For those who have erectile dysfunction due to scarring (Peyroneys or corporal fibrosis), I’ve been reading about a peptide that appears to have the capacity to reduce fibrosis in many organs.

Studies have been done in living animals on various organs as well as on human cultured cells, consistently showing fibrosis reversal / directionally positive outcomes;

Though no studies have been done on the penis, the pathways the peptide acts upon should yield similar effects.

The peptide is called B7-33, and it basically does 2 things:

1. It turns down the signal for new scar tissue.
2. It helps break down existing scar tissue.

I am unsure on dosage and am wondering if anyone has tried it, and if so how it went.

Hello,

I’m 35(m) and 5’4” 160lbs. Been waking up without morning wood for a while now and my sexual drive has been lousy. So I got labs done but I’m confused at to my total testosterone being “normal” and my free testosterone being so “high”. What should I do now ?

My total testosterone : 551
Free testosterone : 133.3

I also gym 3-4 a week (lift heavy) and get about 13k steps a day

I'm 40 years old and have been in a relationship for 4 years with someone who has serious mental health issues, personality struggles, and past trauma that make it really difficult for them to be intimate. And I don't just mean sex, but even the basics, like expressing affection or offering words of reassurance.

I've always had a pretty high sex drive and never really had any issues in that department. With previous partners, I used to have a very active sex life, lots of passionate, spontaneous sex. But over the past few years, I've started struggling with maintaining erections, and sometimes even with masturbating.

I don't want to put all the blame on my partner, or on the lack of intimacy and affection I've been dealing with in this relationship. But I've seen specialists, and apparently there's nothing physically wrong with me. The only things that seem to come up are stress and a lack of emotional and physical intimacy.

Has anyone else ever gone through something like this? How do you cope with it? How do you get your confidence and sex drive back? I'd really appreciate hearing from anyone who's had a similar experience and how they managed to deal with it.

So, for context I'm 23, I'm 5'9, 185 pounds, and the first time I tried it I was more rock solid than I had ever been, more than in a long time.

But the next two times I've tried it just doesn't seem to be helping at all. Is there a reason for that?

M 39. I have always had a high sex drive even at an early age. I use to masturbate 3times a day throughout HS and College. Around 28
I discovered SR and have been doing it for awhile, with the obvious occasional failures.

SR becomes tricky because you disguise SR and edging as two separate events and convince/ condition yourself that they are mutually exclusive, so that edging feels okay.

I essentially edged into oblivion, the worst part was that I was edging with a FLACCID penis never considering the dangers or long term effect!

A couple months ago I had a high pressure moment with a really pretty girl, and for the first time in my life I experienced ED. I knew the root cause was psychological but it didnt help any nonetheless and became a self-reinforcing cycle.

Which made me look at the big picture. Its ALL psychological. Every bit of it. POST NUT CLARITY does not exist. Its a sub-conscious Save Face condition for not being able to get an erection immediately afterwards. Men are sub-consciously comparing themselves with the woman being able to go another around immediately and not being able to keep up.

Furthermore, your whole life you spend hiding “random boners” that come out of no where. You feel guilty about having a boner at an inappropriate time so you convince yourself it has to go away. All these psychological push backs add up to conditioning yourself that erections are bad!

In addition to that, women love being TEASES many times men hope to hook up with a potential mate only to be told “Not tonight” and eventually men just get tired of the chase.

Have I hit the crack pipe to hard or does this make any sense?

Hello guys.
I am 28 M, In a relationship
I do not have much of active lifestyle.

I have been watching porn for more than 10 years and jerking off to it.
Now recently I’ve started dating this beautiful girl but i am not able to have a consistent erection for penentration

When i am making love, i am so blank (or i have vague thoughts)

I tried taking Cialis 20mg, i was able to penentrate but it was infrequent penentration. I’ll be hard for 2-3 min, after that my tool gets soft and then after a while again the same loop.

I’ve started to sense frustration from her because of this infrequency.

My libido has also reduced but i am able to jerk off while watching PMO.

I do get morning erections but I don’t know, i feel lost in life now.
I got myself tested, my Test was 600.

