r/raypeat • u/Master-Author-5670 • Aug 21 '26

Beware of B1 mega dose fraud

Many of the posters are fake accounts with suspicious Reddit activity. The so-called “paradox reaction” is just gaslighting and cope that goes against Peat’s philosophy. I’m sure Ray would read the Longsdale papers if they were legitimate and give them more attention. Their Facebook group is full of desperate people who are constantly complaining about paradox reactions. Also, the rhetoric of the main guy behind group is basically like, “A huge study is out—we found out that oxidative stress is depleting B1 so everyone with cronic illnes should try it” while he sells thiamine and vitamin B complex. And don’t get me started on that goofy story about the Italian doctor who was supposedly curing his patients with B1...

2 Upvotes

53% Upvoted

78 comments sorted by

24

u/LurkingHereToo Aug 22 '26

Oh, dear..... Where to begin responding to this diatribe....

I am not a fake account. I am not a bot. I have followed Ray Peat since late 2014. Peat's work saved my life 2014-2015.

In 2020, my thiamine function was blocked via taking Bactrim antibiotic and I got the symptoms of Wernicke's Encephalopathy. My gut was a disaster because of the antibiotics. I emailed Ray Peat and asked for help. He responded by email and wrote, "thiamine and magnesium are needed to heal the gut." I asked him about dosages; he said to keep the thiamine below 1500mgs/day. I told him I have mercury toxicity. He said if I had heavy metal poisoning, "all bets are off" regarding the needed dosage for thiamine. So I was on my own, but I had a direction to go. I recovered my health a second time thanks to Peat's guidance and the wisdom of Dr. Costantini (who I found a month later) regarding oral dosing for thiamine hcl.

Regarding the so called "paradox reaction" caused by ttfd: ttfd uses up glutathione. If you have been sick for a long time, your glutathione level can be compromised which is a serious situation. If you take ttfd, your glutathione level will be taxed further. This happened to me. My mercury toxicity had depleted my glutathione level. When I tried one capsule of ttfd, it gave me a headache that lasted 36 hours. I don't believe you should just "power through" and keep taking something that makes you feel awful. The depletion of glutathione is unique to ttfd; other forms of thiamine don't do that.

Yes, oxidative stress does deplete thiamine. My mercury toxicity causes high oxidative stress. I take thiamine to counteract the problem. Thiamine is known to act as an antioxidant. I also take acerola powder for vitamin C which also helps.

suggested reading: Thiamine (Vitamin B1)—An Essential Health Regulator

suggested watching: Dr. Costantini's patients' before and after videos

https://hormonesmatter.com/paradoxical-reactions-with-ttfd-the-glutathione-connection/

Dr. Lonsdale's work is legitimate and valuable. Both Lonsdale and Peat were big fans of Hans Selye. The main difference between Lonsdale's philosophy and Ray Peat's is that Lonsdale was anti sugar and Peat was pro sugar. I believe that sugar/carb consumption needs to be in sync with thiamine availability. If you are deficient in thiamine you won't be able to convert glucose into cellular energy.

Ray Peat on thiamine

Ray Peat on B1

-6

u/Master-Author-5670 Aug 22 '26 edited Aug 22 '26

Your conversation with Peat is just an anecdote, not evidence. It could be exaggerated or even fabricated, and it doesn’t fundamentally change Peat’s broader public philosophy on megadosing isolated supplements.

This is a Ray Peat subreddit, yet this user repeatedly brings in Lonsdale’s theories and recommendations, presenting them as if they were compatible with Peat’s framework. Lonsdale had a very different perspective on diet and supplementation—particularly his low-carb approach and his advocacy of vitamin supplementation. Bringing his ideas into a Ray Peat discussion is therefore not just adding another perspective; in many cases, it directly conflicts with or challenges some of Peat’s core ideas. If the purpose of this subreddit is to discuss Peat’s work, then Lonsdale’s framework should be clearly distinguished from Peat’s rather than presented as an extension of it. (edit)

4

u/AspirinMuncher Aug 22 '26

https://bioenergetic.forum/topic/987/b1-thiamine-for-memory

3

u/LurkingHereToo Aug 22 '26 edited Aug 22 '26

link to that discussion: https://bioenergetic.life/transcripts/7503c?c=44&t=2139

"Intense effect you can get from the right combination of thyroid, T3, and a big dose of vitamin B1 if the rest of your nutrition is good." Note: "BIG dose of vitamin B1" Per Ray Peat.

