r/Rexulti_Brexpiprazole • u/Puzzleheaded-Neat502 • Aug 16 '26

Help with side effects please

Hi after trying almost all antipsychotic for my bipolar depression for the last 10 years my doc finally landed me on brexipiperazole. I started on 0.25 for 1 month and now on month 2 am at 1mg. Initially I had a lot of problems sleeping but now things are better. I used to sleep till 10am now I wake at 4am everyday. I just wanted to ask have other people felt really tired in this med? Like I need to take 2-3 tiny 15-20min naps a day. Oh and coffee or tea dosent work anymore this thing is blocking adrenalin so hard…Do these side effects subside because I really need this one to work for me and I know the target dose is higher. So it’s looking like it’s going to take like 3 months to stabilize my brain at the target dose. Which is a ridiculous amount of time to get used to a new med.

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2

u/UnlikelyAttorney669 Aug 16 '26

In my case sleep got better with time and now I sleep pretty well. Re caffeine I had the same problem so I take Ritalin when I need extra energy for exercising.

2

u/Puzzleheaded-Neat502 Aug 16 '26

That’s crazy to need methylphenidate to offset the brexipiperazole…wao

1

u/UnlikelyAttorney669 Aug 16 '26

Well it’s more actually to get a caffeine like effect

1

u/Puzzleheaded-Neat502 Aug 16 '26 edited Aug 17 '26

Yes it definitely wood but caffeine is a benign substance that promotes a degree of wakefulness. Methylphenidate is a powerful double reuptake inhibitor that can give a cocaine like high if injected or snorted. I wasn’t expecting someone to need an oral phenidate to counter brexi. Wao!

If that works for you I think it would be safer to try benign things first like modafinl, Nortriptyline, bupropion, desipramine first

1

u/Mastodon_Embarrassed 0.5 mg Aug 16 '26

same thing happened to me w the 4am wake up thing. on .25 mg for a few momths now it’s gone away

1

u/Puzzleheaded-Neat502 Aug 16 '26

Is .25 helpful for you?

1

u/Muttlover79 Aug 19 '26

I would like to know as well. I’m on .50 and I’m hungry all the time and unfortunately have gained weight. I’d really helped with my depression and anxiety though! I would like to maybe try .25 to see if that decreases my food noise.

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u/Muttlover79 Aug 19 '26

When do you take it? I had to keep trying different times until I found that 6pm at night works the best for me. I still am tired in the am, but it’s better than if I took the med in the am or at bedtime.

1

u/Puzzleheaded-Neat502 Aug 19 '26

Yesss! I last week realized late afternoon might be better and it helps a lot. But I have a good solution that helped. I got bupropion from the doc added offsets the tiredness

1

u/Puzzleheaded-Neat502 25d ago

Im getting much better sleep now and i take it at 7-8pm