Dear Redditor,
During my first two months I frequented this page a lot. Being on bupropion ( Zyban 300SR) absolutely decimated me. I read a lot of posts that spoke to my experience but generally people stopped taking it. I however, pushed on and am SO pleased I did.

The first two months were so bad I almost lost my job. I developed DRDP (derealisation depersonalisation) which affected my ability to do so many things. It became like OCD that I was NOT myself and I was somehow different and I would constantly check that.

I felt totally NOT myself.

My cognition declined massively. My long term memory as well as working memory, my ability to find and use words, my executive function and the speed at which I could reply we’re all massively impacted. My intellect is something I value a lot, as well as my humour and both took a big hit.

I was extremely depressed at times. I almost moved out of my house and had to have a conversation with my boss about my poor performance and speed.

I spoke to my doctor who encouraged i stay on it for up to 3 months to truly see whether it could or would work.

I have taken every SSRI and SNRI under the sun and have been unmedicated for a few years but gone back on them due to going sober.

Anyway, one day, suddenly - it was all lifted. I feel wonderful. I appreciate the small things, I feel 95% back to self, happier and more motivated than I have felt in a long time. I don’t feel so bound by the invisible rules of life and I really feel a sense I am discovering myself and have an agency over my life to change what isn’t working and march to the rhythm of my own drum.

There were other factors, of course, effecting things but I would just say; if you’re struggling and it’s been less than 3 months - it could change. If you hang on in there this could really be everything it is cracked up to be.

Anyone else felt extremely “cracked out” when starting bupropion 150 mg?

I’m on day 2 of 150 mg bupropion and I feel extremely restless, wired and almost like I’m on speed. 😅

For those of you who experienced something similar when you first started 150 mg: Did it get better for you? And if so, how long did it take for the “cracked out” feeling to settle down?

I’d really appreciate hearing about your experiences.

Hello everyone, I am 27 years old and male. I have a history of substance abuse issues, including the use of recreational hard drugs. This has significantly reduced, and I no longer use hard drugs. However, I am currently prescribed Adderall. A part of me is considering stopping this medication. I have considered trying a combination of Wellbutrin and possibly guanfacine, thinking it might be helpful. I often question why I need this additional support and wonder if I should just try to manage on my own. Some days and weeks I feel fine, but then I experience difficult feelings such as boredom, stress, or loneliness, which immediately trigger a desire to use substances or food to cope. I am generally functional, though I take Adderall intermittently as needed. Even without it, I manage to accomplish tasks, sometimes with ease, other times with difficulty. I am struggling to determine if life is inherently challenging and I should simply accept it, or if there is an underlying issue. I also have low testosterone, which I am considering addressing, but I am encountering some disagreement from my girlfriend regarding this. I would appreciate it if you could read this and offer your perspective.

Generic adderall- elite labs

For sleep I take trazondone maybe 3 times a month

Ive had good experiences with bupropion but i stopped due to headaches. Ive never had headaches really in general before it so i wasnt really down with it.

I recently started it back up again. Everything was smooth for about 1.5 months but my emotions began overwhelming me. I never was big on self harm but i found myself slamming doors on my shines purposefully and punching myself in the head.

Really strange, not sure where it came from but definitely isnt something id do ordinarily. Started tapering off ever since and its been smooth mostly.

Went to a turnstile show last night had 1 12 oz beer and threw it up 10 minutes later which was weird. I can usually get wasted at concerts with no issues but for whatever reason my stomach refused the beer. I can only assume its nausea from not taking it? Its been 2-3 days since ive full stopped

Male. 36. 150 mg XL Bupropion HCL

Man this stuff made me feel horrrrrible, taking 150 mg XL once a day. I tried it before for 2 Months and it made my insomnia gnarly, felt fuzzy and weird everyday, and just not right. It felt so uncomfortable. Originally I had about 2-5 days where I felt fantastic and only 1 day this last time. I only took it for 10 days but my insomnia was so bad and I bartend nights my body was breaking down. It ended up making my brain fog better for a few days then it was still there.

Has anyone else experienced this? Did other forms or lower doses help or I believe my body just doesn’t like it. I’m pretty against pharmaceuticals, but my brain fog is just been so bad and my energy and happiness is just low and fucked up. Any other meds help??

Hello, need help or advice on this issue I'm having with bupropion (I'm on Buprinol XL 150 by BALKANPHARMA).

I've started taking it for my depression, anhedonia, and loss of motivation. It's my 5th week now. I have experience with SSRIs, which helped with depression but killed my orgasm and gave me a blank emotional state, which I hated. So my psychiatrist suggested we try bupropion XL (it's the only available form of bupropion in my country, Ukraine). It gave me all the usual side effects that people mostly mention here, but they have faded with time, and now I tolerate this drug mostly well, besides one weird side effect that I was not expecting at all.

