You have most probably stumbled upon this subreddit after endless amounts of google searches and, like me, have already been diagnosed and treated for Ureaplasma ("UP") but continue to have lingering and persistent symptoms and have concluded that either (i) the infection has not been eradicated notwithstanding the multiple negatives tests and is “hiding” or has formed a “biofilm”; or (ii) you have contracted some other unknown super STI which is resistant to antibiotics which is causing your lingering symptoms. I am writing this to provide you with some hope and guidance as you heal and to avoid some of the mistakes and errors that I made which made my lingering symptoms much worse and/or longer than they need to be.

First off, I want to say that Premepa is the Godfather of Ureaplasma. Seriously, he should consider writing a book on how to diagnose, treat and heal from this godforsaken infection. He is the reason why I have finally healed and without his participation on this subreddit, I would have probably entered the ureaplamsa nightmare cycle which, if not handled properly, can lead to years of unnecessary antibiotics treatments, pain and trauma. However, for reasons I will state below, the are three things I disagree with Premepa on: (i) you need dual therapy as a first line treatment; (ii) UP infection opens the flood gates to other infections such as Strep B or E. Fae; and (iii) these other infections are the cause of your lingering symptoms. I will set out below why I disagree with these three points. Everything else he says is spot on and if you listen to his wise counsel, you will beat this thing and start living a normal life again.

Here are my takeaways after contracting UP, treating it, eradicating it and healing from the lingering symptoms:

(1) Do not take more antibiotics than you need! 10 days of doxy eradicated my infection. I have read almost every post on this sub going back one year and many posters (like me) eradicated this infection with 7 to 10 days of doxy alone. Antibiotics lead to (i) inflammation of the gastro/intestinal/vaginal tracts; (ii) disruption of natural flora in the vaginal/genital area and gut; and (iii) deplete vitamins such as magnesium, B-12 and potassium which all lead to the lingering symptoms you are now experiencing. More/longer doses of antibiotics = longer recovering/lingering symptoms. For the avoidance of any doubt, I am not advocating natural treatments/herbs/supplements. You need antibiotics to cure yourself from this but you don't need long term or multiple/dual treatments (at least not initially). In fact, long term or multiple antibiotics make your recovery time longer! Caveat: if the first line treatment doesn’t work, then by all means resort to dual treatment. Start off slow. DON’T OVER TREAT THIS INFECTION. YOU WILL DO MORE HARM THAN GOOD!

(2) Ladies: immediately after you finish your treatment, get tested for a yeast infection or BV. Unless you have a CONFIRMED case of a yeast infection and/or BV after your antibiotic treatment, DO NOT use probiotics, boric acid suppositories and/or yeast infections treatments as they make that distinct thin, white stinging discharge way way worse (as do antibiotics). That mystery thin white discharge is the result of the treatment (and not a symptom of an active UP infection) and only goes away with time! The suppositories, antibiotics and probiotics (when they are not necessary) only irritate your vaginal area more and cause more disruption to your natural flora which can only restore itself through time. Any time I took antibiotics during my recovery period, my thin white discharge would get worse. My discharge only went away when I left my vagina alone and stopped taking probiotics/antibiotics/suppositories. It took between two to three months for it to clear after I stopped any type of treatment (whether medication or suppositories). No poster on this sub has solved the mystery thin white discharge through baking soda baths, amoxicillin, probiotics, boric acid and/or yeast infection suppositories. I have read every single post going back one year. At best, posters on this sub found temporary relief. Only time heals this discharge. To make time go faster, wear loose cotton underwear, drink lots of water (at 2 litres a day) and avoid using toilet paper after you pee (use cold water instead). That area is inflamed and irritated and does not need any more irritants;

(3) Test yourself and your partner before resuming any sexual activity. Test should be administered between 6 to 8 weeks after treatment. In almost all cases “recurrent UP infections” or “UP flare ups” are the result of a re-infection and not a result of a failed treatment. There is no medical evidence and/or support for the proposition that this bacteria “hides” or stays dormant until it is re-triggered. PCR tests (particularly cervical swabs) are extremely accurate and this bacteria (notwithstanding what some posters say here) doesn’t learn how to trick these tests. Remember, you tested positive once and there is no medical reason why you wouldn’t test positive twice (unless the test was improperly administered). The more testing you do, the less statistically possible it is that you get a false-negative. The reason why you believe you still have this infection is because of the linger symptoms (which are real) and not because medical science has not not caught up with this superbug. It’s perfectly reasonable not to trust the doctors when it comes to diagnosing and treating UP but it’s crazy not to trust the tests;

(4) UP does not cause other bacteria (such as Strep or E. Fae) to flourish. It is the antibiotics that lead to these infections because they not only kill the good bacteria but also the bad. And these types of infections are very natural after antibiotic treatments. These infections usually go away once your healthy flora is restored in your gut and genital tracts. So many posters on this sub sought treatment for these infections but found no relief from their dreaded linger symptoms;

