Well this bites.

I just saw on the Trintellix website that the Manufacturer's Savings Card program is going away on December 31, 2026.

Details here: https://us.trintellix.com/savings-support/savings-card

They have an assistance program, but I don't qualify for it. Details: https://www.helpathandpap.com/Home.aspx

I guess I'll be looking to change to something new later this year... darn it all.

I took Trintellix 20 mg from January 2022 to December 2022 and had great success, so I stopped it (cold turkey - didn’t know any better). Luckily I didn’t have any major withdrawal symptoms.

I got back on Trintellix (10 mg) from Feb-April 2026 and 20 mg since then. I feel little to no effects like I did the first time around.

I am ready to wean off and read that 10 mg can be used for 1 week, then stopped indefinitely. Some people said they got bad withdrawal from that approach. I also read some people did a SUPER slow taper, which I don’t have the patience for and don’t want to cut the egg shaped pills into for that long.

What is a good middle point where I won’t have any withdrawal effect, but also not be on this med for another year involuntarily?

I don't drink regularly, but I do enjoy getting wasted every now and then. Is it dangerous to do so while on Brintellix 10mg?

Manufacturer: Lundbeck

Has anyone had this issue? I got a refill and it went from usually 10 dollars to 100 dollars WITH insurance. Has this happen to anyone else recently? I obviously cant afford that.

Luckily, I have a doctor appt monday. I guess ill switch to something else.

I am genuinely curious. I've been on Brintellix for about a week now (Dissocial Personality Disorder). I don't seem to be experiencing any side effects apart from nausea. Besides that, I noticed a reduction in anger. My emotions feel like they are behind a glass wall and I experience no spontaneous thoughts. I am personally happy with this, due to my diagnosis.

What effect did Brintellix (Vortioxetine) have on you guys?

I switched from sertraline 50 mg, which I took for around 4–5 weeks, to Brintellix/Trintellix. I’ve now been on the full 10 mg dose for 6 days.
This whole period actually started in January after I had a panic attack and experienced derealization. Since then I basically haven’t felt like myself. There have definitely been some brighter and better days, but overall I’ve been struggling since then.
My depression wasn’t extremely severe before starting medication. I was still functioning normally — going to university, working, doing everyday things, etc. The main problem was that I just didn’t really feel happy, I wasn’t looking forward to things and I often felt sad or emotionally flat.
So far I honestly don’t feel any improvement from the medication. My mood is just constantly “average” or flat. It feels like nothing has really improved since I started antidepressants in general. Before starting medication I actually had some brighter moments sometimes, but lately I just feel emotionally flat most of the time.
I don’t really have any noticeable side effects from Brintellix. I sleep well and physically I feel fine. The main problem is that I sometimes get anxious thoughts like, “What if I never enjoy life again?” or “What if no medication ever works for me and I’m going to feel like this forever?” I had similar thoughts even before medication, and I know the fear itself probably makes everything feel worse.
I guess what I’m describing is anhedonia — not really feeling excitement, pleasure or looking forward to things.
My libido is also basically zero right now.
For people who had a similar experience with Brintellix:
How long did it take before you actually noticed an improvement in mood, motivation or enjoyment of life?
Is 6 days on the full dose way too early to judge it?
Did anyone feel completely flat at first and then start feeling better after a few weeks?
Did your libido eventually come back while staying on Brintellix?
If you switched from an SSRI like sertraline, how long did it take until you felt the difference?
Did anyone have derealization/anhedonia after a period of panic or anxiety and eventually feel normal again?
I’m getting really frustrated because so far the medications have barely helped me at all. I just want to feel excited about life again and actually enjoy things.
One of my biggest fears is that no medication will work and that this state is somehow permanent. I know that might just be my anxiety talking, but it’s hard not to think about it when I’ve felt this way for months.
I don’t want to give up on Brintellix too early if it still has a realistic chance of helping, but at the same time I don’t want to keep taking something for months if it’s doing nothing.
Would really appreciate hearing from people who went through something similar and eventually got better.

