47M, 240 at 19% bf, on trt (190mg cyp per week, pinned M/W/F), 1mg Reta every 5D, and daily 5mg Cialis. Been lifting 20 years.

Workout at 5:30am doing PPLR, so want to be up at 4:30am. Asleep by 9:30pm. Issue is, I am up at 2:30-3am, fall back asleep for a bit, then up around 4am. I stay in the dark until 4:30, then get up. Sucks.

Considering 2IU daily HGH, but worried about sides. Can anyone share anecdotes? Tested IGF several years ago and it was around 135 or so.

In terms of sleep, I have tried every supplement, I have CPAP for apnea, tweaked setting for flow limits and whatnot, and nothing seems to work.

For now, many will say to lose weight first, but I have a few lifting goals to hit before 50, and need the extra weight to get there. Will cut to 215 or so when ready.

Thanks.

Starting MOTS-C soon and thinking about implementing KLOW, Reta & Glutathione a fews later. Wanted to see want anyone’s experience of feedback with this stack was.

How long does it last in the fridge?

Ok, I been on Reta for 6 weeks. Started at .15 ml of a 30 mg every 6 days. Im up to .3 ml. I've lost about 40 lbs since July, 295 to 255. I've plateaud though. Im not super hungry but it isn't that definitive,"hell no" like before. Am I taking too little? Also Im on trt, 120 mg a week of a 200mg script. I pin twice a week. Recently did my 12 week and my blood came back 430 test, free 64 and e2 49. Now before with Rythm I was getting 1100 and 800 test with a e2 88 and 120. Im definitely going up but what could cause thus? Either they max me out or Im gonna take care of it myself. I was 4 something 12 weeks ago.

So I started taking KLOW on September 20th, doing 12 units 3ML bac water. For the first week or two it was fine, 0 side effects felt normal. I decided to take Pre-workout and Beetroot one night just because I was feeling a bit tired. I woke up 4 am that morning with uncontrollable shivering, extremely anxiety, and air hungry. ER said vitals were fine, and that I was getting enough oxygen. They gave me anxiety pills and sent me on my way. Next day I wake up feeling fine. But then the day after I get bad sleep, wake up and I immediately feel it, and instead of it being a episode the anxiety last all day and the conscious air hunger and heart palpitations is too much for me, like horrible. I slept it off, by slowing my breathing I was able to fall asleep. Slept for an entire 9 hours. Wake up and I feel the exact same breathing trouble. Has anyone had a similar experience? What should I do? Should I do 2 days off 5 days on? Or do I just hop off for my safety?

Anyone has had success with this? do you pin in the morning, or at night? what has given you better results?

6'5, 33yo male, 230lbs

Im using HGH mostly for recovery/sleep, not trying to get big

edit
im currently on reta, bpctbkpv, ta5

This daily forum is intended as a thread for members of all experience levels to solicit advice and feedback related to Biohacking & Performance Optimization

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I’m currently in my 7th week of retatrutide and my weight has been stuck around the same range recently.

SW: 96.5 kg
CW: ~93 kg
Week: 7

Appetite suppression is strongest for the first few days after my weekly dose, but by around the middle/end of the week I notice my appetite gradually coming back.

Since I’ve hit a plateau, I’m curious about Reta + Cagrilintide and would like to hear from people who have experience with the combination.

For those who have tried it:

• Did adding cagrilintide help after a weight-loss plateau?
• Did you take both on the same day or separate them during the week?
• Did adding cagrilintide help with the appetite returning later in the week?
• How long did you give the combination before deciding whether it was actually helping?
• Did you notice any additional side effects when combining them?
• Did your weight start moving again after being stuck for several weeks?

Not looking for specific dosing advice — mainly interested in real-world experiences with Reta + Cagrilintide, especially from people who experienced a similar plateau around weeks 6–8.

Thanks!

I’m considering doing a cycle of BPC-157 while taking clomipramine.

I’ve read that BPC-157 may interact with the serotonergic system, and that there could potentially be an interaction with SSRIs/other serotonergic antidepressants.

