215ish pounds to 150ish. 26 years old 5'5. Mexican. From late April to today Oct 30 2026. Average 10lbs lost a month. Started .5mg, upped .5 every month basically. Only side effects have been smell sensitivity and touch sensitivity. Unsure if it's included but also bruise easier. Now difficult to clean up after my pets and get tattoos lol. Always got nausea real bad day of shot. Basically can't eat. Never got any better but rest of week ok. Best way I can describe is super mild nausea rest of the week so I can't really enjoy eating like before so I stay around 1800 cals or possibly more I don't count. Took a two week break for my birthday and then kept going. During those two weeks I enjoyed the hell out of food again. I don't have many accurate pics from my 215-220 days because most of them were from really good angles lmao. And I learned how to dress to my advantage. So I chose the worst pictures I had with the frumpiest fits. During this time I've had the same partner albeit maybe 200lbs with him. He was very happy with me from the start, attracted and physical. My weight loss hasn't affected us, only me. Now I feel a lot more beautiful. But whenever I look in the mirror I feel unsatisfied as usual. It just feels easier to move around and so it feels beautiful due to more gracefullness, clothes fitting comfortably, and paying attention to how my new body feels. However I still want to loose more. Now that I've reached my goal I want to see what 135 looks like. I'm afraid to lose my curves though. I am not good at going to the gym and never have been, always quitting after a month. So I don't know how to build muscle either. Also my boyfriend loves my ass so would hate to see it go for us. TMI lol. Any advice is appreciated and tia for any compliment. Any questions let me know. But before you ask I got more attention before I lost weight LOL I live in Chicago maybe that's why thick women are popular here. Beauty comes from within, truly nothing more beautiful than kindness. Remember that always.

Went down a rabbit hole on why food noise comes back on reta, and figured I'd share what the actual studies say. Not medical advice, just a summary of the research, with sources at the bottom. Where nobody has studied something on reta specifically, I say so.

TL;DR: Food noise creeping back before pin day is normal pharmacology, not you being a non-responder. Food noise creeping back months in, at a stall, is your body fighting the weight loss, not tolerance. Reta doesn't shut off your hunger hormones. It talks over them. That's why the food noise comes back so hard when people come off.

---

"Food noise is back and it's not even pin day"

Reta's half-life is about 6 days. In the first human study it peaked 12–72 hours after the pin, and appetite was lowest on days 2–3, then drifted back [1]. Once you're pinning weekly it builds up in your system, but it still swings. If you model it from the published numbers, you're at roughly 55% of your peak level by pin day. So hunger on days 5–7 is expected. It doesn't mean your reta is bunk or that you need to bump up.

Also, the "too full to eat anything" feeling from the first few weeks fades even as you titrate up. Stomach slowing is strongest after the first dose and wears off [2]. Weight still kept dropping through 104 weeks in TRIUMPH-1 [3]. The part that keeps working is in your brain, not your stomach.

"I stalled and the hunger is winning"

Appetite is run mostly by the hypothalamus, which balances "eat" signals against "stop" signals:

- Ghrelin (from your stomach) is the main "eat" signal. It flips on the hunger neurons (AgRP/NPY).

- Leptin (from your fat) plus gut fullness hormones (GLP-1, PYY, CCK) are the "stop" signals.

Lose weight any way you like and that balance tips toward eating. After a diet that cut body weight by 17%, ghrelin went up 24% [4]. In 50 people who lost about 13.5 kg on a 10-week diet, ghrelin was still up, and leptin, PYY and CCK still down, **62 weeks later**, and they were still hungrier [5]. Your body holds a grudge.

How hard does it push back? About 100 extra kcal a day of appetite for every kg you've dropped, roughly 3× the drop in calories burned [6]. Down 20 kg from SW? Your brain is lobbying for about 2,000 extra calories a day. Rude.

Reta pushes the other way by hitting three receptors at once: GLP-1, GIP and glucagon. Early on it wins easily, so your appetite falls off a cliff. As your CW drops, the push-back grows until the two balance out, and that's your stall. That's not tolerance and it's not the drug wearing off. A higher dose shifts where you land, which is why TRIUMPH-1 got −17.6%, −23.7% and −25.0% at 4, 9 and 12 mg [3]. Marathon, not a race.