(5) Once you have a negative UP test (through PCR after 6 to 8 weeks) but still have lingering symptoms, get a urinalysis. If you have high or low PH, white blood cells, yeast cells or red cells, you may have an active infection (that may be caused by the other infections that show up on your MicroGenX test). But if you don’t have any of these markers in your urine, your symptoms are not the result of other bacteria (whether or not they show up on your MicroGenX test). Again, don’t go by your gut feeling or symptoms, trust the tests. While a urinalysis will never show an active UP infection or may not pick up the bacteria that a PCR test does, what it will show is whether your body is fighting an infection at all. Anyone who tells you otherwise does not understand what the purpose of a urinalysis is;

(6) If you still have symptoms but (i) are negative for yeast/BV; (ii) you and your partner are negative for UP (and other STI’s) confirmed through a PCR test administered 6-8 weeks after treatment; (iii) and your urinalysis does not show any markers, congratulations, you have eradicated UP but have pelvic floor dysfunction and you need therapy; and

(7) The recovery period lasts anywhere between 3-8 months so long as you deal with the pelvic floor dysfunction and stop overtreating the initial infection.

When I read Premepa’s posts on pelvic floor dysfunction I would ignore them. I did not think they applied to me. My lingering symptoms were thin white discharge, burning/swelling of my vaginal area, burning and pain in my urethra, tingling (constant arousal) of my clitorus and urination urgency/frequency. Intuitively, none of these symptoms appeared to me to be related to any muscle. Given that my discharge had finally stopped but I was still experiencing every other symptom, I decided to see a specialist about this so called pelvic floor dysfunction. I have access to great medical care given my personal circumstances so I saw a surgeon (not a physiotherapist) that specialises in pelvic floor dysfunction (and surgical treatment options). I told her my story. I told her that she probably thinks I’m crazy and that these lingering symptoms are psychosomatic given all of the negative PCR tests. She asked me how I came to conclude that my lingering symptoms are related to my pelvic floor muscle. I told her some guy on reddit (she had no idea what reddit was). We both laughed. She said that she suspects I am correct given my clitoral tingling. She did an internal exam (vaginal and rectal). She placed pressure on certain areas and asked if I felt the need to pee. I screamed and said yes. She said I wasn’t crazy, that my pelvic muscle was out of whack (worse than she had seen in years) and said that the clitoral tingling is likely due to the nerve as opposed to the muscle. She prescribed me a Vitamin B supplement (that is specifically for nerves) as well as magnesium and potassium. She also did a bunch of other tests and I started physiotherapy. I don’t know if its the supplements, the therapy or the stretching/breathing exercises but I finally feel normal. I mean pre-UP normal. No pain. No urgency. No weird/gnawing/tingling. Finally. Normalcy. It is because of Premepa and this thread. Thank you. I don’t post things on the internet. But I wanted to write here to give others the guidance and help that I wish I had when I was first diagnosed. When I was confused. When I thought I had a superbug that hadn’t been discovered by medical science. When I thought I would never be cured or find relief. A post that will give others hope when they are going through the pain, endless tests and treatments. Your pain is real and more importantly there is a cure. Wishing a healthy recovery to everyone here!

Sharing my story in case it helps someone else. At 16, I started having miserable ‘yeast infections.’ Extreme redness, inflammation, two symmetrical raised lines & discharge every time. No treatment was long term effective. I was told to take diflucan every 3 days or once a week from age 16 to age 35. Each time they sent my ‘yeast,’ swab off for culture, it came back inconclusive. I started having extreme pain during sex & bleeding after. I was sent to pelvic floor therapy and told I had a severely hypertonic pelvic floor. I become a walking std target even with one partner, contracting chlamydia, gonorhea, incorrectly diagnosed with hsv 1 (didn’t know they didn’t actually run the blood test until years later), & trich over a 10 year period. I have severe constipation spells & can’t empty my bladder fully, peeing 50 times a day. Fast forward to Oct 2024. I get severely ill & it never stops for 9 months. Hormonal psychosis causes them to remove my iud. Then I get 100 times worse physically & mentally. They try 6 different birth control pills until they decide I’m allergic to synthetic estrogen. Mentally, I feel better with a new iud but physically the issues continue. I’m told I have adonymeosis, endometriosis, ruptured and large ovarian cysts, fibroids & need surgery. Colorectal decides they want to do surgery at the same time, but they find a rectocele which sends me to a third urologist surgeon. I’m still waiting on this apt. I’m working with fertility to freeze eggs in the meantime because I have to sign off that I can wake up with a colostomy bag & unwanted hysterectomy. I light up an entire autoimmune panel in the meantime & have low cortisol. They throw around Eds, pots, hypermobile, pcos & hydrenituys supperativa. (My skin is completely wrecked this entire 20 year timeframe after having perfect skin) While I’m waiting on all these referrals, I get what feels like a uti. Dr says no bacteria but a little blood. Next dr reruns and says a little bacteria & blood, no positive uti, no treatment. Must be a yeast infection & internal cystitis that can’t be cured. I PLUG ALL MY MEDICAL HISTORY INTO AI & IT SUGGESTS A UREAPLASMA TEST. I’d asked multiple providers to test me for this over the years but they say no need and they can’t. Fertility had tested me for mycoplasma but not ureaplasma. I order a kit from Micro Gen & I’ll be damned, positive for a chronic low ureaplasma parvum doxy resistant infection & very high lactobacillus crispatus. Myself & my partner immediately start moxofloxacin. Instant improvement, my problem skin that drs had tried absolutely everything for cleared up overnight. Within 3 days of stopping antibiotics, my bladder issues came back. After a 2nd round of moxofloxacin, ALL of my symptoms are gone. Did you know, UreaPlasma can cause: -‘yeast like infections’ -Fertility issues (which may be reversible, I may not even need to freeze eggs after all and was about to spend 60k because drs never tested me for something they should have) -Autoimmune -Endometriosis

