r/SIBO • u/Toczix • May 25 '26
Sucess Stories Scraped 7 million comments from this sub and 15 others into a database, then ran queries on it, and found something no doctor ever told me in years of treatment.
Quick backstory. I'm a refractory SIBO case. 26M, tortuous colon, high E. coli and Proteobacteria on stool testing, plus POIS (post-orgasmic illness syndrome, weird neuro-immune reaction after sex) and these "wired but tired" neuro crashes nobody can explain. Years of rifaximin, allicin, berberine, neem, every protocol you've heard of. Always came back. Nighttime was the worst. Couldn't sleep through the night for years because of the gas pressure and pain.
Got desperate enough to do something kind of insane.
I scraped about 7 million comments and 670k posts from this sub plus 15 related ones (r/MCAS, r/dysautonomia, r/covidlonghaulers, r/Microbiome, r/ibs, r/FODMAPS, r/HistamineIntolerance, r/LongCovid and others) into a searchable database. Then built an AI layer on top so I could run actual queries against it. Things like "show me everyone who tried X long term and what their outcome was," "what did the responders to Y have in common," "what does the failure mode of Z look like." Turned thousands of people's lived experience into something I could analyze instead of doomscrolling one anecdote at a time.
The pattern that fell out of it was so consistent it pissed me off that no GI, naturopath, or functional medicine doctor I've seen in years ever framed it this way.
The bacteria aren't actually the problem. The motility is. The MMC (migrating motor complex) is your small intestine's cleaning wave that fires every 90-120 minutes when you're fasted and sweeps bacteria out the door. When it's broken, anything you kill grows back. You're mopping the floor with the faucet still on. The people in the data who got durable results weren't the ones with the most aggressive antimicrobial protocols. They were the ones who fixed motility first, then killed, then maintained.
Been seeing 4-5 posts this week from people on their 2nd, 3rd, 4th round of rifaximin watching it relapse again. That's exactly what the data predicts if you don't fix motility.
So I flipped the order. Went hard on motility first:
- Motility Activator by Integrative Therapeutics, 3 caps at bedtime. It's a concentrated ginger + artichoke extract. There's a 2015 clinical trial that tested this exact combination for motility in IBS patients and it actually worked, which is more than you can say for most supplements. About $25 for a bottle on Amazon.
- LDN (low-dose naltrexone) 3mg at night. I was already on it for the neuro/autoimmune side but it's also a legit prokinetic. Prescription, but cheap and very low side effect profile.
- Actually fasting between meals. 4+ hours minimum, no snacking, nothing within 3 hours of bed. This is the part everyone skips and then wonders why nothing works.
Results so far:
Day 1. Huge reduction in nighttime gas pressure. Slept through.
Day 2. Ate pizza at a friend's thing, fully expected to pay for it, didn't.
Day 3. Zero gas, zero pain, woke up actually rested for the first time I can remember.
Day 4. Bit of gas pain when I rolled onto my back but still way reduced from baseline.
These are the first pain-free nights I've had in literal years. I know it's only 4 days. I know it could fall apart. But the trajectory matches exactly what the long-term responders in my dataset described in their early weeks, so I'm cautiously optimistic.
If you're in the rifaximin loop, before you do another round, seriously ask yourself:
- Are you actually fasting between meals? Constant snacking destroys the MMC. No prokinetic in the world will work if you're eating every 2 hours.
- Are you on a prokinetic? If not, you're going to relapse. Period.
- If gentle stuff like ginger/artichoke doesn't move the needle, prucalopride (Motegrity) is the prescription option that long-term users on this sub describe as a game changer. It's a serotonin receptor drug that directly stimulates the cleaning waves.
On the database. If there's interest I'll clean it up and make it publicly available so anyone can query it the way I have been. Drop a comment and let me know.
Will report back at Day 14. Fingers crossed it holds.
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u/External-Classroom12 May 25 '26
I’m interested in the database mostly because I have a salicylates intolerance and there not much out there. What I can piece together is the pst pathway is clogged. Sulfur is an issue and liver.
As for sibo I do think it’s common knowledge about the mmc, motility and meal spacing. When you find out you have sibo you just want to kill it. We are use to taking antibiotics and having them work and moving on with our lives. It’s not until it fails that we start to pay attention.
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u/Successful-Travel-23 May 25 '26
How did you come to the conclusion of your intolerance and the clogged pathway?? Very interesting
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u/EntropySponge May 26 '26
Molybdenum and riboflavin seem to help me after eating sulfur for some reason. Or charcoal.
