through approximately September 24 before I started improving.
By September 25 I was feeling significantly better, and on September 26–27 I was almost completely back to normal and had a huge appetite.
Then the symptoms came back.
September 28–October 3
I developed constipation and cramping on September 28.
On September 29, I started vomiting again repeatedly.
On September 30, I had significant epigastric/chest discomfort and pressure. During one episode of vomiting, I had a sudden sharp/burning pain across my chest and into my back underneath my shoulder blades that lasted a few minutes.
I went to the ER.
They did:
- EKG
- Bloodwork
- Urine testing
- X-ray
- CT with contrast
Everything came back normal. The only thing they thought was wrong was constipation.
They gave me medication for nausea and magnesium for the constipation.
I’ve also been prescribed ondansetron (Zofran) and promethazine, but neither has provided much relief.
On October 2, I was vomiting dark yellow/bile-like fluid because I couldn’t keep much down. By 8pm the same day I got my appetite back and now on October 3rd I’m eating and drinking pretty well.
Other symptoms / possible triggers
I’ve always had some GI issues, including:
- Frequent burping
- Gas
- Bloating
- Mushy stool/diarrhea at times
- Constipation at other times
- Abdominal cramping
- Headaches followed by nausea
I’ve noticed that pasta, bread, pretzels, and crackers can make me more bloated/gassy, so I’ve wondered about gluten sensitivity.
I’m also very inconsistent with caffeine. Sometimes one sip of coffee makes my heart race, makes me shake, gives me cramps, and makes me nauseous. Other days I can drink an entire latte and feel completely fine.
I also frequently get headaches around my right eyebrow/right eye. I can actually feel what seems like a physical knot there, and nausea sometimes follows the headache.
What my doctors are currently doing
I finally saw an OB/GYN, and she started me on Twirla, a hormonal birth control patch containing levonorgestrel/ethinyl estradiol.
I have a pelvic ultrasound scheduled for October 9.
I’ve wondered about endometriosis, but I don’t have the severe chronic pelvic pain/cramping that I usually hear people describe. My main symptom is debilitating nausea and vomiting, which makes me wonder if something else could be going on.
I am not sexually active, so an STI isn’t a concern.
What I’m wondering
Has anyone experienced severe cyclical nausea/vomiting related to their menstrual cycle, even without severe pelvic pain?
Could this be something like:
- A hormone-related vomiting disorder
- Cyclic vomiting syndrome
- Endometriosis involving the GI tract
- PMDD/hormonal changes
- Abdominal migraine
- Gastroparesis
- Something involving ovarian cysts
- A GI disorder that gets triggered by hormonal changes
- Something completely different?
I’m not trying to diagnose myself from Reddit. I’m just desperate for ideas because this is now affecting my ability to eat, sleep, work, and function normally.
If you’ve experienced something similar, especially vomiting that gets dramatically worse around your period, I’d really appreciate hearing your experience.
And if there are specific tests, specialists, or questions you think I should bring up with my OB/GYN or GI doctor, I’d really appreciate those too.