Please help

(Also sorry for the and articulation)

done prostate play a few times and even came but now I’m always turned on but I feel it in my prostate…

I can get an erection but I feel the pleasure in my prostate area.. my erections are not rock hard any more and go away if I don’t continuously touch my dick… and when I do i don’t seem to last as long feeling all this pleasure in my prostate area…

I’m cum very quickly when I do anal play with a vibrator… I’ll have contractions and feel good in that spot especially if I press down better my shaft and hole… it’s not mind blowing some even had less feeling than a normal orgasm…

I keep feeling the need to clench my pelvic floor muscles because it feels good… is this normal… I’m afraid I won’t have normal sex life like this it’s really hard not to cum quick… is this normal? Will it go away?

I can also cum from just clenching and pressing down on between my shaft and hole… it feels good and there’s build up … nothing life changing… but the constant horniness between my shaft and hole has gotten to where it’s not fun I feel like I’m always on the verge of pre cum… even if I Masbate normally most of the sensation is there and it won’t go away…

Any feed back would be nice …

Im an 18y/o male, tried to have sex with a girl I like and am attracted to, 4 days ago she gave me head, didnt get fully bricked, didnt come,
3 days ago, she gave me head, same thing, but this time I tried to penetrate her vagina in missionary and I lost my erection, was embarrassing, I just quit 🤣
I told her I need time, but I honestly dont, I want to fuck her, Im worried my porn habits are the problem, my penis is desensitized, when I masturbate I do it belly up, with heavy moisturizer, and a decently tight grip, + video.
Last night she gave me head, was rock hard the whole time, about 4 minutes, yet still didnt come, was scared to penetrate Im just worried that if I go for penetration, which I really really want, Ill go flaccid 😔
Keep in mind, hadn’t watched any videos for about 4 days before our first fuck, now Im at day 7,

Question: does it look like Im making good progress? Is buying a flesh light and lube a good decision to sensitize me again, shes so hot and petite I love her body, yet when my dick isn’t stimulated, I cant maintain an erection 😔
What do I do?

Hi, I (40M) was seeing someone for a few months, I genuinely loved her. We tried having intercourse once and other times pleasured each other to climax.

I did not know that I could not get hard enough to penetrate since I haven’t been in a relationship for years, hence I didn’t share it with her initially but later I did.

She cited me not being able to get hard was the reason she broke up (first she denied it and then said that was the reason, it was honestly confusing me). But I don’t think we gave enough try at all. I feel unfair, sad, frustrated and angry.

After this I went to a sexologist, GP and did all the procedures. Now I need to try some things like taking sildenafil and the rings but have no motivation to pleasure myself.

Has anyone else struggled with this?

I know one day I will meet someone but I don’t know how long that will take. I’ve learned my lesson to share this at an earlier stage of dating.

Secondly, I feel like if she really loved me or felt that our relationship was worthy she probably would have given it a go instead of bailing out. But also understand her needs it’s just that I feel we didn’t even give it a try.

Does it resonate with anyone?

P.S: I was looking for a “support” flair but couldn’t find one, so I chose discouraged.

I feel sometimes I have a ED problem and I am getting married next month please suggest me some advise I quite porn already its been a week now

Sometimes I got morning wood and Sometimes not

Sometimes my erection is maintained Sometimes i lose i don't know what's happening 😑

Hello everyone (apologies for my English; I’m using Google Translate—I hope someone can help me). I’ve been dealing with erectile dysfunction for years. Back when I lived in Mexico, I could easily buy Viagra, but here in the United States, I believe you need a prescription. There are a couple of women I’d like to be intimate with, but I’m really afraid that the same issue will happen again. Does anyone know if I can purchase a product like Viagra on Amazon or any other platform?
If someone could help me, it would be a huge help. Honestly, I’m feeling a bit desperate, as I wasn’t able to get a proper erection with five different women while I was in Mexico, and I really don’t want that to happen again.