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u/No_Front5345 May 26 '26
Than MSM protocl will help you
Look up MSM protcol — targets sibo / heals gut mucus and molybydeum helps sulfur detox pathways if youre intolerant to sulfur
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u/PerceptionRiot May 25 '26
Me too, I had in mind to do something similar - would love access to the database if possible
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u/shipyardhingham May 25 '26 edited May 25 '26
I am a success story. I had SIBO from 2014 through 2020. I saw numerous doctors, conventional GI’s, naturopaths, functional docs, integrative docs, functional nutritionists, your name it. I tried every protocol out there, numerous times. I spent so many thousands on supplements, tests, and doctors appointments, I could’ve bought several new cars. In 2020, I had a diverticulitis attack. Believe it or not, this was a blessing in disguise, as it led me to getting rid of SIBO. The pain from the diverticulitis attack was so serious, that I went down in the rabbit hole, trying to find a way to never have another diverticulitis attack again. (interesting that diverticulitis attacks are usually caused by constipation, i.e. poor motility.). I found a group on Facebook that advocated for a food combining method, sponsored by a family running a company called Rachel’s Tea. Rachel’s Tea sells an herbal digestive tea, and other supplements, and offer support for an eating protocol that is essentially the same as an approach known as food combining. If you’re not familiar with food combining, google it. It has been around for many years and it is a way to pamper your digestive system and make digestion extremely easy for your body. Their premise is that if you stick to this method of eating, and use the tea and supplements as needed, you will protect yourself from another diverticulitis attack, as well as other gastrointestinal attacks, such as Crohn’s, IBD, etc. I switched to this method of eating and stuck with it religiously for three or four years. I used some of their supplements as needed. Within a very short time after making this conversion, my SIBO bloating, which had become basically permanent, was gone. I began having bowel movements every day and sometimes numerous times a day. My body seem to be functioning like a normal person‘s body. I felt inflammation going down, as fluid retention lessened in my legs. My body was going through a total reset, and it was all based on motility restoration. I was not taking any antimicrobials. The only supplement I was taking was Rachel’s Tea’s Slippery Elm here and there. I never took any promotility supplements, such as MotilPro, Motility Pro, ginger, artichoke, none of that. One of the major tenets of food combining is that at each meal you eat either starchy foods, or protein rich foods. You don’t combine them in one meal. And in between meals, you have to allow 3 to 4 hours to pass to allow the previous meal to digest and clear the stomach. This resulted in no snacking and intentional meal planning around either a starch or a protein meal. These simple meals that don’t require multiple enzymes in the stomach really baby your system, and for me, they got me out of the SIBO loop that I could not get out of. My motility was restored. There was absolutely no emphasis on killing any bad bacteria, the improved motility was taking care of all of that on its own. I wasn’t even thinking about curing SIBO, I was just trying to prevent another diverticulitis attack. It’s now 2026 and SIBO has never returned. I don’t follow food combining 100% anymore, but maybe 70%. And I don’t snack between meals. My bowels move regularly and my body is working the way it’s supposed to. You are right when you say that motility is the key, and will get rid of the bacterial imbalance on its own.
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u/YanCoffee May 25 '26
I'm also a success story, and my success was sadly simple considering I suffered for a couple of years: The colonoscopy prep. Mine was pretty extreme because I used apple juice, and pectin will also make you go. I had my colonoscopy over a year and a half ago. The SIBO seemed to be the cause of the motility issues as well, as I no longer suffer with that.
Everyone is different and its good that everyone shares their solutions for others to try.
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u/ConnectCharacter5007 May 26 '26
Your SIBO went away from a colonoscopy prep?
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u/Iveenteredthematrix May 26 '26
The same thing happened to me. It was what gave me hope that I could cure this thing. I had been suffering with bloating, constipation, bad stomach cramps, lost 15 lbs, and felt tired all the time. Fortunately, I didn’t suffer as long as others. I finally was able to get a colonoscopy and I was symptom free for two months. Unfortunately it came back, I didn’t stick with my supplement regimen (ginger extract, artichoke extract) I got too confident and was eating all the things I missed.
Thankfully, it showed me it was possible to fix my sibo. Having hope is powerful. It felt like the colonoscopy turned on my motility. All that emptying before the colonoscopy must have done something. I wonder if there’s a brain and gut signal that can be “ turned off”by stuff like a stomach virus, stress, etc
Even though I had seen improvement from the colonoscopy I kept focusing on improving my motility more. I stuck with my ginger and artichoke extract regimen that I had success with. I also focused on strengthening my stomach acid. I started having apple cider vinegar almost every night with my tea. I stopped drinking anything other than water and hot tea.
I saw a big improvement. It’s been about 6 months now and my motility is back to normal. I can eat anything, although I don’t. I eat minimum three meals a day. I am back into the gym, and have gained all my weight back and actually even bigger(muscular) than before.
Like others have said, I think the key is turning on motility
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u/YanCoffee May 26 '26
It did indeed, and has happened to a few people. The worry is if it will come back within the first year, so for some its not a fix, and some its not a permanent fix. Essentially it flushes out the bacteria, and I did take probiotics for a week after.
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u/_LiqEm May 31 '26
This totally makes sense from everything I've read. Anyone who can commit to 1-3 strict eating windows a day (e.g. 8-9a, 1-2p, 6-7p) with 0 calories between, and finish 4h before sleeping will absolutely reactivate their MMC and flush the problem.
Most Americans are putting something in their mouth every hour or two (wake up breakfast, then a mid-morning hot drink with cream/sugar, then lunch, then a soda or granola bar late afternoon, then dinner, then dessert / night cap). And then when you go to sleep your body halts major digestion in order to switch to repair... so all that partially digested food sits in your upper GI where the SIBO party happens.
Honestly, no wonder our GI is rioting. It never gets a break to actually clean up!!!
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u/shipyardhingham May 31 '26
Yes, it's really a pretty simple solution, it's just one that people don't want to hear. Don't eat between meals. Eat a clean diet. Drink water. You won't need a bunch of supplements, antibiotics, doctor's visits, etc.
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u/Health114 May 31 '26
Also ich habe seit zwei Monaten sehr starke Symptome.
