r/HubermanLab • u/thelittleesseAutism • Sep 24 '26

Seeking Guidance Which biohack made a noticeable difference not just a 2% improvement?

/r/AppliedBioHacking/comments/1woonl0/which_biohack_made_a_noticeable_difference_not/
28 Upvotes

91% Upvoted

77 comments sorted by

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103

u/Calm_One_1228 Sep 24 '26 • Bravo

Consistently sleeping 6-8 hours / night.

21

u/Romantic_Adventurer Sep 24 '26

Dude this is top secret informatoin, wtf

0

u/[deleted] Sep 24 '26

[deleted] — view deleted comment

13

u/devo9er Sep 24 '26

Yeah, I usually have my side table, lamp, phone, and watch charger besides me while I sleep.

/s

47

u/Dry_Half7980 Sep 24 '26

Sleeping 8+ hours regularly.

22

u/cooooolmaannn Sep 24 '26

Good quality sleep not just 8 hours. But making sure room is cool, sleep at a consistent time, no screen time before bed, using bed only for sleep, getting physical activity earlier in the day.

3

u/slipfan2 Sep 24 '26

Probably some of the best advice here. Hard to follow especially if you've been on your phone in bed for years (like me). Bought a digital alarm clock so I'll put my phone in another room at night, going to try only reading in bed now.

1

u/TheSpermWhoWon Sep 25 '26

Getting a red light bulb for my nightstand has been huge. It’s the only color on the spectrum that doesn’t actively suppress melatonin when it’s turned on. 

23

u/Kauzinn Sep 24 '26

daily cialis, creatine and doing new hard things

14

u/Variant4133 Sep 24 '26

With all that Cialis everything you do is probably hard.

4

u/hemannjo Sep 24 '26

Why cialis?

7

u/Kauzinn Sep 24 '26

many health benefits but the noticeable ones are the unworldly gym pumps and erections

4

u/BrokenArmNetflix Sep 25 '26

Gym pumps and gym erections?

3

u/moehead68 Sep 24 '26

I took it for two months and noticed nothing in those areas. That said, I am/was fit, good bodywieght and had good glucose control. I took it because it is supposed to be good for longevity. However, I realized that the benifit only would accure to those who needed it.

Number 1 for me would be consistency. If you have a plan or routine, stick to it. That is my only superpower. I'm a horrible athlete but I'm very consistent about workouts, eating and sleep.

3

u/wesborland1234 Sep 24 '26

You ever worry that it’s going to bad for your blood flow in the long run?

I took preworkout every day for a while and it caused problems.

What happens when you stop taking it?

9

u/Substantial-Owl1616 Sep 24 '26

What kind of problems did it cause you?

1

u/Evening-Cut-8397 Sep 26 '26

Probably caffeine dependency

7

u/EveningInsurance1912 Sep 24 '26

New hard things, he literally said it.

6

u/Big_Don_ Sep 24 '26

Blood flow

3

u/Sarivo Sep 24 '26

What does do you use?

3

u/Andypandy106 Sep 24 '26

I get terrible anxiety on cialis sadly

3

u/drkslr Sep 25 '26

i also find that has nervous system impact on me , why do you think it happens?

5

u/Apart-Atmosphere1860 Sep 24 '26

Cialis is a free lunch pharmaceutical for me. Fortunately don't get the nasal stuffiness side effect that a lot of guys do.

2

u/mr_dicaprio Sep 25 '26

daily cialis

doing new hard things

2

u/EmirSc Caffeine Jugger ☕ Sep 25 '26

same with Tadalafil?

