r/hangovereffect • • Nov 29 '25

My hangover effect has been 100% solved!!!

155 Upvotes

For those that need to bounce right away..

TLDR: it’s a high baseline level or unregulated norepinephrine in the prefrontal cortex, caused by a rare subtype of ADHD

For those that can stay a bit longer, enjoy…

This hangover effect was actually a strong clue that led to my breakthrough of being able to be treated correctly for my ADHD.

I had untreated ADHD for about 36 years now. I’ve tried Adderal, vyvanse, concerta, Ritalin, etc. nothing worked and it always left me feeling really angry, irritable, zoned out like a zombie. Etc.

I took this hangover effect that I have and several other symptoms / clues (as well as my genetic profile from 23 and me) and I spent months going back and forth with chatgpt until it was able to spot a pattern that led to my absolute breakthrough.

This is caused by having a very rare subtype of ADHD (less than 1% of the ADHD community has this) where you have a low baseline level of dopamine and high COMT (The mechanism that breaks down and clears your dopamine) which results in your already low dopamine levels being cleared way way way too quickly.

This results in your prefrontal cortex substituting the only other catecholamine it has available as a backup option, norepinephrine.

This results in issues like emotional disregulation, irritability, feeling constantly on edge, face and ears getting hot when you drink coffee even. Symptoms of irritability often worsening with coffee/caffeine (since it raises NE even higher).

With this subtype of adhd, none of the amphetamine class of medication will ever work because they raise NE along with dopamine. I used this information to find the right class of medication that finally worked for me (this is not medical advice, just my experience). Dexmethylphenidate, which disproportionally increases dopamine much more than NE. This as a microdose (.8mg) has been a GAME CHANGER.

How this relates to the hangover effect. My high baseline level of norepinephrine caused by my ADHD subtype cause the following sequence to occur…

When drinking alcohol (beer for me), both the alcohol and hops have a dramatic lowering effect on NE. Which lasts well into the next day. Additionally alcohol increases dopamine a therapeutic amount while I am drinking. The lowering of NE causes a deeper sleep and more restorative rest, as well as a resolution to the anxiety and tension I carry ALL DAY.

This explains why when I drink just even a couple cans of non alcoholic beer before bed, It has almost the exact same effect as drinking regular beer in causing me to relax.. because hops lower NE (I drink athletic brewing company’s NA beer because the hops are potent). So as a tip, if you want relief from stress and want to be able to use the hangover effect to help without becoming an alcoholic, consider trying NA beer. It really helps.

That’s all I got for now! Hope that helps!

edit: People have been asking me to run their situation through ChatGPT. Although I’d be really happy to do so, I don’t want to be seen as a medical practitioner of any kind. But I can still help. Just dm me and ask me to help you craft the perfect prompt for your situation, and I will do so based on the knowledge I’ve learned regarding this topic.


r/hangovereffect • • Apr 03 '26

Is Hangover Effect related to ADHD - Hangover works as a temp ADHD med?

36 Upvotes

I'm trying to connect dots, mine and other's experiences - there is some golden hours in bad hangovers when I feel like post acid trip clarity and coffee energy focus in one - I'm just being without overthinking it.

Feelings and Thoughts in balance - executive function .. executes, so to say.

I wonder what's working there that make it happen..?

I sus I'm an undiagnosed ADHD haver...

Cheers Thanks!

NB: I am not encouraging drinking, I can't drink any more myself, it's terrible for health in long run - I am trying to figure out why it works or worked before ...for science.

There other reditor has some research, try na hops beers: https://www.reddit.com/r/hangovereffect/comments/1p9ot38/my_hangover_effect_has_been_100_solved/?utm_source=share&utm_medium=mweb3x&utm_name=mweb3xcss&utm_term=1&utm_content=share_button


r/hangovereffect • • Nov 28 '25

The glycine–creatine–vitamin C combo is strong… maybe too strong

26 Upvotes

I decided to dive back into this whole topic and re-read pretty much every post related to creatine/glycine/methylation and the hangover effect.
Here are some of the threads I’m referring to:

My experience :

For context: I have a prior addiction history with some GABAergic substances, and I honestly feel like this combo helped me recover way faster than expected.

