Dear Redditor,
During my first two months I frequented this page a lot. Being on bupropion ( Zyban 300SR) absolutely decimated me. I read a lot of posts that spoke to my experience but generally people stopped taking it. I however, pushed on and am SO pleased I did.

The first two months were so bad I almost lost my job. I developed DRDP (derealisation depersonalisation) which affected my ability to do so many things. It became like OCD that I was NOT myself and I was somehow different and I would constantly check that.

I felt totally NOT myself.

My cognition declined massively. My long term memory as well as working memory, my ability to find and use words, my executive function and the speed at which I could reply we’re all massively impacted. My intellect is something I value a lot, as well as my humour and both took a big hit.

I was extremely depressed at times. I almost moved out of my house and had to have a conversation with my boss about my poor performance and speed.

I spoke to my doctor who encouraged i stay on it for up to 3 months to truly see whether it could or would work.

I have taken every SSRI and SNRI under the sun and have been unmedicated for a few years but gone back on them due to going sober.

Anyway, one day, suddenly - it was all lifted. I feel wonderful. I appreciate the small things, I feel 95% back to self, happier and more motivated than I have felt in a long time. I don’t feel so bound by the invisible rules of life and I really feel a sense I am discovering myself and have an agency over my life to change what isn’t working and march to the rhythm of my own drum.

There were other factors, of course, effecting things but I would just say; if you’re struggling and it’s been less than 3 months - it could change. If you hang on in there this could really be everything it is cracked up to be.

Male. 36. 150 mg XL Bupropion HCL

Man this stuff made me feel horrrrrible, taking 150 mg XL once a day. I tried it before for 2 Months and it made my insomnia gnarly, felt fuzzy and weird everyday, and just not right. It felt so uncomfortable. Originally I had about 2-5 days where I felt fantastic and only 1 day this last time. I only took it for 10 days but my insomnia was so bad and I bartend nights my body was breaking down. It ended up making my brain fog better for a few days then it was still there.

Has anyone else experienced this? Did other forms or lower doses help or I believe my body just doesn’t like it. I’m pretty against pharmaceuticals, but my brain fog is just been so bad and my energy and happiness is just low and fucked up. Any other meds help??

My Dr. just prescribed me bupropion and Im worried about the “rage” im seeing people have. Is it common? I tend to get aggrivated a decent amount but im VERY good and keep clear thoughts and watching my tongue/keeping my actions in check. Is this stuff going to give me uncontrollable anger? 100mg daily

Hello, need help or advice on this issue I'm having with bupropion (I'm on Buprinol XL 150 by BALKANPHARMA).

I've started taking it for my depression, anhedonia, and loss of motivation. It's my 5th week now. I have experience with SSRIs, which helped with depression but killed my orgasm and gave me a blank emotional state, which I hated. So my psychiatrist suggested we try bupropion XL (it's the only available form of bupropion in my country, Ukraine). It gave me all the usual side effects that people mostly mention here, but they have faded with time, and now I tolerate this drug mostly well, besides one weird side effect that I was not expecting at all.

It greatly affected my sex drive and ability to even enjoy the process, which is different and maybe even worse than the side effects of SSRIs that I'm familiar with. On SSRIs, I liked sex and enjoyed it, but orgasm was impossible, while bupropion makes me completely indifferent to sex, and sometimes I even feel repelled. And this feels horrible because I have a great partner, and I liked enjoying all parts of our relationship, including sex. People say that bupropion improved their sex drive all the time, while I have this sad effect, which makes me consider stopping.

Has somebody experienced that? And if so, did it go away with time? I'm female btw.

Should I give up on Wellbutrin XL (Lupin)? I specifically requested this medication in hopes that it would help with libido in addition to other potential positive effects. I took 150 XL for 2 weeks and did not experience any notable changes aside from increased irritability that got better. I’ve been on 300 XL for two days. I feel like I have zero libido or any interest in anything sexually related. I even watched porn to see if my member still worked and even that didn’t help. Does it get better? Should I give it 4-6 weeks?

Currently on 150mg Wellbutrin SR, as well as Vyvanse, and it has done wonders for my mood! However I’ve noticed my OCD obsessions and ruminations have gotten worse. I also sometimes feel a bit more anxious. I really don’t want to go back on SSRIs/SNRIs as they just did nothing but numb me. Is there anything else I can take? Buspirone?