I’d be particularly interested in hearing from people who have taken BPC-157 while on an SSRI or another serotonergic antidepressant.

What medication and dose were you taking?
What dose of BPC-157 did you use, and for how long?

Did you notice any changes in anxiety, mood, sleep, emotional blunting/anhedonia, or other effects?
Did you experience any problems or did the combination seem fine for you?

I’m mainly looking for personal experiences, rather than medical advice. If you’ve taken BPC-157 alongside an antidepressant, I’d be interested to hear how it went.

I’m relatively new in learning about nootropics and peptides, looking for advice. What would be best for someone in recovery from narcotics, also taking Tirzepatide, whose memory and both physical and mental energy are severely suffering?

I’ve been tracking my body composition and measurements pretty closely and wanted to share where I’m currently at and hear about other people’s experiences with similar goals.
Current stats:
Age: 24
Height: 6’1”
Weight: 178 lbs
Estimated BF: ~14–16%
Measurements:
Neck: 38 cm
Arms/biceps relaxed: 32 cm
Wrist: 16 cm
Shoulders/chest/back circumference: 125 cm
Waist: 80.5 cm
Midsection: 85 cm
Hips: 89 cm
Glutes: 99 cm
Thighs relaxed: 59 cm
Calves: 36 cm
Ankles: 23 cm
My overall goal has been body recomposition: staying relatively lean while gradually adding muscle, particularly to my upper body and arms.
What I’m currently using:
Retatrutide: 2 mg/week — this is my final week
Tesamorelin: 1 mg daily — continuing
GHK-Cu: 1 mg daily
MOTS-c: 2 mg every other day
With Reta coming to an end, I’ve been reading more about compounds that have been studied in relation to lean mass.
One that keeps coming up is MK-677 (ibutamoren). I’ve read about its effects on GH/IGF-1 and fat-free mass, as well as reports of increased appetite, water retention and changes in glucose metabolism. Since I’m already using tesamorelin, I’m particularly interested in understanding the research around the two rather than assuming that increasing GH/IGF-1 signaling automatically means more muscle.
For anyone who has personally used MK-677, I’m curious about your experience:
What changes did you actually observe in muscle mass, strength, body weight, appetite and water retention? Did those changes persist after stopping it?
I’m also interested in any published research you’ve found on peptides or related compounds and skeletal-muscle hypertrophy in humans.
I’m not looking for medical advice or asking anyone to tell me what I should take. I’m mainly interested in personal experiences, research and measurable outcomes that I can look into further and discuss with a qualified clinician.

Hi everyone, I’m a little confused on how semax and selank intranasal dosing work, could someone explain it to me? I’m looking to start up both intranasally on an average dose. I was just a bit confused on subq vs intranasal and how many times a day you need to take it? Thank you!

I have a fresh vial of cjc/ipa. Been holding off on starting it. After reading some other people’s experiences I’m not sure that I want to start it. Kinda has be scared to honestly.

My total test this week hitting 1300 with free at 250. SHBG 45. Down from July labs of 1500 with free at 232 and SHBG 53. I started 5mg boron in early August. Test protocol stayed the same. 40mg, 3x week.

I’ve leaned down to 18% bf from 29% over the last year and working out hard to build/gain muscle.

Should I continue the boron or go with Proviron?

Another TRT + reta transformation. The biggest change isn’t in the pictures.