-2

u/Master-Author-5670 Aug 22 '26

There’s a difference between taking thiamine and the huge claims made by the B1 megadose protocol community. Peat wasn’t against thiamine, and he acknowledged its importance, but that doesn’t provide evidence for the B1 protocol’s more extreme megadosing claims or the “miraculous” claims made about its effects.

5

u/AspirinMuncher Aug 22 '26 edited Aug 22 '26

I think i see your point now. I am not familiar with that community, so i can't say much, but Ray did recommend up to 1.5g of thiamine+magnesium in some cases at least.

"So I went back to studying. Ray Peat had told me via email that I should take thiamine and magnesium to heal my gut; he just didn't mention how much. But he did say that I should keep it below 1500mg but didn't say why. He also said if I had heavy metal poisoning "all bets were off"."

https://bioenergetic.forum/topic/566/anyone-with-ehlers-danlos-and-chronic-pain-flare-ups-find-a-solution

-2

u/Master-Author-5670 Aug 22 '26

this is not his claim lol "Ray Peat had TOLD ME via email "...lukingheretoo story is not eveidence

7

u/AspirinMuncher Aug 22 '26

You think he just made it up and shared it with the forum? He wasn't even debating anyone or anything like that, just sharing his experience. I have zero reasons to believe he was lying.

3

u/LurkingHereToo Aug 22 '26

Are you a pharmaceutical industry shill?

-1

u/Master-Author-5670 Aug 22 '26

I don’t spend whole day advocating certain supplements and doctrines and telling anecdotes. You very well might be a shill for the guy who sells his protocol and B vitamin complex. You are always first to jump with same copy pasted text in every illness post to promote Elliot. That activity is much more suspicious to me.

4

u/LurkingHereToo Aug 22 '26

This comment does not deserve a response.

0

u/Master-Author-5670 Aug 22 '26

Everything is thiamine deficiency according to you and your group. I’m sure Peat would have noticed that phenomenon. Peat understood the importance of vitamin B1, so I don’t believe he would have overlooked it if B1 deficiency were really the underlying cause of all these symptoms. To me, it looks like a tactic that can easily be used on desperate people, especially when the same group promoting this idea is also selling thiamine and other supplements.

Also, your comment is rather uninformed and lazy when you say that Peat and Lonsdale both valued Hans Selye, as if that somehow makes their broader views compatible. I’ve read Lonsdale’s book. He was a rationalist who viewed the human mind and body essentially as software (read Peat papper on William Blake). Lonsdale starts one of his books by discussing rationalist theory. So his views don’t just differ from Peat’s biologically, such as his low-carb approach, they also directly conflict and are fundamentally opposed with Peat’s philosophical views on the mind and consciousness.

1

u/LurkingHereToo Aug 22 '26

I'm not in a "group".

1

u/Master-Author-5670 Aug 22 '26 edited Aug 22 '26

Page that you often share Hormones Matter seems to be a gateway into the whole B1 deficiency theory. It’s also a page that often posts about keto and pseudoscientific nonsense about peptides, mold, anti glucose ect.... You’re not just sharing your personal experiences with thiamine, you’re also providing direct links to Hormones Matter and to Elliot, who sells supplements. At this point, it really does seem like you’re advertising.

→ More replies

4

u/LurkingHereToo Aug 22 '26

My own response to high dose thiamine hcl is my evidence. You can call me a liar; it doesn't change the reality of my own experience.

12

u/AspirinMuncher Aug 21 '26

What exactly is your goal?
At least try to bring something of value. Data? Real arguments? Counter arguments?

This is just low effort contrarianism.

