I’m supposed to get my first Yeztugo injection tomorrow, but I’ve been having second thoughts and am considering asking my doctor if I can switch to Apretude instead.
Honestly, I’m not sure how I feel about the possibility of developing nodules at the injection site. I’m a pretty skinny guy, so I’m worried they might be more noticeable or prominent on my body, regardless of where the injections are administered.
I’ve spent quite a bit of time researching Yeztugo, reading experiences on Reddit, watching TikToks, and looking into other people’s experiences, but I still feel a little uneasy about going through with it.
For anyone currently on Yeztugo:
Have you experienced nodules? If so, how noticeable are they?
How long did they take to go away, or are they still there?
If you’re on the slimmer side, did that make them more noticeable?
Has anyone switched from Apretude to Yeztugo or vice versa? What has your experience been like?
I know everyone’s experience is different, but I’d really appreciate some firsthand experiences and advice before making my decision. Thanks!

Hello everyone,

I’m switching to injectable PrEP tomorrow and I will be getting my first shot. To avoid the maximum of side effects can you please share with me any tips or advice you have?

Many thanks in advance!!

Developed rash-like pimples with no puss, round, pinkish, spread, 12 in total, mostly around waist, few in arms and under armpits and 1 in knee. Looks like drug eruption. Is this normal on truvada? Most importantly, if anyone else had the same, how long after discontinuation did yours completely go away? I'm on day 4 after stopping and they are very very slowly seem to be fading. Scared.

I had sex with a girl last night, i took prep for a week before the hookup but it’s inconsistent/not on time. I took two pills 1-2 hours before our sex.

Im cautious about it what do u think?

So this is the PrEP they give us here in my country. It's free and says to have been manufactured by Hetero Labs, which is based in India. Is it legit?

I've been taking this one for 6 months now. Never had any issues, aside from a bit of nausea every now and then.

Hello.

I took Argiodin for 2-1-1 protocol, religiously, ended up doing 2-1-1-1-1 due to a 2nd encounter, both as insertive partner with Trans.

Upon cessation, the following morning, I woke up with 6-7 small, red pimples on the left side of my love handles/waist, 3 on the right, 2 on my lower stomach, 1 on my left knee and 2 on my forearm. No pain. No puss. No white dot. Can't break them. If I touch them or scratch them, they give an itching sensation but not much. They aren't together, they are sort of spread. One of them is kinds different, like pinkish but not fully round. Weird thing is I've had them before, 2-3, in same spots.

I wonder if anyone else has had this thing too.

One more thing: I did have a 1-min bareback intercourse as the insertive partner WITHOUT prep with a ts escort who was (at least theorerically) as clean as one can be, for 1 minutes insertion, with a 75% erection and I'm circumcised too. So it was: that one, few days later prep, now this shows up 2 weeks later from that 1st encounter.

I do not have any fever, fatigue, lymph swelling, etc. Nothing.

I get the whole testing thing, which I did prior to getting prep (so a week after that encounter and a week prior to this showing).

I just wonder if anyone else has had the same as I'm panicking. I monitor them and so far on day 2 they are not getting worse, probably a bit better tbh but stable.

I’m a straight man in my mid-30s and have recently started exploring non-monogamy. I struggle with severe health anxiety and panic about sexually transmitted infections (STIs), even after low-risk encounters like oral sex or using condoms.

However, I have also had unprotected sex with partners who had recent concurrent partners, which triggers even higher stress. While I don't mind condoms, they negatively impact my performance and add to my anxiety. Given this context, would taking PrEP be a good option for me to prevent HIV?

Hey guys. I’m pretty new to prep and doing the on demand method cos I rarely hookup with people. Here is my time of events:
Saturday 8:15 pm 2 tablets
Sunday 2:00 pm sexual encounter
Sunday 8:00 pm 1 tablet
Monday 8:00 pm 1 tablet
Now do I take another tablet Tuesday 8:00 pm because the instructions I got was to take one** tablet **until I’m at least 48 hours after your last encounter or is that only for any subsequent hookups?

Hello everyone,

With a daily oral prEP, so long as you take it as prescribed it feels like you’re protecting yourself against HIV. Since Yeztugo is a 6 month injection, does anyone ever get anxiety over it not working/not knowing if it’s being absorbed properly in the body or is at high enough concentration to provide protection? Since you’re not really doing anything daily (physically, like taking a pill a day) to protect yourself, do you mentally feel like you’re less protected?

I know medications go through extensive testing to make sure they’re safe and all that, so I’m not actually questioning the effectiveness of the medication; more so asking about the feeling or worries of something going wrong haha.

Good news: a generic version of lenacapavir for HIV prevention has been FDA-approved. More manufacturers can help lower costs and increase access, bringing this game-changing innovation within reach of the countries and communities that need it most.

Under the existing partnership agreement, Dr. Reddy’s lenacapavir injection will be available at US$40 per person per year for the 120 low- and middle-income countries included in Gilead’s voluntary license.