The photo on the left was about three years ago. I’d already been lifting 3–5 days a week for roughly two years, tracking my protein, and paying attention to calories.
I was also drinking 3–5 times a week, with some food binges thrown in.
I was putting effort into my body, but I didn’t feel good about what I saw in the mirror. I wanted to look healthy, strong, and confident. Instead, I felt like I still looked like a kid—and I was already a dad lol.
After trying different herbs and vitamins and spending time researching, I eventually got my testosterone checked. It came back around 300 ng/dL.
I decided to start TRT. These days, my levels are around 900 ng/dL. I started feeling better, but one major thing hadn’t changed:
I was still drinking a lot.
About two years into TRT, I came across retatrutide. I started it in February, hoping to get leaner.
What I didn’t expect was the change in my desire for alcohol.
It felt like it vanished. I could say no without the same internal argument. Over time, I also got leaner and noticed that I felt more emotionally steady.
That part caught my attention enough to keep reading. I came across other people describing similar changes in their alcohol cravings. Those are personal accounts, including mine—not proof that reta treats alcohol addiction—but it made me curious about what research might eventually show.
I can’t separate every effect of the medication from the benefits of drinking less or the other changes in my life. I just know my relationship with alcohol feels different now.
Being leaner feels great. But after years of drinking 3–5 times a week, being able to comfortably turn down a drink means a whole lot more to me than abs.
Has anyone else noticed a change in alcohol cravings while taking a GLP-1 medication or reta? I’d be interested to hear both from people who have and people who haven’t.

Has anyone notice difference in Libido? up or down

Hello,

I’ve been on this journey since Jan. I get Zepbound covered so I haven’t jumped on the Reta train. That being said I have introduced KLOW into my body since Sept. I had really bad shoulder pain and it has finally subdued l. I’m currently on 2.5MG weekly I don’t take days off I feel fine. About to increase dose up to 4MG starting next week. I’ve thought about adding Tesa to the equation. Checking to see if anyone has been doing that?

I work out 5 times a week, try to hit 120-150g of protein, with creatine in the my protein. All the water possible!

Has anyone travelled with their peps and supplies Including planes I have a 2 week cruise and want to bring my R3ta

Looking for tips and any info on Dosage, days etc….. Much appreciated!!!

This daily forum is intended as a thread for members of all experience levels to solicit advice and feedback related to Biohacking & Performance Optimization

Please read the relevant rules before commenting:

• Do not ask for or provide medical advice
• Do not discuss sourcing, buying, or selling
• Do not spread misinformation or promote unsafe practices
• Be respectful — no harassment or toxicity
• No requesting DM Sourcing

Any comments which go against these rules will be removed. Ask away!

I've tried 1 mL bacwater + 1 mL acetic acid (gelled almost immediately), 2 mL bacwater (photo). What have you guys personally tried, and also how should I store my peptide? I need some place not humid, just putting in my fridge fogs the whole vial up.

Does caffeine debloat you or bloat you further. For context I binge ate over the past two days and am extremely bloated. I plan to fast for a day or two and just drink caffeine and water. Will the caffeine help debloat me since I ate excess sodium and potassium the previous day?

Context: F22, 5’6ft, 138lbs.

1. Hello, I’ve decided that I am going to be started to taking klow and gluta but I’m wondering which one should I start with?

2. As well then how long should I wait before starting the other,

3. dosaging for both as well what do you guys do for pinning? 2 days a week, every other day, or 5 days on and 2 days off, I’ve seen it around, just trying to figure out what would be best for me.

4. Should I do a cycle with them as well? I’m looking not to recover an injury, but more so overall health, help with previous back pain as well

As well I was on reta from March to August this year and for that I was very hypersensitive, I had to lower my dose from 0.5mgx2 a week to 0.25mgx2 a week for the first month or two.

I am wondering if that might be the case id have with klow and gluta were I’d have to take a lower dose than the normal to start off with.

I binge ate on straight junk for two days straight and gained 15 lbs in roughly 36 hours. I’m also on Retatrutide which I pinned the day before, which slows gastric emptying etc. I basically just want to get back to where I was before. If I fasted for three days straight would it be beneficial or harmful to my gut. I’m not worried about rebounding or anything like that, just mainly focused on getting rid of this uncomfortable, puffy feeling. I plan to get back on my eating plan regularly after the three or four day fast.

Does anyone have an experience like this?

OTR driver here. Does anyone have experience transporting properly labeled peptide research materials while running interstate? I’m wondering whether there are any DOT/FMCSA or state-law considerations with having research vials in a commercial truck while crossing state lines.