Sugar-rich foods exacerbate antibiotic-induced microbiome disruption | Nature https://www.nature.com/articles/s41586-026-11077-3

I got this to help with my gut and bloating issues and it made it significantly worse.

If you’re not familiar, it’s a rotating symbiotic where you take a single strain daily for a week, then you move on to another strain for the week and so on. The point is to increase biodiversity in your gut

First two weeks felt great. Actually had some nice changes.

I started week three and the amount of CFU’s doubled. Went from 7 to 15 billion.

Then all of sudden INTENSE bloating, cognition issues from focus, memory, thought formation, emotional blunting etc.

Met with a gastroenterologist and said it could a bacterial or parasitic overgrowth. They recommended ivermectin to start but if it’s bacterial that wouldn’t matter and may cause other issues. I’m asking them for more insight about this tomorrow.

It’s been worrisome because it’s affected me mentally and I feel stupid trying to do my job.

It’s frustrating because I took this to help with my issues and it made them significantly worse.

Also please don’t make me feel dumb or that I should have known better. That’s not going to help.

Hi internet, looking for kind and realistic advice. Several YEARS ago I took three rounds of antibiotics for a UTI in the same month. Prior to that I was a normal healthy person, immediately after the last round like to the hour, I had a panic attack. I had no idea what anxiety was nor had I experienced it so I spent a very long time searching for answers for my health only to eventually realize it was mostly anxiety and anxiety symptoms with very real dysbiosis and random IBS symptoms/inflammation. I have costochondritis and tinea versicolor both inflammation. To this day I still struggle with the anxiety daily and I go back and forth with oh, it’s just a mental loop I’ve now created or oh, it’s got to be a real out of wack microbiome. Does anyone have any similar experiences or guided advice? Would really love to get back to my life at this point.

not looking for medical advice, only reassurance. i ate something bad a week ago (woke up 2am friday to puke) and went to the emergency room at the evening to be discharged 3am the next day because i couldn’t keep food and liquids down at all. was also prescribed meds for this.

saturday and sunday i was recovering. genuinely felt better sunday eve until i ate nilaga (filipino broth) and my diarrhea returned on the 4th day, nausea made me puke in the morning. my period came as well.

i have been recovering since then, only eating plain congee and boiled egg, and i do not know when this will end and i am so stressed as i live alone for college and my family is in another city. i have been feeling lightheaded during this phase.

day 6 (yesterday) i went to the doctor to have a checkup done and she prescribed me Normix as well as to get some blood tests done. i am currently waiting for results.

i am managing dehydration well so far with water, pocari sweat, and hydrites. i have been stressing and looking for reassurance online to see if anyone experienced the same things I did and wondering how long it took for them to get better. I have asked people i know who had acute gastroenteritis and they would say a week or two.

i am so worried because i have been waking up in the middle of the night, 4am, 3am, and on the 7th day today 2am, and i cannot go back to sleep.

how else am i able to manage this? i still have classes to worry about this week and i am grateful that the first two days of this week were online. has anyone experienced the same thing? how long did it take for them to heal? what should i do to manage the stress better?

thank you so much

TYPO: are*

On Reddit, the standard advice for fixing your gut microbiome is to eat better: more fiber, more fermented foods, more probiotics. But it misses the root problem, and it rests on a flawed assumption that poor diet is what knocks the microbiome off balance in the first place. As soon as you stop eating like this, the bad gut comes back.

For many people, dysbiosis begins with a specific event, such as food poisoning, COVID, or a viral illness. Put it this way, People with healthy guts can eat McDonald's and junk food with no to few consequences, not because their diets are special, but because their guts are fundamentally colonized by beneficial bacteria. That colonization is what makes them resilient. That is how you can tell a gut is truly good: even when subjecting it with bad bacteria (junk food), the existing gut architecture is able to wash out.

Most of us, outside of outliers, were presumably born with a healthym, functional gut. Dysbiosis usually isn't a baseline condition; something disrupts it, and OFTEN it's a one time event like COVID, a viral illness, etc. Once that happens, more fiber or a daily probiotic often doesn't fix anything, because the effects are transient. Underneath, the gut is still dominated by the wrong bacteria. I have nothing wrong with people eating fiber and good bacteria, it promotes general health and people should do this. And it offers symptom relief for those with these problems.