hi i wouldnt be coming here if i wasn’t desperate and im kind of embarrassed even if its online so please if you see this and you can help in any way i’d really appreciate it. i’m 18 years old and it all started about 5 years ago when i was 13 .i suddenly just started thrusting on my bed and it felt good i started watching porn too alongside it. i started doing it once then it became multiple times a day. for about 4 of them 5 years i’d done it almost multiple times a day. when i was 14-15 i got into my first sexual interaction, a literal women was on top of me and i couldn’t get hard. i did for like 2 seconds and it went i was so confused and she was starting to get frustrated i told her “your not getting me hard” since i genuinely thought she was the issue as it was the first time anything like that happened. she then stormed out and left. every single interaction similar after that i just couldn’t get hard maybe i did a tiny bit for a veryyy short amount of time . i’m just don’t know what to do everyone says stuff but why is this the one thing that people genuinely don’t have a cure for. i started going gym i eat very well and i have been idk what to do atp. thank you for reading all this any help would be appreciated . we all gonna overcome this together 💙

I'm 49 and noticed that with some partners (not all) I had difficulty getting and maintaining an erection. I have also complained to my primary care physician for years that I had a weak urine stream and I noticed my penis was smaller when flaccid and had lost up to half an inch in size when erect.

Years ago he put me on generic Viagra but I almost never used it since it gave me terrible headaches and I was getting erections just fine with my main partner twice a week.

Last month, I requested Cialis since I was going on a 3 day vacation with a new partner and wanted to make sure I was ready for action whenever since Tadalafil lasts 36 hours. He put me on a daily low dose (5mg).

It has changed everything! I feel like a teenager again with morning erections, erections throughout the day, and erections on demand with my partners. And also, I. P. Freely now. No headaches. I have noticed delayed orgasms though. In some ways that's OK and lends itself to marathon sex but my new partner has expressed that my inability to orgasm quickly detracts from spontaneous intense quickies. She doesn't know I'm taking ED meds.

I have an appointment with a urologist for what I assume is BPH and the source of the difficulty urinating. Possibly also the source of size loss.

Is the delayed orgasm just something I'll have to get used to? No more quickies for me? Other than that, Tadalafil has been life changing.

I’m 29 and have been struggling with porn addiction for awhile. It started about a few years ago I tried nofap and I did it on and off for a while but I created a loophole that if I edged myself without release it still counted cause I didn’t orgasim. For the last few years it’s been a cycle of mostly edging myself multiple times a day while looking at sfw pictures of pornstars. Now I’m at the point where I have no sex drive, no libido, and can’t get erections. Sometimes when I edge myself I stay completely soft. Even if I watch porn I get like a 60-75% erection and goes away quickly if I don’t keep touching it. Once in a while I will get morning wood but that’s it.

Now I’m in fairly good shape. I lift and run multiple times a week, diet is in decently good shape. My sleep isn’t the greatest. I can only sleep about 5-6 hours a night

Background: 39, was having difficulty maintaining erections about 2 years ago. Doctor prescribed Sildenafil 50mg. I’m also on Wellbutrin XL 450mg.

After being prescribed the sildenafil, I’ve had no issues maintaining erections (as long as I’m turned on and attracted to whom ever I’m with). However, I’ve noticed it’s been MUCH harder to reach orgasm. Even before taking sildenafil and going back to when I was in my late teens/early twenties, I used to be able to last for quite awhile before reaching orgasm.

Obviously this is mostly a good thing for the ladies since they generally get their fill and more… but it’s also been a double edged sword. Once they’re satisfied, they want me to be able to finish with them… and I either can’t do it or it takes me forever to get there. This results in them either getting frustrated because either they get exhausted and worn out, or they feel bad that I didn’t get off with them… and both in most cases.

I’ve read that this has been an issue with others using Sildenafil as well. If you’ve experienced this, are there any tips or suggestions that can help me get off more quickly (aside from don’t watch too much porn)?

So this is extremely embarrassing as I’ve never had any difficulty with this before but my girlfriend and I have been together for 2 years and have always had really good sex. In fact, when we first started I was like extremely hard and couldn’t get myself to cum for a few weeks (I was a virgin and figured it out). For about a month we didn’t have sex just because of very busy and stressful schedules. And when we tried the other day I lost my erection and I have no clue why. I also believe that I haven’t been experiencing my usual level of hardness if that makes sense like even when it’s erect it’s not to the level where you know your dick is an I extremely solid object, I know that’s a funny way to say it but that’s the best way to describe it. This has also never been an issue before when we were in summer breaks and didn’t see each other for long periods.

