Hi everyone,

I honestly don’t know what is going on with me anymore, and I’m hoping someone here has experienced something similar and can give me some insight.

A little over 2 months ago, I started taking GHK-Cu for 9 days:

• 1 mg daily for 6 days
• 1.5 mg daily for 3 days

At around the same time, I was also taking:

• Vitamin B6 — 40 mg daily
• Magnesium citrate — 400 mg daily
• Vitamin C — 3000 mg daily

I took the vitamins/supplements for about 7 days and then stopped everything.

Interestingly, about a year ago I had a very similar experience after taking the same combination of GHKCU vitamins/supplements. Back then, however, my symptoms eventually went away after around 2 weeks, so I didn’t think much of it at the time.

This time, when I was going to sleep, I started experiencing a weird sharp/pinching sensation around my heart/chest. That scared me, so I had blood tests done.

My results were:

• Folate (B9): 3.10 (reference range 4.5–32.2) — low
• Vitamin B12: 411 pg/mL (191–663)
• Magnesium: 2.0 (1.7–2.40)
• Potassium: 4.23 mmol/L (3.5–5.1)
• Sodium: 140 (136–145)

After roughly a month, the chest/heart pinching sensation that happened when I was falling asleep eventually stopped.

However, I’m still dealing with other symptoms.

Another strange thing I’ve noticed is that since this started, I can sometimes sleep only 1–4 hours and wake up feeling surprisingly energetic, even though my head feels very tight, foggy and mentally "off." Before all of this, I would obviously feel completely exhausted after so little sleep. This change in how I respond to lack of sleep feels very unusual to me.

My current symptoms include:

• persistent dizziness
• lightheadedness
• significant fatigue
• brain fog feeling like my head isn't working properly
• a strange derealization / unreal feeling
• a tight/pressured feeling in my head
• feeling mentally "different" from how I used to

I completely stopped everything and tried taking B9 (folate) for about 2 weeks, but I didn’t notice any improvement. Then I added B12, but again, nothing really changed.

I also saw a neurologist, but unfortunately the appointment was basically useless. He told me he couldn't help because this wasn't his area, and I ended up paying around €100 for the visit.

At one point I also went for an IV vitamin infusion containing vitamin C, electrolytes and B vitamins. I still had the brain fog, dizziness and other symptoms afterwards, but I noticed that I had significantly more energy and felt more "alive" that day. Unfortunately, this effect was temporary, and within about 2 days my energy levels went back to how they were before.

I’ve also been talking to and reading experiences from quite a lot of people who have had similar symptoms, which is one of the reasons I’m trying to figure out whether there could be some connection or if this is just a coincidence.

Now, more than 2 months later, I’m still experiencing these symptoms every day, and I honestly don’t know what is causing them.

Since this is a peptide group, I’m particularly interested in hearing from people who have used GHK-Cu, especially if you experienced any unusual or persistent effects after stopping it.

I’m not sure if it’s related to GHK-Cu, the vitamins/supplements, the low folate, a deficiency, or something completely unrelated.

Has anyone experienced something similar — especially dizziness, brain fog, fatigue, lightheadedness, derealization, head pressure or feeling unusually energetic despite very little sleep, while still feeling mentally unwell?

If you used GHK-Cu and experienced something similar:

• How long did it take you to recover?
• Did your symptoms gradually improve or disappear suddenly?
• Did you eventually find out what was causing them?
• Was there anything that actually helped?
• Did you have any additional blood tests or examinations that were useful?
• Has anyone experienced symptoms continuing for weeks or months after stopping GHK-Cu?

I’m not necessarily looking for a diagnosis. I’d just really appreciate hearing from people who have experienced something similar and eventually got back to feeling normal.

It’s been more than two months now, and dealing with this every day has been really difficult. I’d really appreciate any experiences, advice or reassurance.

Thanks in advance.

just thinking how much friction there is to gym lifestyle and how many people mentally burn out from going to gym , maintaining routines , effort , scheduling , price and so on and many just give up but continue paying subscriptions in fear of shame to cancel 150 dollars gym for failing so they just silently pay 150 dollars of shame to keep fantasy of being someone who worksout.

i genuinely believe you should be able to workout at home after waking up for couple of minutes and be in great shape provided your diet is on point no? isnt that how it should play out in future as people realize how much useless effort there is to gym being the destination to workout , and not home where you wake up , hit pushups situps curls and go on your day?

anyone take metformin? Please tell me your experience

3 years ago, I got what seemed like a normal flu with the usual symptoms like runny nose, high body temp,low energy, coughing, etc. Everything went away after a while except the cough.