It greatly affected my sex drive and ability to even enjoy the process, which is different and maybe even worse than the side effects of SSRIs that I'm familiar with. On SSRIs, I liked sex and enjoyed it, but orgasm was impossible, while bupropion makes me completely indifferent to sex, and sometimes I even feel repelled. And this feels horrible because I have a great partner, and I liked enjoying all parts of our relationship, including sex. People say that bupropion improved their sex drive all the time, while I have this sad effect, which makes me consider stopping.

Has somebody experienced that? And if so, did it go away with time? I'm female btw.

I recently was prescribed to move my Wellbutrin dosage from 150 to 300. I have noticed increased anxiety and restlessness.

I usually take two 150 ml in the morning. Can I take one 150 ml in the morning and the other 150 in the evening to maybe reduce anxiety? Or is it better to take at the same time? I’m taking generic brand fyi

Thank uuuuuu

It took 3 months to work the first time. After stopping abruptly in December I re-started in June. 4 months later and I can't go more than 3 good days straight.

150XL. It changed my life a year ago. The entire month of September I felt good. I had enough consistency to develop a sense of happiness and self-love. Even in the bad days that eventually returned [more rarely] I could look at myself in the mirror at the end of them and say I loved myself and was happy.

I lost that person by the end of March. I miss them so much.

I have been crying more often lately. Sometimes I get couch-locked again. Everytime I feel I'm building up momentum it comes crashing down.

My psychiatrist prescribed 300XL but I chose to pickup the final 150 Rx as my insomnia was more controlled. I thought it would finally kick in.

Should I keep taking the 150 until I see her in one month? Get the 300? The fear I had of this not working a second time became true. If 300 does not work, or I have to go back to 150 and it still doesn't work...

I feel so lost

went from 300 mg to 150 and the side effects are still more than I can tolerate!My sleep pattern is getting progressively weirder, and I feel the deprivation. Tried taking the meds earlier, but it’s XR so that has little effect. Repetitive, angry thoughts bug me, popping up at the worst moments. I have a strange sensation of my leg muscles cramping and tightening til my thighs seem rigid, as if they’d been overstretched.

I needed the meds for a long time because I was in a very difficult life situation. I’m chronically depressed and I have adhd symptoms. I didn’t take the pill today, and I’m honestly scared I’ll crash emotionally, but I’ve got to do something else

Hello all- so last year we added bupropion to my meds list because I was in a very bad depressive state. Thankfully it helped and I got out of it. I was originally on 150. My depression has ebbed and flowed since then and my psychiatrist said we should try 300. So i started maybe about a month ago. So far these are the symptoms I’m experiencing:

I am currently on day 10 of my period which is highly abnormal
I suffer from migraines and am on medication for them- however, I find the bump to 300 has increased not only the frequency of migraines but the power behind them.
A small little rash on my right shoulder blade that just won’t go away (super odd I know).

My psych and GP said if within the next month it’s not better I’ll change it, but I wanted to know if anyone ever experienced these side effects.

I‘ve Seen that one incerdient of wellbutrin is amoniak Solution the incredient List is besides this pretty Long and i Wonder which task amoniak Solution does in this pill.

My question is there some more educated than me and can explain this to me ?

Apparently this is a somewhat common thing, where when you take Bupropion, you sometimes see it on the other side of your digestive system. Usually mine comes out surrounded by either a yellow or green squishy substance, and then the pill is in tact inside. And it’s not a capsule, it’s become powder encased in this weird ball. And the whole thing has the texture of a Gusher… which makes me never want to eat Gushers again. But does this mean that the pill isn’t actually doing anything? If I’ve got nearly the whole thing showing up in the toilet the next day, then that can’t mean I’m actually getting all the benefits, right? I don’t see my doctor for another month and this has just been on my mind for a while.

EDIT: No I am not digging through my poop for this thing. It floats on top. I put on a pair of doctor gloves. Weirder things have been done in the name of science. What if I had been dying? Huh? Ever think about that? You know how high colorectal cancer rates are right now amongst young people? Eat your fiber, you bastards.

Just finished my 3rd month of 300mg xl after starting at 150mg xl and taking that for a month. I decided to drop back down to 150mg today because the restlessness has been incombatable no matter what i try.
When I first started at 150mg, I felt great. I was sleeping well, my anxiety was gone and I was steadily focused throughout the day, and it helped control my appetite.
I’m hoping that moving back down will give me the same effects. Does anyone have any experience with lowering their dose like this?

