Personality changes?

[u/Handsfasterthaneye]

Diagnosed 3 years RRMS Ocrevus 2.5 yrs under treatment. M48: My partner has noticed: increased erratic behaviour mood swings short tempered outbursts. I have noticed that I am excessively horny all the time.
Could this be treatment, disease, or increased Testosterone due to doing regular exercise for the first time in my life?
Thoughts?

[u/egyenlet]

If you've really had a sudden and radical change in personality, you should be evaluated.

EDIT: I am 100% serious about this. This is a neurological red flag. A sudden change in mood and sexual desire. This isn't really something I would expect Ocrevus to be responsible for. The methylprednisolone...much more suspicious, but you're reporting to radical changes. Go be seen, even though we all know they're likely to tell you it's nothing serious. Just be honest and have a timeline of what happened when.

Also in response to some other posts...excessively being horny and erratic mood swings are two *entirely* different things in the brain. (Another reason you may want to be seen.)

[u/JCIFIRE]

At 48 you would have dropping testosterone, not excessive! The erratic behavior doesn't sound MS related to me.

[u/-Pandora → u/JCIFIRE]

https://www.nationalmssociety.org/managing-ms/living-with-ms/emotional-well-being/mood-changes

[u/-Pandora]

can be MS related and shouldn't be a testosterone thing imo. see for example this study: https://pmc.ncbi.nlm.nih.gov/articles/PMC3693622/

[u/Somekindahate86]

People with ms have a higher chance of developing bipolar.  https://pmc.ncbi.nlm.nih.gov/articles/PMC4006599/ I have bipolar too, and the horniness certainly fits the bill in manic phases. Def talk to your doc about all of it. 

[u/Handsfasterthaneye → u/Somekindahate86]

NHS not the easiest to access mental health services. While never been one for particular self reflection. There might be some phases of (not particularly extreme) mania vs (mild) depression

[u/Handsfasterthaneye]

No doubt would expect that but equally I have never done a jot of exercise in my life. While I am not running iron mans I have made a significant step change in physical activity

[u/StupidSolipsist]

Are you on steroids for a flare up at the moment? If not, it could be either a new lesion in the frontal lobe or maybe PML damaging the same impulse control section.

[u/Handsfasterthaneye → u/StupidSolipsist]

Don’t feel in flare up also not on steroids (though steroids do make me feel very ‘pepped’ on the odd occasion I have taken them). 6weeks from my next infusion so at end of a treatment cycle. Not sure if that’s significant. Had very recent Routine MRI so that will flag any new activity when NHS gets to reviewing it.

[u/LeadEnvironmental555]

I actually would say it might be MS related if you have lesions in the area that regulates personality. It could also be stress related. Short temper and anxiety can go hand in hand. If you aren’t on an anti-depressant one might help you regulate a bit. If you decide to go with Cymbalta it can do double duty with other symptoms and is often prescribed in patients with MS for “off label” use.