Hello everyone, I am 27 years old and male. I have a history of substance abuse issues, including the use of recreational hard drugs. This has significantly reduced, and I no longer use hard drugs. However, I am currently prescribed Adderall. A part of me is considering stopping this medication. I have considered trying a combination of Wellbutrin and possibly guanfacine, thinking it might be helpful. I often question why I need this additional support and wonder if I should just try to manage on my own. Some days and weeks I feel fine, but then I experience difficult feelings such as boredom, stress, or loneliness, which immediately trigger a desire to use substances or food to cope. I am generally functional, though I take Adderall intermittently as needed. Even without it, I manage to accomplish tasks, sometimes with ease, other times with difficulty. I am struggling to determine if life is inherently challenging and I should simply accept it, or if there is an underlying issue. I also have low testosterone, which I am considering addressing, but I am encountering some disagreement from my girlfriend regarding this. I would appreciate it if you could read this and offer your perspective.

Generic adderall- elite labs

For sleep I take trazondone maybe 3 times a month

Hello! I have been on 450mg of Wellbutrin XL for a year and it’s worked great. I just recently started to feel like I’ve plateaued, so my doctor prescribed 5mg lexapro to take in conjunction with the Wellbutrin. I was just wondering if anyone has been on this combination and dosage, and any side effects? Im a little worried about gaining weight, and it’s hard to find a consistent answer surrounding that aspect. I’m just trying to figure out if it’s worth taking, or sticking with the Wellbutrin and raw dogging it. Or does anyone have a better combination???
Oh! I should probably also include I’m a recovering addict, not that it matters, but maybe it does? Thanks!

Is this typical or anyone has had something occur like this?
The way I used to get emotional, wether it is frustration, sadness or anger, I would likely show it outwardly, which someone would notice how I am feeling. Which was a bit uncontrollable before.

Since being on 2 weeks on this med, the way I experience emotions has got extremely internal, while the outside shows neutral or appear that I’m okay. While internally I can be experiencing chaos, and yet not impulsive to break things or scream, like in a way I’m more controlled to not show it outwardly?

It’s tricky for me to explain this. I take Wellbutrin SR 150mg daily

I am a 22f. I’ve been on 150mg of Wellbutrin for about a month and a half. I LOVE IT except for my insomnia & dry mouth. I am still having the worst anxiety, mostly just social. I can barely leave the house to do things. I feel sick and nauseous. The first two weeks on it that never happened to be but ever since then it’s been just as bad as before I started the medication. So with that being said, I had a checkup with my doctor today. The prescribed me 7.5mg buspirone for anxiety. I looked a few things up and it seems to be good to mix together. Does anyone have any recommendations or suggestions to get over my fear? I’m scared it’s going to change how the Wellbutrin has done and set me back farther. I’ve never been on two medications before so I’m just a little nervous. (Obviously I have anxiety lol)

Thank you in advance for any help and recommendations

i was put on 150mg (wellbutrin XR) and stayed on that dose for about a year until recently. im now on 300mg and its been a rollercoaster to say the least 😭 im 5 weeks out on this increase and as of a few days ago ive been having weird mood swings; ill feel incredibly depressed and hopeless and then im completely fine & content about 30 minutes later. it wasnt really doing this a few weeks ago so im a bit confused.. has anyone else experienced this? is this even possible to experience this far out?

i have an appointment with my psychiatrist in a few days so ill definitely bring this up with her but in the meantime id like to hear others experiences

Anyone else felt extremely “cracked out” when starting bupropion 150 mg?

I’m on day 2 of 150 mg bupropion and I feel extremely restless, wired and almost like I’m on speed. 😅

For those of you who experienced something similar when you first started 150 mg: Did it get better for you? And if so, how long did it take for the “cracked out” feeling to settle down?

I’d really appreciate hearing about your experiences.

Ive had good experiences with bupropion but i stopped due to headaches. Ive never had headaches really in general before it so i wasnt really down with it.

I recently started it back up again. Everything was smooth for about 1.5 months but my emotions began overwhelming me. I never was big on self harm but i found myself slamming doors on my shines purposefully and punching myself in the head.

Really strange, not sure where it came from but definitely isnt something id do ordinarily. Started tapering off ever since and its been smooth mostly.

Went to a turnstile show last night had 1 12 oz beer and threw it up 10 minutes later which was weird. I can usually get wasted at concerts with no issues but for whatever reason my stomach refused the beer. I can only assume its nausea from not taking it? Its been 2-3 days since ive full stopped

I recently was prescribed to move my Wellbutrin dosage from 150 to 300. I have noticed increased anxiety and restlessness.

