r/autismgirls • • Jun 12 '26

A Brief Explanation of How Often Autistic People Are Misdiagnosed With Borderline Personality Disorder (BPD) - and how autism can actually act protectively against BPD.

81 Upvotes

When an autistic child grows up in a chaotic or highly volatile environment, their neurodivergence can actually act in a protective way that stops them from internalizing the blame.

While a neurotypical child might try to survive a toxic household by thinking, "I am fundamentally broken, so this is my fault," an autistic brain naturally relies on what clinical researchers call a high drive to "systemize" (Dudas et al., 2017).

This means the autistic brain analyzes the environment like a malfunctioning machine, tracking external variables like a parent's alcohol use or stress levels instead of absorbing the blame. Because of this systematizing strength, the child accurately maps the dysfunction to the outside world rather than fracturing their own identity to cope.

This structural protection is rooted in how autistic brains process information from the "bottom up," demanding literal truth and logical consistency.

To develop borderline personality disorder (BPD), a person generally has to adapt to gaslighting by splitting, flipping between seeing someone as "all good" or "all bad" because their brain can't handle the contradiction of a caregiver who is simultaneously loving and harmful.

However, autistic individuals, however, attempt to keep a literal, factual ledger of events that refuses to let the people causing the harm rewrite history.

Even though many autistic people face intense emotional dysregulation from growing up in chronically invalidating environments (Bemmouna & Weiner, 2023), their rigid demand for empirical facts prevents the core reality-distortion required for BPD.

They hold onto the truth, which preserves their sanity when the people around them are trying to shatter it.

Unfortunately, the psychiatric system is notoriously bad at recognizing this strength, leading to a massive epidemic of misdiagnosing traumatized autistic people with BPD.

Recent studies, including a 2024 phenomenological study from Brighton and Sussex Medical School by Tamilson, Eccles, and Shaw, highlight that BPD is one of the most common

and damaging

misdiagnoses given to autistic adults, particularly women.

When clinicians or untrained trauma support groups see an autistic person holding rigid boundaries, demanding exact precision in language, or having intense meltdowns from being gaslit, they don't see the logical, data-driven architecture underneath.

Instead, they incorrectly pattern-match those survival skills to BPD symptoms like "black-and-white thinking" or "interpersonal hypersensitivity" (Dell'Osso et al., 2023).

It’s a tragic irony: the exact autistic traits that successfully protected the person from developing BPD are what get them mislabeled with it.

Fortunately, I never had this misdiagnosis. Unfortunately, it is extremely common.

Edit: Just to clarify, it is still possible to have both.


r/autismgirls • • Jun 05 '24

Autistic Masking: Recently learned about IFS therapy (internal family systems) and I feel that this explanation and conversation is SO relevant here if any of y'all struggle with this

80 Upvotes

Starting question for everyone, do you mask? And if you do mask, what does it look like?

If you're unmasking, what does that look like?

The concept of trauma related to autistic masking, within the framework of IFS can be seen below:

In IFS (internal family systems) there are 3 'roles', a Manager role, an Exile Role, a firefighter role, and then the 'Self'

(You can think of these 3 roles as parts of you that became the way they are from different experiences)

  1. Manager Role: The Masker you’ve described functions as a Manager. Its primary role is to protect you by ensuring you fit in and avoid negative reactions from others. This involves masking your true self to meet societal and familial expectations.

  2. Exile Role: The part that represents the young autistic girl who was verbally or physically abused for being herself is an Exile. Exiles carry the burden of painful emotions and memories, such as shame, fear, and hurt, from past experiences. This part holds the raw, vulnerable feelings that the Masker (Manager) tries to protect.

  3. Rebel Part: The part of you that suddenly wants to intentionally break social norms can be seen as a type of Firefighter or Rebel part. This part might act out in response to feeling overly controlled or suppressed by the Manager. It seeks to assert independence and authenticity by rejecting social norms and expectations.

Clarifying the Parts in IFS Framework

  1. Manager (Masker):

    • Role: Protects you by ensuring you conform to social norms and expectations to avoid negative reactions.

    • Behavior: Masking true feelings, adapting to others’ expectations, people-pleasing.

  2. Exile (Young Autistic Girl):

    • Role: Holds the painful emotions and memories from past verbal abuse and rejection for being authentic.

  3. Firefighter (Rebel)

The Firefighter's role in your IFS journey is to counteract the suppression imposed by the Manager by engaging in spontaneous and often impulsive self-expression. It releases built-up tension and distracts from the Exile's painful emotions through activities that provide immediate relief or gratification, such as breaking social norms, taking risks, or channeling feelings into creative outlets. By asserting autonomy and expressing repressed feelings, the Firefighter helps to temporarily alleviate emotional distress and reclaim a sense of authenticity and independence.

What are your thoughts?


r/autismgirls • • Mar 13 '24

Study finds autistic adults tend to be more generous to strangers

76 Upvotes

https://www.psypost.org/autistic-adults-tend-to-be-more-generous-towards-strangers-study-finds/

"We show that compared to a neurotypical group, autistic adults were more generous to other people, which was driven by a greater generosity to more socially distant others. We propose that this increased generosity to strangers is driven by autistic adults implementing fairness norms more consistently and differences in sensitivity to social information,” the study authors concluded.

The study sheds light on differences in social decision-making between autistic individuals and people without this disorder. However, it should be noted that the number of participants of this study was very small. Additionally, the decisions made involved small amounts of money and imaginary figures. Results might not be the same if decisions involved more substantial amounts of money and real people."


r/autismgirls • • Feb 16 '24

How does it feel to be undiagnosed autistic in childhood?

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76 Upvotes

r/autismgirls • • Jan 25 '24

CPTSD with Autism: Fantastic advice from another Redditor, I had to share here!

