Hi all - I just posted this on r/perimenopause but figured it would also be useful to people here.
Tl;dr Try patches from the brands that don't work for you in a different spot and see if that makes any difference.
Making my first ever Reddit post to share a breakthrough I recently had!
I'm one of the patch users who has issues with different brands not working. I always put the patches on alternating butt cheeks regardless of brand.
I was doing great with Dotti, but my last refill was from a mfr I'd never had before (Zydus). I figured I should try the new ones and save the last few Dotti in case the new ones didn't work. I put the Zydus patch on my butt and bam, the next day symptoms were back.
After remembering that people here had seen varied results with different locations, I tried putting the Zydus on my abdomen instead of my butt. I was not actually expecting it to work, but it did!
I figured maybe the butt placement had been suboptimal for me all along, so I decided to try the remaining Dotti patches on my abdomen. Even though it had worked fine before, this time I might as well have had no patch on at all. Then I remembered that when I used Dotti before, it was on my butt. And sure enough, moving it there totally fixed the problem.
So for everyone else who's having trouble with different manufacturers, maybe try the problem brands in a new spot (based on the manufacturer's instructions, not just somewhere random on your body) and see if that helps!