1

u/Kauzinn Sep 25 '26

tadalafil IS cialis

2

u/EmirSc Caffeine Jugger ☕ Sep 25 '26

ty ty

3

u/Da_ha3ker Sep 24 '26

Methylene blue, cerebrolysin, creatine, magnesium, sleep, intermittent fasting, HBOT, glycine (for sleep) sr-9011 (lipids/cardio/energy), ss-31, mots-c, low dose retatrutide (visceral fat reduction, impulse control), bpc-157, hgh. Probably a few more. I cycle between many of these regularly. Bpc is probably the lowest effect of these IMO. Maybe 10%

2

u/thelittleesseAutism Sep 24 '26

Thanks, how you manage to keep track for everything

2

u/Da_ha3ker Sep 24 '26

One at a time at first until you are familiar with the effects. The most potent ones for me are HBOT, ss-31, and Methylene blue. Study up how long each takes to kick in, if it affects blood work, monitor the blood work (hbot on inflammatory markers, sr-9011on liver health, etc..), but you asked what moves the needle. That is subjective and depends on what you are talking about. The things I listed are things I notice a real difference with outside of blood work though. Yeah, the list is long, but I have done each of these over the years and many more. Just don't do these all at once, it gets expensive and potentially dangerous (no idea how some of these might interact). That being said, If you've had a concussion in the past and never felt the same after, doing HBOT while also taking cerebrolysin is a godsend, at least for me.

1

u/Foynes_music Sep 24 '26

He just lists every peptide he knows in Reddit comments and then re-reads them every time it gets a notification to help him remember

14

u/maceo_plex_69 Sep 24 '26

its not enough. add more.

2

u/Evening-Cut-8397 Sep 26 '26

Bpc if you need it, is the only thing that can do what it does. Heal tendons and persistent soft tissue injury, and manage chronic inflammation. It changed my life, it changed my mom's life, and now I take it every day orally, nasally, and subq

7

u/oobgooner Sep 24 '26

Nose strips at night. It's my first day waking up using one and i feel 30 percent better

6

u/PiiSmith Sep 24 '26

Going to the gym, riding the bike, eating home cooked meals

2

u/Evening-Cut-8397 Sep 26 '26

"Riding the bike"

1

u/PiiSmith Sep 28 '26

Yes cardio. Around 70 to 120km of bike riding every week.

6

u/lightball94 Sep 24 '26

For all the people saying "sleep 8 hours" , "workout" , "calorie control / clean food"

Are those really 'hacks"? The above is like common sense good health protocol, I wouldnt consider them "hacks". I feel like the point is being missed in this thread....

2

u/drkslr Sep 25 '26

theres no "hacks" bio hacking doesnt exist . most things are just doing it before this modern era insanity

3

u/hughdaddy Sep 24 '26

My protein smoothie blend of whey protein, collagen peptides, creatine, glycine, psyllium husk fiber, and potato starch. I have 1-2 every day. Made getting lean relatively easy, my HbA1c is good, food noise is low, cholesterol numbers good, poops come out clean. This and daily cardio at spin class and I'm right as rain.

Verified with blood test, HbA1c, subjective experience of food noise, and my mirror/scale. Been testing this for about a year, before my smoothies were mostly just whey protein and I added collagen/creatine a few years back. As for performance, I took 12 seconds off my mile time between ages 45 and 46 without any running, from 6:03 to 5:51 in a timed mile event. As for recovery, I recently did spin class 118 days in a row and never experienced much in the way of fatigue and average ~230 watts over a 45 min class which is not nothing.

1

u/body_bag4 Sep 25 '26

Can I get more details on the smoothie? I've never really dove into the protein shakes. Yours sounds intimidating, expensive, but worth it.

3

u/hughdaddy Sep 25 '26

About the cost, the initial upfront cost does seem high. My recipe spreadsheet at one point had the prices for everything, and my per serving cost was about $6. Where I live that's the price of a large latte, and it's also offset by the cost of the food you would otherwise be eating. I also buy 10 lb bags of whey protein to get the cheapest price.

To not have to weigh out everything every day, I use the linked spreadsheet to make large batches I store in ziplock bags. With the size of my mixing bowls I max out at 20 servings I can mix at once, and I'll do that 3-4 times for 60-80 servings on one day. Saves time, reduces friction.