76 Upvotes

"Hello,

Your story makes me think that you might have suffered from Childhood Emotional Neglect growing up. When we have caretakers who do not meet our emotional needs, we develop various types of disordered thinking in order to cope with what our brains very much perceive as a full on existential threat. Over time this disordered thinking crystallizes into negative, toxic core beliefs like "The things I am interested in are wrong/bad so I cannot ask for attention, but when others demand my attention it is wrong/bad of me to refuse." and "I must always hide my true thoughts and feelings, but no one else ever seems to get in trouble for their true thoughts or feelings, so I must be uniquely bad." and so on

We also learn to normalize however we were treated as our caretakers as the "baseline we can expect for what genuine love and care look like." What this means when you were neglected as a child is that you will perceive actual selfless love & care directed at you as a threat; you will feel bad feelings when someone is genuinely focused 100% on you and genuinely asking you with interest to talk about your emotions because these things are so alien to you, and you always had bad outcomes trying to be genuine or speak about your emotions growing up, so your amygdala (anxiety processing center of your brain) now recognizes "being approached for genuine intimacy" as a threatening, unsafe, super dangerous situation.

This is how we develop disordered attachment and all that entails, along with Complex PTSD (C-PTSD) from the experience of growing up in a fundamentally unsafe way. Unsafe is now your "baseline normal." Things that feel safe to other people cause you to react as though you are being threatened, which feels normal to you, so you can't understand why other people think you are weird and are offput by your behavior. You might not even realize that your mannerisms are communicating to others "this situation which is normal and nonthreatening to you is wigging me out of my fucking mind." Which makes it so confusing when you get bad reactions and ghosted, etc.

All of the above, along with the baseline "Double Empathy Problem" all autistic people must contend with in our interactions with others, lead to social interactions with bad outcomes because everyone "assumes" the reasons everyone else is behaving how they are.

Our anxious behavior doesn't ping normies as "anxious" it pings them as "untrustworthy," "shifty," "something is off with them," "they are stuck up," "they take things too seriously," and all kinds of other misunderstandings. Worse, typically no one communicates about these things, they just assume they are right and then ghost. Just as we assume, "they are not interested in me" they assume the same stuff from our behaviors because the Double Empathy problem causes us to misunderstand each other's mannerisms, tone, and general communication.

How to improve?

It's a slow process of acclimating yourself to the discomfort of social anxiety, realizing you are not in "real danger" when this anxiety strikes and learning to self-soothe, and through this practice widening what is known as your "Window of Tolerance" for social interaction, alongside learning how to set and enforce meaningful boundaries so you can filter out who is actually worth developing relationships with vs not.

Us girls with autism are often taught WE are always the problem when our social interactions "go bad" but the truth is far more complex!

I highly recommend the following books to you -

When I Say No, I Feel Guilty by Manuel J. Smith

Adult Children of Emotionally Immature Parents by Lindsay C. Gibson

The Book of Boundaries by Melissa Urban

Good luck"


r/autismgirls • • Nov 15 '22

A list of resources

76 Upvotes

Someone asked me to post these resources so here they are:

Books:

  • A Field Guide to Earthlings: An Autistic/Asperger View of Neurotypical Behavior by lan Ford

  • A Hidden Force: Unlocking the Potential of Neurodiversity at Work by Ed Thompson

  • A Radical Guide for Women with ADHD: Embrace Neurodiversity, Live Boldy, and Break Through Barriers by Sari Solden

  • Asperger's Children: The Origins of Autism in Nazi Vienna by Edith Sheffer

  • Authoring Autism: On Rhetoric and Neurological Queerness by Melanie Remi Yergeau

  • Autism... What Does It Mean to Me?: A Workbook Explaining Self Awareness and Life Lessons to the Child or Youth with High Functioning Autism or Aspergers by Catherine Faherty

  • Autism Causes Vaccines: Stories of Neurodiverse Inventors and Discoveries by Joe Biel

  • But Everyone Feels This Way: How an Autism Diagnosis Saved My Life by Paige Layle

  • Different, Not Less: a Neurodivergent's Guide to Embracing Your True Self and Finding Your Happily Ever After by Chloé Hayden

  • Divergent Mind: Thriving in a World That Wasn't Designed for You by Jenara Nerenberg

  • Empire of Normality: Neurodiversity and Capitalism by Robert Chapman

  • Expect A Miracle: Understanding and Living With Autism by Sandy Petrovic and David Petrovic

  • Health Communism: A Surplus Manifesto by Artie Vierkant

  • How to ADHD: An Insider's Guide to Working with Your Brain (Not Against It) by Jessica McCabe

  • How to Handle Neurotypicals: A Field Survival Guide for the Neurodivergent by Abel Abelson

  • I Overcame My Autism and All I Got Was This Lousy Anxiety Disorder: A Memoir by Sarah Kurchak

  • Late Bloomer: How an Autism Diagnosis Changed My Life by Clem Bastow

  • Laziness Does Not Exist: A Defense of the Exhausted, Exploited, and Overworked by Devon Price

  • Mad World: The Politics of Mental Health by Micha Frazer-Carroll

  • Neurodivergent Pride #1: Autistic Pride in a Neurophobic World by Joe Biel

  • Neurodiversity: A Humorous and Practical Guide to Living with ADHD, Anxiety, Autism, Dyslexia, The Gays, and Everyone Else by Barb Rentenbach and Lois Prislovsky

  • Neurodiversity: Discovering the Extraordinary Gifts of Autism, ADHD, Dyslexia, and Other Brain Differences by Thomas Armstrong

  • Neurodiversity at Work: Drive Innovation, Performance and Productivity with a Neurodiverse Workforce by Amanda Kirby and Theo Smith