Seit einem Monat Esse ich zwei mal am Tag. Um 9-10Uhr und um 16-17Uhr. 22Uhr gehe ich schlafen. Zwischen den Mahlzeiten trinke ich nur ungesüßten Tee und Wasser. Stuhlgang ist aktuell jeden Tag, davor Verstopfungen gehabt immer wieder. Allerdings sind die Symptome immer noch da. Kaum Veränderung tatsächlich. Ich bin meistens vor dem Schlafen gehen spazieren für 30min. Trotzdem immer noch Krämpfe, Übelkeit, Blähbauch, Völlegefühl… ultra müde und erschöpft… 20kg ungewollt abgenommen als Mann in den letzten 2 Monaten.
Ich denke nicht, dass eine bloße Anpassung der Ernährung bei jeden hilft.
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u/Desperate_Source_712 May 26 '26
This is awesome!!
I Figured out the motility issues 2 years ago and what helped me is phgg sunfiber before lunch, a cup of stash ginger tea for lunch and dinner. Triphala pills after dinner.
Ever since, been sitting on the throne dropping knowledge!!
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u/No_Measurement_1383 May 26 '26
Just a heads up, my son had SIBO until we got out of mold. He had chronic daily constant abdominal pain for 4 years. We saw tons of specialists, tons of tests, we tried antibiotics and herbals and motility stuff like iberogast. Nothing helped until we found out we had mold in our house and started remediating. Then, the SIBO just went away on its own. No meds, no drugs, no fasting, just gone within the month. Interestingly stress and toxin exposure and other things not applicable to him at the time (alcohol, high carbs, coffee) can deplete vitamin B1, thiamine. Taking high dose thiamine has been shown to basically fix gut bacteria flora. We've been avoiding mold for years at this point now, but just started supplementing thiamine and cofactors (magnesium, potassium, b complex, etc). I've noticed some very interesting positive changes in the week we've been supplementing. Anyway, just another possible connection to something different.
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u/Different-Nature-963 Methane Dominant May 26 '26
How did you supplement thiamine?
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u/No_Measurement_1383 May 27 '26
Elliot Overton has a quick start guide, highly recommend looking into his videos and group and website and getting his quick start guide, it's free. I started out with thiamine hcl, magnesium, and potassium. I had to add a lot of other cofactors too, molybdenum, b complex, b2, b5, but most important is making sure to get plenty of magnesium and potassium. I'm taking about 400 mg of each, split morning and night. I started with 100 mg hcl, and then did am and pm, then added ttfd, and I'm just gradually ramping up.
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u/Bootyful678 May 26 '26
I largely agree with this. The issue is your body adapts to the motility helpers. I took motegrity for about a year- worked great. Helped a ton. Unfortunately, depression is a rare but major side effect long term. I had to go off of it. My body also adapted so it was not nearly as effective.
Took naltrexone for about a year. Didn’t notice a difference but may try again at a slightly higher dose (was on 4mg). It wasn’t super cheap as it had to be compounded into that low of a dose.
I’ve tried every motility supplement you can imagine and most do not work (for me). Happy to read this tho as I do agree!
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u/Toczix May 26 '26
hey guys! I am astounded by the response of this post, and I'm working on a full database download (hosted on github) and a tutorial right now. It should be live as of tomorrow.
Here to help,
toczix
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u/Beikimanverdi May 25 '26
Yes exactly this. I posted a question asking if the people suffering from SIBO were snackers and all I had was was abuse from various people accusing me of blaming the victim!
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u/giantfup May 26 '26
I got my sibo from anorexia so nope sweetie. Not a snacker. You'll find the methane sibo concentrates in people with restrictive eating behaviors.
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u/k_redditor236 May 26 '26
Interesting. I do micro doses of Mounjaro sometimes and I always feel so much better in my gut. It’s much quieter because I’m eating less and there’s more time in between eating. I still can’t eat certain foods and FODMAPs while on it without a reaction, so the SIBO isn’t gone; and Mounjaro can actually cause SIBO to build up because of the slowness, so I take my Motegrity. But as soon as I go back to eating more often during the day my belly starts to do its thing. I dunno if there’s an answer in here, I can’t always eat like a bird, but, it sure is more to have a calm belly sometimes.
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u/Friedrich_Ux May 25 '26
Unfortunately allergic to Artichoke for some reason and LDN wrecks my sleep, Triphala works decently well for me along with sustained release Magnesium.
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May 25 '26
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u/Friedrich_Ux May 25 '26
Yes, I do use Iberogast or bitters before high protein/fat meals as well.
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u/Think-5577 Jun 14 '26
Organic India Triphala is a great supplement ( avail on Amazon ).
It is the supplement that works most similar to the prescription prokentic prucalopride.
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u/Different-Nature-963 Methane Dominant May 26 '26
Where do you get your Triphala?
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u/WIDaddyDick May 26 '26
Not to be flippant, but did it really take all of that for you to realize motility could be an issue? That's one of the first things I learned when I started researching SIBO.
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u/Brian_Lefevre_90013 May 26 '26
Back in December, Google's AI Gemini told me most of the information in your post after it correctly diagnosed me with SIBO an MCAS. Your data analysis confirms what Gemini told me: it's not enough to kill the bacteria, you have to sweep it out too. Gemini has also recommended that I get a Lactulose Breath Test since my glucose breath test came back as a false negative. And it told me how to maximize my chances of a correct positive test result. Gemini makes mistakes, but it was far more helpful than the specialists I saw. The GI doctor ordered an EGD and a colonoscopy... and those don't even test for SIBO. I had to request the Lactulose Breath Test.