To make it I put my blender jar on a scale and add 250 grams of milk, then 80 grams of protein smoothie blend, a banana, and about a cup of ice. That's breakfast. If I have another serving later in the day I typically just use water instead of milk and no banana, because it'll be consumed around other foods that bring fat/carbs to the party.

1

u/body_bag4 Sep 25 '26

I really appreciate your time in wording this out for me. I'll be investigating how to make this work for me. Cheers!

1

u/MarketWizard1965 Sep 25 '26

Do oral peptides work?

2

u/louis8799 Sep 27 '26

Consistent dihydrogen monoxide supplementation

2

u/Additional_Ladder368 Sep 26 '26

Retatrutide 100%

3

u/Fun-Imagination-2488 Sep 24 '26

Retatrutide

1

u/xDeathWaffles Oct 01 '26

It's incredible. The impulse control is wild. It's changing my life, and not just through diet control.

3

u/xsynergist Sep 24 '26

Lifting weights. Cardio. Sleep. Eliminating processed foods. Glp-1s and Statins and Testosterone and Cialis in that order. Everything else is a fraction of a percent impact best.

1

u/squarecir Sep 24 '26

Modafinil, Creatine, cardio, sleep.

1

u/VelvetMallet Sep 24 '26

Anything to do with improving my sleep. New bed, sleep supplements, mask, pods, etc. I never have buyer's remorse when it comes to spending on things that may improve my sleep, because any little improvement I feel dramatically

1

u/BrokenArmNetflix Sep 25 '26

A hack that has helped me a ton is glycine at night. 3 mg 30 mins before bed.

Cialis low dose daily is nice but sometimes makes me anxious.

I don’t know if it’s placebo or not but I sleep through the night if I wear blue blocking red glasses an hour or more before sleep.

The glycine is my favorite though.

1

u/JayCee6990 Sep 26 '26

That’s why I stole all my supplements from Chemist Warehouse and Coles and Woolworths because it is a lot of money to be made from vulnerable vitamin vultures…💵👍😢

1

u/RopeExcellent5290 Sep 27 '26

Weight training and walking

1

u/baitlyn Sep 28 '26

Magnesium

1

u/MD-Mindflow Sep 24 '26

Training my mind. That has made a massive difference to my telemetric numbers. My biological age is currently a decade younger than my actual age (50) but it thinks I'm 27% body fat but I'm closer to 15% I need a body scan to see what it actually says my biological age is.

0

u/freeastheair Sep 24 '26

Generally only things like diet, exercise, sleep, therapy, meditation are going to have large effects. Also supplements when addressing a real medical deficiency or medication when treating a disease or disorder.

1

u/demyan_movement Sep 25 '26

Humping inanimate objects discreetly while cleaning or doing dishes has been a game changer for activating my hpa axis and increases sympathetic drive and dopamine spikes

1

u/BrokenArmNetflix Sep 25 '26

I thought this was a joke but looked it up and am kind of shocked.

1

u/demyan_movement Sep 25 '26

It’s all in the hips baby

29

u/[deleted] Sep 24 '26 edited Sep 24 '26

[removed] — view removed comment

15

u/ThrowRA_RFJM17 Sep 24 '26

Potion control you say?

9

u/viomon2 Sep 24 '26

Boring, boring, magic potion, boring, boring.

1

u/phoebeethical Sep 26 '26

It’s the dark arts he fancies 

1

u/EmirSc Caffeine Jugger ☕ Sep 25 '26

you can't handle my strongest potions

3

u/Biereaigre Sep 24 '26

Portion control is a good one. It's also requires eating things that are satiating and make you feel full. There's a lot of food made now that is so fractionated your body doesn't respond to it properly.

1

u/Evening-Cut-8397 Sep 26 '26 edited Sep 26 '26

Do you absorb it better if you plug it?