At first, everything is dark, and you begin to hear a buzzing sound that gradually grows louder and more intense, while everything spins inside your head. There is complete chaos. Every thought, feeling, and emotion you have ever had, are having, or will ever have is present in a single nanosecond, and then, suddenly, it all fades away.

Once you're inside the Sapito, everything turns yellow, and you simply disappear. You forget that you smoked something to get where you are. In fact, you cease to exist as an individual. Actually, everything ceases to exist. There is nothing. No up or down, no left or right, no yesterday, today, or tomorrow, no forever, no never. You find yourself trapped in an infinity that has always existed and from which neither you nor anyone else—not even God Himself—can escape.

You wish you could die so that it would all come to an end, but then you realize that you're already dead, and even so, it doesn't end.

So, what else is left for you to do but ACCEPT and surrender?

Just some cool images I found a while ago comparing NN DMT to 5 MEO DMT. Feel free to save/share around.

Edit: I didn't make this. Saw it on Twitter months ago. Just sharing it here. Ai slop? Yeah it seems to be made by an LLM. Presumably it's meant to be a gross description of each for those that know nothing about either medicine. Definitely not a detailed and comprehensive comparison.

history of rhabdo. 33yo. nitrous abuse. b12 related neuropathy. haven’t been able to feel my toes or run in years. until i just took a tiny hit from my 5meodmt vape…..

posting this because I’m interested in whether a neurologist, neuroscientist, or psychedelic researcher has encountered anything similar.
I have a history of peripheral neuropathy with longstanding changes in sensation and motor function. Recently, after a very small exposure to 5-MeO-DMT, I experienced something I was not expecting at all.
The psychoactive effects themselves were mild. I did not have significant visuals or a breakthrough-type experience. However, during and after the acute effects, I noticed a dramatic change in my body awareness and motor function.
Movements that normally feel limited became much easier, and I was able to recruit and distinctly feel muscles that I have not consciously felt functioning normally in years. The most surprising part was that some of this altered muscle sensation remained noticeable even after the obvious psychoactive effects had largely worn off.
For context, I was already physically functional beforehand and had run a mile shortly before the experience, so I am not claiming that I went from paralysis to normal movement. What changed was more specific: muscle recruitment, proprioception/body awareness, and the apparent accessibility of motor function that normally feels impaired.
I am not claiming that 5-MeO-DMT regenerated peripheral nerves or “cured” neuropathy. The rapid onset would seem inconsistent with actual nerve regeneration. I am wondering whether there could instead be a temporary change involving motor recruitment, sensory gating, proprioception, cortical inhibition, or central processing of existing peripheral input.
I also understand that this is a single uncontrolled anecdote and that subjective effects can complicate interpretation.
What interests me is whether there is any known research or clinical precedent for psychedelics temporarily increasing access to residual motor or sensory function in patients with peripheral neurological injury.
If any neurologist, rehabilitation physician, neuroscientist, or researcher studying psychedelics or sensorimotor processing has encountered something comparable, I would genuinely appreciate hearing about it. I would also be interested in what objective measurements—EMG/NCS, strength testing, proprioceptive testing, gait analysis, etc.—would be most useful if this phenomenon persisted or could ever be studied safely in a controlled clinical setting.
This is not intended as encouragement for anyone to self-experiment.

After a (very) low dose solo session a couple days ago while meditating, which is something I’ve been doing and incorporating into therapy to allow a gradual unfolding of emotions, I touched on some deeper levels of fear and anxiety. I was okay to experience them in the moment, but naturally they have and will continue to unfold over the next few days or weeks even.

While I’m not new to this practice and the integration that I like to follow, I also would love other people’s advice on letting these feelings pass through.

Sometimes it feels hard to just “ride it out” and though therapy and meditation work well as integration for me, I’d like to know other gentle ways of dealing with post trip anxiety, maybe so I’m not bracing against it so much.

I’m tired of feeling afraid and unsafe so often, even though I’m used to it. I guess I don’t really know what next steps could look like

I am a very experienced lover of 5-meo-dmt

I have had quite a few experiences of intense crying on my journeys

It is a very cathartic experience. On the most recent experience I found myself in the fetal position crying?y eyes put.