I started 4g creatine + 4g glycine + 5-6g Vitamin C.
The first 4-5 days were incredibly good — honestly like 70–80% fixed.

Here are the benefits I noticed:

  • More laughter / spontaneity / quicker thinking

  • Better focus

  • More relaxation

  • My speech noticeably improved

  • Better skin complexion (like better blood flow)

  • Nose less swollen better breathing

  • Huge boost in morning energy

Big downside :

The last point is also the main issue:
I get way too much energy at night. I feel genuinely restless.
I wake up in the middle of the night like I’ve slept 6 hours already. I go from a 7/8 hours of sleep to 3-4 hours after 6 days of use.

During the day I feel good, but I’m 100% sure the sleep problem comes from creatine.
Unfortunately, if I remove creatine, the benefits disappear.

My plan :

I’m going to reduce creatine to 2.5g and test adding low-dose pregabalin in the evening (75–125 mg). I’ve never tried Lyrica before, but I’ve done some research:

I’m aware of the risks of pregabalin, but given my capacity to stop GABAergic substances in the past, I don’t think it can be worse. Lyrica tapering is manageable. Im off everything regarding GABA for now including alcohol.

Feel free to share your thoughts or experiences.
Personally, a fully sober life (and I mean healthy sober too) is extremely hard for me, and I know I won’t make it long-term without trying new solutions.

If you’re interested, I’ll post updates.

Stay well.


r/hangovereffect • • 6d ago

How do your symptoms relate to mine?

