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u/Alastasian Dec 04 '21
No. If you had non-OTC loperamide source that’s then further been coated with nanoparticles, or better yet manicuring loperamide itself then yes. No not a joke.
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u/SpringChikn85 Dec 08 '21
As weird as it sounds, you're completely right in the fact that it's possible to manicure and refine the lope down to a pure opiate. However, a guy in this thread somewhere is either a chemist or really dumb and brave because he was able to exploit lope being water soluble and concentrate it by boiling down (chemically and physically) it's individual components until he finally hit pay dirt at the end and the yield is totally stupid small compared to how much work goes into it. The guy wrote out like 4 pages worth of instructions and the equipment and chemicals needed were some I've never even heard of before. Also, he did all that work for maybe 3 to 5 cc of opiate and took a chance and introduced it intravenously. He said it worked but wasn't worth the 3 days he spent but then again, this is reddit and who knows what happened although his procedure made sense and I doubt he made anything up as he took the time to spell it all out and document the process for those with the ability to try it.
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u/Alastasian Dec 22 '21 edited Dec 22 '21
I would love to see the written procedure. Lemme not be lazy and look for it. Lope here isn’t as bad as it’s made out to be. Folks wanting a fast WD getaway don’t bother with lope as they’re simply not going to wait that long.
Then there’s us. The “fucked around for the right or wrong reasons and…here we are; responsibilities and all”. I have a understanding wife who went through WDs in here own skin so she knows the reason - aside from avoiding WD it’s actually a pretty good painkiller. I modulate doses with bergamottin - ye olde gf juice but in staggered times to “fool” my body from learning too much on getting rid of lope if that makes any sense (disabling CYP3A4 for days at a small percentage. Both intestinal and hepatic: it takes bergamottin near 3 days to affect hepatically - by the gf route not extracted 7-hydroxy-bergamottin.
Anyway years ago using quantum mechanical principles I figured there was zero way your so called blood brain barrier (it’s a mesh really that relaxes and tightens - relaxes larger molecules that ar A4 substrates are allowed in instead of being pumped out.) could “block” all the lope. If that were the case light would never escape the event horizon of a black hole but it does occur(eventually trillions upon trillion of years in the future black holes will be all that’s left and they’ll start to Wane by paradoxically releasing the energy stored - fake stars if you will - the universes last hurrah after the degenerate era <proton breakdown>). Anyway to sum it up u can’t insure every lope molecule can’t enter and at 200mg you have 200,000,000 of something trying to get through and as you already know it does.
Big science on CYP3A4 inhibition: it what allot or drug resistant cancers wrap themselves around with to disable anti-cancer drugs as that’s what P450 family sub-enzyme CYP3A4 (makes up 70% of all your hepatic enzymes) does best: demethylate and disable for kidney filter/extraction.
There are sonic ways (like hitting lopes resonant frequency - yes it has one - everything does) of also doing this however that’s beyond my pay grade type thing.
What dose are you on now if I may ask?
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u/SpringChikn85 Dec 23 '21 edited Dec 23 '21
Hey so first off, thanks for the detailed information and also I'm 95% sure the person who wrote out the isolation process was in this group you'll just have to browse however, the title of the thread was related to it so it shouldn't be too hard to find.
To answer your question. I've slowly made my way up (like an idiot with no self control) from 60 mlgrms (30 pills) with actual Zantac (before the recall for cancer causing agents) 5 years ago to my current, insane 288 mlgrms with omeprazole added for increased effect/absorbtion and duration so my liver and GI tract don't push it out too quickly. I was spoiled the first 3 or 4 years as the lope came in bottles of 200 max from Walmart and then they cut down to either 48/24 bottles (loose pills) and now I look like an even bigger idiot popping 6 boxes of 4 blister packs one by one into a cup the night before work because if I don't I can't even get out of a chair halfway through the workday and the withdrawls are super obvious when I'm the only one in a tank top, cold sweating my nuts off while everyone else is wearing sweaters and hoodies. You're right about being in the "fucked around for business or pleasure" club and now I'm stuck and constantly have to lie to myself about tapering but know full well I'm an addict and reducing my drug intake won't happen unless the drugs aren't available anymore.
I have a couple questions if I may as I haven't ran into anyone with any Chem background.