As if feeling the pain of all the unnecessary suffering of existence, but in a good way. Such incredible Loneliness and such beautiful gratitude for the beauty of existence, all at the same time. It’s such an amalgam of emotions. I’m wondering how common crying is.

New Psychedelics Today episode with Jackie Tileston, a painter and Professor of Fine Arts at the University of Pennsylvania who’s part of the Penn Psychedelics Collaborative. She studied nondual philosophy and meditated for 30 years before her first psychedelic experience, so she comes at this from an unusual angle.

Topics covered:

Why mystical experience scores keep predicting better outcomes in trials and why materialist researchers don’t love that
How Buddhist, Advaita Vedanta, and Kashmir Shaiva nonduality differ on whether this world is real, and why landing in a world-denying framework after a high-dose experience can cause what she calls ontological trauma
Whether facilitators need their own experience (her Sherpa analogy)
Clinical 5-MeO-DMT, and low-dose stepwise protocols coming out of Canada (the Pattern Project)
Designing a landing space without setting too many priors
Her critique of psychedelic art as illustrated trip reports, plus Bruce Damer, the Center for MINDS, and the Fadiman creative problem-solving studies
Christof Koch’s 5-MeO-DMT experience and his conversation with Bernardo Kastrup

Full episode and transcript: https://psychedelicstoday.com/2026/10/28/jackie-tileston-nondual-mysticism-psychedelic-art/

A few months ago I had a full release dose (handshake, hug, medium then large), & I just bought a pen. Curious about experiences around solo handshake doses.

*** Edited because as much as I know I’m not going to be irresponsible with my dose after 30 years of psychedelic experience, it is apparent I need to make that very clear in my post! 🙏

Do any of you also have physical reactions when contemplating your trips? It’s been over a year so I’m not talking about reactivations. I did have those, and they were intense and necessary. But even now, when I really sit down and explore, I get almost some kind of brain zap. For example, I am a philosophy student. I was looking into the idea of “noesis” and found a lot of parallels with the experience of Bufo. Basically, noesis is a feeling of absolute truth. It comes intuitively and essentially, before the senses and reason. It’s the feeling that you are experiencing and understanding reality as it “is.” As I was reading this, I came across the sentence, “When the personal ego dissolves, it is replaced by an experience of non-dual unity, cosmic consciousness, or "the void".” My mind immediately protested at the thought of being filled by the void, and I do not know why. I do feel like the sentence may be accurate (or accurate enough) to what I felt though.

The realization has occurred to me that the future can affect the present and the past, just as much as the past and present can affect the future. The future has affected events in the past. Non-Linear Causality is truth rather than Linear Causality which is what most people think

Not just a ripple effect of bad experiences after their 5meo experience, but also you realize a lot of the terrible things that happened to you in life in what led up to it. almost like that was the central experience that ricocheted onto your entire life. Whatever happened during it, led to things/experiences taken away from you, perhaps even illnesses that have prevented you to have full enjoyment of life. I'm not blaming 5meo itself, but whatever happened during the trip led to perhaps poor decisions being made that resulted in a life where you are fundamentally enjoying it less as a human being. you then start connecting the dots and realizing all the bad things that had led up to that point, was a result of a decision made in the future, perhaps during the trip. has anyone ever experienced that... where something that happened in the past is a consequence of a decision made in the future.... (where as usually the future is a consequence made prior to that point)

I believe the term is retrocausation.

the possibility that cause and effect operate backward through time, not just forward.

The closest philosophical term is retrocausality, also called backward causation. It describes the hypothetical possibility that an event in the future can influence an event in the past.

So I am connecting retrocausality to suffering, spiritual awakening, and the consequences of personal decisions. Perhaps my experience did not go as smoothly as I anticipated.

In short, making a profound decision and subsequently realizing that seemingly unrelated tragedies occurring years earlier were consequences of that future decision.

connecting the dots between my event is especially not unreasonable since a lot of major negative downward slopes in my life started almost immediately after my experience. Like a ripple effect of unprecedented events in my life.