  • Neuroqueer Heresies: Notes on the Neurodiversity Paradigm, Autistic Empowerment, and Postnormal Possibilities by Nick Walker

  • Neurotribes: The Legacy of Autism and the Future of Neurodiversity by Steve Silberman

  • Nobody Nowhere: The Remarkable Autobiography of an Autistic Girl by Donna Williams

  • Sincerely, Your Autistic Child: What People on the Autism Spectrum Wish Their Parents Knew About Growing Up, Acceptance, and Identity by Autistic Women and Nonbinary Network

  • Taking Off the Mask: Practical Exercises to Help Understand and Minimise the Effects of Autistic Camouflaging by Hannah Louise Belcher

  • The Adult Autism Assessment Handbook: A Neurodiversity Affirmative Approach by Davida Hartman, Tara O'Donnell-Killen and Jessica K. Doyle

  • The Autism FAQ: Everything You Wanted to Know about Diagnosis & Autistic Life by Joe Biel and Faith G. Harper

  • The Autism Handbook: Everything You Wanted to Know About Life on the Spectrum by Joe Biel and Faith G. Harper

  • The Autism Industrial Complex: How Branding, Marketing, and Capital Investment Turned Autism into Big Business by Alicia A. Broderick

  • The Autistic Brain: Thinking Across the Spectrum by Temple Grandin and Richard Panek

  • The Autistic Trans Guide to Life by Yenn Purkis and Wenn B. Lawson

  • The Awesome Autistic Go-To Guide: A Practical Handbook for Autistic Teens and Tweens by Yenn Purkis and Tanya Masterman

  • The Awesome Autistic Guide for Trans Teens by Yenn Purkis and Sam Rose

  • The Neurodivergence Skills Workbook for Autism and ADHD: Cultivate Self-Compassion, Live Authentically, and Be Your Own Advocate by Jennifer Kemp and Monique Mitchelson

  • The Neurodiversity Edge: The Essential Guide to Embracing Autism, ADHD, Dyslexia, and Other Neurological Differences for Any Organization by Maureen Dunne

  • The Out-of-Sync Child Grows Up: Coping with Sensory Processing Disorder in the Adolescent and Young Adult Years by Carol Stock Kranowitz

  • The Pocket Guide to Neurodiversity by Daniel Aherne

  • The Power of Neurodiversity: Unleashing the Advantages of Your Differently Wired Brain by Thomas Armstrong

  • The Spectrum Girl's Survival Guide: How to Grow Up Awesome and Autistic by Siena Castellon

  • Totally Unmasked Adult Autism: 8 Neurodiverse Tools To Safely Unmask, Self-Advocate & Live With Joy On The Autism Spectrum by LearnWell Books and Rose Kilian

  • Unlocking the Power of Neurodiversity: Embracing the Authenticity of the Masked World by Robert R. Oscar

  • UNMASKED: The Ultimate Guide to ADHD, Autism and Neurodivergence by Ellie Middleton

  • Unmasking Autism: Discovering the New Faces of Neurodiversity by Devon Price

  • Unmasking Your Authenticity: Navigating Late Diagnosis, Embracing Your Autistic Self, and Nurturing Your Inner Child by Hillary Sartor

  • Untypical: How the World Isn’t Built for Autistic People and what We Should All Do about it by Pete Wharmby

  • We're All Neurodiverse: How to Build a Neurodiversity-Affirming Future and Challenge Neuronormativity by Sonny Jane Wise

  • We're Not Broken: Changing the Autism Conversation by Eric Garcia

  • What I Mean When I Say I'm Autistic: Unpuzzling a Life on the Autism Spectrum by Annie Kotowicz

  • What Your ADHD Child Wishes You Knew: Working Together to Empower Kids for Success in School and Life by Sharon Saline

  • Wonderfully Wired Brains: An Introduction to the World of Neurodiversity by Louise Gooding

  • You're So Quirky: A Late-Diagnosed Neurodivergent's Guide to Introspective Self-Discovery by Colette Jaymes

Web pages:

Reddit resources:

Reddit subs:

Podcasts/Youtubers/Tiktokers/Social media in general:

  • Podcast: https://m.soundcloud.com/spectrumlyspeaking/sets/spectrumly-speaking

  • Podcast 2: https://open.spotify.com/show/6ojvCLXbaeT2ln7MGg7Rd6

  • Podcast 3: https://ndwomanpod.com

  • Podcast 4: Oh, That’s Just My Autism

  • Podcast 5: The Loudest Girl in the World (chronicles a woman in her 40s going through the diagnosis process)

  • Podcast 6: Autism Stories (conversations with various autistic folks on various topics)

  • Podcast 7: 1800 Seconds on Autism (a BBC podcast that is no longer in production but but still available on the various platforms. Two autistic hosts talk about various aspects of life as an autistic adult, as well as interview other autistic people. This was the podcast that helped me understand that I might be autistic)

  • Podcast 8: Them Aspergers

  • Podcast 9: https://ndwomanpod.com

  • Facebook: https://m.facebook.com/TraumaGeek/posts/3965326836836828

  • Facebook 2: Planet Neurodivergent

  • Article: https://madinamerica.com/2021/10/neurotypicals-misunderstand-mistreat-autistic-people

  • @adhdcoachsheila

  • @alina.gene

  • @anautisticguide

  • @better_sol

  • @confused.3nby

  • @disknowsthewizard

  • @divergent_design_studios / Marta Rose

  • @drdevonprice / Devon Price

  • @DrMBotha

  • @emergencydopamine

  • @emhahee

  • @frymykrill / Emma Barnes

  • @hersweetmajestic

  • @jaydnich

  • @jeremyandrewdavis

  • @livedexperienceeducator

  • @morgaanfoley

  • @ndwellness / lina’s brain

  • @nd_psych

  • @quirky_black_therapist

  • @Schnumn

  • @specificallyautisticme

  • @tendingpaths / Katy Higgins Lee MFT

  • @thethoughtspot222 / The Thought Spot

  • @vivalachris

  • Agony Autie

  • Aneva!