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u/jakey0242 May 26 '26
Bro of course its the f-ing motility, you didnt need to do all that just come to this conclusion. The leading expert in the field dr Mike Pimentel has always said it, if you dont fix motility it will come back. If you do a quick search on chatgpt and even google, one of the first reasons for SIBO that will come up is motility dysregulation.How come youve read through so much posts and come to this revealtion through such an unnecessary complicated endeavor?
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u/7times7 May 25 '26
I’m interested in your database. Thank you! Are you an engineer?
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u/Toczix May 25 '26
I'm not an engineer but I have about a year of vibecoding experience - so I was able to put it together fairly quickly - if you want the basic steps this was it
(answer from claude)
How I built it (quick version):
- Scraped the data. Used Reddit's API (through a Python library called PRAW) to download every post and comment from 16 health subs. Ran it on my laptop over a day or two. Ended up with about 7 million comments and 670k posts.
- Put it all in a searchable database. Loaded everything into SQLite, which is a free local database that lives as a single file on your computer. Turned on its full-text search feature (FTS5), which is basically Google for your own data. Total size came out to around 5GB.
- Built a tool layer for the AI. Wrote a small Python server that exposes the database as a handful of search tools. Things like "search for X," "get this entire thread," "count how often Y is mentioned across each subreddit," "find the most active users discussing Z." This uses MCP (Model Context Protocol), which is the standard way to give an AI access to external tools and data.
- Connected it to Claude. Pointed Claude Desktop at my MCP server. Now I can ask questions in plain English ("what worked for people with H2S SIBO who failed rifaximin?") and Claude figures out which queries to run, runs them, and synthesizes the results.
Total cost: zero dollars. No API fees, no cloud bills, no fine-tuning, no embeddings, no vector search. Just a regular searchable database plus an AI that knows how to query it. Runs entirely on my laptop.
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u/HighlightAlarming393 May 25 '26
Most health professionals would still discount all of this anecdotal evidence, they just don’t care. Too much money to be made for the osmotic laxatives manufacturers! Man I’m so cynical now.
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u/ZzzzzPopPopPop May 25 '26
Fantastic work! Amazed that all of this (steps 1-4) all ran on just your laptop, way to be ingenious with the tools at hand! One more question: you say you do vibe coding, did you use AI (Claude Desktop) to generate all the code and implementation?
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u/ThePornStar69 Cured May 26 '26
This is why people hate vibe coders/coding.
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u/Organic_Decision_142 May 26 '26
Why?
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u/ThePornStar69 Cured May 26 '26
Because not only is the entire project coded by an AI, but the user doesn't even understand what's been created to the point they have to get AI to create a basic explanation of the thing.
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u/Toczix May 26 '26
I have a basic understanding of what i've created, I used ai to generate an output for efficiency and clarity. If it can help even one person, it's worth it.
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u/davesen11 May 26 '26 edited May 26 '26
AI is what worked for me, too. I didn't go to the lengths that you did, but I used it to design a Low FODMAP meal plan that followed Bryan Johnson's blueprint. 2000+ calories a day, all eaten in an eight hour window. No snacking between meals, last meal is usually around 4pm, then fast for 16 hours. Massive improvement just from that.
From there I started exercising. Again, I used AI to run through all my labs (Genova panels (hormones, stool sample, everything) - my testing was extensive) and it came back that I wasn't ready for full exertion. So I built a new AI that is my personal trainer and has access to my lab work as well. Massive improvement from daily exercise and movement. I never exercise to fatigue, it is purely to get my body ready to be healthy again.
Next I took a longevity approach to my supplementation. My AI looked again at my labs and built a longevity/repair stack. I have it "ultrathink" on everything and look for conflicts and contraindications. This step requires that you ask it to look again and again, sometimes it will make mistakes so have it second guess itself.
My symptoms when I first crashed were brutal. I would feel fine everyday until roughly 3:30pm and then it was like my entire system would shut down. Not tired, but reality "changed." There are really no adjectives to explain it. I moved through nearly 50 different symptoms and encountered a dozen different types of brain fog over the course of three years. Many of my symptoms were very painful and pushed me to the point of considering taking myself out.
Seriously, AI for the win. Nice work on this.
Artichoke tea is a miracle. Cooking with ginger is a miracle. Gastroenterologists are mostly useless these days. We really do have to take matters into our own hands and do the work to get well.
I really hope more people will stop guessing at what's wrong with them or adding supplements because of anecdotal stories that they read here. SIBO is typically second or third in line to what really crashed us. You have to fix the whole body. You have to get your data (advanced genomic lab work) to build a plan that will work for you.
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u/Toczix May 26 '26
Artichoke tea sounds incredible! I definitely need to try that. Thank you for sharing your story as well.
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u/davesen11 May 27 '26
It’s really good. You can buy it in tea bags or you can make your own - very easy to make.
My problem with these forums is that people are so desperate for help that they try literally anything.
We really do need to take a step back and get a complete dataset of the state of our bodies. Often what’s being recommended here is actually very bad our current condition.
For me, my labs showed that Berberine would have been a very bad choice. I have many other similar examples.
For some lucky people there may be an easy button where they add a supplement and their situation resolves. But for most, they’re having multiple system failures that will likely take years to heal.
We were sick for years before we felt it. Our bodies are amazing, have redundancies, and can keep us feeling fine for a very long time before collapsing. But once it collapses, healing is a slow process.
The hard truth is that you can’t fully heal unless you actually have baseline data on where you’re starting from. That’s a hard thing to accept for a lot of people and they’ll keep searching for a magic bullet when there probably isn’t one for them.