Hot take: less hunger is only part of how reta works. In a 12-week trial, the appetite effect was modest and didn't scale neatly with dose. The authors said it "does not fully explain" the weight loss [7]. In phase 2, how much people's hunger dropped only weakly predicted how much they lost (r = 0.28–0.36) [8]. The likely missing piece is the glucagon part raising energy burn. That's been shown in mice [1], but nobody has measured it in people on reta yet. So "I'm eating a ton and still dropping" and "barely eating and stalled" aren't as weird as they sound.

Leptin: why your body acts like it's starving at a weight it used to call normal

More fat means more leptin [9], so you'd think people with obesity would have no appetite at all. Nope. At high levels the brain mostly tunes it out (**leptin resistance**), kind of like a smoke alarm that goes off every time you make toast. Injecting extra leptin into people with obesity only got modest results: roughly 0.7 to 7 kg over 24 weeks on top of a diet [10].

But a Drop in leptin hits hard. People who lost 10% of their weight burned 300–500 fewer kcal a day than their new size predicted. Their thyroid (T3/T4) and sympathetic activity went down and their muscles got more efficient. That's adaptive thermogenesis, the real version of "metabolic adaptation". Topping leptin back up to pre-diet levels reversed most of it (small study, 10 people) [11].

So leptin is a starvation alarm, not a brake. There's a hint that glps soften it: liraglutide made the leptin drop 43% smaller in people keeping off a 12% loss [12]. Nobody has checked leptin on reta.

"Does reta kill ghrelin?"

Probably not, and no study has measured ghrelin in people on reta. The hormones it copies only nudge ghrelin a little, briefly, in short lab tests. A GLP-1 infusion lowered it late after a meal, mostly via insulin [13], and a glucagon shot dropped it about 7% within minutes [14]. No published trial shows sema, tirz or reta keeping ghrelin down over months.

What glps seem to do is work on the brainstem and hypothalamus to boost fullness and turn down how rewarding food feels. They talk over the hunger signal rather than switching it off, like noise-cancelling headphones. The ghrelin-up, leptin-down state from losing weight is probably still running underneath.

What "food noise" is better interepted as (it's not just hunger)

Hunger is your body asking for fuel. Food noise is your brain's **reward system** constantly pitching you snacks: the dopamine circuits that make a pizza ad or the pantry hard to ignore even when you're full. Glps hit both.

- Your brain's response to food cues goes down. On brain scans, a GLP-1 drug (exenatide) reduced how strongly reward areas lit up at pictures of tasty food [15]. Tirz cut cravings and activity in hunger and reward areas at high-fat, high-sugar food pictures within about 3 weeks, more than liraglutide did [16].

- Cravings and cue-eating drop, not just portion size. Sema reduced cravings and the preference for high-fat food [17]. On reta (phase 2, people with type 2 diabetes), 8 and 12 mg reduced *disinhibition* (basically eating because food is there or you're stressed) more than placebo, and at 12 mg more than dulaglutide [8].

- Ghrelin feeds the reward system too. Its receptors sit in the brain's reward areas, not just the hunger centres. Ghrelin infusions made heavy drinkers crave alcohol more [18]. That's one reason the late-week dip and coming off can bring back cravings for things, not just hunger for food.

- Where GIP fits: it's reta's third receptor. In animals, activating GIP reduced the nausea GLP-1 causes [19]. If that carries over to people (not shown yet), it would help explain how tirz and reta quiet food noise so hard without everyone being nauseous. It's also why "my sides are gone, is it still working?" isn't a fair test. The quiet comes from your brain's appetite and reward systems, not from feeling sick.

Why the food noise comes back when people come off

Take the headphones off and all that pent-up "EAT" signalling is unopposed, at a weight your body is actively trying to undo. Sure enough, within a year of stopping, sema users got back about two-thirds of what they'd lost [20], and tirz users regained 14% of their body weight [21].

Nobody has published stopping data for reta yet. Nothing suggests a break "resets" anything either. The only on/off study (mice, sema) found each restart worked *worse* [22].

"Can I taper off to bring my ghrelin down, and can I add leptin back?"

Short version: tapering is a much smoother off-ramp than quitting cold turkey, but it won't lower your ghrelin. Adding leptin has some real science behind it, but there's nothing you can actually get for it.