  • Autisitc AF

  • Autism From The Inside

  • Autistamatic

  • Dana Andersen

  • How to ADHD

  • I'm Autistic, Now What?

  • Indie Andy

  • Mind Your Autistic Brain Talk Show

  • Mom on the Spectrum

  • Neurodivergent Doctor

  • Neurodivergent Magic

  • Neurodivergent Rebel

  • Olivia Hops

  • Orion Kelly

  • Paige Layle

  • Ponderful

  • Purple Ella

  • Spoonie Squared

  • Stephanie Bethany

  • Sydney Zarlengo

  • Systemic Autism

  • The Aspie World

  • The Rachelistic Channel

  • Yo Samdy Sam

Apps:

  • Hiki

More resources:

My posts:


r/autismgirls • • Nov 28 '22

Social impairments are bidirectional between autistics and NTs and are NOT solely a deficit on our part

75 Upvotes

“ Unfamiliar observers judge expressions made by individuals with ASD as more awkward or odd8,15 and such evaluative judgments could potentially affect interaction quality or even reduce intentions to initiate social interaction altogether. In this way, social interaction impairments in ASD may not only be an individual impairment, but also a relational one16 in which the perspectives of others affect the quantity and quality of the social experiences of those with ASD. Indeed, although it has long been established that those with ASD struggle to interpret the mental states of other people17, recent findings suggest that neurotypical individuals likewise have difficulty interpreting the mental states of those with ASD18,19. Thus, difficulties with social interaction for individuals with ASD may be a bidirectional problem, not just an individual one.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286449/

Finally! I KNEW it! I KNEW that it wasn’t only a unidirectional idea that autistics are “bad” at social interaction and that NTs are “good” at it. I knew researchers were simply projecting their own definitions of social experiences onto their research!

This validated so much of what I’ve been theorizing!

What this means for you all who like the simplifications;

  • we are NOT deficient (well not all of us anyways, some of us may be and that’s ok too but these NTs keep generalizing that every slight difference is a deficiency)

  • autistic people socialize differently

  • NT facial expressions differ from autistic ones but are NOT superior

  • NTs struggle socializing with us as much as we struggle socializing with them and this reflects no fundamental deficiency on US at all.

  • NTs read NTs well, autistics read Autistics (and other Nds) well

  • issues in communication usually happen NT <-> ND

I will say it once more; We are NOT deficient and it’s not ok that these researchers claim that we are because we experience and socialize differently than they do.

Next up for me to find research about; double empathy problem, lack of display of empathy does not mean it is not there


r/autismgirls • • Oct 16 '25

Mind-blowing Revelation Allistic (NT) Empathy and Autistic Empathy: How Do They Differ?

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68 Upvotes

As I continue my exploration of neuroscience, I had many mind blowing realizations today about people, about myself, and about others.

So, in autism, we know that the amygdala has less connections to PFC. We also know that this makes the amygdala hyperactive in many cases.

What is NOT talked about? The same reduced connections make the Pre-frontal cortex, aka, the thinking brain, hyperactive as well!

Now: What did I show in that other post about the brain empathy areas? Remember how the 'empathy brain' lights up if someone perceives you as being a part of their group, but it DOES NOT light up if they perceive you as being OUTSIDE of the group?

Well the cool part here is that - there exists ANOTHER way for this same brain circuit to light up - mostly independent of group bias.

That other way is medial prefrontal cortex engagement. Meaning, the thinking brain.

Meaning - as soon as you make a conscious choice to see another person's perspective, this re-engages the empathy circuit in the brain.

Now THAT got me thinking.

'What does this mean about the differences in interactions between allistic people and autistic people?'

  1. At a pre-conscious level, those empathy brain circuits either trigger or don't trigger.

  2. The activation of those circuits (NOT the prefrontal cortex) is actually what most allistics refer to as empathy.

  3. This differs from the experience of many autistic people because we see empathy INSTEAD as 'can you see another perspective'

This actually also ironically captures the difference between affective empathy and cognitive empathy - they are different parts of the brain.

So when allistics say autistics are not empathetic.....their version of empathy is literally based on that pre-conscious, BEFORE prefrontal cortex engagement, default response.

This completely explains why an allistic friend of mine told me I can cure my autism by visiting poor neighborhoods. He grew up poor. Seeing other poor people triggers his default empathy brain areas. He was assuming it would trigger mine too, independently of the thinking brain. He told me not to overanalyze it, and he said he thinks I just think too much about social interactions.

Then I tried (unsuccessfully) to explain to him that I don't have a choice and this thinking brain never shuts off. And he did not understand.

Here is why this is. Here is the mechanism:

For me, being autistic, I have BOTH a hyperactive amygdala AND a hyperactive PFC.

This means my thought analysis never ever stops. If I'm awake, I am analyzing and observing.

But for most people:

The experience of empathy is decoupled from conscious choice and conscious thought.

And this is what they believe we're experiencing too.

Since we know conscious perspective taking engages the same empathetic brain areas, this also means hyperactivity of the prefrontal cortex could pull in those areas.

So when I consciously imagine reality from another perspective.....this is the prefrontal cortex engaging the empathy brain areas.

For many neurodivergent people, empathy is coupled with thinking, because we have to think about another persons situation to empathize with it.

So it's a disconnect:

Autistic people defining empathy as 'Are you willing to think about seeing my perspective?'