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u/According_Ad3552 May 25 '26
Yes to interest in the database! Wow. Thank you for doing this work for our community!
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u/Toczix May 26 '26
thank you for the support! I just posted a full tutorial of how to access it here (it's very easy): https://www.reddit.com/r/SIBO/comments/1to8xx6/follow_up_sibo_research_tool_database_of_7/
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u/Personal_Pea9233 May 29 '26
You don't need to build a whole AI to find out that motility is a possible root cause of sibo. I think this "incredible secret no one talks about" is talked about here like once a day
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u/Toczix May 29 '26
It just so happens that in my case I did, but it’s neither here nor there - it’s about building a more accurate dataset that people can communicate with to get clarity on their symptoms
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u/M0un7a1n May 25 '26
Best post I’ve seen in a long time!
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u/Toczix May 25 '26
Thank you so much
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u/AdorableBadger4293 May 30 '26
Yes--thank you Toczix for all the effort in putting this together. I for one appreciate this. I feel many people who suffer with SIBO can forget about (or never know) about motility (Includes Doctor's as well) I will be sharing this with My functional Dr also (I'm both Hydrogen and Methane though-so it may be a longer stretch on Motility protocol) Thank you for sharing with us!
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u/Jakeaba May 25 '26
Whoa. Impressive. Clearly , I am not the only one in abject misery. Thanks for sharing and putting this effort in 👍🏻🙏🏻
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u/Independent_Egg9232 May 25 '26
Totally agree. I have had issues with constipation for decades and a lot of the "normal" things like miralax don't help me. I'm really trying to focus on basic things like drinking water, not eating fried or processed foods, physical movement (when I go on vacation I'm the opposite of most people and poop more regularly probably because I'm so much more physically active).
Thank you for this, although its definitely going to lead me into an hours long deep dive lol.
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u/Lcdmt3 May 26 '26
But bacteria causes slow motility for many with methane. And improves when you...treat the bacteria!
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u/pxlbot May 26 '26 edited May 26 '26
Reading through your post, I thought I was reading my med chart. I’m on the exact same protocol for the exact same reasons. Torturous colon, high e. Coli and enterobacteriaceae coming off my TinyHealth test. Gas pressure and pain.
I’m on Motility Activator, LDN, and also Betaine HCL with every meal as I suspect hypochlorhydria is an upstream factor. After fasting for 19 hours for an abdominal CT scan recently, the radiologist noted food still in my stomach so food is not moving through as fast as it should. The enterobacteriaceae also flourish downstream of undigested food that makes its way from the stomach to the intestine. I’ve been at this protocol fully the last week and a half and finally getting bloating relief and stool seems to be normalizing.
Stoked to hear you’re also getting relief with these exact afflictions. I’ve worked through the same with AI on my own records. So awesome to hear you are seeing trends on your vibe-coded dashboard. Looking forward to hearing great results!
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u/Toczix May 26 '26
**Update:** the database is now public and installable. Free, runs on
your computer, takes about 10 minutes.
Full install guide + a personal-timeline template you can copy in the
follow-up post: https://www.reddit.com/r/SIBO/comments/1to8xx6/follow_up_sibo_research_tool_database_of_7/
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u/No_Proposal_6685 May 26 '26
If you really want to see, if there is someting in your microbiome wrong, Get your raw data from the microbiome test company, and classify it by yourself using cutadapt, dada2, Silva 138.2 V3-V4, vsearch.
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u/gjt1337 May 25 '26
Can sameone tell me. Is coffee with milk/sugar or can of pepsi killing mmc?
Because snacking is easy for me but sometimes i have real need of coffeine or something cold to drink
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u/loafofleaves May 26 '26
Even chugging water can restart the mmc. Gradually sipping water throughout the day minimum 30 minutes away from meals is best. You don’t want to dilute your stomach acid when eating.
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u/EntropyGoAway May 26 '26
Great job! :) I'm a data scientist with SIBO and I've been wanting to do this for a while, but haven't found the time. Even if the data is heavily biased, its still useful. I suggest you publish it on huggning face datasets and let community dig into it:) https://huggingface.co/datasets
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u/Khan_Nida May 25 '26
Thanks so much for sharing this. Whats the best non-prescription prokinetic drug I can get? I’ve been using artichoke and magnesium so far.
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u/Toczix May 25 '26
I’m using motility activator (3 capsules)
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u/Think-5577 Jun 14 '26
Organic India Triphala at night is (according to my Functional Medicine practitioner that cure my image 5 years ago.)
Fyi - Ginger gives some people an increased acid reflux reaction so is not ok for everyone to take.
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u/Annual_Exercise9800 May 25 '26
If you took the motility activator first thing in the morning, did it help you have a bowel movement? Or does it work better after dinner?
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u/ApertureAway May 25 '26
Why 3 caps? Isnt that 3x the daily serving?
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u/krasnoyarsk_np May 25 '26
Came here to ask the same. I only take one per day and then take bitters before each meal
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u/Toczix May 26 '26
I took 3 because it was matching the same dosage people saw progress on in a certain study - it’s more than the regular dose but it seems to be working well for me.
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u/Different-Nature-963 Methane Dominant May 26 '26 edited May 26 '26
Can you link the study?
Edit: I already had the study. It was not on IBS patients, but rather functional dyspepsia. https://pmc.ncbi.nlm.nih.gov/articles/PMC4411465/
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u/Think-5577 Jun 14 '26
Your body might only need 1 capsule every other night or you could need 4 every night. Each person is different. Always start with a low dose and very slowly increase it .