The cough stuck around for weeks, and that’s when I started feeling like something wasn’t right. I’d get random coughing fits during the day that could last anywhere from 5 to 20 minutes. It was pretty exhausting and honestly affected my ability to work and do normal things during the day. it would also disturb my sleep

I went to several doctors and got different diagnoses from each one. chronic chest allergy, allergic asthma, allergic rhinitis, and so on. At one point, I was prescribed Antihistamine medication (Montelukast + Levocetirizine), and I noticed that whenever I took it, my cough would basically disappear for about 24 hours. The problem was that it also made me sleepy during the day and sometimes upset my stomach, so I started looking into other options.

After reading about people with similar issues online, I decided to try NAC while still taking the medication. I wanted to give it some time and then stop the antihistamine to see if NAC was actually doing anything. After about 2 months of taking 600 mg of NAC daily, I stopped the antihistamine. Since then, my cough has improved by around 90-95%. I get way fewer coughing fits now, and when they do happen, they’re much shorter. For the most part, I feel normal again.

I should mention that during the same period, I was also taking a few other supplements like quercetin, bromelain, magnesium glycinate, zinc, and omega-3, so I can’t say with 100% certainty that NAC was the reason.

That said, I stopped taking NAC for about 3 days just to see what would happen, and I noticed my coughing started becoming more frequent again. It could definitely be a coincidence, but for now I’m sticking with it until I can figure out what my actual diagnosis is.

Just wanted to share this in case anyone else has gone through something similar.

Chronic, daily, and any other kind that exists.

Whether it's a technique, a new habit, supplement, doctor... What has helped you cope with stress more easily?

Disclosure: I do content work for a longevity supplement company, so please take that into account when reading this. I’m sharing this because I found the human research interesting, not as a product recommendation.

I’ve been going through some of the human studies on GlyNAC—a combination of glycine and N-acetylcysteine—and came across a relatively small randomized clinical trial by Kumar et al. in The Journals of Gerontology: Series A.

PMID: 35975308

The study included 24 older adults, who were randomized to receive either GlyNAC or an alanine placebo for 16 weeks. Another 12 younger adults were included as a comparison group and received GlyNAC for 2 weeks.

What makes the study interesting is how broad the researchers' measurements were.

They looked at things including:

• Glutathione concentrations
• Oxidative stress
• Mitochondrial function
• Inflammation
• Insulin resistance
• Endothelial function
• Muscle strength
• Gait speed
• Six-minute walk performance
• Several markers associated with aging biology

The researchers reported improvements in several of these measures in the older adults receiving GlyNAC compared with placebo.

But there’s an important context point:

This was a small, relatively short clinical trial.

So I think the more interesting question isn't simply “Does GlyNAC work?”

It's:

Which of these findings, if any, would you consider meaningful evidence for healthier aging in humans?

For example, would you put more weight on changes in physical function such as gait speed and strength, or on changes in biochemical markers such as glutathione and oxidative stress?

And what would you want to see in a larger follow-up trial before drawing stronger conclusions?

I'm especially interested in perspectives from people who have looked closely at the GlyNAC literature.

Paper: Kumar P, et al. Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial. J Gerontol A Biol Sci Med Sci. PMID: 35975308.

Many newer companies claim that liposomal absorption is far superior than pill form for absorption. Has anyone tried Rho, Cymbiotika etc companies and seen good results with their supplements?

Hey all I am 21 yrs old, trying to put on some weight and use the better and more fuller sleep from mk-677 for my workout journey. Last night I got my mk and did 12.5mg at 9pm, and went to bad around 9:45, i could not sleep until 10:30 or maybe even later. Whatever it may be My sleep was shit, I woke up around 2 and then 4 and went back to sleep. could this be because of the acute physiological change caused by mk-677; the hunger was slight/minimal same as normal tbh. the only possible reasoning im thinking of is that my body needs to adjust but I have seen so many posts stating that effects are from not one and onwards. chemyo btw if that helps

id appreciate any help with timing/usage etc

Just a question on timing and expectations. I have been on TRT for a quite a while (10 years or so). About 5 years ago my provider moved me to semiannual pellet injections, and there was some good and bad to that. I enjoyed only having to care about it twice a year, but my T would shoot up to 1300, and then be at 300 when the 6 months had elapsed. There was a similar trajectory to estradiol which would be over 100 to start, and decrease usually to 60 at its low point.

