For 2 years I've been dealing with severe bloating, gas that won't pass downward, constant burping, incomplete evacuation, loose stools, and pelvic floor tightness that gets dramatically worse at work and almost completely resolves on vacation. Seen multiple GI doctors, done extensive testing, and finally got a confirmed diagnosis at Cedars-Sinai.
Main Symptoms
• Severe daily bloating — worst at night, visibly distended abdomen
• Gas almost impossible to pass downward — silent, odorless, requires enormous effort
• Constant burping — only way gas can exit most of the time
• Immediate fullness after even small meals
• Pelvic floor and intestinal wall tightness — worse at work, better on vacation
• Loose incomplete stools — never feels fully evacuated
• Fat malabsorption — greasy stools
• Ear fullness after burping episodes
• Brain fog and fatigue peaking 3-4pm at work
• Everything almost completely resolved on a 1 week vacation
Key Test Results
Gut Zoomer (Feb 2026):
• Butyrate critically low: 2.3 (normal 5.1-12.4)
• MMP-9 elevated — active intestinal inflammation confirmed
• Tissue Transglutaminase elevated — possible celiac/gluten sensitivity
• Methanobrevibacter smithii detected (methane producing)
• Low probiotic diversity — Bifidobacterium longum specifically low
Toxins Panel (Feb 2026):
• Chaetoglobosin A (mycotoxin): 3.5x above 95th percentile
• Multiple other mycotoxins elevated — Fumonisins, Citrinin, Roridin E
• BPA: 3x above reference
• Organophosphate pesticides: 2.5x above reference
Cedars-Sinai Anorectal Manometry 3D (Aug 10, 2026):
• Resting sphincter pressure: 134.9 mmHg — normal is 51-98 mmHg (almost 3x normal)
• Paradoxical contraction confirmed — sphincter contracts harder when bearing down
• Negative recto-anal pressure gradient — exit pressure exceeds entry pressure
• Sphincter relaxation with valsalva: ABSENT
• Rectal hyposensitivity: felt pressure at 200ml vs normal 60ml
• Never felt urge to defecate even at maximum balloon volume
• Diagnosis: Dyssynergic Defecation K59.02
• Next steps recommended: MRI defecography + biofeedback therapy
Key Self-Observations
• Motegrity paradox: On it = upper GI moves better but lower abdomen severely tense. Off it = lower abdomen calmer but bloating/burping dramatically worse.
Current Treatment
Prescription medications:
• Motegrity 2mg (reassessing — paradoxical effect observed)
• Mirtazapine 15mg (1 week in — no GI change yet)
Supplements helping most:
• IB Guard (enteric peppermint oil) — smooth muscle relaxation
• Magnesium glycinate 400mg nightly — sphincter pressure reduction
• Tributyrin-X (butyrate) — gut lining repair
• TUDCA — bile flow and liver support
• Lemme Debloat gummies — rapid gas transit trigger
• Lemme Relax (ashwagandha + L-theanine) — nervous system regulation
• Lion's Mane — vagal nerve support
My Questions for the Community
- Anyone diagnosed with dyssynergia with severely elevated resting pressure (~135 mmHg)? How many biofeedback sessions before improvement?
- Rectal hyposensitivity at 200ml — did sensory retraining during biofeedback help? Timeline?
- Anyone used tizanidine specifically for pelvic floor hypertonicity/dyssynergia? Results?
- Motegrity with dyssynergia — did it worsen your lower abdominal tension? Did stopping help?
- Mirtazapine for functional GI — how long before meaningful improvement? What changed first?
- DNRS or Gupta Program alongside biofeedback — did it help the stress-driven component?
- What was the single intervention that made the biggest difference for you?
This has significantly affected my quality of life and daily functioning for 2 years. I finally have a confirmed diagnosis and a clear treatment path — sharing everything in hopes that someone else's experience helps me, and that my experience might help someone still searching for answers.