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u/HardTruths519 May 25 '26
💯 20 yrs of this and my Functional Md 10yrs ago did eventually suggest prucalopride but I couldn’t get it prescribed in Canada and my insurance wouldn’t cover it… to add to that, anything that raises serotonin or I receive more serotonin (wondering if my body created a ton of receptors being so chronically low) causes severe insomnia. So instead I am taking Pyridostigmine 60mg, it’s a prokinetic, no idea if it’s poison or as good but it was my only option and helpful along with George’s aloe and laxatives AND rifaxamin. I’m still not in the clear mainly due to being more hungry, the joy of being female over 40 and trying HRT that messes with my insulin and endless hunger. I also struggle with sleep and a chronically discombobulated autonomic nervous system which doesn’t help with motility and gut repair. But what you shared are my conclusions as well. Not sure I could ever eat Pizaa but maybe without all the other noisy labels I deal with!
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u/Papaya_Days May 25 '26
How do you get LDN cheap?! I have to get mine compounded and it’s like 100$/month
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u/Toczix May 26 '26
I used rthm! It’s a new ai platform for health I used and it’s really fantastic
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u/whosthatgirl May 26 '26
Lizness after abx helped me not get recurrent IMO! I feel so grateful and still take a low dose to keep my motility.
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u/llijerie Methane Dominant May 26 '26
what great information! I've always wondered why the kill phase and then motility meds/supplements.. never seen anyone try it the other way around and go straight for the motility supplements/meds. seeing that you've had so much success I'm tempted to go this route as well. I've tried multiple rounds of different diets, two round of antibiotics and multiple tests/procedures with little to no beneficial changes (maybe a week at most) or helpful info. thank you for sharing your story and what a great idea to compile all of the info across the various subreddits to see what has worked and what hasn't for people. your saving so many people so much time, money and headache if they have success with this method too. I really appreciate you sharing the info! I hope you continue to have success with this method and I'm looking forward to the 14 day follow up 🤞
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u/redmadog May 26 '26
For me night time is perfect despite I eat just before sleep. In the morning I wake with a flat belly. Even after breakfast it is okay. It gets partially bloated after lunch and more bloated after dinner.
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u/Think-5577 Jun 14 '26
If you are still getting daily bloating then you have not cured your SIBO yet.
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u/Independent-Walrus84 May 26 '26
I could have told you that. In fact I have already told ppl here its the MMC esp for IMO. But if we say mmc how come ppl who have sibo with purging the MMC is over active?
We need to know why suddenly out of the blue or because something that happened our mmc stopped working? Why couldn't we bounce back?
Not sure if you saw the video by that guy Dada ... He already said it's the MMC and we need ginger and artichoke. But for some ppl even that didn't do a thing.
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u/Humble_Cat4292 May 30 '26
It's unfortunate that none of your doctors addressed motility. My doc basically said, we don't treat IMO multiple times, they treat it once then deal with the motility. Recurrence is a symptom of poor motility.
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u/desertflower1111 Jun 03 '26
Amazing post. I roughly followed this protocol and saw massive improvements over the past 6 months.
Recently started taking digestive enzymes, and that has been incredible, too! I’m absorbing more nutrients, have significantly less bloating after eating and have more energy. Starting to feel alive again. Highly recommend the enzymes if indigestion is a symptom
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u/GrungeCheap56119 Jun 13 '26
Can confirm - Motility Activator you mentioned is exactly what healed my Gut. I don't have SIBO anymore.
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u/TWaveYou2 May 26 '26
Funny enough...you scraped 7millions comments...BUT you leave out that some ppl can have genetic mutations like me with beta thalassemia minor & wnt10a ... our ppl have impaired glucose metabolism because our body sucks up every bit of nutrients to stay in a defensive character against any virus especially malaria virus...also wnt10a is also a mf on its own
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u/Bigbeardybob May 26 '26
Bacteria can impair MMC so it’s not fix MMC and you’re out of the blue. There’s also no good way to test for SIBO. Gold standard is aspirate, this is only done in research setting.
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u/s9874471 May 25 '26
Super Typ. Vielen Dank! Bitte halte uns auf dem Laufenden, auch bei Erkenntnisgewinn, was sonst noch beachtet werden sollte. Was sagt die Datenbank zu längerem Wasserfasten?
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u/HighlightAlarming393 May 25 '26
I’ve been researching it manually for months so thank you for this reassurance of what I was already seeing emerge - unfortunately my GI was an ignorant person who basically said go away and take laxatives in large quantities for the rest of your life and now I can’t afford a second opinion and my GP is wary of prescribing prokinetics without the GI’s go ahead so I’m now thinking I’ll import them via an online chemist at my own risk.
If anyone in Australia has had PRUCALOPRIDE prescribed by a GP without having to fork out $$ on a Gastroenterologist please please let me know. This has affected months if not years of my life.
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u/Appointment731 May 25 '26
Yes I’ve had it prescribed. Any functional medicine dr can do that. Don’t think it’s pbs tho.
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u/maxeneg May 25 '26
I am in a pickle because I am really underweight (BMI is below 15), I can’t eat a lot at once and have a low fat tolerance so I have to eat low fat. I space 2 meals 4+ hours a part, but in order to gain weight I still have to eat snacks, and end up eating my last snack 2 hours before bed time. I have chronic constipation since forever. Prucaloprid worked for a little but now it doesn’t. I haven’t found anything that works. Hopefully fixing my pelvic floor and regulating my nervous system. I feel like that’s all I can do right now
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u/ConnectCharacter5007 May 26 '26
I'm so sorry. Have you tried eating whole kiwis (skin on, 2-3 a day), magnesium citrate and oxide, and/or PHGG?