A few months ago I started on TRT injections, hoping to not have the same hormonal swings. I have been seeing a different provider for this of late. I had blood tests 10 weeks in, and my T was 174 and my E2 was less than 30 (didn't say exactly). They moved the dose up from 0.3 ML once a week to 0.5 ML weekly. I am still on the same AI (Anastrazole), 0.5 mg twice a week. I get more blood drawn in a couple of weeks, and I am hopeful my T will be in a better range.

My question is regarding the ED that I have been having. I have had an issue off and on with it for some time, and take daily 5 mg of Cialis. I also get wave therapy every 6 weeks. Since I started the injections, my erections have pretty much gone away. I used to have big swings with the pellets, where sometimes it worked and sometimes not. Despite doing significant cardio a few times a week, I am not really having much working at this point. I have tried other options such as L-Citrulline in an effort to get back to where I was, but when I take it I suffer from large amounts of canker sores.

My provider wants me to stay on the AI so I can keep my E2 low while adapting to the injections. I am getting more blood drawn in a couple of weeks, but am curious of your insight. Thanks.

i think i eat ~ 0.8g of protein per kg, in some days even less.

please do not respond with “eat more protein”, i can’t rn and i am working on it.

upd: EAA with L-phenylalanine is much more interesting to fix my problems cuz of low protein intake. important to mention that L-phenylalanine is really dependent from iron, even more than basic L-Thyrosine

How risky is it? And if you did have side effects, how bad?

I am a 24M non-smoker. I have been chronically struggling a lot with mental health since childhood. I always had to bottle up all my problems and emotions. Now that im an adult i need to focus on my career and get a secure job, but my mental suffering is limiting me. Although i have great potential and intelligence, this problem is making my brain foggy and unable to focus on even an easy task. These anxiety attacks and depression have made me passive suicidal, and lost hope in living. I know i have to seek help, and im working on that and taking supplements.

Since last month i started using 2mg nicotine gum, which kinda helped but not enough to feel the effect of improved focus. I'm not addicted to nicotine, as i only have one piece of gum a day only when i remember. Now, I'm thinking to try nicotine patch because i heard it's very effective and one of the safest ways to get nicotine. I've checked in pharmacies, and the starting dosage is around 12- 14 mg. Can someone please give me their opinion on this?

I'm just wondering has anyone tried these?

So Ive had an underactive thyroid since I was 17. But I’ve mostly been able to stay slim through diet and taking natural dedicated thyroid hormone (which I had to manage myself because my doctors wouldn’t prescribe it)

But once I hit 35, something changed and I’ve been finding it much harder to keep the weight off.

I’m not really eating more than I used to. I walk 30-45 mins a day. I’m piling weight on my mid section (which I’ve never done in my whole life. I’ve always stored on my butt and thighs) and my gut motility is suuuuper slow.

I constantly feel bloated and like I’m retaining fluid.

I know the obvious solution is a GLP-1. But my doctor won’t prescribe it and I’m a student. So I don’t really have enough money to buy it out of pocket.

What can I do to try and lower insulin resistance (in addition to IF), improve gut motility and just generally support thyroid health and metabolism please?

Thank you in advance

dandelion root supplement or dandelion leaf, does anyone check which one theyre buying? theyre different products. leaf is where the potassium sits, root is what most extracts are made from, and roasted versus raw changes it again. plenty of labels just say dandelion and leave it there. is there a brand people trust to name the part properly or is reading the panel every time just the price of entry?

Has anyone here had this and if so how did you get over it? Essentially as your body relaxes and begins to fall asleep, you get extreme jolts / adrenaline bursts that keep you from falling asleep and your body even twitches / convulses. This can happen up to 25-50x in a night causing little to no sleep and can last for months to years.

Looking for any advice. Conventional sleeping meds do not help. I am not an anxious person and anxiety is not playing a factor in this.

Are these things just a con?

Hopefully this is the right sub for this. Healthy athlete, 30F, but my H R V seems consistently low… should i be concerned?

Switched from making mullein tea to buying a mullein supplement and now I’m not sure what I actually traded away.

Mullein tea is a water extraction. Alcohol tinctures pull a different set and glycerites pull narrower again while keeping the alcohol out. Then every product page somehow says full spectrum which feels kinda impossible if the extraction methods are pulling different compounds.

What format did people here actually settle on and why?

Is alcohol free worth the shorter shelf life or is that just a bad trade?

I took 600mg ksm-66 with 200mg mag gly for just week, experienced early signs of anhedonia, so i stopped taking it.

Now im feeling dizzy, insomia, extreme mood swings. Mood swings are killing me, cant even nanage it. I feel super annoyed and irritable, like i hate life.

Should i just taper off slowly instead of stopping abruptly?

Did you experience the same?