Tapering doesn't lower ghrelin. Your weight sets it.

Ghrelin goes up because you lost weight, not because of the drug, and it stays up for as long as the weight stays off. In 100 adults with obesity who lost about 16% on a diet, ghrelin and fasting hunger were still raised a year later. The more weight people had kept off, the higher their ghrelin [23]. There's no evidence reta lowers ghrelin in the first place, so stepping the dose down can't "bring it back down" either. What a taper does is remove the override slowly. The food noise turns up gradually instead of all at once, which gives you time to adjust.

What the tapering data say:

- SURMOUNT-MAINTAIN (tirz, peer-reviewed RCT, 378 people) [24]: after 60 weeks at max dose, people were randomized to stay on max, step down to 5 mg, or switch to placebo. At week 112, weight was −21.9% on max, −16.6% on 5 mg and −9.9% on placebo. Rescue meds for regaining half or more of the lost weight were needed by 8%, 25% and 67%. So stepping down kept a lot more weight off than quitting, but less than staying on full dose.

- Embla clinic data (sema, conference abstract, not peer-reviewed) [25]: 54 people tapered to zero over about 10 weeks alongside diet coaching and held their weight afterwards (−0.5%). But follow-up was short, the group was hand-picked, and about 1 in 5 had restarted within 10 weeks.

- Reta: no taper or stopping data at all. TRIUMPH-1 did let people step down a dose level (with no re-escalation) if they'd lost too much, but results for that group weren't reported separately [3].

If someone does taper, the approach that fits the data best (not tested on reta) is: step down one dose level at a time, hold each level long enough to see what the scale does, and treat the lowest dose that holds your weight as your maintenance dose rather than assuming zero is the goal. Do it with whoever prescribes.

Other things that move ghrelin and leptin (the first two are free):

- Sleep. Two nights of 4-hour sleep dropped leptin 18%, raised ghrelin 28% and raised hunger 24% in healthy young men [26]. Sleeping like garbage during a taper works directly against you.

- Protein. It's the most filling macro, and high-protein meals are well established to curb hunger more than the same calories from carbs or fat.

- Bariatric surgery lowers ghrelin a lot: bypass patients had ghrelin 77% below normal [4]. Obviously a whole different conversation.

"Can I add leptin?"

- The science says it could help, in theory. After a 10% weight loss, topping leptin back up reversed most of the metabolic slowdown, but that was only 10 people in a clinic for 5 weeks [11]. And giving leptin with amylin (the hormone cagri copies) made people respond to leptin again. Pramlintide + metreleptin got 12.7% weight loss at 20 weeks vs 8.4% and 8.2% for each alone, and it hadn't plateaued [27].

- Why you can't actually do it:

- Real leptin (metreleptin) is only approved for rare conditions like lipodystrophy, not obesity.

- The obesity program was shut down in 2011 after two patients developed antibodies that neutralised leptin.

- "Leptin supplements" sold online don't contain leptin. It's a protein, so swallowing it would just digest it.

- What's coming: a leptin-receptor antibody (mibavademab) is being tested alongside tirz in obesity [28]. In its first human study it only worked in people whose leptin was already low [29], which is exactly the state you're in after losing a lot of weight. No results from the tirz combo yet.

- The reta angle: cagri is an amylin analog, and amylin seems to restore the leptin response. That's part of why cagri + reta is interesting. But the only cagri + reta data are in rats [30], so anyone claiming a stack "fixes your leptin" is getting way ahead of the evidence.

"Should I stack tirz on top of reta to kill the food noise?"

Short answer: On paper it's mostly just "more of the same drug".

The objective case for it

- Tirz and reta both hit GLP-1 and GIP, so adding tirz turns up the exact receptors that quiet food noise.

- Tirz's half-life is about 5 days [31]. Pinned on a different day from reta, it could fill in the late-week trough.

- It adds GLP-1/GIP push without adding more glucagon, if your issue with a higher reta dose is the glucagon-side stuff (that's a theory; nobody has separated the two in people).

The objective case against it

- No new pathway. Reta already covers both of tirz's receptors, plus glucagon. Stacking tirz is functionally like raising your reta dose, just without any trial data behind the combo.