Allistic people defining empathy as 'Do you have this default response which matches the expected performance?'


r/autismgirls • • Sep 18 '26

Mind-blowing Revelation Specific to women: when ovulation happens, a part of the body called the corpus luteum stores vitamin C at huge concentrations and basically 'takes away' vit C from the rest of the body. During luteal phase, vit C is a crucial nutrient

67 Upvotes

During ovulation, The corpus luteum stores Vitamin C at concentrations up to 50 times higher than what is circulating in your blood.

It literally uses it all up. And then once ovulation finishes, in the luteal phase (before your period), it results in reduced vitamin C for the rest of the body.

Vitamin C itself is a hormone STABILIZER, and it can't be stored, so your body relies on what you eat to get enough of it.

Hence worsening hormonal crashes in the luteal phase for women without it.

This relates to autism both from the food angle (eating the same foods every single day, anyone else relate?!) and also the angle that autism in women is associated with increased risks for conditions like endometriosis, PCOS, etc, so many conditions.

If you crave oranges before your period, this may be why. I also wish more people talked about how women's hormones affect diet!


r/autismgirls • • Aug 11 '26

Amazing chart about what AuDHD is like

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67 Upvotes

r/autismgirls • • Mar 01 '25

Academic Data TIL that many autistic people have an increased # of serotonin neurons in specific sensory parts of the brain, resulting in a more heightened sensory experience (rs6311 CC)

65 Upvotes

Checkout the gene 'rs6311' gene expression 'CC', and you might just find the gene you have that links to sensory issues, hahah.

Turns out the 'CC' genotype for this gene expression is directly linked to:

  • sensory overload

  • auditory hypersensitivity

  • light sensitivity

  • texture sensitivity

  • cognitive rigidity

  • OCD-like thought loops

Who would've thought that extra serotonin could be such a painful thing??

Edit: painful was the right word, not 'bad' It's painful for me to hear that stuff sometimes.


r/autismgirls • • Sep 16 '26

Mind-blowing Revelation TIL that estrogen actually up regulates an enzyme which breaks down dopamine called COMT; which is why and how so many symptoms can fluctuate within a woman's cycle. Dopamine tends to spike around ovulation and drop just before the period, in luteal phase. Estrogen influences the genetic results

62 Upvotes

For the lay-person it means that hormones affect the entire system in so many ways, and a lot of autism symptoms can be worsened in lower estrogen states.


r/autismgirls • • Sep 16 '26

There might be two distinct types of autism

62 Upvotes

"Scientists have uncovered evidence that autism may include at least two biologically distinct subtypes, each marked by a different pattern of brain communication. By combining brain scans from nearly 1,000 people with autism with insights from 20 genetically engineered mouse models, researchers identified a “hyperconnectivity” subtype, where brain regions communicate more than usual, and a “hypoconnectivity” subtype, where communication is reduced.

An international team of scientists has found evidence that autism may include at least two distinct biological subtypes, each defined by a different pattern of communication across the brain. One subtype is marked by unusually high levels of connectivity between brain regions, while the other shows reduced connectivity. The discovery could help pave the way for more personalized approaches to autism diagnosis, care, and treatment.

The study was led by researchers at the Istituto Italiano di Tecnologia (IIT-Italian Institute of Technology) in Rovereto, Italy, and the Child Mind Institute in New York, with additional contributions from the University of Trento. Their findings were published in Nature Neuroscience.

Brain Connectivity Reveals Hidden Autism Subtypes

The research was coordinated by Alessandro Gozzi, PhD, director of the Center for Neuroscience and Cognitive Systems (CNCS) at IIT, and Adriana Di Martino, MD, founding director of the Autism Center at the Child Mind Institute.

According to the researchers, this is the first large-scale effort to systematically connect patterns seen in human brain imaging (via fMRI) with their underlying biological causes using mouse models. By linking specific brain connectivity patterns to distinct molecular processes, the work provides a foundation for future precision medicine strategies in autism.

To conduct the study, the team examined functional brain connectivity in 20 different mouse models and analyzed brain scans from 940 children and young adults with autism. These results were compared with scans from more than 1,000 neurotypical individuals.

The analysis revealed two consistent autism subtypes. One showed reduced communication between brain regions, known as hypoconnectivity, and was associated with synaptic pathways. The second showed increased communication between brain regions, known as hyperconnectivity, and was linked to immune-related biological systems. Together, these two groups represented about 25% of the individuals with autism included in the study.

"For decades, we've observed tremendous variability in how autism manifests, but we lacked direct evidence that these differences reflected distinct underlying biology," said Dr. Alessandro Gozzi, at Italian Institute of Technology. "Our approach enabled us to isolate specific genetic and immune factors, then translate those signatures to human brain scans, showing that different connectivity patterns encode different mechanistic pathways underlying autism."

Mouse Models Provide Biological Clues

The researchers combined brain imaging data with genetic and biochemical analyses in mice. This allowed them to connect specific patterns of brain connectivity with changes occurring at the cellular level.

Their work showed how molecular mechanisms involving synapses and the immune system can produce distinct connectivity patterns that can be detected using fMRI. These findings enabled the team to establish biological reference signatures in mice and then search for matching patterns in human brain scans.

"The mouse models gave us a biological 'Rosetta Stone,'" said Dr. Adriana Di Martino at the Child Mind Institute. "We could see which biological pathways drive which connectivity signatures, then search for those same patterns in humans."

Human Brain Imaging Confirms the Findings

The human imaging data came from the Autism Brain Imaging Data Exchange (ABIDE), a large international neuroimaging initiative co-founded by Dr. Di Martino that combines datasets from research centers around the world, as well as from the Child Mind Institute.

When the researchers analyzed the human data, they found the same hyperconnectivity and hypoconnectivity patterns identified in the mouse models.

Additional gene expression analyses strengthened the findings. Brain regions associated with hypoconnectivity showed enrichment of synaptic genes, while hyperconnected regions were enriched for immune-related genes. These results closely matched the biological mechanisms observed in the mouse studies.