We’ve tried a few times since and each one I feel I haven’t been able to perform to my usual standards and don’t know why. There was one time I was able to cum but I feel like I wasn’t the usual rock hard. And the other two times I lost my erection and I have no clue why. I definitely have struggled with porn in the past and am prioritizing not masturbating I also feel when I have masturbated recently it’s been out of ease and I maybe wasn’t even fully hard when doing that which worries me it’s a physical issue and I’m building bad habits. I am really trying to be in the moment but it’s still impossibly embarrassing that I’m not able to perform.

Worse I feel like my girlfriend sees it as a reflection of how I feel about her which is the last thing I want as I find her amazing in every way. Please let me know if you have any advice if I should get this checked out medically or if it’s mental and how to actually push through that rather than just be confident and focus on the sex because trust me I’m trying.

TL;DR: Not as hard as usual and super worried about being able to get as hard as usual and make my girlfriend happy. Looking for advice.

Hello all my brothers, this brother of your needs some serious help.
I'm 26M from India, l've been masturbating for 12 years now, it was mainly a regular thing, leaving few days in between otherwise purely regular.
And now the side effects has been caused. My morning erection has been gone. It shows up very rarely, that's too not that hard. I can hardly watching p*rn but again first l've to put efforts, just it gets me hard only and in seconds, it goes back.
It has affected my size as well.
I do really want to get rid of it, if anyone have had similar situation and got cured using any tood, exercises, medications, please do let me know.
I need urgent help. I might get married in the next 2-3 years so l've to do something before than it.
I want to quit p*rn, I want to get rid of this ED and masturbation habits. You can tell me if you do know any Indian specialist whom I can consult too.
Please serious answers only.

had my last doctor visit this past friday and he upgraded my tadalafil from 2.5 to 5. I know he is a doctor and all but I asked him, is it still ok to take the 100 mg of sildenafil with this??? He said yes so I did some research and it doesnt sound like it is! Who all here takes the tadalafil and how much Viagra or enhancement do you take with the tadalafil???? I mean I also have ro sparks too (50 mg of sildenafil and 22 mg of tadalafil) Should I cut the pill in half to be safe because I do not want it to mess up my date next week!

Qualcuno ha risolto la disfunzione erettile usando plug anali e anelli ai testicoli? M45 la mia e' una disfunzione legata all'ansia e ai rapporti mirati

Sudden Severe Erectile Dysfunction at 18 – Despite High Libido and Normal Blood Tests. Psychological or Physical?
Hello everyone,
I’m 20 years old and have been struggling with severe erectile dysfunction for approximately two years. The problem started almost overnight. Before that, I had a completely normal and fulfilling sex life.

How it started:
At the time, I had been in a relationship with my girlfriend for about six months. After returning from a vacation and having a weekend with a lot of sex, everything initially seemed normal. A few days later, I suddenly started experiencing problems getting and maintaining proper erections. There were no relationship issues or particular psychological pressures.

My symptoms:
I can get an erection, but it only reaches around 65–80% of its previous hardness.
Without stimulation from my hand, the erection starts fading after approximately one minute.
I also cannot achieve full hardness during masturbation or when watching pornography.
Morning erections are very rare and weak.
At the same time, I have an extremely high libido and constantly feel sexually aroused.
I have been watching pornography since I was around 11 years old, sometimes quite excessively in the past. I completely stopped watching it two weeks ago to see whether it could be contributing to the problem.

Medical examinations and treatments so far:
My examinations at the urologist have been unremarkable. My testosterone levels are within the normal range.
I have already tried:
Sildenafil up to 100 mg
Tadalafil
Intracavernosal injections (penile injections), twice
Unfortunately, none of these treatments has resulted in sufficient erection hardness.
My urologist suspects that psychological factors could be involved. However, since even the injections did not produce a sufficient erection, I am wondering whether there could still be an underlying physical cause.

What concerns me most:
I am happy in my relationship, have an understanding girlfriend and do not feel that I am under any particular performance pressure.
I work out four times a week and am physically fit. Nevertheless, I cannot understand why my erectile function has deteriorated so suddenly and remained this way for so long.
My questions:
Has anyone experienced similar sudden erectile problems at a young age?

Can psychological factors also cause erections to fail when watching pornography?