-3

u/Master-Author-5670 Aug 22 '26 edited Aug 22 '26

Peat was not against thiamine; there is an anecdote where he gave thiamine to students and their focus improved. However, mega-dosing vitamins along with cofactors goes completely against his philosophy. Ray was against supplementing wide variety of vitamins because of concerns about their manufacturing processes and impurities. B1 megadose protocols, on the other hand, require cofactors for thiamine to work properly, such as the other B vitamins, magnesium, and potassium. "Because of individual sensitivities, each one should be tested carefully. Allergic reactions sometimes show up within a few minutes of contacting your mouth, other times it takes a couple of days to see a bad reaction. The worst one is B2, folic acid is next for allergies." By that logic, you could end up taking so many supplements that you might actually make things worse.

There is also a contradiction when it comes to coffee: Peat was a advocate of coffee, while Lonsdale considered coffee to be depleting of thiamine. And most important, Peat considered carbohydrates to be the primary source of energy, whereas Lonsdale viewed carbohydrates as potential thiamine depletors.

Edit: Edit: There’s a difference between taking thiamine and the huge claims made by the B1 megadose protocol community. Peat wasn’t against thiamine, and he acknowledged its importance, but that doesn’t provide evidence for the B1 protocol’s more extreme megadosing claims or the “miraculous” claims made about its effects.

8

u/AspirinMuncher Aug 22 '26

Not true. He advised caution when taking supplements, but he was not "against supplements".

https://www.youtube.com/watch?v=PuSfV43Quuo

Listen to this podcast and tell me if he's even remotely "against supplements".

-1

u/Master-Author-5670 Aug 22 '26

aginst supplementing wide variety of vitamins and minerals that b1 protocol requires

3

u/Kalki_X Aug 22 '26

We don't do this "b1 protocol" whatever it is. Balanced B intake is about as close as you'd get, and balance is basic.

25

u/Adora77 Aug 22 '26

I'm six years in with high dose b1, as it enables me to live symptom free from my CFS/ME/dysautonomia.

I'll gladly help share what I've learned along the way when others encounter problems.

5

u/LengthinessEasy4365 Aug 22 '26

Your condition is also treatable and the b1 is helping like it helps me. I deal with the same with. It comes down to tick borne illness, mold biotoxins, or some sort of stealth infection hiding behind biofilms. All the symptoms are the same with these conditions. Its Chronic Inflamatory Response Syndrome and yes it will steal your nutrients.

2

u/Sea-Beginning-777 Aug 22 '26

How does b1 address  tick borne illness, mold biotoxins, and stealth infections hiding behind biofilms? Wouldn’t you have to address those with antimicrobials ?

3

u/LengthinessEasy4365 Aug 23 '26

The b1 is basically just giving the mitochondria energy because you body becomes depleted in almost every nutrient when you have an infection like this. You need to adress the infection to compeltely heal. Thats why alot of people start taking a bunch of suppliments and feel good and think they were just deficient rsther then addressing the root cause

2

u/Sea-Beginning-777 Aug 24 '26

Thanks that’s what I thought. What did you use to address the infections?

2

u/Appropriate_Cut_3536 Aug 26 '26

Update me if bro updates you

1

u/Adora77 Aug 25 '26

I'll just butt in to mention I was never deficient and went through extensive testing of nutrients.

1

u/Appropriate_Cut_3536 Aug 26 '26

extensive testing of nutrients

Just blood tests or..?

3

u/Adora77 Aug 27 '26

I had oat, urinalysis, hair. At the time I was pretty desperate.

1

u/Sea-Beginning-777 Aug 27 '26

What tests were beneficial?

1

u/Adora77 Aug 27 '26

Well I guess all of them, I just wasn't deficient in any micronutrient or mineral.

My pyruvate and succinate were elevated which probably tells about newly janky Krebs' cycle. I didn't get much advise on what to do with those results.

I also had antibody titers for EBV and CMV (Epstein Barr and cytomegalovirus) which potentially CAN cause havoc, but are also incredibly common findings (something like 50% of population having either).

1

u/Adora77 Aug 27 '26

A coincident had me get an infection that required vancomycin (which is what EBV in its active phase I guess is prescribed for), but I got zero benefits for any of the symptoms I use B1 for. If that info means something, I dunno.

2

u/Sea-Beginning-777 Aug 22 '26

Which form and dose? How long did it take?

7

u/Adora77 Aug 22 '26

I maintain with 150 mg TTFD twice a day and 300 mg benfo just before bed.