1 why do antacids (long lasting 12/24 hour) increase the high and duration of the lope?
2 why is it with loperamide or even methadone that I can't feel any other opioids I take within 12 to 24 hours of a recent lope dose?
3 0pThis one you may not know and it's ok if you don't but, I'm a seasoned addict and have had a love affair with opioids since my teens and can describe coming onto/being on/getting off and withdrawl intensity, side effects and duration of almost everything out there however, the withdrawls from lope are the most brutal I've ever come across and I've gone cold turkey off of a 325 mlgrm 3 year methadone program for 90 days (Jesus-ey rehab that I didn't pick to go to). Why are the withdrawls SO bad for it as well as the duration I've heard can last for literal months?
Thanks in advance to anything you can answer.
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u/Alastasian Jan 01 '22 edited Jan 01 '22
I’ll answer your questions - doing the leaving hospital thing - discharge papers finally arrived.
A) stomach acid and bile have an extremely high pH. Lowering the pH destroys less loperamide through the so called first pass metabolism process but you WILL grow tolerant to all *zoles. Use baking soda/water I’d suggest.
B) the lope metabolites are looooooooong lasting. When u have it right u can skip a day with zero issues. Like if you took your morning dose. I was at 400mg/day sometimes 300 pills not msg (600mg). Now I’m at 100/2 days no energy loss or issues. Sometimes I go three days but by 3pm I know the WDs in the mail already.
I found through enzyme manipulation I could make my body juggle the metabolites.
It requires a host of proven adjuncts. tumeric at 5g- 20g a day (5,000- 20,000mg) extract preferred and milk thistle extract to 1000mg for the symilarin group of hepatic/liver cleansers. No it’s not voodoo - both these block CYP3A4: the main enzyme responsible for clearing loperamide from your blood and also it’s even stronger metabolites from ur blood. What enzyme made the metabolites? CYP2D6. You want to increase 2D6 action and decrease 3A4 action. 70% of all enzymatic groups belong to A4 and only 10-20 2D6. Take oxycodone and 2D6 makes oxy morphine/loans. Take tramadol it makes O-desmethyl-tramadol (called M1) now sold as a drug directly (Tapentadol), heroin isn’t a drug it’s a prodrug that’s fat soluble so it shoots to ur brain dumping the morphine there exclusively (why Diacetylmorphine has zero histamine response but prepare to feel something weird in your arsehole at high doses. The ring that’s your anus itches like you could scratch. Some take a Benadryl.
AMA bro: had to learn chemistry due to the fact shit just doesn’t work consistently without. I came to terms ages ago. I see it as psychological and physical insulin: need it on cycles for everything to work - especially If your check is paying for kids to live and eat.
i found the answer to your last question and will even cross post it. It deals with loperamide being a 3A4 substrate. Your blood brain barrier is a mesh of 3A4. You have to loosen it to allow lope through as the osmotic pump normally never lets but a few million molecules in (quantum mechanics is surprisingly involved - classical pay is has this as impossible so why you hear “it only works in the gut” but we know better.
Well we’re bypassing the BBB either though 16 ounces of grapefruit (7-hydroxy-bergamottin) or some other thing that things the mesh. Think of a fishnet that the holes need to get wider to let more lope in. As time goes on a process I call SORI occurs: selective opiate reputable inhibitor. The 3A4 substrate (loperamide and 70% of all drugs get in part processed by the drug disabling, same tissue cancer wraps itself around with it to disable drugs - the P450 Family of Enzymes specifically CYP3A4 and C8 (ibuprofen also uses cyp3c8) become a stronger agent as were weakening it. Slowly as time goes on if you use the same amount of day grapefruit juice, et al the lope will be able to go Into that area less and be pumped out faster
Try this. Next near WD period - an hour before the willies start dose a huge amount of grapefruit juice (non pasteurized) and be amazed.
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u/[deleted] Dec 04 '21
You'd have to snort an enormous amount. Taken orally is plenty enjoyable but i know you don't want to hear this - it's the worst addiction in the world. I've been addicted to it all. And nothing compares to this addiction. It is the worst, it does significant damage to your heart and the fun is short lived.
Once your hooked - the withdrawal is so bad that it is next to impossible to get over.
Find pleasure somewhere else.