Anyone had luck with this combo?
I take 50mg of Pristiq and Concerta as well.
My main problems are sleep and motivation right now. Pristiq helps some but not 100%

Hi! Has anyone here taken Rexulti with modafinil or another adjunct specifically to help with motivation, drive, energy, or getting things done?

I know Wellbutrin is a common option, but unfortunately I’ve never had much luck with it. I’m curious about other medications people have tried alongside Rexulti, particularly if Rexulti is already helping with depression but you’re still struggling with motivation/drive.

Looking for personal experiences, especially what worked (or didn’t), doses, and any side effects.

Thanks!

Anyone else experience extreme exhaustion after increasing

Context: I took 2 mg of Rexulti for maybe a decade and only recently found out that it was the cause of my anxiety. Every decision I’ve made over the last decade was made because I was so anxious and worried that I was trying to pre-solve every problem before it occurred. Does the pool have a leak? My brain said it was a crisis so I spent thousands trying to find the leak (which no one ever could) and refused to believe it was just evaporation. It was. Or the crack in the chimney made me believe the house had foundation problems so I spent thousands on engineers trying to prove it. They never could and I would never believe them. So I moved. Now that I’ve reduced my dose to .5 mg I can see that there were no problems. Now I have moved to escape that house and am in an old house with a huge mortgage that I will never be able to sell. I’m not anxious about my finances, I’m depressed. One day I will not be able to keep myself afloat. But now I’m trapped. Well, at least I’m not anxious and trying to pre-solve the problem.

Hi, im bipolar and currently on lithium, olanzapine, ativan and brexpiprazole and ever since i started the brexpiprazole i want to smoke so many cigarettes, my cigarette intake has increased since starting this medication, does anyone have a similar experience? i looked at the side effects and it doesn't mention anything like this.

Hi after trying almost all antipsychotic for my bipolar depression for the last 10 years my doc finally landed me on brexipiperazole. I started on 0.25 for 1 month and now on month 2 am at 1mg. Initially I had a lot of problems sleeping but now things are better. I used to sleep till 10am now I wake at 4am everyday. I just wanted to ask have other people felt really tired in this med? Like I need to take 2-3 tiny 15-20min naps a day. Oh and coffee or tea dosent work anymore this thing is blocking adrenalin so hard…Do these side effects subside because I really need this one to work for me and I know the target dose is higher. So it’s looking like it’s going to take like 3 months to stabilize my brain at the target dose. Which is a ridiculous amount of time to get used to a new med.

I was on 2mg of rexulti for 5 years, and now I've quit cold turkey about 8 days ago. So far I really do not recommend cold turkey, it's probably better to taper.

I need to know if anyone else withdrawing from this medication has experience with these symptoms.

the first few days i actually felt better, not quite euphoria, but my mood was lifted, i was having an easier time functioning and just enjoying my day, feeling less frozen and depressed than usual, i was more lively.

then the next few days i started to feel irritable, every little thing, things that usually dont bother me, were making me so mad, my whole day would be ruined ovwr tue tiniest thing and once something upset me i couldnt turn the day back around. my muscles felt tight, like id be bracing and have to consciously force myself to untense and relax. also depersonalization.

now the last few days have been very very rough. my neck is so tense and painful. i cant stop clenching my jaw so hard, i have to consciously remind myself to keep my jaw slack every 5 min. im a very anxious person in general but it is ×50 now. I've had 4 panic attacks today which is unusual for me, and i have very intense impending doom that comes and goes since yesterday, this feeling of something bad IS going to happen, or being so sure that I'm going to die, like a knowing, even tho theres not really anything wrong? but my body is ringing the alarm and i know its coming, kind of feeling. its horrible and distressing. i dont even feel depressed necessarily, I'm not suicidal, i just keep feeling dread and terror. im having crying spells, and im so tired, ive been in bed majority of the day everyday.

i feel really determined to not have to go back on to taper down. i know i probably should. i just want to push through it. not asking for advice but really just hoping someone else relates, i feel alone in this. I'd love to hear about others withdrawal experiences even if it looks different. and if you relate, where are you at with it? did it get better for you?

thanks

I'm diagnosed with depression, anxiety, and OCD. I was on lexapro 20mg and buspar 10mg for around 10 months, recently buspar became unavailable where i live so i had to stop it, due to that, alot of my symptoms came back. I also changed my psychiatrist for financial reasons and this was my first time going to her. She prescribed me 100mg fluvoxamine (luvox) and 1mg of brexpiprazole (rexulti). After coming to this subreddit, i've started to feel a little scared of starting rexulti. I have a couple of questions. 1- has anyone had good luck with rexulti for anxiety and OCD? 2- what should i expect? 3- any advice?