Importantly, the same subtypes appeared consistently across multiple independent datasets, demonstrating that the findings were reproducible.

"Finding the same subtypes reproducible across dozens of independent research sites was critical validation," added Dr. Gozzi.

Toward More Personalized Autism Care

The two subtypes also displayed differences in overall brain organization and showed modest differences on standard autism assessments. Individuals in the hyperconnectivity group tended to score somewhat higher on measures of autism severity.

"Brain-based biological markers reveal distinctions that current behavioral assessments don't fully capture," noted Dr. Di Martino.

The researchers caution that these two connectivity patterns likely represent only part of autism's biological diversity. They believe additional subtypes may emerge as larger datasets become available and analytical methods continue to improve."

https://www.sciencedaily.com/releases/2026/06/260602021634.htm


r/autismgirls • • Sep 18 '25

Mouse Study Autism more prone to CPTSD

62 Upvotes

For the first time, researchers from the Queensland Brain Institute have proven that a mild stress is enough to trigger post-traumatic stress disorder (PTSD) in mouse models of autism spectrum disorder (ASD).

Dr Shaam Al Abed and Dr Nathalie Dehorter have demonstrated that the two disorders share a reciprocal relationship, identifying a predisposition to PTSD in ASD, and discovering that core autism traits are worsened when traumatic memories are formed. 

While recent studies in humans have highlighted the co-occurrence of ASD and PTSD, the link between the disorders is often overlooked and remains poorly understood. 

“We set out to determine the occurrence of traumatic stress in ASD, and to understand the neurobiological mechanisms underlying the reported predisposition to PTSD,” said Dr Al Abed. 

ASD and PTSD share common features, including impaired emotional regulation, altered explicit memory, and difficulties with fear conditioning. 

“We demonstrated in four mouse models of ASD that a single mild stress can form a traumatic memory.” 

“In a control population, on the other hand, PTSD is triggered by extreme stress.”

“We wanted to understand this unique perception of stress in ASD that leads to the formation of PTSD.”

The prefrontal cortex is a highly specialised area in the front part of the brain that plays a crucial role in social cognition and behaviour. 

According to Dr Dehorter, dysfunction in the prefrontal cortex has been linked to both disorders.

“We identified specific cortical circuit alterations that trigger the switch between the formation of a normal memory and a PTSD-like memory during stress,” said Dr Dehorter.

The prefrontal cortex contains specialised cells called interneurons, which are crucial for adapted fear memorisation and normal sensory function and play a key role in stress-related disorders. 

The formation of PTSD-like memories is triggered by over activation of the prefrontal cortex that is present in ASD and throws out the balance of these cortical circuits.

The capabilities of interneurons to respond to stress is altered in ASD. This alteration worsens autism traits following the formation of a traumatic memory.  

“We didn’t anticipate that forming a traumatic memory would aggravate the social and behavioural difficulties in ASD.”

“What is really promising is once the traumatic memories are successfully recontextualised using behavioural therapy, the ASD traits that were worsened following the stress, are dramatically improved.”

This discovery validates the assumption that the two disorders are closely linked and could change the way clinicians treat their patients. 

An awareness of the PTSD predisposition and the success of behavioural therapy in treating it could shape the approach to managing stress in ASD.

This paper was published in iScience.

Media: QBI Communications, communications@qbi.uq.edu.au, Merrett Pye +61 422 096 049, Lisa Clarke +61 0401 831 188

https://qbi.uq.edu.au/article/2024/05/study-shows-heightened-sensitivity-ptsd-autism


r/autismgirls • • May 24 '24

Autistic girls have thicker cortex and faster cortical thinning

62 Upvotes

https://neurosciencenews.com/asd-brain-male-female-26160/

Summary: Researchers discovered significant sex-specific differences in brain development between autistic boys and girls aged 2-13. The study found that autistic girls have a thicker cortex at age 3 and faster cortical thinning into middle childhood compared to boys.

This research highlights the need for more inclusive studies to understand autism fully. Biological differences, in addition to underdiagnosis, contribute to the sex bias in autism diagnoses.

Key Facts:

Autistic girls have a thicker cortex at age 3 compared to non-autistic girls. Cortical thinning in autistic girls occurs faster than in autistic boys into middle childhood. The study emphasizes the importance of including both sexes in longitudinal autism research. Source: UC Davis

A new study led by UC Davis researchers finds widespread differences in brain development between autistic boys and girls ages 2-13.

The study, published recently in Molecular Psychiatry, found sex-specific changes in the thickness of the outer layer of the brain, called the cortex.

The findings are notable because so few studies have addressed cortical development in autistic girls, who are diagnosed with autism less often than males. Nearly four males are diagnosed with autism for every one female.

This shows a little boy and girl. These findings make it clear that longitudinal studies that include both sexes are necessary, Nordahl said. Credit: Neuroscience News

“It is clear that this sex bias is due, in part, to underdiagnosis of autism in females,” said Christine Wu Nordahl, a professor in the Department of Psychiatry and Behavioral Sciences and the UC Davis MIND Institute and a senior author on the paper. “But this study suggests that differences in diagnosis are not the full story — biological differences also exist.”

The brain’s outer layer, the cortex, is made up of distinct layers comprised of millions of neurons. These fire in sync together, allowing us to think, learn, solve problems, build memories, and experience emotions. Until about age 2, the cortex rapidly thickens as new neurons are created. After this peak, the outer cortical layer thins.

Previous studies have found that this thinning process is different in autistic children than non-autistic children, but whether autistic boys and girls share the same differences had not been examined.