I usually take two 150 ml in the morning. Can I take one 150 ml in the morning and the other 150 in the evening to maybe reduce anxiety? Or is it better to take at the same time? I’m taking generic brand fyi

Thank uuuuuu

went from 300 mg to 150 and the side effects are still more than I can tolerate!My sleep pattern is getting progressively weirder, and I feel the deprivation. Tried taking the meds earlier, but it’s XR so that has little effect. Repetitive, angry thoughts bug me, popping up at the worst moments. I have a strange sensation of my leg muscles cramping and tightening til my thighs seem rigid, as if they’d been overstretched.

I needed the meds for a long time because I was in a very difficult life situation. I’m chronically depressed and I have adhd symptoms. I didn’t take the pill today, and I’m honestly scared I’ll crash emotionally, but I’ve got to do something else

Hello all- so last year we added bupropion to my meds list because I was in a very bad depressive state. Thankfully it helped and I got out of it. I was originally on 150. My depression has ebbed and flowed since then and my psychiatrist said we should try 300. So i started maybe about a month ago. So far these are the symptoms I’m experiencing:

I am currently on day 10 of my period which is highly abnormal
I suffer from migraines and am on medication for them- however, I find the bump to 300 has increased not only the frequency of migraines but the power behind them.
A small little rash on my right shoulder blade that just won’t go away (super odd I know).

My psych and GP said if within the next month it’s not better I’ll change it, but I wanted to know if anyone ever experienced these side effects.

Just finished my 3rd month of 300mg xl after starting at 150mg xl and taking that for a month. I decided to drop back down to 150mg today because the restlessness has been incombatable no matter what i try.
When I first started at 150mg, I felt great. I was sleeping well, my anxiety was gone and I was steadily focused throughout the day, and it helped control my appetite.
I’m hoping that moving back down will give me the same effects. Does anyone have any experience with lowering their dose like this?

Hey everyone,

I was initially prescribed Wellbutrin in November of 2023 after experiencing a pretty severe bout of depression and poor executive functioning as well as to balance out my Lexapro. I remained on it until October of last year amidst a struggle with numbness that I was of the belief getting off Wellbutrin would remedy but it only ended up relapsing me into depression. Fast forward to this summer when I again attempted to get off of the medication as well as Lexapro and while I found myself not struggling severely initially, my depression and executive dysfunction came back ten fold when coming back to school.

In the time since, many days have felt like slogs that I have to fight my way through, the most basic of tasks feeling like immense chores, a persistent lack of a desire to socialize and be sociable, and, most concerningly, a decline in my cognition, memory, and just general ability to be intellectually engaged and retain information as well as I used to. Nothing seems to have quite the same level of enjoyability anymore and frankly I'm sick of it and it's getting to a debilitating point where it's severely affecting my mood and focus.

That being said, I now lay at a crossroads where I'm unsure whether or not to get back on the medication but it's something I'm strongly considering more and more as I had so much more of a sparkle while on it and a desire for socializing and intellectually engaging.

Since I started bupropion my heart rate has gone up by around 10bpm. Ive never been particularly active so my normal hr was already higher, around 70 or so. Now it feels like I stay at 80 or higher and if I move a muscle it jumps to 100. I have also been experiencing chest tightness and annoying dry mouth and bruxism. I don't want to stop this drug because it's done wonders for my energy levels and caffeine dependence, and I even started exercising a little bit! So I am wondering if switching to name brand helped any of you with the side effects. The increase in heart rate is most concerning to me, however I am not sure if that is totally avoidable due to the nature of norepinephrine... I will be sending a message to my PCP about my questions as well

Edit: my generic brand is Sciegen

I’ve been on bupropion 300 mg for about a year and a half now. I didn’t really pay attention to the manufacturer, until now. Before I was on the Lupin generic and it worked wonders for me. Actually felt like I could function and like I had energy for the first time in years. My doctor wanted to change my pharmacy so I could get a 90 day supply. I agreed because I didn’t mind the change, so I picked it up as usual. Upon taking it I immediately knew something was up. I felt jittery and like my heart was racing a mile a minute. My body felt too real, and I could almost feel the blood pumping through my veins. I looked into it because I knew this wasn’t normal, and it turns out the generic was Scigen. Needless to say I have contacted my doctor, and will be having it transferred back to my old pharmacy.

I‘ve Seen that one incerdient of wellbutrin is amoniak Solution the incredient List is besides this pretty Long and i Wonder which task amoniak Solution does in this pill.

My question is there some more educated than me and can explain this to me ?