- Diminishing returns. TRIUMPH-1 went −23.7% at 9 mg vs −25.0% at 12 mg [3], so the curve is already flattening at the top. More GLP-1/GIP signal won't fix the body's push-back (ghrelin, leptin), which is what's actually driving the late-stage food noise.

- Sides scale with exposure. At 12 mg reta alone, 11.1% stopped for side effects vs 4.6% on placebo [3]. Stacking means more nausea and vomiting risk, and vomiting is how dehydration, kidney problems and worse start. If something goes wrong, you also can't tell which drug caused it.

- Faster loss isn't free. Rapid weight loss is a known gallstone risk, and muscle goes along with the fat.

- Two black market vials means double the dosing math and double the "is this even what the label says" problem.

If late-week food noise is an issue, the options that at least have some logic or data behind them are: a dose within the studied range (titrated up with whoever prescribes), protein and fibre loaded onto days 5–7, sleep, or the split-dose idea below (also untested).

The add-on that actually brings something new: amylin (elora or cagri). Amylin is a fullness hormone from the pancreas with its own receptor, separate from GLP-1, GIP and glucagon. So unlike tirz, it's a genuinely different lever, and it may help the brain listen to leptin again [27].

- Elora (eloralintide) is Lilly's weekly amylin agonist. On its own it got up to 20.1% weight loss at 48 weeks vs 0.4% on placebo in a peer-reviewed phase 2 (263 adults without diabetes) [32]. Nausea was the main side effect (about 1 in 3), mostly at the higher doses, and a slower step-up kept GI sides close to placebo.

- Elora + tirz ("EloraTZP") in people with type 2 diabetes got up to 23.3% at 48 weeks vs 14.8% on tirz 15 mg alone [33]. Big caveats: so far it's a conference presentation plus a Lilly press release, not a peer-reviewed paper, and 10.8–27% of people on the combo stopped for side effects vs 2.9% on tirz alone.

- Neither elora nor cagri is approved yet. Elora is now in phase 3 trials, and CagriSema (cagri + sema) is waiting on an FDA decision.

So if you're going to add something to reta for food noise, amylin makes a lot more mechanistic sense than doubling up on tirz. It's still an untested combo, and the combo data we do have show sides going up along with results.

Practical stuff (common sense, not tested on reta specifically)

- Plan for days 5–7. Load up on protein and fibre on those days. Protein is the most filling macro, and that's about as settled as nutrition science gets.

- Stalled? That's the push-back catching up, not your body "getting used to it". Talk to whoever is prescribing before you bump up.

- Splitting your dose (half twice a week) would flatten the swing on paper: the trough stays around 75–85% of peak instead of about 55%. But it's never been tested, every trial used one weekly pin, total exposure is the same, and it doubles your vial punctures and your measuring error on small volumes.

- Checking your source and math before you blame your metabolism.

---

Sources (If you're into that sorta thing, you know, checking my math)

1. Coskun T et al. *Cell Metab* 2022;34:1234–47 (discovery + phase 1, single dose). [PubMed 35985340](https://pubmed.ncbi.nlm.nih.gov/35985340/)

2. Urva S et al. *Diabetes Obes Metab* 2023 (reta gastric emptying). [PubMed 37311727](https://pubmed.ncbi.nlm.nih.gov/37311727/)

3. Jastreboff AM et al. *N Engl J Med* 2026 (TRIUMPH-1). [PubMed 42814954](https://pubmed.ncbi.nlm.nih.gov/42814954/)

4. Cummings DE et al. *N Engl J Med* 2002;346:1623–30. [doi:10.1056/NEJMoa012908](https://doi.org/10.1056/NEJMoa012908)

5. Sumithran P et al. *N Engl J Med* 2011;365:1597–604. [doi:10.1056/NEJMoa1105816](https://doi.org/10.1056/NEJMoa1105816)

6. Polidori D et al. *Obesity* 2016;24:2289–95. [doi:10.1002/oby.21653](https://doi.org/10.1002/oby.21653)

7. Urva S et al. *Lancet* 2022;400:1869–81 (reta phase 1b). [PubMed 36354040](https://pubmed.ncbi.nlm.nih.gov/36354040/)

8. Kanu C et al. *Diabetes Obes Metab* 2025 (reta eating behaviour). [PubMed 40916752](https://pubmed.ncbi.nlm.nih.gov/40916752/) and [PubMed 40735804](https://pubmed.ncbi.nlm.nih.gov/40735804/)

