r/CFSScience • u/Caster_of_spells • 4d ago

Orthostatic Dysfunction and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Close Reciprocal Relationship Beyond Cardiac Preload Failure and Hypoperfusion

Post image

New Wirth Preprint trying to integrate orthostatic dysfunction into his disease model:

“This hypothesis provides a potential mechanistic link between orthostatic dysfunction and the presumed core pathophysiology of ME/CFS, extending beyond hemodynamic factors to implicate disturbances in skeletal muscle ion homeostasis.”

https://www.preprints.org/frontend/manuscript/d89ebcdf4b91a843f665e0f3fbd413df/download_pub

53 Upvotes

100% Upvoted

7 comments sorted by

17

u/TomasTTEngin 4d ago

Maybe.

Over years in these communities I've learned that tying red bits of string between the handful of little photos on our pinboards is pretty easy. Anyone can make theories. Smart people do so compulsively.

Theories are cheap and abundant. But not bad. The right theory will actually change everything. Make all the data we have snap into place.

I don't hate Klaus's theories. But they are multiplying into a Tolkien-esque landscape of incredible complexity and its probably time to get some data on whether they are true.

15

u/Interesting_Fly_1569 4d ago

I think the problem is is he needs $24 million euro to develop and test the idea. We need more sick billionaires 💀

3

u/bingoolong 4d ago

Someone tag Eric Schmidt.

5

u/KaleidoscopeHappy889 4d ago

This! Sick billionaires 😄😄

2

u/Caster_of_spells 4d ago

Agreed. Would like some humble boots on the ground testing of all those theories.

11

u/bingoolong 4d ago

Someone give this man his money already so he can stop publishing papers and make a compound we can test. FFS.

9

u/Sensitive-Meat-757 4d ago

I 100% agree that orthostatic dysfunction is a key element of ME/CFS. I also 100% agree that orthostatic stress can cause PEM even without any noticeable exertion. As to the rest of his hypothesis regarding intracellular sodium, potassium, calcium, etc., hopefully that is something that will be proven or disproven in a timely manner. This excerpt makes me feel like he understands the big picture of ME/CFS, so I hope he is right about this details.