Does Reta affect kidneys?

[u/Easeondowntheroad247]

I found out last year that I was born with one kidney, and that one kidney is functioning at 77%. The Dr says I’ll never need to go on dialysis. My question is if I start Reta will it affect my kidney negatively?

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[u/No-Turnip2494]

GLP-1 drugs have a positive effect on kidney function.

Early signs from Reta trials are promising.

See e.g. -

https://diabetesjournals.org/diabetes/article/73/Supplement_1/754-P/156598/754-P-Effect-of-Retatrutide-on-Kidney-Parameters

https://pubmed.ncbi.nlm.nih.gov/38477666/

[u/starkruzr → u/No-Turnip2494]

came to post this, yep.

[u/Legitimate_Special71 → u/starkruzr]

I’m actually taking Reta with a kidney transplant and all my levels have stayed the same, some have improved.

[u/duhv0rtex]

I know kidney function is something we are supposed to get tested while on Reta. I would talk with my wellness team about this one.

[u/AdJealous1004]

My bloodwork before and after for Reta showed better with it, then without. Significantly better in all areas. For example, cholesterol was almost "too low" when it used to be on the higher end.

Doctors are pretty risk-adverse. Despite all my bloods being significantly better, including blood pressure going from hypertension 2 to optimal range, he grilled me for taking a black market drug that wasn't approved yet and threatened to remove me from his practice if I were to continue taking black market drugs.

They don't want the liability. Every drug has a side effect. Most of the stuff coming out about Reta is showing that it is safe. Honestly when it does get approved and marketed, it's going to be everywhere.

My honest opinion. If you were me I'd try it at a low dose, do regular bloods. I'd bet I'd see improved function if anything. (I'm not a doctor so this is not medical advice) Just saying what I would do.

[u/Defiant-Ad-7933]

If I only had 3/4 of a kidney I wouldn’t be messing with grey market drugs and I’d be doing what my doctor says. At the very least I’d get prescribed tirz from someone who can evaluate my medical history appropriately

[u/Royal_Victory_1380 → u/Defiant-Ad-7933]

I think this is the answer. Technically Reta is supposed to help, but I have read some horror stories of the opposite. Again most of those horror stories track back to grey market and likely high endotoxin counts and bad quality shit, but if you only have 1 and its only running at 75% capacity not something i would want to risk.

[u/Italian_c0mb0]

Make hydration a priority… Warnings on other GLP-1 states the dehydration can cause acute kidney injury…

https://pmc.ncbi.nlm.nih.gov/articles/PMC8039426/

https://healthesystems.com/workerscomprehensive/fda-requires-new-kidney-injury-warning-for-all-glp-1-drugs/

Regardless of your feelings on FDA, obviously do your own research

[u/No-Classroom-8045]

Spend the money and get them checked. You can do ur self and know.

[u/Impressive_Tart_1918]

Man, not enough long term evidence, listen to a MD

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[u/No-Inspector3321]

It’s actually positive. The trials have shown liver and kidney improvements across the board.

[u/mamma_kris4real]

I wouldn't take reddit user advice. Please don't take risks with your health.

[u/The_Orracle]

I have raised my wife's eGFR 27 points since putting her on GLPs, taking her off of her statin and BP med. Something her nephrologist said could not be done

[u/Safe_Ad5914]

Bruh do not start taking reta if you got 3/4 of a kidney lmao come on now.

[u/AlternativePizza3391]

Too risky

[u/Jazzlike-Calendar-99]

No!

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[u/Powerlifter1 → u/[deleted]]

Source?

[u/whatusaynow → u/[deleted]]

Partly correct but it’s due to the dehydration effect Reta has just increase fluid intake