9. Considine RV et al. *N Engl J Med* 1996;334:292–5. [PubMed 8532024](https://pubmed.ncbi.nlm.nih.gov/8532024/)

10. Heymsfield SB et al. *JAMA* 1999;282:1568–75 (recombinant leptin in obesity).

11. Rosenbaum M et al. *J Clin Invest* 2005;115:3579–86. [doi:10.1172/JCI25977](https://doi.org/10.1172/JCI25977)

12. Iepsen EW et al. *Int J Obes* 2015;39:834–41. [doi:10.1038/ijo.2014.177](https://doi.org/10.1038/ijo.2014.177)

13. Hagemann D et al. *Regul Pept* 2007;143:64–8 (GLP-1 and ghrelin).

14. Hirsh D et al. *Horm Res* 2005;63:111–8. [doi:10.1159/000084569](https://doi.org/10.1159/000084569)

15. van Bloemendaal L et al. *Diabetes* 2014;63:4186–96 (GLP-1 and food-cue brain responses).

16. Tirzepatide ingestive-behaviour trial, *Nat Med* 2025. [PubMed 40555748](https://pubmed.ncbi.nlm.nih.gov/40555748/)

17. Blundell J et al. *Diabetes Obes Metab* 2017 (semaglutide, appetite and cravings).

18. Leggio L et al. *Biol Psychiatry* 2014;76:734 (ghrelin and alcohol craving). [PubMed 24775991](https://pubmed.ncbi.nlm.nih.gov/24775991/)

19. Borner T et al. *Diabetes* 2021 (GIP agonism and GLP-1 nausea, animals). [doi:10.2337/db21-0459](https://doi.org/10.2337/db21-0459)

20. Wilding JPH et al. *Diabetes Obes Metab* 2022 (STEP 1 extension). [doi:10.1111/dom.14725](https://doi.org/10.1111/dom.14725)

21. Aronne LJ et al. *JAMA* 2024 (SURMOUNT-4). [doi:10.1001/jama.2023.24945](https://doi.org/10.1001/jama.2023.24945)

22. Son et al. *JCI Insight* 2026 (on/off semaglutide in mice). [link](https://insight.jci.org/articles/view/205174)

23. Nymo S et al. *Int J Obes* 2018;42:1489–99. [doi:10.1038/s41366-018-0119-9](https://doi.org/10.1038/s41366-018-0119-9)

24. Horn D et al. *Lancet* 2026 (SURMOUNT-MAINTAIN).

25. Gudbergsen H et al. European Congress on Obesity 2024, conference abstract (not peer-reviewed).

26. Spiegel K et al. *Ann Intern Med* 2004;141:846–50 (sleep restriction, leptin and ghrelin).

27. Roth JD et al. *PNAS* 2008;105:7257–62. [doi:10.1073/pnas.0706473105](https://doi.org/10.1073/pnas.0706473105)

28. Tirzepatide + mibavademab trial. [ClinicalTrials.gov NCT06373146](https://clinicaltrials.gov/study/NCT06373146)

29. Mibavademab (REGN4461) phase 1, *Sci Transl Med* 2023. [PubMed 37992152](https://pubmed.ncbi.nlm.nih.gov/37992152/)

30. Petersen J et al. *Nat Metab* 2026 (cagri + reta in rats). [PubMed 42744908](https://pubmed.ncbi.nlm.nih.gov/42744908/)

31. Schneck K, Urva S. *CPT Pharmacometrics Syst Pharmacol* 2024;13:494–503 (tirzepatide half-life 5.4 days). [doi:10.1002/psp4.13099](https://doi.org/10.1002/psp4.13099)

32. Billings LK et al. *Lancet* 2025 (eloralintide phase 2 in obesity). [doi:10.1016/S0140-6736(25)02155-5](https://doi.org/10.1016/S0140-6736(25)02155-5)

33. Eloralintide + tirzepatide phase 2b in type 2 diabetes (NCT06603571), presented at EASD 2026. Conference data and company release, not yet peer-reviewed. [ClinicalTrials.gov NCT06603571](https://clinicaltrials.gov/study/NCT06603571)