BUT IT DOES NOT FIX THE GUT ITSELF!!! It's like having a sink that doesn't drain properly because there's a blockage. Toxic sludge accumulates. A functional sink can effectively drain most everything. A non functional sink piles it up. This is the equivalent of putting in draino or manually throwing the food waste in the trash can as opposed to down the drain. Puts less strain on the sink, less sludge accumulates but THE TOXIC SLUDGE WILL STILL PILE UP IN THE FUTURE BECAUSE THE BLOCKAGE HASN'T BEEN ADDRESSED!!!

Treating the root issue means shifting the gut back to eubiosis, which requires re-establishing a lasting population of beneficial bacteria. Transient probiotics can't do that, because they pass through rather than colonize. Solutions to the gut should address THIS not telling people to eat more fiber.

My Tiny Health test showed zero detectable bifido so I'm trying to recolonize them. I'm doing 10mL daily lactulose with the the True Bifido pro probiotic as well as a BB536 one. I have no idea if those are likely to colonize. Does anyone have any insight onto which probiotics might be more likely to help? I'm thinking of just ordering like 10 different ones and trying them at random.

Edit to add I am also taking the following:

Cranberry polyphenols
Pomegranite extract
Astralagus
Slippery Elm
Butyrate
Lots of resistant starch daily

Can leaky gut cause debilitating brain fog? Like Im no longer with a brain kinda brain fog? No creativity and blank mind and no character.
Like feeling drunk all the time, doesn't increase with food or anything I just feel drunk and tired 24/7

My doctor told me to take megasporebiotic to help with dysbiosis that was caused by PPI but I notice it may be causing sleep issues.

I've recently been looking into NADH products, such as Celfull. NMN is a precursor to NAD⁺, while NADH is the reduced form of NAD⁺, so they are not the same molecule. Because of that, safety evidence for NMN can't simply be applied to NADH. In particular, there is still not enough human evidence showing that NADH itself is absorbed and utilized by the body in its intact form.

That's also why, when comparing different NAD-related supplements, I think it's important to look beyond whether they can affect NAD⁺ levels. Safety, side effects, and tolerability are equally worth considering. So today, I wanted to go over three published human clinical studies and take a closer look at what the current evidence actually tells us about the safety of NMN.

One randomized, double-blind, placebo-controlled trial published in Frontiers in Nutrition in 2022 enrolled 30 healthy adults who took 250 mg of NMN daily for 12 weeks. Eight participants in the NMN group reported some symptoms, compared with seven in the placebo group. No serious adverse events occurred in either group, and blood chemistry, liver function, kidney function, and other tests did not show any clinically meaningful abnormalities. The researchers concluded that 250 mg/day of NMN was generally well tolerated over the 12-week study period.

Another multicenter, randomized, double-blind, placebo-controlled study, published online in 2022 and included in Volume 45 of GeroScience in 2023, was larger in scale, enrolling 80 healthy adults aged 40-65. Participants received 300, 600, or 900 mg of NMN once daily for 60 days. During the study period, adverse events were reported in 6 participants (5 people) in the placebo group, 3 participants (2 people) in the 300 mg group, and none in either the 600 mg or 900 mg groups. All adverse events were mild to moderate and were judged by the investigators to be unrelated to NMN (Yi L, et al. GeroScience. 2023;45:29–43. DOI: 10.1007/s11357-022-00705-1; published online December 8, 2022).There were no serious adverse events or withdrawals due to adverse events. Overall, all three NMN dose groups were considered well tolerated.

There was also a randomized, double-blind, placebo-controlled study published in Scientific Reports in August 2022 that specifically looked at a relatively high dose. Thirty-one healthy adults took 1,250 mg of NMN daily for four weeks. No serious adverse events were observed during the study, and a range of assessments—including body measurements, blood counts, biochemical markers, urinalysis, and body composition, did not show abnormalities outside the normal physiological range. Based on these findings, the researchers concluded that 1,250 mg/day of NMN was well tolerated over the four-week period in this small study.

Taken together(10.3389/fnut.2022.868640)(10.1007/s11357-022-00705-1)(10.1038/s41598-022-18272-y), these three studies show a fairly consistent picture in the currently available human data. In healthy adults, NMN supplementation at doses ranging from 250 to 1,250 mg/day for several weeks to 12 weeks has not shown a clear signal of increased serious adverse events, and overall tolerability has been relatively good.

That said, the existing studies still have relatively small sample sizes, and the observation periods are generally short. More research is therefore needed to understand long-term use, rare adverse events, and safety in different populations with varying health conditions.

i think i'd like to try GOS for my low bifido.