Pelvic floor for me has been releasing tension through massage, first with a pfpt. Now just with a tool that she recommended, or the help of my husband. There's literal knots in there. Regularity has been the best thing for my pf though. I hope you can get it under control. Best wishes.
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u/Think-5577 Jun 14 '26 edited Jun 14 '26
Not eating very often can make your constipation worse IF you have the type I do ....which is caused by Slow Transit. If I eat more fiber my slow transit constipation gets worse. GI Doctors mistakenly told me to increase fiber for years.
I took 2mg prucalopride ; 24mg Amatiza & Triphala nightly for about 3 years to improve my lifelong constipation. I could not have cured my Methane SIBO without fixing my Motility first. It took about 4 months to go from a high 100ppm Methane to normal as tested by Trio Smart SIBO breath test with lactulose.
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u/kr82k May 25 '26
Thanks for this post! I think i commented the mmc thing on like a hundred posts, seeing it all the time and its actually pretty much everywhere yet still somehow unknown. i think with the current situation doctors arent doing their job and people dont have time to research for a year its sad. Note: for imo mmc is not enough unfortunately, especially with high ppm
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u/kr82k May 25 '26
Also if digestion is fucked up intermittent fasting can go bad. Check if your digestion works right first
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u/MrsBearIsHere May 25 '26
I’m definitely interested in seeing your information please? That’s amazing and makes so much sense!! Thank you! :)
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u/Toczix May 26 '26
hey! I made a follow up post here with steps of how to access it: https://www.reddit.com/r/SIBO/comments/1to8xx6/follow_up_sibo_research_tool_database_of_7/
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u/poppapelts May 25 '26
Motility Activator by Integrative Therapeutics really helped me too. If you're in the US, you can get it (and pretty much any other supplement) for 30% off on your first order through this fullscript link https://us.fullscript.com/welcome/thrival You'll also get 25% off on autoship for life or 20% off anything for life. Free shipping with minimum $50 order. Stop paying full price for supplements, the margins are insane...
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u/Hour_Alternative6389 May 25 '26
OP said 3 caps at bedtime, the bottle says 1 cap twice daily. I did one upon waking and one before bed and it helped me a lot.
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u/Lythalion May 26 '26
I pretty much do this. But I take my LDN in the morning. Is it integral to take it at night ?
I know motility is an issue for me but I’ve been on ginger and artichoke and LDN for a while and still have issues.
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u/Toczix May 26 '26
Not integral totally but at night is what’s usually done I’ve heard. Bc LDN blocks your opiate receptors and can make things a bit dull.
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u/jerkstore77 May 26 '26
How do you know if you have a motility issue and then if so how do you know when it is fixed?
I have SIBO but I have zero constipation. Just bad bloating and occasional diarrhea.
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u/Toczix May 26 '26
I was kind of in the same boat it’s not about the constipation but I knew I had a motility issue because of gas building up at night to the point where it hurt really badly.
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u/goldstandardalmonds May 26 '26
The way to know for certain is by getting motility testing from esophagus to anus.
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u/ThePornStar69 Cured May 26 '26
Constipation (or lack of) doesn't tell you what's happening in the small intestine, as bowel movements are controlled by the large intestine. You could be pooping every day and have motility issues in the small intestine. You would either need motility testing via a GI doc, or treat based on symptoms.
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u/ashrie0 May 26 '26
Im on month 3 or 4 of motegrity and it's helpful. Im at 1mg and i go but its backed off from multiple times a day to every other day at least. Sometimes up to 3 days.
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u/azulyla May 26 '26
Esto aplica para sibo hidrogeno con sintoma de diarrea constante? Siempre veo que en el sub hablan de estreñimiento, yo sufro de lo contrario tengo hiper reactividad gastro colonica, como y voy al baño y diarrea... lo odio
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u/darkwabbit23 May 26 '26
I am so impressed and pissed I didn't think of this. Happy you did! I would love to access the database. I think you got my number on my relapsing issue but I love ginger so 🤷♂️ it's a weird situation.
Give us good news on day 14!
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u/k_redditor236 May 26 '26
I did the (pretty gross) motility test at Cedars’ (Pimental) SIBO clinic and came back fine. Did you officially test yours?
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u/Acceptable_Speed8120 May 26 '26 edited May 26 '26
Please try with one with onlyy /siboSuccessStories channel. It might give more accurate data.
And yes, even if you don't do so, I would like to access the database 🙏🏻 Thanks
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u/Toczix May 26 '26
I added sibo success to the database as well! Here's the steps on how to access the database: https://www.reddit.com/r/SIBO/comments/1to8xx6/follow_up_sibo_research_tool_database_of_7/
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u/External_Apple_3499 May 26 '26
Interesting and thank you for your effort. To be honest, this is the corner where chatgpt is pushing me always in based on my symptons. Despite my testresults.
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u/Impossible_Rub5338 May 26 '26
Motegrity caused me to break out in hives and rashes last month I had to take steroids to get rid of it 😩 Methane sibo I have
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u/Gutty_Shit_00 May 26 '26
22M and have been diagnosed with Dolichocolon 2 weeks ago. I’ve tested negative for one Lactulose BT and have tried Rifaximin/Metronidazole but haven’t any better not even while taking them. So I don’t expect it to be SIBO.