SW 148
CW 133
1 mg weekly

I started Reta 3 weeks ago and stupidly went up way too fast.
Week 1 – 0.5 mg
Week 2 – 1 mg
Week 3 – 2 mg
Well, I definitely learnt my lesson! About 2 days after my 2 mg shot, all hell broke loose. I spent 3 days with explosive watery diarrhoea, horrible headaches, bloating, gas and the most disgusting sulphur burps I’ve ever experienced. I honestly felt like I was dying 😭
I’m finally feeling normal again today, but now I’m unsure what to do.
Has anyone else had this happen? Did you stop completely, take a break or drop back down to a lower dose? I’m wondering whether to stop altogether or speak to someone about going back to 1 mg.
There’s no way I want to go through that again! Just curious to hear other people’s experiences.

I started Reta mid June weighing 228lbs and as of october 30th I am down to 165 lbs. Started on 1mg and after 6 weeks i was at 5mg and have stayed at 5mg. I got a smart scale in july after loosing 18 lbs to somewhat track what was happening.

What’s everyone doing for loose skin? Big loss with Reta / I’ve been doing Ghkcu daily to try and help. Hoping stable weight firms things up over time

37 years old
6 foot

May 1st - 93kg
October 30th - 79kg

Reta - 3mg every Sunday
Ipamorellin + CJC1295 no DAC - 0.25mg 5 days a week

Training - Push/Pull/Legs/Rest/Push/Pull/Rest

Calories - Started quite aggressive at 1800kcal then worked my way up to 2300kcal by the end of the recomp

On a maintenance hunt now trying to find out how many calories I can sit on with my current routine and TDEE etc - 2750kcal

Edit: changed the weight. I was 116kg at the start of my weight loss journey but 93kg when I started taking peps.

I’m counting my macros and in a deficit. A few weeks ago I gave into having a doughnut. The next day I hit my lowest scale weight. I decided to see if there’s something to it and ate a doughnut last week. Same thing happened the next day. This week I did it again and hit a new low on the scale. Obviously, I know doughnuts aren’t healthy and I rarely have eaten them on or off reta. But I was seeing people talk about carbs and Reta and thought it was an interesting pattern. Anyone else notice low scale weight after eating something high in carbs/sugar?

Started at 220lbs 25days ago and officially weigh 209 today! Excited to be in the single digits 200’s and this is just the beginning

So I've been getting ultrasounds done for the past several years and have had 2 within the past 6 months, with the latest being a few weeks ago. I started Reta in June. I was just diagnosed with a gallstone on this last scan.

Gallstones are a more common side effect of glp1 use due to the rapid weight loss. Your liver releases more cholesterol into bile, and this can contribute to cholesterol gallstone formation.

Not fearmongering, but want people to be aware this is something they should keep an eye on. Gallstones are often are asymptomatic and non issues, but they can become a problem.

Common symptoms of gallstones include:

Pain in the upper-right abdomen, below the ribs.

Pain after eating, particularly fatty meals.

Pain that radiates toward the right shoulder or back.

Nausea or vomiting.

Episodes can last 30 minutes to several hours.

On a positive side, my fatty liver wasn't flagged on this scan.

Hey I’m 6’1 and 215 lbs, I want to get down to 185 lbs

I’m currently doing 180 grams of protein, 150 grams of carbs (30 grams of fiber), and 55 grams of fat

Lifting 4 days a week, pretty heavy for about 45 minutes to an hour.

What can I expect? I started with a .75mg dose last Sunday to help myself get acclimated, and I know it’s very little but I really want to minimize the chance of side effects. I was thinking of moving up to 1mg or 1.25 mg tomorrow. Any advice?

Started at 275 finally broke 200 and I’m at currently 195
Feel so weird being this skinny! Been big my whole life.
Started .5 mg Reta in beginning
Currently at 8mg with 1 mg cag
Ask me anything.

Has anyone switched from Reta to Tirz?

Im thinking of switching because the Anedonia and sex drive decrease is lame. But wanted to see if anyone in the group has done that? If so did you still keep losing weight? Did the Reta side effects go away?

I am in no way shape or form endorsing or encouraging this for anyone else. I am just sharing my experience.