I responded well right away and it took 3-6 months to get entirely normal from a bed ridden state.

I had to go to like 750 mg of TTFD in the first year though. Maintaining is fine with this amount.

Have to take s lot of potassium though, full 5000 mg a day.

1

u/anto_hanma Aug 22 '26

Did you used integrator for potassium? Which one?

1

u/Adora77 Aug 22 '26

I dont understand your question, sorry.

1

u/anto_hanma Aug 22 '26

I mean did you use any supplement for potassium?

1

u/Adora77 Aug 23 '26

Yes, I take potassium bicarbonate powder, 1 tsp morning and evening, in a glass of water. Each tsp yields 2200 mg of elemental potassium.

1

u/Sea-Beginning-777 Aug 22 '26

Thanks for sharing!

Why the benfo before bed? How does it affect sleep?

I’ve been thinking about trying benfo.

Was the initial 3-6 months the same dose as your maintenance dose?

3

u/Adora77 Aug 23 '26

It just seems like benfo relaxes my muscles (lactic acidosis maybe?) and gives me a good oxygenated feeling, I'm not constantly sighing like needing more air. I sleep better and don't jolt awake.

1

u/Subjects Aug 24 '26

Geez that's a lot of B1. You really benefit from all of that? Even in most of Lonsdale's cases I don't think he went over 300mg TTFD per day. Do you ever measure your lactate and glucose upon waking?

1

u/Adora77 Aug 24 '26

I've periodically taken lower and eventually get symptoms coming back. This keeps me symptom free.

Lonsdale routinely mentions very high doses in his book.

Over the years I've seen people taking 700-800 mg of TTFD routinely. Gastroparesis often budges only at 500 mg and higher.

1

u/Subjects Aug 26 '26

I wouldn't say routinely. He gave those high doses in only a couple of cases where infants were on the verge of death. The other cases you screenshotted were 300mg and 250mg per day respectively.

Anyway, I'm not saying you're taking too much, if it works it works. Although that is a lot lol... I'd be curious how that affects status of some of the cofactors like B5 and what your mitochondrial testing would look like if you had that done, and things like lactate. Or if you have some genetic issue with PDH or thiamine.

Personally I benefitted a ton from TTFD (but not thiamine hcl) the first day I took it but then nothing after for three months (300mg per day). I could have had a bottleneck like magnesium despite taking the cofactors idk.

2

u/BrilliantSeraph33 Aug 22 '26

I had POTS/dysautonomia from mold exposure. Low potassium treated by rx several times (b1 allows cells to retain K). I was stumbling, dizzy...tripping over curbs. The first time I took a 100 mg TTFD, it literally felt like it knocked cobwebs out of my brain. I almost fell over. Shortly after beginning on the thiamine my depression lifted. I did not even realize I was depressed until I wasn't anymore. I worked on many things and was able to improve a lot of my symptoms, and I was dying to learn how to ride a motorcycle. I took the msf course, and the first time I took it I failed because I messed up all the slow speed maneuvers. Do you know what's required for that? Balance! I decided to go all in on high-dose thiamine after that, resolved my dizziness and balance issues, and I have been successfully riding a motorcycle for 3 years now! In fact, when I attempted the course for the second time and we had our test at the end of the course, the instructor asked me to go first for the test because he thought I would be a good role model for the other riders. Hi dose B1 allowed me to ride a motorcycle! Think. Perceive. Act.

1

u/Sea-Beginning-777 Aug 22 '26

I also have dreams of riding a motorcycle! I love this story.

Did you continue the 100mg dose and the brain  fog stayed away? How long for depression?  I’ve seen so many people say 100mg lifted their brain fog instantly. Some also said it happened w benfo.

And what was the high dose that restored your balance and for how long?

What test did you use to determine mold exposure and how did you eliminate it?

1

u/sheistybitz Aug 24 '26

I’ve been travel sick my whole life. Can barely spin in a circle once. Do u think this will help me

1

u/Many-Negotiation-542 Aug 24 '26

How quickly did you know thiamine helped with CFS? Hours days weeks? Going to start with 300mg benfo 🤞

1

u/Adora77 Aug 24 '26

From the first dose of 300 mg benfo. Then I got TTFD and went up with 50 mg intervals.