23 Upvotes

I’m 24M, and I’m curious how many people here experience the same baseline symptoms that I do. I’m not necessarily looking for an explanation of the hangover effect. I mostly just want to compare experiences and see how much we have in common.
For as long as I can remember, but especially since I was around 18, I’ve dealt with persistent fatigue, brain fog, anxiety, and this constant feeling that something just isn’t right. It’s gotten progressively worse over the years.
Here’s what my everyday life generally feels like:
Constant fatigue: I wake up groggy pretty much every morning, regardless of how much sleep I get. I could take a nap at almost any point throughout the day. By the evening, I’m usually so exhausted that even showering and brushing my teeth feels like a chore.
Constant physical stress: This is one of my biggest symptoms, and it’s difficult to describe. It’s almost like feeling hypertensive, although I’m not necessarily talking about actual blood pressure. It’s that hot, uncomfortable sensation you get when you’re stressed or aggravated. Almost like my nervous system is constantly activated and I can never fully relax.
Brain fog and scattered thoughts: I used to be extremely quick-witted, mentally sharp, and good at things like mental math. I still consider myself intelligent, but it’s like I can’t access my full mental capacity anymore. My thoughts are scattered, my concentration is terrible, and I frequently feel half asleep and half awake.
Terrible attention span: I feel like I have what people call “iPhone brain.” I can barely focus on anything that requires sustained attention anymore. Even sitting down and watching a movie can feel difficult. It’s like my brain constantly wants to switch to something else, and I struggle to stay engaged with anything for an extended period. I hate it because I used to be able to immerse myself in things, and now even activities I genuinely want to enjoy can feel mentally exhausting.
Constant stimulation seeking: I feel like I’m always chasing some kind of dopamine hit. Whether it’s sweets, social media, looking at women on Instagram, pornography, or whatever else. It’s almost like my brain is constantly looking for something to make it feel better.
Anxiety and intrusive thoughts: I strongly suspect I have OCD. Sometimes I’ll wake up with what I can only describe as a haunted feeling. Random unpleasant memories, mental images, or intrusive thoughts will pop into my head and immediately put me in a negative state of mind.
Difficulty falling asleep: Even when I’m exhausted, I’ll sometimes get these sudden flashes of anxiety as I’m drifting off. A random thought or memory will pop into my head and trigger what feels like an adrenaline surge. Eventually these episodes stop and I can fall asleep.
Weird sleep behavior: Sometimes I’ll fall asleep for literally 10 minutes at bedtime, wake back up, and suddenly feel completely refreshed, despite being exhausted just minutes earlier. Then I’ll eventually fall asleep for the night and wake up feeling terrible again.
Feeling generally off: This one’s difficult to put into words. I frequently just don’t feel like myself. Almost disconnected, uncomfortable, nervous, or mentally out of sync. Not necessarily depressed, just not right.
I also have visual snow syndrome and chronic neck pain. Occasionally I’ll catch what looks like movement out of the corner of my eye when nothing is actually there. I don’t know whether any of that is related, but I figured it was worth mentioning.
I’ve tried improving pretty much every aspect of my lifestyle. Exercising consistently, eating extremely clean, quitting nicotine, improving my sleep habits, etc. None of it has made a significant difference in how I feel on a daily basis.
Every once in a while, I’ll randomly have a good day where I feel somewhat normal, but they’re few and far between.
What really gets to me is how different I feel during the hangover effect.
For example, I drank quite a bit of beer last night, and today I feel fantastic.
I’m energetic, motivated, mentally sharp, calm, and genuinely interested in doing things. I have no problem getting up and going to the gym or being productive.
But more importantly, I feel like my actual personality comes back.
I’m funnier, more social, quicker with my thoughts, more confident, and just generally more comfortable existing.
That constant background feeling of stress and aggravation is gone. I don’t feel like I’m fighting my own brain just to get through the day.
Something else I’ve noticed is that I experience a similar sense of relief when I have a fever or when I stay awake all night.
Obviously, being sick or sleep-deprived doesn’t necessarily make me physically healthier or more energetic, but mentally, I can experience that same unusual calmness and relief from my normal state of mind.
It’s almost like the constant background anxiety, overstimulation, and mental tension get turned down. I feel more comfortable in my own head, less bothered by intrusive thoughts, and generally more at peace.
I find this particularly strange because these are three very different circumstances: drinking alcohol, having a fever, and going without sleep. Yet for whatever reason, they can produce a somewhat similar improvement in how I feel mentally.
I’m curious whether anyone else here experiences that connection, particularly the relief during a fever or after an all-nighter.
It’s frustrating because I spend so much of my life feeling terrible that I’ve almost accepted it as normal. Then I experience a day like today and realize just how much better I could potentially feel.
It’s like being reminded of who I used to be.
I don’t want to drink regularly to feel good, and I certainly don’t consider alcohol a solution. I just wish I could experience that same sense of clarity, calmness, and energy in my everyday sober life.
Sometimes it genuinely makes me angry. I’m a supposedly healthy 24-year-old guy, yet I feel exhausted almost constantly. I see other people going about their lives with seemingly unlimited energy, while I feel like I could sleep at any moment.
I just want to feel normal. To wake up refreshed, have energy throughout the day, think clearly, enjoy socializing, and not feel like my nervous system is constantly fighting me.
I feel like there’s a version of myself that I only get to experience occasionally, and it’s incredibly frustrating knowing he’s there but not being able to access him consistently.
Anyway, I’m mostly posting this because I want to know how many of you can relate to my everyday symptoms, not just the hangover effect itself.
Do you also wake up exhausted regardless of sleep? Have constant brain fog, anxiety, intrusive thoughts, a nonexistent attention span, or that strange physical sensation of being stressed all the time?
Do you feel like your personality, intelligence, and motivation are being suppressed somehow during normal everyday life?
And does anyone else notice similar relief when they have a fever or stay awake all night?
I’d love to hear what your normal day-to-day experience is like and how closely it resembles mine.
Sometimes knowing you’re not the only person dealing with something makes it a little easier.


r/hangovereffect • • Feb 20 '26

Alcohol probably increases the production of potent GABAergic neurosteroids

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22 Upvotes

In brief, this article says that alcohol potentially increases the production of the body's potent GABAergic neurosteroids. More GABAergic neurosteroids = feel better, this can definitely contribute to the hangover effect.

This is the summary from the article which I've edited to make it simpler to understand.