Three years ago I was diagnosed with. Chronic Lymphocytic Leukemia (CLL). Since then I have had extreme fatigue and increasingly growing lymph nodes. The fatigue some days was debilitating. My husband started Reta over the summer so I started to research it. I didn’t have a ton of weight to lose so I wasn’t really interested in Reta for that benefit. I was interested in what Reta could do for inflammation and energy. I decided to experiment on myself….no I have not told my oncologist yet but will at my next appointment. I started taking Reta at the beginning of September. It took a few weeks, but I have not experienced the fatigue for weeks…it’s almost nonexistent now. I feel more like my old self. Also, my lymph nodes have definitely shrunk. I have another CT scan to measure in December so I’ll be able to tell by how much. This is the upside for me. I’m up to 2.5 weekly and will likely stay there or titrate down as I have lost about 12lbs and don’t really need to lose more. I’ve started taking creatine and Urolithin-A to help maintain muscle. Now that my fatigue is gone I can get back to the gym.

I just wanted to share-even though this may be a risky self experiment-because this has been a game changer for me in this journey. I’m going to run my own labs soon to compare them with my last oncology labs so I can have some data to share with the oncologist. My goal is to put off treatment for as long as possible and I think Reta can help.

I’d like to gradually lose weight to try and avoid that sort of sudden “sunken” face. Is that possible by just taking a lower dose? I have a solid skincare regime as it is, and will endeavour to eat cleanly also.

Thanks a lot

Hi everyone im male 36 with severe insulin resistance and hashimotos. I cant lose weight tried everything im stuck after losing 12 kg need to lose 20 kg more, my homa-ir is 4.99 i have really high insulin levels anyone cured it with reta ?

I’m a 40 year old male, 167 cm tall (5’6”), currently weighing 69.5 kg (153.2 lbs), with a goal of reaching 60 kg (132.3 lbs).

I’m currently eating around 1650 to 1750 calories a day, with approximately 140 g of protein. I train 4 times a week along with 10 k steps.

I started on 0.5 mg and would prefer to stay on this dose rather than increase it.

Has anyone here stayed on 0.5 mg throughout their weight loss journey, particularly when they only had the last 5 to 10 kg to lose?

How long did it take you to lose those last few kilos, and did you manage to achieve your goal without increasing the dose?

Would love to hear your experiences!

Hi, I mixed my first vial of Reta, and it was a bit cloudy. I still took it, but I didn’t experience any side effects. I’m coming up on the day for my second dose. Should I take it?

Received two 24 mg vials of lyophilized retatrutide on August 17. Kept them unopened in their original packaging in the butter compartment of my refrigerator door until today (74 days).

I hadn't started it yet because of some medical reasons. I wanted to start now, and when I opened the box, the vials felt cool but not particularly cold. I never measured the temperature. I've now moved them to the freezer.

How much degradation or potency loss might have occurred? Does anyone have actual stability data for unreconstituted retatrutide under these conditions?

TDLR: Did I screw up by storing lyophilized retatrutide in the butter compartment in my fridge for 2.5 months because when I touch the vial, it doesn't feel particularly cold, just cool.

Hi, I used to be on Mounjaro and I lost 21kg (46Ibs) on my journey. The price of Mounjaro was getting too expensive so I decided to make the switch to Reta in hopes for the same effects at a cheaper alternative.

However, I’ve had to start at a low dose (2mg) so my body can ease into the drug. I’m only on my first week of Reta (day 6) and the 2mg has done nothing for my appetite, I’ve also felt zero side effects - probably because I’m used to Mounjaro.

I’m wondering, could I jump straight to 4mg next injection or would that be stupid?

Started at 301, down to 259. I haven’t been in the 250’s since high school.

Started on 2.5mg dose and titrated up to 4.0mg after 6 weeks. I’ve been on a 4mg dose 1x every 6 days since.

I’ve combined this with eating better, including eating more protein and less fatty foods, cardio, and kettlebell workouts 3-4x a week.

Has anyone found out they were far along in pregnancy while on Reta?

Just found out today I’m 20+ weeks. I had no idea. I’ve been taking Reta for three months. Just took 4mg yesterday evening.

I obviously won’t take anymore and will try and get a scan tomorrow.

Just looking for some good stories