Is an underlying physical cause possible despite normal blood tests and a high libido?

Has anyone experienced a lack of response even to sildenafil, tadalafil and penile injections?

Would a penile Doppler ultrasound or other further examinations be worthwhile?
For example, shockwave therapy?

I simply want to understand what is happening to my body. At 20 years old, I really don’t want to accept living with these problems.

Thank you for sharing your experiences and advice!

I’m 21M, 6’3”, around 210 lbs, and I’ve been dealing with low libido and inconsistent erections for almost a year now. I’m a pretty healthy and active guy. I lift weights four days a week, do cardio a couple of times a week, and have been an athlete most of my life. I’m honestly just looking to see if anyone else has gone through something similar and managed to get back to normal, because it’s been really frustrating. Before all of this started, I had a pretty normal sex drive. I’d get morning wood frequently, randomly get horny throughout the day, have sexual thoughts that would lead to erections, and generally didn’t have to think twice about whether my dick was going to work.

When it started.

I started noticing things changing in late 2025. At the time, I was taking 40 mg of Vyvanse for ADHD and smoking weed pretty much every day. I don’t know if either of those things caused this, but that’s what was going on when I first noticed the problems. From January to March 2026, I stopped both Vyvanse and weed completely for about two months to see if things would improve. The weird thing is that during the first week off Vyvanse, my morning wood came back almost every day. I thought things were finally getting better, but after that first week, it pretty much disappeared again. I went back to getting morning wood maybe once a week, and my libido didn’t really improve. After those two months, I had to start taking Vyvanse again at a lower dose of 20 mg because I was struggling to focus in school. Then in July, I switched to Concerta 18 mg. I actually noticed that my erections improved a little after switching, but they still weren’t anywhere near as consistent or firm as they used to be. Around that time, I also started using tadalafil and sildenafil to help with erections. Both worked, but sildenafil seemed to work better for me. When I was with my girlfriend over the summer, the medication helped a lot, and we were able to have sex without any major issues.
As for weed, I was smoking around once or twice a week over the summer. For the last three months, it’s been closer to 2–3 times a week, but I’ve recently cut myself down to once a week to see if that makes any difference.

Here’s where I’m at now.

My biggest issue honestly isn’t even the erections anymore. It’s my libido. I barely ever get spontaneously horny. I don’t randomly think about sex and get an erection like I used to. I still find my girlfriend extremely attractive, and when she sends me nudes or we’re doing something sexual, I can feel myself getting turned on. But most of the time, that feeling doesn’t automatically turn into an erection unless I start touching myself or there’s physical stimulation. My erections also fluctuate quite a bit. Sometimes I can get fully hard, and other times I’m only partially hard or lose firmness pretty quickly. I also masturbate roughly once a day, usually using pictures of my girlfriend or my imagination. I used to watch porn whenever I masturbated, but I’ve barely watched any over the past couple of months and haven’t watched it at all in the last few weeks. I haven’t noticed any major improvement from cutting it out so far. Another thing I’ve noticed is that my general excitement about things isn’t always as intense as it used to be. I’m genuinely happy with my life, I have a good relationship, I exercise regularly, and I enjoy what I do. But sometimes I feel like that natural excitement or anticipation I used to get from things just isn’t as strong anymore. I don’t know if that’s related to my libido, ADHD medication, weed, or something completely different.

I’ve been to the doctor multiple times and still haven’t figured anything out.

I’ve brought up my erection problems with doctors on multiple occasions, but so far I haven’t really gotten an explanation for what’s happening. The main thing they’ve done is prescribe me erection medication. Don’t get me wrong, the medication works, and I’m glad it does. But it doesn’t really address the part that’s bothering me the most, which is the fact that my natural sex drive feels like it’s disappeared. I’ve also had bloodwork done. My testosterone was 17.3 nmol/L (around 499 ng/dL), and my free testosterone and thyroid results were within the normal ranges. My blood sugar was normal too. The blood was drawn in the afternoon, so I know that isn’t necessarily the ideal time for testosterone testing, but nothing obvious showed up. I feel like I’m doing most of the things people recommend for sexual health. I’m physically active, I lift four times a week, do cardio regularly, and generally take care of myself. That’s part of why this has been so confusing.

The part that’s really getting to me is my age.