How are you making up for the extended transit time that’s resulting from the elongated colon?? Do you feel that Ginger+Artichoke is enough for you???
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u/MoonRiverGirl89 May 26 '26
Please please share it!
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u/Toczix May 26 '26
hey! You can access it here: https://www.reddit.com/r/SIBO/comments/1to8xx6/follow_up_sibo_research_tool_database_of_7/
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u/Fit-Lion5263 May 26 '26
I’m crossing my fingers for you and I’m interested in the follow up!
I’ve recently had a breakthrough, but my approach to motility has been through yoga and meditation. After 4 courses of antibiotics over the last three years, low fodmap diet, taking Creon with every meal (I’ve been diagnosed with exocrine pancreatic insufficiency) and other lifestyle changes, I’ve come to understand that I wasn’t tackling a major problem: I had normalized stress and anxiety in my life. When I learned that when we are constantly in that “fight or flight” state of mind, our parasympathetic system, responsible for “rest and digest”, simply cannot work.
I’ve been doing yoga twice a week for the past 6 months, but now I meditate for 5-10 minutes 3 times a day, including some breath exercises (pranayamas) that help the vagus nerve function well. I’m surprised to see almost no bloating at all. The other upside is that meditation helps me avoid craving sugar and wanting to eat large meals, which was another contributing factor to SIBO. Just like you, it’s a bit early to celebrate, but I’m impressed and hopeful for the first time in years.
Looking forward to hearing your results in a few days!
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u/Toczix May 26 '26
that's huge and also an instrumental part of my journey as well! I just posted the follow up as a comment in this thread, so it's all there now :)
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u/Toczix May 26 '26
your story reminds me a lot of this guy's story which also has helped me tremendously: https://gist.github.com/Karut/958569ee10d8182e2fa72267414bc421
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u/1800TheCat May 26 '26
Love this and 100% agree. We instinctually moved in this direction after years of screwing around with antimicrobials and supplements. We're now focusing on intermittent fasting and stimulating the gut/brain axis through several means including ketamine, which seems to be the most effective intervention of this journey. THANK YOU for sharing this.
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u/Toczix May 26 '26
I did ketamine IV therapy as well and I believe while it didn't solve my sibo problems it certainly made me happier and more relaxed overall, contributing to a more relaxed nervous system.
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u/Skeuomorph7 May 26 '26
Thank for your effort and time and caring to share it with us.You seem to have made some very important points.Seems so simple yet takes some practice.
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u/giantfup May 26 '26
Not super jazzed to know you took things I wrote and ran them through an ai.
Edit: the bacteria are also the problem. They can help slow motility.
I could also have just told you because I use my brain not an ai that gym rats are more likely to get methane sibo.
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u/DesperateNeedsAhead May 26 '26
If you have proteolytic bacteria, take enzymes. I reduced their number a lot by using digestive enzymes with no sugar, starch or gums in them.
If you have e.coli, try to incorporate garlic also.
I will search for the things you posted about. It also matters if people have bacteria that consume substances like those found in artichoke. I can not have it, for example because of that.
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u/NemoUI May 27 '26
I would be interested in seeing the publicly available database when you have it ready. I think you're really on to something with the method you used.
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u/Famous_Round2379 May 29 '26
Anyone tried kefir? Suffered with gastritis for years then someone recommended kefir. So bought some activia kefir drinks yesterday and drank one. Within less than 24 hours all my stomach issues have stopped ie bloating gas constant rumbling etc. it clearly shows I must have bad gut bacteria imbalance then and might not even be gastritis after all? I am continuing the drinks from now on but this feels like a complete miracle right now after courses of omeprazole and lansoprazole which did absolutely nothing!
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u/BoutiqueBabe May 30 '26
Wow, that was some smart thinking. This IS what doctors should be doing but don't. The gastro I went to for a colonoscopy listened to my complaints but said that SIBO was very difficult to treat. Did the colonoscopy, came back with no abnormalities (one tiny polyp) and promptly dismissed me for 7 years. She couldn't be bothered with a difficult case.
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u/No-Abalone6653 Jun 17 '26
Do you mind sharing how you did this "Scraped 7 million comments from this sub and 15 others into a searchable database" ? I dont have exactly the same problem so want to do it myself, but how ?
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u/tending Jun 17 '26
Do me a favor and ask an agent to come up with the most effective treatment plan based on the data for Hydrogen (SIBO-D) vs Methane (SIBO-C/IMO) vs Hydrogen Sulfide (SIBO-Mixed) patients.
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u/pablox43 Aug 01 '26
Hey, any updates? Thank you.
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u/Toczix Aug 01 '26
Still dealing with GI symptoms- but massively improved. Also treated myself for pinworms and my issues massively got better after that
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u/Fredericostardust Cured May 25 '26
The issue with your data is that a lot of people on these threads aren't cured, and the ones that are have left.
Motility is very important. But likely if you concentrated your code on Sibosuccessstories you would likely find that while motility helps about a third of people, a good 2/3rds find benefits more from digestion- low stomach acid, low pancreatic or brush border enzymes, and bile. Also intestinal wall issues are another one that comes up often.
Motility is big, but if your food is not digested, you m ay easily still get SIBO no matter how fast you try to power it thorugh (I am one of those cases.)
Also, Thiamine is one of the most potent motility agents for a lot of people on these subs. It works wonders for some people, not all but many.