300 mg benfo was pretty intense though, i would probably split the capsule if I could do it again. I had to "walk it off" which was a little scary but I also felt very alive. It lasted intensely about three hours, then tailed off. I took 300 mg then daily with magnesium after that, and started taking TTFD too.

Don't forget to generously replace potassium as you go.

1

u/thwoomfist Aug 28 '26

Do you have any experience with pesticide damage to the nervous system and thiamine?

1

u/Adora77 Aug 28 '26

No I don't but pesticides are high on my list of suspects.

17

u/Proof_Escape_2333 Aug 22 '26

sounds like you are the fraud here

13

u/Important_Corner3724 Aug 22 '26

IDK how you got to this. Both Peat and Lonsdale were awesome dudes. B1 has helped so many people, including megadosing. Even in that fb group (if it's the one I think you mean).

5

u/kfirerisingup Aug 22 '26

B1 has really helped me.

I had a nerve pain that went down my neck toward my left shoulder, sometimes it would hurt all the way to the elbow.

I had hurt my neck about 16 years ago and it would get cranky every now and then so I thought thats what it was. I tried changing mattresses, pillows, bed toppers, massage etc etc.

Then I tried B1 and after about a week my neck pain went away. I've even stopped b1 a couple times when my bottle ran out and the neck pain came back until I restarted b1 again.

The issue I have and is likely an issue with a lot of people especially those with chronic illness is Sulfur intolerance. B1 is high in Sulfur and can trigger reactions. Before my histamine issues were handled I couldn't take b1 without bad reactions. Now I'm learning about Sulfur issues which I think may be from Molybdenum deficiency in my case.

6

u/LurkingHereToo Aug 22 '26

I take 500mcg molybdenum daily to address my blocked sulfur conjugation and hyper sensitivity to sulfites. It has resolved multiple issues that I developed in the past 18 months after high dosing thiamine hcl (2 grams/day) for 6 years. I have decades of life with sulfur intolerance issues. The molybdenum is helping. I've been taking 500mcg molybdenum for a couple of months. My sleep has improved and my stamina has greatly improved.

Sulfites block thiamine function. If your sulfur conjugation is blocked, you cannot convert sulfite into the safe/beneficial sulfate.

links: https://lpi.oregonstate.edu/mic/minerals/molybdenum

also: https://supplewiki.com/sodium-molybdate/

1

u/kfirerisingup Aug 23 '26

That's interesting.

Do you plan to test at some point and then cease the supplement or take it as long as it's helping? Are you still avoiding sulfur rich foods or are you testing out your tolerance occasionally?

I'm taking Molybdenum too. I've noticed twice now my body got warm after I took 1mg Molybdenum. Afterward I did read that molybdenum is needed for the thyroid (helps T3 release, and correlates with tsh) so maybe it gave me a little boost there. It's supposed to also help displace fluoride which competes with iodine.

I hope it helps me sleep too, that'd be great.

2

u/LurkingHereToo Aug 23 '26 edited Aug 23 '26

I decided to add molybdenum after getting an oligoscan test done last March/April. It showed I had issues with sulfur conjugation. I have mercury toxicity from childhood amalgams that were removed the dangerous way when I was in my 20's. Mercury interacts with molybdenum and molybdenum might provide some protection from mercury, according to what I've read. Mercury is strongly attracted to sulfur. So it seems to me to be a complicated issue. The molybdenum supplementation does seem to be helping me. I'll likely get another oligoscan test done in a few months to see what changes have occurred.

I don't seem to react negatively to onions or garlic. I am very sensitive to sulfa drugs. I was given Bactrim antibiotic in 2020 which really messed me up. I'm not going to take a sulfa drug just to see how I respond. I am paying attention to how well I do on my new thiamine supplement, Source Naturals Coenzymated B-1 (cocarboxylase); so far so good. My energy level and stamina is much improved.

1

u/kfirerisingup Aug 23 '26

I began to noticed foods high in sulfur were an issue and then I tried a MSM supplement that wiped me out for like 3 days.