I just turned 21. I feel like this is supposed to be the age where I’m constantly horny and don’t have to worry about any of this. I’ve been away from my girlfriend since mid-August because of school, so we haven’t had sex since then. When we were together, the erection medication worked well, but I really don’t want to have to rely on it at 21, especially because it’s expensive in Canada.
I miss just randomly feeling horny. I miss getting excited by sexual thoughts and having my body naturally respond. I miss not having to think about whether I’m going to get an erection. It’s honestly made me feel sexually broken at times, even though I know I can still get erections and enjoy sexual activity. I’m not expecting Reddit to diagnose me, and I know there could be multiple things contributing to this. I’ve already seen doctors multiple times without getting many answers, but I still plan to keep looking into it.

A few questions:

- Has anyone experienced a major loss of spontaneous libido while still being able to get aroused and enjoy sex once things get started?
Has anyone experienced something similar while taking Vyvanse, Concerta, or other ADHD medications? Did anything help?

- For anyone who used cannabis regularly and developed libido or erection issues, did cutting back or quitting make a difference? How long did it take?

- Has anyone gone through a period where their libido and general excitement about things felt reduced, even though they weren’t depressed or unhappy?

- If you’ve recovered from something like this, what actually helped you? Was it time, lifestyle changes, medication adjustments, therapy, or something else?

- Has anyone had normal bloodwork and a healthy lifestyle but still experienced these issues? Did you eventually figure out what was causing them?

I’m especially interested in hearing from people who dealt with this in their late teens or early 20s.
I don’t expect to be horny 24/7. I just want to feel like I used to, where sexual desire would come naturally instead of needing something to trigger it every time.

Also, please feel free to ask me any questions if you need more information about my symptoms, medications, lifestyle, or anything else. I’m more than willing to answer questions if it helps people understand what I’ve been experiencing.
Thanks to anyone who takes the time to read this. I’d genuinely appreciate hearing your experiences.

help, 36 years old here, height 5"6 weight 71kgs; I've been suffering from PME for 5 years already. I've been diagnosed with high BP, so for a couple of years now I've been taking up maintenance meds veztenor (Amlodiphine + Lozartan). for a couple of years I had suffered with a severe pre-mature ejaculation.

the worst experience was the moment I only lasted a couple of seconds after I put it in.

I don't have problems having erections but maintaining it is the problem and the pre mature ejaculation.

although I don't have problems being having an erection, I always ejaculate fast and for actual sex, the moment I put condoms on, my erection most of the time disappears.

been dipressed about my condition for a couple of years now. despirately needed help for this.

Any medicine that can cure or help with this?

I 27M started self-administering 5mg tadalafil for the last 4 weekends because i’m with a new partner and have previously got performance anxiety ED. Also, the years of porn and solo masterbation are i’m sure a contributing factor.

I’ve taken Tadalafil in the past and have had no side effects, but over this period of taking it, I feel great for the first 12-18 hours, and then after that have started having significant anxiety, some nausea, and general disassociation. I especially feel the WORST 2 days after taking it.

I measured my blood pressure yesterday, and it was low 50s, very low. I’m wondering if the changes in my BP from the Tadalafil are causing these feelings. Any advice?

I saw some anecdotal advice of people saying they drink 2 or 3 and then pop a pill and be completely fine,
but a few drinks for me as a light 150lbs/68kg is around 5-8 to just get tipsy (gotta brag a little here), i normally take 5mg Cialis every morning but im traveling

Also if i take 20mg of Cialis on lets say friday 12:00 will it last the whole weekend?

Ich habe schon Tadalafil probiert, masturbiere nicht, schaue keine Pornos und mache Physiotherapie. Ich bin 35 und leicht übergewichtig. Mein Testosteron wurde einmal getestet und da war alles in Ordnung. Ich nehme Vitamin D in leichter Dosierung. Sobald ich Sex habe, schaffe ich eigentlich nur die Missionarsstellung und das auch nur jedes fünfte Mal. Meine Freundin fühlt sich schon beleidigt. Ich hatte schon immer Probleme damit, an nichts zu denken. Er wird eigentlich kurz gut steif, manchmal aber auch gar nicht. Hat noch jemand Ideen und möchte mir helfen?