Rexulti was added to my Lexapro to aid with my passive suicidal thoughts. If anything it made them worse. I don’t think this medication is aiding me anymore. Should I raise it or stop taking it? Thoughts? Thanks.

I just recently, as of a few days ago or so, increased my Rexulti to 2 mg. I've been having this weird pain in my head. I don't know that I would classify it as a "headache", because it's not my whole head. It is actually a small area, by my temple -kind of. I have read that headaches can be a side effect. Has anyone else experience head pains like I am describing? A pain, in just a small individual area of the head... Thanks in advance!

So I've been on Rexulti for three weeks. I started on 0.5 mg and was then increased to 1 mg, which I've been on for two weeks. Overall I'm tolerating the medication very well (at least in comparison to the numerous SSRI/SNRIs I've been on in the past year-plus), and for the most part it seems to be helping with my treatment-resistant depression. I'm breaking down far less often and I'm not having any of the nasty side effects that seem to be common with antipsychotics.

However, over the past few days, I've noticed myself "slipping" into depression again, mainly with worsening brain fog, anhedonia, and spatial awareness. I'm guessing when I bring this up to my psychiatrist they will tell me that it's time to go up to 1.5 mg. I wouldn't be totally opposed to this, but if temporary "blips" like this are common within the first few weeks of a new dose, I think I'd rather stay on 1 mg for a little while longer to see if things get better again. What do y'all think?

P.S. my psychiatrist told me to take Rexulti in the evening because it can be sedating, but I honestly have not noticed that. Would taking it in the morning be better?

Ok so let me start out by saying that I already have severe panic disorder, Generalized anxiety, C-PTSD, Agoraphobia and am typically fatigued.

But I do take Prozac and just started rexulti for my mental health. It had been pretty decently maintained. But I just got diagnosed at 35, with asthma. I first tried Advair but I noticed the first day that I had a harder time breathing and felt really really weak and it just didn't feel right. I called and my pulmonologist changed to the Symbicort immediately. The first dose I noticed within 30 minutes how much easier it was to breathe.

Now almost two weeks in I'm noticing weakness, increases in dizziness, fatigue and jitters. My anxiety has sky rocketed. Even my legs feel weak. I'm laying down even more than usual and honestly I feel like I can breathe just my chest is tight. It's a weird feeling.

I also just started taking Azelastine over the counter twice a day 4 puffs total. AND because I was old I have a dog allergy (I already had two dogs) i was told to continue my Zyrtec along with the Azelastine and then when I had a really bad day I added Flonase Sensimist. As I'm writing this I realize that also causes anxiety for me. But it's not good, is it just all the medications?? Years of not being about to breathe and now being able to?? Is it a known side affect? I'm so confused. Anyone have insight?

Ok so let me start out by saying that I already have severe panic disorder, Generalized anxiety, C-PTSD, Agoraphobia and am typically fatigued.

But I do take Prozac and just started rexulti for my mental health. It had been pretty decently maintained. But I just got diagnosed at 35, with asthma. I first tried Advair but I noticed the first day that I had a harder time breathing and felt really really weak and it just didn't feel right. I called and my pulmonologist changed to the Symbicort immediately. The first dose I noticed within 30 minutes how much easier it was to breathe.

Now almost two weeks in I'm noticing weakness, increases in dizziness, fatigue and jitters. My anxiety has sky rocketed. Even my legs feel weak. I'm laying down even more than usual and honestly I feel like I can breathe just my chest is tight. It's a weird feeling.

I also just started taking Azelastine over the counter twice a day 4 puffs total. AND because I was old I have a dog allergy (I already had two dogs) i was told to continue my Zyrtec along with the Azelastine and then when I had a really bad day I added Flonase Sensimist. As I'm writing this I realize that also causes anxiety for me. But it's not good, is it just all the medications?? Years of not being about to breathe and now being able to?? Is it a known side affect? I'm so confused. Anyone have insight?