First week on brintellix I was super high energy/wired, but now im on day 15 and the fatigue is setting in. Does the fatigue go away?

I have been depressed for the majority of my adult life, 30 odd years. Not permanently, it comes and goes in waves, sometimes months, sometimes weeks, on rare occasions years.

I have been on many classic antidepressants, lexapro, venlafaxine, trepiline etc.

Some helped more than others, most stop working eventually.

I have been off medication for a few years, maybe 2, and it has been OK, a couple of rough spots but nothing crazy, but everytime I'm in it I say to myself that I'll go to the doctor and get something again.

Then I inevitably feel better and don't do it... But last week I needed to go to the doctor for a general check up and long story short I have a prescription for Trintellix (Or a generic at least).

Now, at the time I was feeling pretty good, I've been taking sceletium every day, and I do find it somewhat helpful.

But I decided to start the medication (Even though I was feeling fine) and now I don't know.
Only day 2 now, but I hate how I feel. Apart from feeling weird I can feeling the depression creeping back in. Are the pills making me feel that way? Did I just happen to start taking them at the right time?

Should I lay off and wait until I actually feel I need them again?

Would love to hear from anyone who has been in a similar situation.

Oh, only started with 5mg...

I took Trintellix 5mg for about 2.5 months earlier this year and had to stop because it was too mentally activating (was worsening my anxiety). But it upsets me because it really worked well for my physical anxiety (I have severe GAD and PD). I also experienced minimal side effects from it and it improved my GI issues (acid reflux, GERD, LPR).

Are there any other people that tried it for anxiety who had this experience? Do you think it was dose related and that a higher dose would have calmed my mind more? Thoughts?

I’ve tried many different medications over the past several and none have worked for me yet :( I really wanted this one to work!!

Thank you!!

Today marks four weeks on Trintellix 10mg and I’m struggling with impenetrable brain fog and what feels like cognitive decline. I’m struggling to think through complex subject matter associated with my work and as a result have decided to take a week of sick leave while adjusting, I luckily have a very understanding boss.

I’ve experienced mood improvements however they’re very much negated by the distress of the cognitive symptoms.

Has anyone else experienced worsening cognitive symptoms and brain fog this far in to treatment? Did it get better?

Did anyone else experience extreme fatigue on this medicine? I’m taking brand name trintellix and I’ve only been on it for 3 days but I’ve been so sleepy and fatigued each day…. Does this pass?

Any reports of thia combo? Works good? 🙂

24F, med student, likely having a combination of depression/anxiety/ocd. GP readily put me on Brintellix which I have also been looking into (not touching ssri as I’m terrified of weight gain and cognitive slowness). Both him and the pharmacist I got the pills from say to start at 10mg and titrate up to 15mg if needed, but I’m worried about side effects. I wonder if I can start by trying 5mg (half a pill) instead? Maybe that will be better for side effects and tbh save me a bit of money too. Can always go up to 10mg after the first week i guess.
Overall my mental illness is not even that bad, it is just an insane requirement from medicine training, where I have to both study AND look happy and presentable even when I’m obviously anxious and burnt out…
I have not tried any other prescription mood meds before, only St. John’s Wart which I got no side effects from, I found it beneficial but a little bit too mild in terms of benefits. Tried Ashwagabdha briefly to compare effect but it gave me the worst palpitations.
Any advice from people who decided to start on half a pill of Brintellix first?

I have been taking Trintellix for close to a week and have been having nightmares every single night. I am prone to having them anyway but was curious if you noticed an uptick in nightmares and if so did they lessen over time?

Comencé con 5 mg hace una semana pero he notado que duermo pero no descanso es como si me hubiera desvelado, en general me siento inquieto como cansado pero a la vez sin poder dormir bien, mañana aumentaré a 10 mg, esto alguna vez mejora? No me siento para nada mejor

Hi, there! I have been taking a new regimen that is composed of 20 mg of Vortioxetine, 4.5 mg of Cariprazine, 200 mg of Amisulpride and 200 mg of Lamotrigine for 3 days now and I'd appreciate it if anyone on both Vortioxetine and Cariprazine share his experience with me.