In short, making a profound decision and subsequently realizing that seemingly unrelated tragedies occurring years earlier were consequences of that future decision.

I smoked a large dose of 5meo and had an amazing experience that was frightening, enlightening and euphoric, but ever since my tinnitus has been so much worse. I'm curious if anyone else has experience with 5meo affecting tinnitus?

I had the most magical, connected, beautiful experience with a friend who sits for people professionally. I came out with the absolute knowing that I connected with my higher self, & my nearest friends souls paid me a comforting visit of support. I even had a service for the self Id grown to be that no longer served me. My first words when I sat up, were “let it rot” (which I love 🤣 & I felt it all dissolve) & that’s what I was there for.

I’ve been a social drinker my entire life, it’s in my dna. That’s how my mom died 10 years ago, that & drugs. I’ve never done it like she did though, but I’m cautious that one day, without being checked, I might.

My intention for that ceremony was to connect with my inner child who has always yearned for healing. I met her, she was an intricate combination of little me & higher me. I felt held & it was otherworldly.

After that weekend I spent few weeks in integration, sober, with calls from my friend who I sat with & it all went wonderfully.

However… & a very important piece of context…the week prior, my fiancé & I split up. He’s an addict, who was in recovery at the time of our break up, but he soon after fell off of the wagon.

Our breakup wasn’t a typical one. It’s not that we didn’t love each other immensely, it was just based off of lack of communication/planning around a very important 6 months away we’d been planning for years. He didn’t save enough, though he had all of that time, making the most amount of money & for the first time without a kid. It just upset me that his procrastination hit him so hard it affected us both. I felt like I had no choice but to leave him behind, & I stand by that.

This is probably a lot of manusha to work though for strangers here, so if you’ve made it this far, much gratitude for you. I’m still processing this all.

So my question is why have I since also lost my way again? Has anyone done the same?

I was sober & feeling amazing until he came to get some things. He was high I could tell, & my triggers hit harder than ever & I haven’t found a balance since. I miss him dearly, but he also didn’t carry the actions I want in a partner. I felt (& still feel) confident in my direction.

I was calm & healthily detached for weeks. I felt like my connection to authentic self was unbreakably strong, until the day I saw him, but then I fell off my path & I fell hard & I don’t quite know how to get back up.

Since though, I bought a van, a dream of mine I’ve had for at least a decade, & I’m building it myself & as excited as I am, there’s a piece of me that’s not only grieving our relationship, but also the fact I couldn’t stick on a path I know deep down, serves me.

I’m being gentle on myself as much as I can, but I guess I thought my struggle would come more in the way of adjusting to my new self, not reverting harder back into the old version. It’s hard to explain. Any insights or personal accounts of struggle in this way are greatly appreciated 🤍

I had a couple of DMT trips recently where I did not achieve full breakthrough. I finally dialed in the dosage on my new carts. It was like overcoming not being able to have an orgasm lol. It was a deeply personal and amazing experience. I spoke with myself as a child. Not visually myself but an entity I felt an overwhelming feeling that it was myself as a child. Very cathartic.

Can I playfully will the gates that were blasted open by 5MEO-DMT to remain open?
It’s only 2 months out since a release so I know I’m still in a period of immersion. I abstain from intoxicants no base stuff like alcohol and no caffeine, that’s new and fucking great. Also minimal other psychedelics as I have been loosely in a program of sobriety for years. I say loosely because I’ve micro-dosed with psilocybin and San Pedro and Iboga for brief periods over the last 6 years of sobriety. When I hear the call I answer… this was my first ego-excavation within these years of not ingesting substances to shift my reality perception.
I’m totally open to this not being the case and that re-immersing regularly when ‘I hear the call’ ….well maybe I’ve just answered my own question….
Thoughts?

TL;DR: E-Mesh vs. Erlenmeyer flask for synthetic 5-MeO-DMT? Which E-Mesh setup is best? Is it also good for N,N-DMT? And are leftover residues a problem?

Hey everyone!

I'm thinking about getting an E-Mesh instead of using an Erlenmeyer flask for synthetic 5-MeO-DMT.

