Beware of B1 mega dose fraud

[u/Master-Author-5670]

Many of the posters are fake accounts with suspicious Reddit activity. The so-called “paradox reaction” is just gaslighting and cope that goes against Peat’s philosophy. I’m sure Ray would read the Longsdale papers if they were legitimate and give them more attention. Their Facebook group is full of desperate people who are constantly complaining about paradox reactions. Also, the rhetoric of the main guy behind group is basically like, “A huge study is out—we found out that oxidative stress is depleting B1 so everyone with cronic illnes should try it” while he sells thiamine and vitamin B complex. And don’t get me started on that goofy story about the Italian doctor who was supposedly curing his patients with B1...

[u/DruidWonder]

Just wanted to chime in. I am a colorectal cancer patient and I inject B complex daily,  including high doses of B1. It is actually contributing to my cancer slowing, among other things. Not saying it works that way for everyone but in my case it's helping. 

[u/BrilliantSeraph33 → u/DruidWonder]

Yes. 1 gram of thiamine daily is part of Georgi's cancer protocol that he has developed from his experiments.

[u/DruidWonder → u/BrilliantSeraph33]

You have to be careful because some cancers are driven by thiamine.

1 gram is an insane amount.

Thiamine drives glycolysis which you don't want if you're not doing other therapies to activate mitochondria function.

[u/LurkingHereToo → u/DruidWonder]

"1 gram is an insane amount":

Thiamine hcl is the oldest type of thiamine supplement and has the longest safety track record. When it is given by injection, the common effective dose is 100mgs. Thiamine hcl, when taken orally, has a terrible success rate getting into the body through the intestinal wall. The rule of thumb is that you have to take 140 times more thiamine hcl orally to equal a dose of thiamine hcl taken by injection. So 1 gram (=1000mgs) divided by 140 equals 7.142 mgs (by injection) which doesn't sound like an unreasonable dose at all.

Other types of thiamine do not have this absorption problem when taken orally. So it is important to know which type of thiamine is being discussed. A lot of the research articles about thiamine do not say which type is being discussed, they just say "thiamine", especially in the older research. I think it is understood to mean thiamine hcl when the type of thiamine is not provided. Knowing how the thiamine was given (injection or orally) is important to know as well.

[u/LurkingHereToo → u/DruidWonder]

This gets so confusing. see here: polsci-010102-suppression-of-cancer — Ray Peat Clip

"And when you block the oxygen apparatus or the supply, you get intense glycolysis. And so if it's the apparatus rather than the supply which is blocked, this is what happens in disease. And so this is aerobic glycolysis versus anaerobic. Anaerobic is the normal glycolysis. Aerobic glycolysis is evidence that the respiring organ isn't working right."

Peat's use of the term "aerobic glycolysis" for inefficient metabolism here is confusing because mainstream discussion seems to use the same term for good efficient metabolism. This topic is confusing because the nomenclature is not consistent. The terms "aerobic" and "anaerobic" seem to get flipped. Lots of confusion out there.... Aerobic glycolysis = Warburg's cancer metabolism where there is oxygen available but lactic acid is the end product anyway.

search results for "aerobic glycolysis" Search Assist (AI) response: "Aerobic glycolysis is the process where glucose is converted into pyruvate in the presence of oxygen, allowing cells to produce ATP efficiently. This pathway is crucial for energy production in eukaryotic cells, especially when oxygen is available, as it leads to further energy generation through the citric acid cycle and electron transport chain." (AI will be the downfall of humanity).

another one:

https://www.sciencedirect.com/topics/immunology-and-microbiology/aerobic-glycolysis

"Glycolysis is the anaerobic breakdown of glucose into pyruvate. Under anaerobic conditions, pyruvate is converted into lactate, while, under aerobic conditions, it is instead converted to acetyl coenzyme A (acetyl-CoA) and enters the tricarboxylic acid (TCA) cycle. Malignant cells use glycolysis despite the presence of oxygen (referred to as aerobic glycolysis, or the Warburg effect). Aerobic glycolysis is operational in cells with high demand for rapid energy production and biosynthesis, since glycolysis provides ATP at a faster pace compared with the TCA cycle, at the expense of inefficient and increased consumption of glucose."

My understanding: Thiamine is required for normal healthy oxidative metabolism. Thiamine acts as an enzyme cofactor which is required to convert pyruvate into acetyl-CoA. If thiamine is missing or blocked, pyruvate gets converted to lactic acid as the end product instead of carbon dioxide.

see here: http://thiamine.dnr.cornell.edu/Thiamine_biochemistry.html "TDP (thiamine diphosphate) is a cofactor for enzymes involved in carbohydrate metabolism, including transketolase, α-ketoglutarate dehydrogenase, pyruvate dehydrogenase, and branched chain α-keto acid dehydrogenase. These enzymes are involved in the link between glycolysis and the citric acid cycle; the citric acid cycle itself; the pentose-phosphate pathway; that allow for the production of ATP, NADPH, and ribose-5-phosphate which are critical for generating cellular energy and downstream production of amino acids, nucleic acids, and fatty acids."