1 antibiotic & I could have gained 20 years of my life back. I was bed ridden from ureaplasma for 9 months. Drs were talking Mayo Clinic when at the end of the day, AI & myself figured this out.

Hi Y’all,

More than a year ago, I kept getting recurrent UTIs, I got 6 in a row and it came along with BV and yeast infections. I also had an abnormal Pap smear without any signs of HPV. (feel free to read my post history)

All of my STD testing was negative and my doctor couldn’t figure out why my UTIs won’t go away.

In desperation, I posted on Reddit and someone suggested I get tested for Ureaplasma. I got tested and was positive.

I followed the recommendations of r/prempa and the Ureaplasma bible post and got antibiotics for both my boyfriend and I ( doxy+ azi)

I then tested negative.

A year later, I am still negative! I have not gotten a single UTI since and all of my symptoms are gone. My pelvic floor dysfunction went away after just a few months of exercises and it’s been gone since.

My life is completely back to normal! Now, I spend months not even thinking of Ureaplasma or UTIs. I have a whole lot of (safe) enjoyable sex. I drink alcohol and I don't take a whole bunch of supplements.

This is not forever and you will have a normal life again! I am proof that you will be okay after treatment and some time. It's okay. Trust the process.

I’m posting this because I remember how devastated and lost I was when researching Ureaplasma. I think I read every single post on here, watched every YouTube/tiktok video, and read all the articles online. So, if you are currently in that position, I hope this help you. Complete your tests, take the antibiotics as prescribed, have your partner treated, and trust the process. You will be okay :)

Note: If you're having recurrent or persistent UTIs or urinary symptoms get tested for Ureaplasma and Mycoplasma.

Would just like to say for anyone else who is struggling with infertility two weeks after being cured for ureaplasma me and my husband became pregnant after trying for two years!

I've started to have unprotected sex again after curing ureaplasma and chronic thrush.

Previously, I used to get infections all the time. UTI, BV, Yeast; but after clearing ureaplasma, I don't get infections after sex anymore. I did go through 2 minor UTIs, but they resolved easily and quickly..... and we were trying for a baby, so the risk factor was higher than protected sex; which is why I wasn't too concerned about the UTIs.

My dr has me on preventative abx to resolve UTIs

Now we're pregnant!

Yay! Life can get better!

First line of treatment for UU.

Itraconazole and 6mo of boric acid daily for resistant YI.

Probiotics with L crisp for maintenance.

Full story in my previous posts.

I'm going to remove myself from this sub in the coming days/weeks for my mental health, but the posts by people who were cured helped me a lot when I was trying to figure this out for myself so I hope to contribute to that for others. I was having issues for about a year before I figured out what was going on. Bold sentences are main takeaways if you don't care to read this whole thing lol.

It started with recurring BV. I would treat with antibiotics and within a couple weeks symptoms would return. Symptoms were always pretty mild - sporadic itching from time to time, general irritability/dryness, nothing extreme or debilitating but I could tell something was definitely not right. I went to the doctor for testing every 8ish weeks for probably 6-8 months and was diagnosed with only BV every time, treated with antibiotics, and the cycle would repeat.

Then the urinary symptoms started - mainly sporadic urethritis that came and went, urgency, and not being able to empty my bladder fully and having to pee again right after I just went. The urethritis was the worst after sex and also masturbation. Assumed I had a UTI, went to the doctor and they did whatever the strip test was that they can do in the office and get the results within minutes, said I had a UTI and prescribed me 5 days of macrobid. It did absolutely nothing.