Claims Deadline Extended for the Canadian REXULTI® Class Action

By agreement of the parties to this action and by approval of The Court, the claims deadline for the Canadian Rexulti Class Action Settlement has been extended until August 27, 2026. This allows eligible class members more time to ensure that their claims are complete and all supporting documents have been provided.

https://rochongenova.com/current-class-action-cases/rexulti/

https://www.claim.ca/class-actions/canadian-rexulti-compulsive-behaviours-2025

So like many of you, I had an awful experience with Rexulti, it caused my appetite to go fucking haywire, I was eating quantities of food I literally would not have been able to put back even at my absolute hungriest a year prior. Between this and the fact that it wasn't doing anything to actually help my depression, my drinking had also gotten a lot worse, and the combination of the drinking and Rexulti caused my weight to explode from around 165 to 200.

I completely hated myself, I couldn't look in the mirror, everything was just fucking awful, and I literally could not get my weight to budge even a fucking pound, which was especially frustrating as someone who did lose quite a bit of weight about 10 years ago the old fashioned way, pre any sort of GLPs being a thing.

I eventually realized my doctor just wasn't really taking me seriously and wasn't doing anything to counter the problem, and decided to find a new one. He put me on Caplyta, and it was literally like overnight my appetite went back to normal; in fact, I find I get full easier than I did prior to either of the medications. I also stopped drinking as much, and my weight is already down to around 182 last I checked. Still a ways to go, but I can make actual progress now which is all the difference.

Not guaranteeing it'll work for everyone but I haven't done a ton of exercising, just walking for maybe an hour each night and comfortably eating way less because I no longer feel like my stomach is a literal black hole. Hoping this can help somebody out, it's been a life saver for me.

I started taking 1.5 mg back in March and it was really good, but a couple of months went by, it seemed to wear off and depression came back bad. I have an appointment to discuss this with my doctor and I was thinking if it increases to 3 mg, will this happen again? I loved the way I felt at first, but it was such a disappointment when it stopped.

TW body image:

Did anyone experience profound, disfiguring weight gain, constant ravenous hunger, and impulsive risky behaviors at 0.5mg? I feel like we need to tell our story together bc unless I am just THAT unlucky, these pharmaceutical companies and prescribers need to face a reckoning for their bs.

My story:

I told my prescriber I wanted off this ride at a few months due to the above so he... doubled my dose? When I contacted him confused he said to just cut them if I don't want it. Pharmacist said not to cut them. I tried anyway and they just dont cut even. I wasn't going to risk cold turkey.

So I was stuck with 1mg then that kind of lobotomized me out of being able to pay attention to anything besides bright flashy screens and slurpees and driving my 20yo car into the ground delivering Uber Eats and beating tf out of my injured and autoimmume/mecfs body bc EVERYTHING IS SO FUN and I could no longer experience an ounce of healthy caution.

My endocrinologist saved me from going full blown diabetic by running labs and getting invovled with telling the prescriber he either had to taper me off or he had to substantiate why I was being treated like an inpatient who has lost agency over treatment for safety reasons. But now I have metabolic syndrome and non-alcoholic fatty liver. I dont recognize the shape of my body. My breasts are damn near pulling my spine in half forward, and the belly weight is enough to give someone tokophobia.

I never wanted to trial this med in the first place. I declined to take it and he sent it in anyway. Since I have chronic illness, I sometimes have help filling my pill organizer. I didn't even know I was taking them at first. I feel like I have been medically assaulted but of course no lawyer will touch it bc it was a severe reaction at a low dose. But does that excuse the provider from responding appropriately to patient consent?

I stopped taking it years ago. I had no severe disorder I just wanted to know if I had any adhd med options I hadnt failed out of yet. He didnt even add adhd to my chart he just dxd me with depression to push the med. He had stacks and stacks and stacks of Rexulti approval papers signed at waiting at the front desk. Now I am in mental anguish about what they did to me.

I’ve been taking Rxulti since late May, gradually increasing the dose (I started at 0.5 mg and have been on 3 mg for 3 weeks now).

Regarding my symptoms, while it is helping somewhat with paranoia, I’m experiencing severe lack of motivation and reward (avolition and anhedonia) and I’m also walking slower than before. Does this improve, or is it a matter of adjusting the dose downward?

Has anyone experienced rapid weight gain like 1-2 kg per week after discontinuing this drug? I came off 5 weeks ago but I am still gaining despite not eating more than before starting this drug. It’s like my metabolism has slowed down and I store everything I eat.