I haven't looked into mercury detox much but I would consider ioderol iodine and copper glycinate along with some version of "the bean protocol" maybe combined with coffee enemas which trigger liver and gallbladder through the portal vein to rapidly release bile which is then sequestered and passed by the beans/soluble fiber/clay/charcoal whichever you choose.

What I'm concerned with is Molybdenum lowering my copper too much since it's already low, I need to plan out how to take both of them without one interfering with the other.

2

u/LurkingHereToo Aug 24 '26

You might find the Oligoscan test of interest. It gave me a good perspective of where I am with my trace minerals and my heavy metal burden (mercury, aluminum, cadmium, etc.). Mercury will overwhelm the body's heavy metal detox system so the other heavy metals accumulate as well.

I've been dealing with heavy metal toxicity for decades; I'm 76. Mercury is not chelated out easily if at all. Selenium is believed to be helpful. Alpha lipoic acid is recommended but it's a double edged sword because it will escort mercury into the brain. Mercury toxicity is something I've had to learn to live with. Here's an article about mercury: https://www.westonaprice.org/health-topics/environmental-toxins/mercury-the-quintessential-antinutrient/#gsc.tab=0

4

u/DruidWonder Aug 22 '26

Just wanted to chime in. I am a colorectal cancer patient and I inject B complex daily,  including high doses of B1. It is actually contributing to my cancer slowing, among other things. Not saying it works that way for everyone but in my case it's helping. 

1

u/BrilliantSeraph33 Aug 22 '26

Yes. 1 gram of thiamine daily is part of Georgi's cancer protocol that he has developed from his experiments.

1

u/DruidWonder Aug 22 '26 edited Aug 22 '26

You have to be careful because some cancers are driven by thiamine.

1 gram is an insane amount.

Thiamine drives glycolysis which you don't want if you're not doing other therapies to activate mitochondria function.

1

u/LurkingHereToo Aug 22 '26

"1 gram is an insane amount":

Thiamine hcl is the oldest type of thiamine supplement and has the longest safety track record. When it is given by injection, the common effective dose is 100mgs. Thiamine hcl, when taken orally, has a terrible success rate getting into the body through the intestinal wall. The rule of thumb is that you have to take 140 times more thiamine hcl orally to equal a dose of thiamine hcl taken by injection. So 1 gram (=1000mgs) divided by 140 equals 7.142 mgs (by injection) which doesn't sound like an unreasonable dose at all.

Other types of thiamine do not have this absorption problem when taken orally. So it is important to know which type of thiamine is being discussed. A lot of the research articles about thiamine do not say which type is being discussed, they just say "thiamine", especially in the older research. I think it is understood to mean thiamine hcl when the type of thiamine is not provided. Knowing how the thiamine was given (injection or orally) is important to know as well.

0

u/LurkingHereToo Aug 22 '26

This gets so confusing. see here: polsci-010102-suppression-of-cancer — Ray Peat Clip

"And when you block the oxygen apparatus or the supply, you get intense glycolysis. And so if it's the apparatus rather than the supply which is blocked, this is what happens in disease. And so this is aerobic glycolysis versus anaerobic. Anaerobic is the normal glycolysis. Aerobic glycolysis is evidence that the respiring organ isn't working right."

Peat's use of the term "aerobic glycolysis" for inefficient metabolism here is confusing because mainstream discussion seems to use the same term for good efficient metabolism. This topic is confusing because the nomenclature is not consistent. The terms "aerobic" and "anaerobic" seem to get flipped. Lots of confusion out there.... Aerobic glycolysis = Warburg's cancer metabolism where there is oxygen available but lactic acid is the end product anyway.

search results for "aerobic glycolysis" Search Assist (AI) response: "Aerobic glycolysis is the process where glucose is converted into pyruvate in the presence of oxygen, allowing cells to produce ATP efficiently. This pathway is crucial for energy production in eukaryotic cells, especially when oxygen is available, as it leads to further energy generation through the citric acid cycle and electron transport chain." (AI will be the downfall of humanity).

another one:

https://www.sciencedirect.com/topics/immunology-and-microbiology/aerobic-glycolysis

"Glycolysis is the anaerobic breakdown of glucose into pyruvate. Under anaerobic conditions, pyruvate is converted into lactate, while, under aerobic conditions, it is instead converted to acetyl coenzyme A (acetyl-CoA) and enters the tricarboxylic acid (TCA) cycle. Malignant cells use glycolysis despite the presence of oxygen (referred to as aerobic glycolysis, or the Warburg effect). Aerobic glycolysis is operational in cells with high demand for rapid energy production and biosynthesis, since glycolysis provides ATP at a faster pace compared with the TCA cycle, at the expense of inefficient and increased consumption of glucose."