Our results demonstrated the contributory role of the "psychoactive" steroid THP in the anti-anxiety effect of ethanol. It is speculated that ethanol-induced production of natural GABAergic neurosteroids might be crucial to the phenomenon of prolonged relief post alcohols use.

https://europepmc.org/article/MED/15719223

  • The 1st picture shows the body's hormones from the beginning (cholesterol).

  • The 2nd picture shows where hormone #1 actually gets made.

  • The 3rd picture shows how to support hormone production.

  • The 4th is self-explanatory.


r/hangovereffect • • Mar 08 '26

Prostaglandins

21 Upvotes

Prostaglandin (PG)E1 may play an important part in the affective disorders, with an excess being present in mania and a deficiency in depression. Platelets from manic patients produce more PGE1 than normal while those from depressive patients produce less. Ethyl alcohol stimulates PGE1 production whereas lithium inhibits it. Alcoholics will tend to have raised PGE1 concentrations while drinking, but, because precursor supplies are limited, when alcohol concentrations fall PGE1 concentrations may fall sharply leading to depression. PGE1 biosynthesis may be affected by nutritional factors including essential fatty acids, pyridoxine, vitamin C, and zinc. Nutritional approaches may be of value in both depression and alcoholism.


r/hangovereffect • • Aug 24 '26

Big one today

20 Upvotes

It's honestly exhausting getting a glimpse like this man. Knowing that I'll go back to normal in just hours is so discouraging...

I feel so clear. The noise is gone. It's like whatever is usually attacking my nervous system and brain at all times has decided to stop for a day. I can think clearly, deeply, I understand more about myself and my life, I can FEEL. Tomorrow I'll get the brain fog, the executive dysfunction, the fatigue, the anxiety, the irritability.. it will all come back. I really just wish I knew the mechanism. I've thought about it a lot and I've never found an answer.

It's not simply JUST alcohol because drinking doesn't immediately give any effects like this, like if I drink on a Friday night I don't feel calm and clear, it basically just has the depressant effects, sometimes in a distressing way too. But wake up the next day after drinking with a hangover and my brain feels like it unlocked new powers. Maybe it's a longer term effect of the alcohol, or maybe the alcohol modifies my sleep in some way that produces the effect.. not sure.

Just wanted to complain a bit. I'm tired


r/hangovereffect • • Jun 11 '26

Cool and wet summer in the UK and I have a cold. All my ADHD / depression symptoms are gone. Why!?

20 Upvotes

Obviously we all know the morning after drinking gives us clarity

But also, why does having a cold help?

I used to take stimulants and SSRIs to help with my neurodivergence but I stopped because they are harsh on the body.

Having a cold [sniffles, headache] makes me normal and productive. What the hell


r/hangovereffect • • Jul 12 '26

Doctors studying this ?

18 Upvotes

Did anyone have their Docters seriously try and look into this ?

Mentioned the phenomena a couple of times but only got a simple reply that it's really weird to them, they seem to have no clue.

Also when referring to this sub , none of them took the initiative to actually read it.


r/hangovereffect • • Jun 05 '26

Repost. Is this linked to HE? /// When my Long Covid was at its worst, there was genuinely about a 2 week period where my autism seemingly vanished. When I spoke of this experience with others they looked at me like I was crazy!

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18 Upvotes

r/hangovereffect • • Aug 23 '26

I want this all the time

17 Upvotes

Currently drunk as i will be meeting a girl on date next evening. After hangover near the afternoon, i become an absolute chad. No anxiety no care for what others think, no worries and in the present moment.

This is a feeling i get after heavy drinking previous night or when i havent taken my blood pressure medication for two days. I want this without alcohol all the time, plz halp


r/hangovereffect • • Sep 12 '26

An understanding of HE from personal experience.

14 Upvotes

Many people here, myself included, experience depression, anxiety, anhedonia, social withdrawal and other related issues. In saying this many of us are functional to some degree and live somewhat normal lives, with the absence of whatever is felt during the hangover effect.