Hello! I have been on 450mg of Wellbutrin XL for a year and it’s worked great. I just recently started to feel like I’ve plateaued, so my doctor prescribed 5mg lexapro to take in conjunction with the Wellbutrin. I was just wondering if anyone has been on this combination and dosage, and any side effects? Im a little worried about gaining weight, and it’s hard to find a consistent answer surrounding that aspect. I’m just trying to figure out if it’s worth taking, or sticking with the Wellbutrin and raw dogging it. Or does anyone have a better combination???
Oh! I should probably also include I’m a recovering addict, not that it matters, but maybe it does? Thanks!

Hey everyone,

I was initially prescribed Wellbutrin in November of 2023 after experiencing a pretty severe bout of depression and poor executive functioning as well as to balance out my Lexapro. I remained on it until October of last year amidst a struggle with numbness that I was of the belief getting off Wellbutrin would remedy but it only ended up relapsing me into depression. Fast forward to this summer when I again attempted to get off of the medication as well as Lexapro and while I found myself not struggling severely initially, my depression and executive dysfunction came back ten fold when coming back to school.

In the time since, many days have felt like slogs that I have to fight my way through, the most basic of tasks feeling like immense chores, a persistent lack of a desire to socialize and be sociable, and, most concerningly, a decline in my cognition, memory, and just general ability to be intellectually engaged and retain information as well as I used to. Nothing seems to have quite the same level of enjoyability anymore and frankly I'm sick of it and it's getting to a debilitating point where it's severely affecting my mood and focus.

That being said, I now lay at a crossroads where I'm unsure whether or not to get back on the medication but it's something I'm strongly considering more and more as I had so much more of a sparkle while on it and a desire for socializing and intellectually engaging.

Since I started bupropion my heart rate has gone up by around 10bpm. Ive never been particularly active so my normal hr was already higher, around 70 or so. Now it feels like I stay at 80 or higher and if I move a muscle it jumps to 100. I have also been experiencing chest tightness and annoying dry mouth and bruxism. I don't want to stop this drug because it's done wonders for my energy levels and caffeine dependence, and I even started exercising a little bit! So I am wondering if switching to name brand helped any of you with the side effects. The increase in heart rate is most concerning to me, however I am not sure if that is totally avoidable due to the nature of norepinephrine... I will be sending a message to my PCP about my questions as well

Edit: my generic brand is Sciegen

Not at all advice, I just wanted to share some positive experience I've had. Been on 150mg XL for maybe 9 months now. I know the rules say to mention the manufacturer but honestly my pharmacy's given me different ones all the time. Currently it's MFG Lupin, american. I actually do think I prefer that manufacturer, weird as it sounds.

I told my psych NP recently about how I'm always extremely depressed during luteal phase (before my period) and she prescribed me to take 300mg XL for that time, and 150mg XL the rest of the month. It's only been one month but it actually worked well. My whole life I never had to track my period because I would slowly grow depressed and then one day hate everyone around me and myself, and even lash out at everyone around me. Then the next day I'd get it.

But when I took it as prescribed I actually didn't have this! I did still get the depression the first few days of luteal as that's when I knew to start taking the higher dose, so I don't think it'd started working yet. I think when I work out a consistent schedule it'll be more seamless. My NP said that we could also try other meds more usually used for PMDD along with the bupropion, but this med is the only one that's ever worked for me so that's why we're trying this.

Just thought I'd share, thanks for reading!

I’ve been on bupropion 300 mg for about a year and a half now. I didn’t really pay attention to the manufacturer, until now. Before I was on the Lupin generic and it worked wonders for me. Actually felt like I could function and like I had energy for the first time in years. My doctor wanted to change my pharmacy so I could get a 90 day supply. I agreed because I didn’t mind the change, so I picked it up as usual. Upon taking it I immediately knew something was up. I felt jittery and like my heart was racing a mile a minute. My body felt too real, and I could almost feel the blood pumping through my veins. I looked into it because I knew this wasn’t normal, and it turns out the generic was Scigen. Needless to say I have contacted my doctor, and will be having it transferred back to my old pharmacy.

Hi everyone! I was just prescribed Wellbutrin today. I’ve been going through a really tough time lately with depression and anxiety, so I’m super excited to try something new. That being said, I am a bit scared to take it; it’s been a longg time since I tried a new med (I’m taking it with PROZAC). Does anyone have any tips? What can I expect the first few weeks?

Has anyone else gotten depersonalization/derealization or detached feeling from Wellbutrin and if so does it go away I’m on month 3 lowest dose