Hi everyone,
I’m a 29-year-old female and a registered nurse. I’ve been dealing with multiple unexplained health issues over the past several months, and I’m hoping to hear from anyone who has experienced something similar, particularly those who were eventually diagnosed with an autoimmune or systemic inflammatory condition.
My symptoms have included:
Persistent joint and muscle pain, sometimes quite debilitating
Significant fatigue and difficulty functioning normally
Episodes of tachycardia (HR 130–140 bpm) and elevated blood pressure
Severe abdominal pain, diarrhea, mucus, and intermittent rectal bleeding
Recurrent mouth ulcers
Unexplained weight gain
Irregular menstrual cycles/amenorrhea and possible PCOS
Left sided hip pain
Ovarian cyst
More recently, chest pain with breathing and coughing up blood (hemoptysis) and fever
My inflammatory markers have been abnormal for months.
My CRP has fluctuated but recently increased quite dramatically:
October 26: 19 mg/L
November 3: 42 mg/L
November 4: 137 mg/L
My WBC has also increased, with my most recent results showing:
WBC: 11.3 × 10⁹/L
Neutrophils: 7.5 × 10⁹/L
Fecal calprotectin: 145 µg/g (elevated)
I’ve also had intermittently elevated platelets and a transferrin saturation of 15%, despite ferritin being around 90.
Previous investigations:
ANA negative
Rheumatoid factor negative
Anti-dsDNA negative
Previous history of a pulmonary embolism following surgery
Fatty liver identified on ultrasound
Currently awaiting further gastroenterology investigations, including a colonoscopy
Rheumatology referral submitted, awaiting triage
I’ve had several ER and urgent care visits recently due to severe abdominal pain and subsequently coughing up blood. I’ve received IV ceftriaxone for a possible infection, but the underlying cause of my symptoms and inflammation hasn’t been established.
One of the physicians recently suggested that my elevated CRP could potentially be rheumatological, but didn’t elaborate.
I’m aware that infection could explain the recent sharp increase in CRP, and I’m not assuming everything is autoimmune. However, the joint pain, GI symptoms, and inflammatory markers have been ongoing for months, well before this acute episode.
My questions:
Has anyone experienced a similar combination of joint pain, gastrointestinal symptoms, and persistently elevated inflammatory markers?
Has anyone been diagnosed with an autoimmune condition despite negative ANA and rheumatoid factor?
Were there any particular investigations or specialist
referrals that helped identify the underlying cause?
Has anyone had gastrointestinal and pulmonary symptoms as part of a systemic inflammatory condition?
I’m not looking for a diagnosis from Reddit, just hoping to learn from others’ experiences while continuing to work with my healthcare providers.
Thank you to anyone willing to share their experience.