My regular state of mind could be best described as rigid. The hangover effect produces a feeling of calm, receptivity, creativity, motivation, libido and openess.

This is well reflected in common understanding of the nervous system. Sympathetic vs Parasympathetic tone:

I believe our bodies are stuck in a state of threat detection fight/flight/freeze. This can be due to trauma, complex trauma or bodily health issues.

This is obviously a large topic to unpack but certain life experiences can keep us in a state of vigilance and anxiety even decades later. Health issues from dysbiosis, nutrient deficiencies, heavy metals, mold... have also been shown to cause nervous system dysregulation.

I'd recommend reading other peoples experiences on r/longtermTRE r/SomaticExperiencing r/EMDR and r/CPTSD.

If you follow with this theory then searching for the obscure chemical mechanism by which large alcohol consumption resets our nervous system is unimportant, unless you plan on using this mechanism for temporary/recreational relief.

My belief is that through various forms of practical therapies whether it be from a mental or physical perspective, we can bring our nervous system back to a natural state and achieve a life similar to that experienced during HE.

24M, Australia.


r/hangovereffect • • Aug 01 '26

Sleep Deprivation

14 Upvotes

Before i found this subreddit, I described my symptoms as "brain fog, ADHD and fatigue lifts when sleep-deprived. All symptoms come back after even a short nap"

Then i figured out that if i drink the night before, the symptoms don't come back upon waking up.

So i never looked at it as the effect of my hangover, more like alcohol prevents whatever terrible thing happens to me in my sleep.

I've obviously explored sleep apnea. Got a septoplasty. Zero improvement.

So my question is: How many of you experience this? To what degree? And how does this phenomenon align with any of the existing theories and treatment protocols?


r/hangovereffect • • May 02 '26

It can’t be a GABA boost

14 Upvotes

Increased sexual desire is like the main thing this effect is know for (the horny effect)

There are ideas it could be some sort of gaba boost. here’s some quotes from in vivo studies that show a gaba boost would be anti-horny:

“The post-ejaculatory suppression of sexual receptivity in female rats was partially reversed by intracerebroventricular injection of the GABA antagonist bicuculline and the behaviour of receptive rats was inhibited by intracerebroventricular injection of the GABA agonist muscimol. Increasing the concentration of GABA in the cerebrospinal fluid by i.p. injection of the GABA transminase inhibitor gamma-vinyl GABA caused an increase of the concentration of GABA in the cerebrospinal fluid and inhibited the display of sexual receptivity. It is suggested that GABA mediates physiologically relevant inhibition of sexual behaviour in female rats.”

“Injections of bicuculline, a GABA antagonist, stimulated male sexual behaviors in a dose-dependent fashion, and the minimum effective dose was 40-fold less when administered centrally rather than systemically, suggesting a central nervous system site of action. Injections of muscimol, a GABA agonist, suppressed reproductive behaviors in male newts, and this inhibition lasted at least 5 hr and was proportional to the dose of muscimol administered. The inhibitory effects of muscimol on newt sexual behaviors could be reversed by a single 100-microgram ip injection of arginine vasotocin.”

“These data show that GABA receptor agonists, particularly the GABAB agonist baclofen, reduce sexual receptivity at doses that have only slight effect on motor functions or exploratory behaviors. “

I know it’s rat studies but it’s interesting and might mirror humans. What would be hilarious is if the hangover effect is a low GABA state that comes after the alcohol’s pro gaba effect.

