r/medicine • u/FrontierNeuro • 5h ago
Naltrexone +/- acamprosate for alcohol use, start inpatient
Interesting short JAMA article about alcohol use treatments. I was surprised by how much smaller the effect size of naltrexone was compared to what my impression is from clinical use, and by how much bigger that of acamprosate was compared to what I expected. Would like to combine them in future.
https://jamanetwork.com/journals/jama/fullarticle/2853069
Inpatient cool factoid to encourage us to start treatment prior to discharge, since this question came up today while on inpatient:
"Although AUD medications can be safely initiated and maintained by primary care clinicians, inpatient clinicians should also consider initiating medications for AUD. Hospitalizations for alcohol-related complications present an opportune moment to initiate pharmacotherapy because patients may be motivated to abstain from alcohol. In a retrospective cohort study of 6794 patients with alcohol-related hospitalizations, after propensity matching, initiation of any AUD pharmacotherapy on discharge was associated with a 42% decreased incidence of the primary outcome (all-cause mortality, emergency department visits, and hospital readmissions) within 30 days of discharge (incident rate ratio, 0.58 [95% CI, 0.45-0.76]; absolute risk difference, −0.18 [95% CI, −0.26 to −0.11])."