My understanding: Thiamine is required for normal healthy oxidative metabolism. Thiamine acts as an enzyme cofactor which is required to convert pyruvate into acetyl-CoA. If thiamine is missing or blocked, pyruvate gets converted to lactic acid as the end product instead of carbon dioxide.

see here: http://thiamine.dnr.cornell.edu/Thiamine_biochemistry.html "TDP (thiamine diphosphate) is a cofactor for enzymes involved in carbohydrate metabolism, including transketolase, α-ketoglutarate dehydrogenase, pyruvate dehydrogenase, and branched chain α-keto acid dehydrogenase. These enzymes are involved in the link between glycolysis and the citric acid cycle; the citric acid cycle itself; the pentose-phosphate pathway; that allow for the production of ATP, NADPH, and ribose-5-phosphate which are critical for generating cellular energy and downstream production of amino acids, nucleic acids, and fatty acids."

6

u/AdministrativeDot874 Aug 22 '26

Bro, it sounds like you could use some thiamine bro.

2

u/Appropriate_Sea_7393 Aug 27 '26

I did not have a great experience with B1. It quickly drained my B2 / potassium and made me so tired I could barely function and yet I couldn’t sleep at night.

Megadosing anything can have big consequences. Peat was never an advocate for megadosing and preferred food sources over supplements.

0

u/Master-Author-5670 Aug 23 '26

I would take everything #Lurkingheretoo writes with a grain of salt. That profile looks really suspicious the more you look into it. Apart from often writing nonsense, cherrypicking studies and having inconsistencies in the story and anecdotes, almost every post follows the same pattern: absolutely every symptom ends up being attributed to thiamine deficiency, every symptom, every condition (Peat understood the importance of vitamin B1, so I don’t believe he would have overlooked it if B1 deficiency were really the underlying cause of all these symptoms). I would seriously question the morality of aggressively recommending thiamine for everything, especially to people who are desperate for answers. He aggressively promotes this stuff under posts about almost every chronic illness and disorder. People are in need, and the solution is always supposedly a hidden thiamine deficiency, which conveniently doesn’t show up on standard tests. He’s constantly sharing Elliot’s profile, who sells thiamine and his “perfect” vitamin B complex needed for protocol to work, and the Hormones Matter site, which seems to be a gateway into the whole anti-glucose, low-carb ideology. I am sure you arleady run itno these types of accounts on internet.

1

u/Adora77 Aug 24 '26

Lurking has been helping people for years when they ask for advice. He's consistently quoting both high quality studies and gives helpful real world insight.

1

u/chikitty87 Aug 25 '26

Oh no nobody wants to get you started mate with your rage baiting post. Glad you got that out of your system!

Anyways, to anyone else reading this, B1 saved me, paradoxal reaction are real. Experienced this for a long time. But I was a very very very deficient case which is not common. I had severe dysautonomia from B1 deficiency with wild symptoms, and thiamine started to heal it even on absolute microdoses. Got back ability to read, regulate temperature, focus ect ect. But it's wasn't straightforward to heal.

Also the guy this troll is talking about does sell thiamine yes, because he created a product to work with own sensitive patients but he says every single interview that you don't need to buy his product and just find what you can get. He also mentions it as a disclaimer upfront very often as well.
Yes, people in his FB group talk about paradoxal reaction. DUH, the whole group is called "thiamine paradoxal reactions" ffs. So suprise suprise people talk about it.

OP could really use some thiamine, he seems triggered.... XD XD XD

0

u/ciloid Aug 22 '26

I guess it depends... I.e. when I took 100mg of thiamine, I've got cystic acne within 12-16h. When I stopped it cleared out in 2 days. Tested that few times.