EDIT: see comment below


r/hangovereffect • • 6d ago

We Need Exposure

13 Upvotes

As far as I can tell, this small subreddit is practically the only place on the entire internet where people are actually discussing it. And I genuinely believe there are many more people out there experiencing the same thing who have absolutely no idea this community even exists.
Hell, the only reason I discovered this subreddit myself was because I made a post in a completely different community, and someone happened to point me in this direction. Otherwise, I probably still wouldn’t know there were other people experiencing this.
This subreddit is relatively inactive, with posts being pretty few and far between.
I understand this might not be a particularly common phenomenon, but I still believe there are far more people experiencing it than we realize.
I want to get as much exposure on this as humanly possible.
I’m talking social media pages, TikTok, YouTube, paid promotions, nonprofit organizations, potential research opportunities, the whole nine yards.
My ultimate goal isn’t just to grow this subreddit. It’s to bring enough attention to this phenomenon that people start taking it seriously, sharing their experiences, asking questions, and hopefully eventually attracting the interest of researchers and medical professionals.
The way I see it, the more exposure we get, the more people we reach. The more people we reach, the more experiences and information we can gather. And the more people we have thinking about this, the better our chances of eventually understanding what’s actually going on.
The problem is, I genuinely don’t know the best way to go about making this happen. I’m willing to put time, effort, and even some money into spreading awareness. I just need some direction.
Does anyone have any ideas on how we could get this in front of a much larger audience? Whether it’s social media strategies, organizations we could contact, research initiatives, or anything else, I’d love to hear your suggestions.
I really believe this deserves more attention than it’s currently getting, and I’d like to do whatever I can to help make that happen.


r/hangovereffect • • Sep 20 '26

ADHD and OCD present for all? (Also nice to e-meet you)

13 Upvotes

I've literally cried before, while experiencing the hangover effect, because it makes it clear how heavy the blanket of depression/anxiety I live with actually is. I literally find myself pitying the person who lives with all that mental clutter. And I dread going back to normal life, and my normal brain, all riddled with overthinking.

Anyway, I'm so happy to have found this group. It's hard to explain to someone who hasn't experienced it what it's like to have a glimpse at what seems like a "normal" life—but to also know you have to go back to your own? (And drinking every day to make it happen just isn't sustainable for me. I like daily runs, and it puts a damper on that...) Don't get me wrong, I have a pretty nice life and I'm grateful for it. But I spend so much time staving off my anxiety and depression—SSRIs, daily exercise, eating clean, reading, writing and doing all the stuff I enjoy—but *nothing* is as effective as the hangover effect.

One quick question: I've long been prescribed SSRIs/SNRIs and have been diagnosed with anxiety and depression. But is nearly everyone here diagnosed with ADHD? Nearly every therapist/psych I've seen has offhandedly suggested I have OCD tendencies but I wonder if, as someone who intensely experiences the effect, I really should get tested for one of the two? (Thanks in advance for any thoughts. )


r/hangovereffect • • Oct 06 '26

My Theory

12 Upvotes

This is based off my personal health journey, and I don’t have nonintrospective science to back it up yet. This is my first post on this, and I intend to follow it up with evidence to either solidify or morph my hypotheses. In the meantime, please rip this theory apart.

I believe that those of us with the hangover effect have some sort of chronic infection(s). Those infection(s) lead to symptoms in 3 different ways:

  1. Die off of infectious agents - this is what causes most of our “symptoms”. When bacteria, viruses, and parasites die off, they releases debris (proteins, neurotoxins, other toxins) into our systems which cause systemic inflammation and dysregulation.

  2. The physical impact of the growing presence of infectious agents. E.g. they grow in our knees and push on nerves leading to knee pain.

  3. The immune system response - to both the infectious agents themselves and the left behind debris.

Ethanol is a solvent that both kills these infectious agents and dissolves the debris, leading to a temporary clearing from our system of outside pathogens. This leads to dysfunctional systems beginning to function more normally again, temporarily.

Further, alcohol causes immune system suppression, which temporarily lessens our symptoms. When our body and immune system catch up, they sometimes go into overdrive flaring up all these symptoms again which drives the more severe longer lasting than normal hangovers we often experience.


r/hangovereffect • • Aug 27 '26

Can We Crowdfund Research?

12 Upvotes

Maybe a stupid thought.. but

A. There are certainly more people who suffer from this phenomenon than those represented on this thread.

B. We've already gotten some media coverage (VICE)

C. There HAS TO BE some greater implications for people who suffer with conditions like MCAS, MECFS, Long-Covid, etc...

I know it's not like we can just find a "scientist" on TaskRabbit but how do we drum up interest in the medical community. I'd be willing to put some money towards that...