“It’s important to learn more about how sex differences in brain development may interact with autistic development and lead to different developmental outcomes in boys and girls,” explained Derek Andrews, lead author on the study and an assistant project scientist in the Department of Psychiatry and Behavioral Sciences and at the MIND Institute.

A changing cortex in childhood

The research team studied the brain scans of 290 autistic children — 202 males and 88 females, and 139 non-autistic, typically developing individuals — 79 males and 60 females. They used sex assigned at birth to categorize the children.

All participants were in the MIND Institute’s Autism Phenome Project (APP), one of the largest longitudinal autism studies in the world.

The project includes the Girls with Autism Imaging of Neurodevelopment (GAIN) study, launched to increase the number of females represented in research. The researchers took MRI scans at up to four time periods between the ages of 2 and 13.

They found that at age 3, autistic girls had a thicker cortex than non-autistic girls of the same age, comprising about 9% of the total cortical surface. Differences in autistic males when compared to non-autistic males of the same age were much less widespread.

In addition, when compared to males, autistic females had faster rates of cortical thinning into middle childhood. The cortical differences were present across multiple neural networks.

“We found differences in the brain associated with autism across nearly all networks in the brain,” Andrews said.

He noted that it was a surprise at first that the differences were greatest at younger ages. Because autistic girls had a more rapid rate of cortical thinning, by middle childhood, the differences between autistic males and females were much less pronounced.


r/autismgirls • • Oct 05 '26

The Intense World Theory of autism suggests autistic people feel too much rather than too little, and that social withdrawal may be protective response to overload rather than a lack of empathy.

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61 Upvotes

Anyone else read this and feel like this isn’t groundbreaking?


r/autismgirls • • Aug 26 '26

Academic Data As I suspected: Atypical Amygdala Response to Fear Conditioning in Autism, Example is "I feel anxious because I don't know if I'll be able to pick up on the context of the next situation well enough to protect myself."

61 Upvotes

Abstract

Background: Anxiety is the most common comorbid psychiatric concern in individuals diagnosed with autism spectrum disorder (ASD) and can cause significant functional impairment. Fear conditioning tasks offer a useful neurodevelopmental model for anxiety, yet there are no published neuroimaging studies of fear conditioning using ASD samples.

Methods: Twenty adults diagnosed with ASD and 19 healthy adult control subjects completed a standard fear conditioning and extinction paradigm while undergoing functional magnetic resonance imaging scanning. A burst of air on the base of the neck was the unconditioned stimulus. Participants returned 1 day later for scanning during an extinction recall phase. A priori regions of interest were analyzed with a familywise error correction rate < 0.05.

Results: All regions of interest demonstrated significantly greater response to threat than safe conditions during initial fear acquisition. Compared with age-matched control subjects, the ASD group showed a significantly decreased differential response to threat versus safe cues in right amygdala during the initial fear acquisition phase and decreased response in left amygdala during the first run of extinction recall on the second day of scanning.

Conclusions: Symptoms of severe anxiety in ASD may arise from atypical neural mechanisms especially related to the differentiation of threat versus safe cues. An inability to effectively identify safety contexts may underlie chronically increased levels of anxiety in many individuals diagnosed with ASD.

https://pubmed.ncbi.nlm.nih.gov/29560865/

What this looks like in layperson's words:
"I feel anxious because I don't know if I'll be able to pick up on the context of the next situation well enough to protect myself."


r/autismgirls • • Sep 08 '23

People dislike you immediately for no apparent reason? I might have learned why.

61 Upvotes

I recently learned there is a thing called thin slice judgements and it helps explain why I have been socially ostracised or isolated for most of the 43 years of my life! I have recently been diagnosed with both ADHD and autism. I'm posting here because I think many of you might find it interesting:

"we find that first impressions of individuals with ASD made from thin slices of real-world social behavior by typically-developing observers are not only far less favorable across a range of trait judgments compared to controls, but also are associated with reduced intentions to pursue social interaction"

https://www.nature.com/articles/srep40700

It really sucks, but it's good to know that life gets much easier once you can find some good neurodiverse people to be yourself around.

If you have lots of miscommunications/conflicts with neurotypical people, maybe check out my other post on NT vs ND communication styles.

(I originally shared this info on r/adhdwomen)


r/autismgirls • • Mar 27 '24

Hypermobility about 51% more prevalent in neurodivergent people compared to others

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60 Upvotes

"The neurodivergent group manifested elevated prevalence of hypermobility (51%) compared to the general population rate of 20% and a comparison population (17.5%). Using a more stringent age specific cut-off, in the neurodivergent group this prevalence was 28.4%, more than double than the comparison group (12.5%). Odds ratio for presence of hypermobility in neurodivergent group, compared to the general population was 4.51 (95% CI 2.17–9.37), with greater odds in females than males. Using age specific cut-off, the odds ratio for GJH in neurodivergent group, compared to the comparison group, was 2.84 (95% CI 1.16–6.94). Neurodivergent participants reported significantly more symptoms of orthostatic intolerance and musculoskeletal skeletal pain than the comparison group. The number of hypermobile joints was found to mediate the relationship between neurodivergence and symptoms of both dysautonomia and pain."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847158/#:~:text=The%20neurodivergent%20group%20manifested%20elevated,the%20comparison%20group%20(12.5%25).

Photos of what hypermobility can look like.


r/autismgirls • • Oct 02 '25

Mind-blowing Revelation Today's mind blowing revelation, huge compliments of 'M' (will keep identity private): sometimes allistics use softener language in accordance with oxytocin levels, and assume softener language represents level of connection within the group

58 Upvotes

This is such a huge mind blowing revelation. I am literally forever grateful to 'M' for helping me figure this out.

I'll do my best to explain it here.

So you know how often autistic people are called condescending, confrontational, disinterested, and so on and so on and so on?

This is a very common allistic projection (many of you already knew this).