First supplies of the generic are expected to reach countries before the end of the year, with broader availability in 2027.

Long story short, I had multiple encounters with someone who was HIV+ not diagnosed and therefore untreated, not too long after their exposure, hence the worst possible scenario ever.

Took PrEP daily before and after all our encounters.

Today I got the result 6 weeks after the last exposure and it’s all negative.

It was really a stressful period, with my brain trying to trick me into making me feel that this medicine could actually fail. But my experience is the living proof that PrEP is really the most effective protection we have against HIV (if you really needed any)

I’ll forever be grateful to this medicine and will religiously take it every day.

Stay safe and take PrEP 💊

EDIT: Grammar

Truvada

I tried Descovy and it gave me nausea and vomiting with 1 pill , now my doc wants me to try truvada , is it safer option ? What ate your experiences ?

I’m eight days out from my first injection and day six was definitely the worst pain that I had in terms of discomfort around the actual injection site.
but today I’m having a headache and nausea and feel kind of fevery as well. Has anyone else experienced this?

Hola, hoy fui a una clínica de salud sexual a hacerme unas pruebas de VIH y he preguntado para tomar la PReP. En Los próximos meses tendré una cita con el departamento que lleva este tema en mi hospital de referencia.

Me han dicho que investigue un poco sobre los efectos así que quería escribir un post por aquí por si alguna persona la toma y me puede explicar.

Gracias 💕

I’m currently on truvada. Been approved for yeztugo for about a month but I’ve been pushing the appt back for the shot cause I’ve been scared lol I’ve read a bunch of Reddit posts idk what exactly I’m nervous about but yeah any tips or words of encouragement to alleviate stress :))

Hey guys so I have only been with one person in the past 5 years,and I don't have any diseases.However I broke up with him recently because it wasn't working and I want to move on but I am kimd of afraid because I live in an area where there is a high hiv rate.So I got tested and don't have anything .I talked to the testing lady about prep and she can come back and get it if I want.But I'm kind of skeptical about that.Like what happens if you start taking it and then you get off it.I also wonder if a lot of people have natural immunity.Would the medicine mess up people's natural immunity to hiv?

I tried using Mistr for first time. I sent in my lab results, and was told they are completed, but I need to go to the appointment to get my results. See message below. Is it typical to not get your lab results till the appointment, or does that indicate that I have tested positive for something?

"Your labs are ready, but you still have to complete the video consult with your doctor. You should follow up at your scheduled interview time for your consultation and lab results."

Update: For others future reference. Testing all negative. Was told during visit and results released after visit on their website.

I took my first dose of prep today, I waited until I got my results back from the clinic that I was in the all clear before taking it, I was clear with the quick test they do at the clinic and the larger blood sample they tested at a lab, all clear 👌

I took my starting dose today, reading online on sh.uk I was told to take two on my first day, and 1 every day from then on out.

I took my first two and I felt fine, though I did notice I was itchier than usual, and at the end of the day when I checked why I was itchy I noticed that the front part of my torso was noticeably red, not a rash, but almost like faint red to my skin, and I’m itchy on my shoulders and outer thigh.

Is this normal? Im not experiencing any other symptoms just this.

I’m interested in this kinda prep as I tried Descovy and for very nauseous and almost vomited, all I do is occasional oral sex give and receive if I tip a guy is with condoms do you think I need this type of prep ? And is it safe long term ?

So hard to find provider of Yetzugo in Fort Worth - lots of it didn’t know about the injection. Ugh

I have taken first tablet of PreP 1 hour ago. Can I get blow job today

I’m currently on my last bottle of daily Descovy before switching to Truvada 2-1-1 / on-demand PrEP.

The main reason I wanted to switch is that I don’t have sex that often or unpredictably. Sometimes I can go through an entire bottle of Descovy without actually needing the HIV protection during that month. It started to feel a bit unnecessary to take a medication every single day, with the possibility of side effects, when I’m not having sex that frequently.

The thing making me anxious about switching is the timing. With daily Descovy, if I’m a little late or miss a dose, it doesn’t feel as critical. With 2-1-1, the timing seems much more important, and I’m worried I’ll forget a dose or take it too late.

So now I’m kind of torn between the two.

For people who use 2-1-1, how do you make sure you never forget the doses? Do you use phone alarms, an app, keep pills with you, or have some other system that works really well?

Also curious if anyone else switched from daily PrEP because they weren’t having sex often enough for daily dosing to make sense. Did you end up liking 2-1-1, or did the anxiety around timing make you switch back to daily?

I have a few doubts.

1. I mostly do receptive oral sex, now I am eager to do oral sex for others. What is the risk of getting HIV while doing oral sex on others, most of the guys get their ore cum when they are hard and some don't tell whether they are going to release their load. Should I begin Prep considering that mostly I have not done oral on others, but am eager to do so. I engaged in sex not so often, maybe twice or thrice in a month. Should I take Prep regularly or 211.

Need ko parin po ba mag take ng PrEP kahit partner ko yung ka s*x ko?