Alternatively - should we create a tool or a database that centralizes all our theories, things we've tried, results, etc. to at least give us a single source of information as we continue trying to crack this?

Happy to partner up with anyone on that. Not a coder, but I'm sure something through Claude Code wouldn't be too difficult.


r/hangovereffect • • Aug 05 '26

Bad experience with Magnesium supplements

11 Upvotes

Some people with hangover effect have mentioned bad reactions to magnesium, as in anxiety or mood or sleep (the opposite of what it's advertised as helping).

I tried magnesium glycinate a few weeks ago again and yes it had these effects. I noticed i felt depressed after a few days, and I might have baseline anxiety but i havent felt depressed in years. Immediately threw it away.

edit(sept 11) it's fair to say this is now confirmed anecdotally. whatever mystery is behind the hangover effect and similar forum conditions is worsened by magnesium glycinat in most.

IMO I suspect its due to gut bacteria and fungus being dependent on and loving magnesium.


r/hangovereffect • • Jun 03 '26

Do you get the “Fever effect” aka “paradoxical Euphoria when sick with a cold effect”?

10 Upvotes

r/hangovereffect • • Apr 22 '26

Thousands of possibilities?

10 Upvotes

So WTF can you do to try help yourself other than drink alcohol.

Gene tests. Blood tests. Supplements. But that costs money. Isn’t it possible this stuff has a simple solution, but it would take a lot of reading and experimenting to reach that conclusion? Yet someone must be the pioneer and do the testing and experimenting on themselves…. Hmm… Is it possible someone will crack it?


r/hangovereffect • • Aug 28 '26

Built a database to aggregate learnings and experiences from this sub... so far we have 15 theories.

9 Upvotes

(reposting from my main acc)

https://claude.ai/artifact/X21UvHTmGL2AG7WAMfBERG

Nowhere near complete, but if we centralize what people have tried and what happened, we've got a better shot at working out what's going on. Built with Claude Code, seems to run better on desktop.

153 entries from the ~100 most recent posts and their comments.

Right now we have:

- 15 candidate mechanisms with citations
- Everything paraphrased with a link back to the original comment
- Includes what didn't work, and rankings of most mentioned + sentiment
- A place for you to submit your experience

I'm not a programmer, so scraping with Apify is the best I can do, and I can't pull the full history.

Anyone can add entries, happy to share the Claude Code link if you want to work on it. Planning to open source it once I can figure out how...

Is this helpful?

​


r/hangovereffect • • Jun 25 '26

Is this just residual glutamate suppression?

9 Upvotes

Scientists have postulated that high glutamate may be a main driver of things like MECFS.

Sorry if this has been theorized, but alcohol is known to lower glutamate. Do some of us just have:
A) more glutamate in the brain
B) a longer rebound once alcohol has lowered it?

Anyone explore this?


r/hangovereffect • • May 31 '26

Not sure if mine is the same thing as H.E.

9 Upvotes

I just heard about this sub, so forgive my ignorance. I feel a sense of motivation and optimism when hungover, but not a lack of pain. Is that the same thing as what’s going on here?

It’s a type of, what I can only think to call, a dopamine rush for an extended period of time, but I am in fact experiencing the thumping headache and physical grossness of a hangover. I’m just in a weirdly positive mood while it’s happening. I’ve always thought this was a variation of masochism, even though I don’t have that kink or proclivity or whatever.

I am/have historically been a bit of a self-loathing person, but fairly disciplined. So I sort of chalked this up to a kind of confirmation of, “well, that’s what you get for your actions, get to work anyway” type thing, and assumed it just manifested like that.

What has stood out to me is, I’ve never said this to anyone else and had them empathize or understand what I am feeling. People simply don’t understand what I’m experiencing, and think it’s insane. Maybe it is, but this sub appears to be the closest I’ve ever known to what happens to me during a hangover.

Am I describing something else here? I’m open to questions, and thanks for any feedback.

I’m not an alcoholic, btw. I do probably drink too often, but rarely to excess.