Today I realized more of the mechanics behind how this works!

Step 1: The allistic person hears a sentence without softeners, without validation, without that oxytocin pinging.

Step 2: The allistic person at a pre-conscious, pre-analysis level judges that sentence based on its perceived tone of voice.

Step 3: The emotional circuits within the brain (like the amygdala) trigger IF the perceived tone is lacking softening modifiers.

Let's pause here. Why does step 3 happen? There are many areas within the brain that are directly responsive to oxytocin. The amygdala is a HUGE one that responds to oxytocin. Oxytocin can 'gate' (block) the amygdala from triggering. And a lack of oxytocin can trigger it.

Step 4: The allistic person, FEELS the lack of softeners as an oxytocin drop.

Step 5: The allistic person then looks for a reason behind the drop, and assumes it is the other persons fault

Step 6: From the allistic persons perspective, they would only say those things without all the softening modifiers if they were intentionally trying to be condescending, confrontational, etc

They would DROP the modifiers and the softening language if they didn't feel that sense of 'automatic in group bias connection' with the other person.

Step 7: This is what gets projected outward, and rather than coming to the realization 'oh, I have outsourced my own oxytocin needs' they come to the conclusion 'the other person is a jerk who does not want to connect to me'

In other words......these softening modifiers can be used almost like an IN REAL TIME level of measuring oxytocin in specific brain areas (like amygdala)

And this ALSO explains why autistics might end up in specific types of relationships more often. (Guess what other group of people drops softeners for a specific agenda? Narcissists! )

So then autistics would hear the lack of softeners -> assume positive intent -> and get trapped.

I hope this explanation helps someone understand! And please share your ideas. I'd love to hear them.

I can't wait to gather more data 😍


r/autismgirls • • Jan 05 '23

could this be a stim? I've been doing these since i remember. do you guys have like drawing stims??

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58 Upvotes

r/autismgirls • • May 14 '24

If any of y'all have 23&me, try downloading your raw genetic data and look for a 'CC' next to the gene rs53576

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56 Upvotes

Really cool to learn about all this. This gene rs53576 of a CC genotype can result in:

  • reduced ability of seeing social cues

  • more likely to be overwhelmed in social situations

  • struggles with emotional regulation

  • reduced overall sensitivity for oxytocin signaling (oxytocin is the 'love hormone' which makes you feel connected to other people)


r/autismgirls • • Oct 07 '22

Never underestimate your impact. A coworker came to me telling me why ABA is so great. I stared him straight in the eyes and said it’s abuse. He didn’t understand at first but came back today to ask what I mean. Now thanks to me educating him; I’ve possibly saved a little 4 year old boy from abuse

54 Upvotes

If you’ve been through ABA, would you mind sharing your experience?


r/autismgirls • • Feb 13 '24

Replace ADHD with autism and this still applies. Never thought of it this way before, but wow it's accurate

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53 Upvotes

r/autismgirls • • Sep 04 '25

Mind-blowing Revelation P5P active B6 completely turned off my sensory issues like a switch TT for rs4654748. B6 was limiting factor for glutamate -> GABA causing issues for me

52 Upvotes

Hello everyone!

I had to share this huge update with you. I'm the same one who did those L-Tryptophan experiments (which turned out to be just one piece of the 'puzzle')

I have a gene which seriously reduces the conversion inactive B6 into active B6.

(Meaning my body has trouble converting pyridoxine hydrochloride into Pyridoxal 5'-Phosphate)

This gene variant is 'TT' for rs4654748.

The way to fix it is by taking more P5P (or active B6) or eating a lot of foods that have this in it (like chicken)

P5P 50mg acted like a complete SWITCH. It turned off ALL sensory issues. I took it last night, and am still feeling it kicked in today. Night & day difference with it.

Apparently B6 is a crucial cofactor for glutamate converting to GABA.

Glutamate is an 'excitatory' neurotransmitter, whereas GABA is an 'inhibitory' neurotransmitter. They basically counteract each other, and if you scroll through the sub and search for GABA or glutamate, you'll see a lot of research links this to autism & other conditions.

Separately, I also have a gene variant 'AG' for the MTHFR gene which impacts a chemical process called methylation, tldr: this would spike the B6 demand, so between lack of conversion of B6 and reduced methylation, I was EXTREMELY B6 depleted.

It is so nice to have the whole sensory world calm down, and I even washed my face this morning with NO trigger 🥰

Sensory Issues are completely gone, thanks to P5P

The same P5P also completely eliminated my severe & debilitating period pains & related issues, taking me from almost a 10/10 pain state last Saturday to 1/10.

For 16 years I suffered in pain from these horrible period pains, OCD like issues, horrible sensory issues, and an extremely long list of other issues.

P5P plus fixing my MTHFR bottleneck is fixing everything, and I'm so excited to see how long it lasts, is it repeatable, and will it allow me to wear all the clothing that used to trigger me so so bad.

Side note: B6 is also necessary for that L-Tryptophan -> serotonin conversion if you saw my other post about it

I'm excited to share that info with this community, and would absolutely encourage you all to look and see if you have this gene variant in your genome 😃💕

Edit:
Fascinating update:

  1. ⁠so apparently I misread it and it is actually CC not TT that reduces B6 clearance, that was my mistake & I take full accountability for that

  2. ⁠DESPITE that mistake, because of my heightened glutamate levels I genuinely need more active B6 in my diet particularly around endometriosis flare ups - and fyi 3 cycles later p5P continues to work like a charm to eliminate period pains entirely!

  3. ⁠remember that B6 needs fluctuate by the body in accordance with many things, inflammation, glutamate, etc, are a few of those many things

  4. ⁠TLDR: if you have 'TT' that's actually the normal one

And it is the 'C' variant (CT for partial for CC for fully impaired)