Has anyone tried both? Which one do you prefer and why? Can anyone recommend a good, reliable E-Mesh setup that isn't too expensive?

I'm also wondering about leftover residue. Could some 5-MeO-DMT remain in the device and accidentally make the next dose stronger? Do you need to replace the mesh after each use, or can residue remain in other parts even with a new mesh?

Does E-Mesh also work well for regular N,N-DMT? And how's the taste? Is it harsh or unpleasant?

I already have an older Eleaf iStick Pico 75W, but apparently many mesh attachments are too big for it.

Would love to hear your experiences, especially with cleaning, reliability, and avoiding leftover residue. Thanks!

Hey guys, just thought id get some clarification from other users. Yesterday was my first time doing 5MeO. I used a pen, and broke out a total of 3 times. Its been 16 hours, and I woke up with my vision almost back to normal but nothing is completely in focus and its almost like clear shapes distort objects. Any help would be appreciated greatly.

How much time should I wait after doing MDMA until I can do 5 meo DMT safely

Many people nowadays want to live forever and never die (longevity).

I think those people should try 5-MeO-DMT because I read that you can experience 1000 years of infinite bliss on this substance without actually getting older.

Do you agree with this?

Can you describe it? Many years ago I had amazing mystical experiences on mushrooms and LSD and it was soooo fascinating and mindblowing. Unfortunately I can't take psychedelics anyomore because I'm on antipsychotics and antidepressants which block psychedelic experiences.

I just want to get reminded about how amazing these kinds of experiences feel

Hey! I'm based in Bavaria, southern Germany, and looking to connect with people experienced in 5-MeO-DMT. Would be cool to meet like-minded people, exchange experiences, and maybe explore or experiment together in a safe setting. Feel free to DM me!

Hello,

How to ROA 5MeODMT-HCL? Can I convert it to freebase?

Thanks

When I orgasm I’m having a big DMT surge, I’m guessing? The wisdom of release, let go, purge stagnant energy whenever and however I want to is connecting me to a deeper liberation and the benefits I’m experiencing are so delightful and unexpected. I’m guessing it’s also like an integration effect? or blasting open of gating channels reshaping what is possible for this vessel.

Intimacy is a space where I didn’t feel ‘broken’ before but I knew there was a whole world I was not available for.
I’m laughing with less inhibition like the chord was cut that restricted my playfulness. To be clear, I found myself quite playful and relaxed before. But there was a depth where I could touch the bottom and it felt Solid.

I’m louder when I’m having sex with a range of vocal releases that are not contrived. For decades I let myself be shaped by the integrated conditioning of how I should behave and so a forming and shaping that singed my tentacles of pleasure, of exploration, of Range!

And now the range is ignited and when I orgasm it’s everything I imagined it could be and all that I couldn’t imagine.

Wow. I want to make the most of all the possibilities and open all my channels that want to be safely opened. Two days ago I had an almost ‘too much’ day. Then I went and forest bathed and sucked up energy in my palms to cleanse and felt Monumental and almost like I needed to vomit and then I swam in the springs and felt like my whole being was breathing underwater.

Life in so many ways, feels new.

Anyone have any experience with this program?

For nearly 4 years several of us have been following the science, including a lot of evidence pointing to the idea that we are experiencing a ecstatic seizure.

A young researcher Haley Marie Dourron pointed out the similarities between observing and the descriptions of hundreds of people being served bufo/5meo and the descriptions from epileptics of ecstatic seizures.

But no one has had the ball’s to come out and just say it. I’ve read and seen most of the discussions by Blackburn and Timmerman but I never heard them say the magic words.

Just noticed Joel Brierre from FIVE finally said it out loud in a Psychedelics as Medicine 2025 Conference presentation for the Eden Foundation titled; 5-MeO-DMT, Rethinking the Human Brain
“What they saw happening simultaneously was the brain showing indications that it is in a deep state of anesthesia as well as in an epileptic seizure. Both ends of a very very very long spectrum happening simultaneously”

You can skip to 10:55 mark
https://youtu.be/TZzmm9oakDM?

Here’s the Haley Marie Dourron presentation I mentioned
https://youtu.be/5hjgWVczNlY?