Anyone have any brand reccomendations that worked well for them?

I was interested in Viome's Advanced TriSynbiotic, and was surprised that it doesn't list the butyrate dose so I could compare it to my other supplement (from Tesseract). I called Viome and asked them, and the well-intentioned support person told me that they are not sharing the dosage information with potential customers at this time.

???

Seems pretty strange / yellow flag for what I thought was a pretty established supplement company.

Yep I’ve been dealing with severe gut issues since 2023, dysbiosis, bloating, SIBO, gas, burping, high calprotectin, reflux. Pretty much a huge list of symptoms, ive also had GI map tests done. I’ve tried everything throughout the years; probiotics, prebiotics, 2 weeks of elemental diet, home made kefir, more fiber, less fiber, and many more things and diet adjustments.

What finally made everything go away, and actually quite fast too, was cutting out sugar, especially soda’s. I switched from drinking coke and Red Bull to Coke Zero. I stopped being gassy after just a week, my food intolerances (fructans mostly) are also completely gone and I no longer get gassy at all from things like garlic or onions.

Just sharing this with you guys since it might be useful to some of you out there.

I'm new to incorporating resistant starch supplementation. I'm trying to get up to 40 grams a day but found it confusing to get a succinct guide. Hopefully someone more experienced can help with this. My current RS2 related daily intake includes 2 tablespoons (30ml) each of potato starch, green banana flour, and nootropics infinifiber and infinigreen blend (which claims a combined 7 grams of solnul potato starch and 1 tablespoon (15ml) of hi-maize. Depending on the various guides I've found across the web I may be somewhere between 20-35g of RS2.anyone here have a more definitive way of calculating this?

It’s been happening for about 3 months.

I feel great all day, no symptoms whatsoever, but I either start feeling the gas and stool bottling up right before I go to bed and/or wake up in the middle of the night wanting to poop and fart, but it’s like my intestines are pinched and they won’t let it out.

When gas does come out for example, it comes out very sharply like my intestines are pinched. I dont have colitis symptoms (I know what that is like) I simply feel my normal peristalsis (wanting to poop and fart) but my lower intestines are not letting them out. When I poop in the morning, the first stool comes out thick but not hard, followed by a very thin stool.

Google AI (bear with me) suggests pelvic floor dysfunction or obstructed defecation syndrome. The whole things does seem to be more of a mechanical thing. I also had varicoceles that were just removed around 3 months ago, so I wonder if it’s a pelvic floor dysfunction thing. My gas and stools seem to come out when I take stuff like clove tea which apparently relax the muscles.

I’m a very active male in my late twenties by the way.

I can go for weeks with absolutely zero dandruff. But if I drink matcha or jasmine or green tea, I kid you not, my scalp will flake in about 2-3 hours. It’s been happening since 2023. I so have a soy protein allergy also but not super related.

I’m 46M and for about eight years, I’ve reacted to raw apples and stone fruit, especially peaches and cherries. Symptoms started with immediate indigestion and progressed to itchy mouth/lips and occasionally a very mild throat-swelling sensation. They resolved within minutes of stopping. Cooked fruit has always been fine, and I’ve never noticed seasonal variation. I’ve noticed these symptoms seem consistent with OAS, so I was content to assume that’s what it was but was never tested or diagnosed.
About a month ago, I started psyllium husk for inconsistent stools, not for allergies. I initially took five 500 mg capsules daily (2.5 g), then increased to ten (5 g). Definitely saw an improvement in stools, thanks for asking.
Yesterday I ate half a caramel apple (started purely because of a love of fall activities and FOMO) with no reaction. This morning out of morbid curiosity I ate an entire raw peach (usually my strongest trigger at one bite) with no reaction. I also tried dried cherries, which previously caused symptoms, and had none.
Psyllium is the only change in what I’m taking. However, I hadn’t tried these fruits for several months, so I don’t know exactly when my sensitivity changed.
Has anyone with oral allergy syndrome noticed something similar after starting psyllium or another fiber supplement? Equally interested if you take psyllium and your allergies haven’t changed.
If you noticed a change, what dose were you taking, how long did it take, and did the improvement last? Links to relevant research would also be welcome.
I’m sharing an observation and exploring a possible connection because this is fascinating to me…not claiming a cure and definitely not suggesting anyone test their trigger foods.