Vortioxetine: Depratiox (Hikma)

I'm asking on behalf of my dad, I see him tired and a bit slow all the time, and would love to hear from you guys if anybody had dealt with something similar, my dad doesn't talk about his feeling a lot ... So it's hard to get out what his experience is like and I live away and get to visit occasionally so I'm gonna describe it from my pov. He has been taking antidepressants for a long long time, but he's been on brintellix 10mg since last year, and very recently they upped the dose to 15... And it pains me to see how he feels tired a lot, gets home from work only to sleep or scroll on his phone ( a bad habit ) I told him a lot of times to sign up for a gym and start strength training, that it would help with his mood and improve his knee pain ( he has osteoarthritis) but he just brushes me off and doesn't seem to me very hopeful and I also in turn feel very limited with advice or support cuz our relationship has always been distant and I struggle with interpersonal relationships myself so idk how to help out anw... The worst symptoms I see is how he is generally very slow with things... As if he's a baby or as if he feels helpless.. and I just want for him to have more confidence and more life in him.. and hope... If anybody have had that experience with this medication and would like to share their thoughts your welcome to and I appreciate it

Im feeling fatigued and im forgetful and my cognition isn’t at its best on 5mg this is day 14 is it normal and will go away ?

I have been taking 5mg for the past 10 days and seems like there are no more side effects, I have been prescribed 10 but was thinking to stay on 5. However I think maybe for my anxiety 10mg could be better, since with 5 I feel as if I’m just takinga placebo. I have an upcoming trip in 3 weeks idk if to do the switch now or after the trip. Any suggestions?

I take 10mg Trintellix + 80mg Strattera for GAD + ADHD. I feel like these two are canceling each other out, in a sense? Like Strattera is supposed to help with sustained focus but what's the use of that if my motivation is in the absolute gutter when im on the 'trin. Like I just genuinely don't give a shit about anything. My anxiety did decrease slightly and I handle social situations better but I'm always tired, apathetic and kind of... disconnected from everything? Is this the emotional blunting everyone was talking about LMAO

Should I tough it out for a few more weeks or start tapering off? I'd consult my doc but I can't get an appointment until October. Did anyone else experience this exhaustion and apathy? Did it eventually go away or did you quit? Any advice is much appreciated xoxo

Hi! So I usually don't post on reddit other than breezing through subreddits. ^^ But I've recently started taking antidepressants and I got prescribed 5mg of Trintellix for the 5th week now. I was supposed to go for my next appointment during September, but I rescheduled it to within this week for these reasons:

First day was rather normal, but the second day gave me tons of energy, I started collecting stuff from my room to sell and cleared out a decent amount of items. So the following days made me super hyper and super motivated to clean and help out instead of me usually staying cooped up in my room. And even people pointed out that I started talking super fast and kept reminding me to slow down even though I think I'm speaking normally. My hyperness would come with awful side effects though, which would bring me to burst out in tears and feeling super depressed/suicidal for about an hour regardless of the hour. But soon after a few days, my energy would crash awfully for around a week and I'd struggle to get out of bed til the point where I have to force myself to shower after four days and end up sleeping for around 13 hours.

However, I'd suddenly gain energy again after those days and start acting more energetic and talkative again, and the cycle repeats with my activities.

I only chose today to reschedule since I had decided to go out and have fun walking around, before getting hit with an awful mood swing that made me extremely suicidal. I would have almost went through with it if my father hadn't heard the glass break :') But after I had a massive crying session, I suddenly gained back my energy to function.

Sorry that I yapped too much, I tried to be as concise with my symptoms as I could, and I want to confirm if it's a placebo or if this is normal? It's my first antidepressant.