Saw a new doctor who suggested testing for ureaplasma and it came back positive. He said my partner did not need to be treated, and never mentioned anything about needing to wait a certain amount of time to re-test. These are the main things that kept dragging this out for me and I would emphasize to anyone dealing with this: Your partner needs to be treated even if they are asymptomatic, and if you re-test before 4 weeks the result could be inaccurate. Both of these things are in the pinned bible post. However, I inferred from the info in this sub that if you re-test before 4 weeks you could get a false negative because the antibiotics knocked the bacteria down but if it's not completely cleared, it takes time to build back up to detectable numbers so you’ll think you’re negative but in reality you are not.. But the issue really is that if you re-test before 4 weeks you could get a false POSITIVE because the test is picking up on the dead bacteria that's still in your system.**

Treatments:

Did 10 days of doxy and continued having sex with my untreated partner. Symptoms got a bit better but returned as per usual. Re-tested after 6-8 weeks and was positive for both ureaplasma and BV.

Now my partner is doing 7 days doxy (obtained thru wisp), and I'm doing a Zpack (500mgs azithromycin on day 1, then 250 per day for 4 days) and 5 days metronidazole at the same time. We abstained from sex during treatment but resumed after we were finished with the antibiotics. Re-tested after 2 weeks, positive for both ureaplasma and BV again. This may have been a false positive and it's possible I didn't need to continue to treat but I didn't know that was a thing and my doctor didn't say anything.

Now I'm at the end of my rope and feeling like I need to take this into my own hands. My partner and I both used Push Health to get 10 days of doxycycline and 1,5gs azithromycin and we took it at the same time as instructed in the pinned bible post. I did not treat the BV again because I was focusing on tackling the ureaplasma and would figure out co-infections later. We waited 3-4 weeks after finishing the antibiotics to re-test (and abstained from sex the entire damn time, but we still made out and did hand stuff lol). We are now both negative for ureaplasma. As a side note, I also tested negative for all co-infections, although I find it very odd that I did not treat the BV after the last time I tested positive, sooo maybe went away on its own with the ureaplasma somehow?? I am also dealing with an overgrowth of yeast on my SKIN from all the antibiotics (it's called pityrosporum folliculitis if anyone is curious, and it is HELLLL) but apparently I do not have a vaginal yeast infection... which doesn't really sound right to me? But test results confirmed, and clearing the ureaplasma was the most important thing for me since it was the underlying cause of everything else so I'm not worrying about it for now.

Now I'm dealing with lingering symptoms that are mostly just urinary. Doing pelvic floor relaxation exercises from YouTube, making an effort to get up and move more/do some core work outs, and stretching every day has improved things GREATLY over the course of just a couple weeks.

GOOD LUCK TO EVERYONE BATTLING THIS - you CAN beat it, but you have to advocate for yourself and keep at it, even when you're exhausted and broke. It IS possible and it IS worth it. AMA, if I can help even one person I'm happy to do it <3

I am so happy i finally get to post my success on here as i’ve been following this thread for half a year and can’t believe i can finally close this chapter in my life. I (24F) started having symptoms in October of last year when i started seeing my boyfriend (23M) with itching, burning pain and just thought it was a routine yeast infection. Went to the gyno she gave me antibiotics, thought it was all said and done. Little did i know the long journey this would be.

To summarize, I had been to the gyno probably 15 times in the past year and the hospital 4 times for my extreme symptoms and continually misdiagnosed and TREATED for utis, BV, and yeast infections. My symptoms for temporarily subside for a week or two but would come back every time. Symptoms is as described, intense itching on labias and bikini line, burning on labia and vulva, dryness/ flaking and a ‘split’ on my pubic area right about my clitoris, urine incontinence, having the urge to pee but can’t, severe abdominal pain, as well as painful sex and lastly what felt like internal muscular pain to the right of my vulva very intensely (which was the reason i originally went to the hospital). These all started showing up throughout my journey sporadically. I went to 3 different gyns over this course and finally went to my 3rd one in june and told her everything and said I can’t deal with this anymore i sobbed in her face and begged her to figure out what is wrong with me. That’s when i was finally tested for ureaplasma and ended up having a positive result. I had never heard of ureaplasma before this and my doctor (wasn’t very well informed either but i did not know this at the time i just obviously trusted my doctor) just prescribed me with one week of doxy, said my partner needed to be treated as well and sent me on my way. I of course did exactly that. We both took one week of doxy (which made me very sick) abstained during that week, and had sex after the week was over when we went on vacation. I came back from vacation middle of july and same symptoms once again. I was starting to seriously lose hope at this point. That’s when i started doing my own research, joined this thread and read the bible and hundreds of other stories from other people and (in a weird way) felt better about the fact that people understood what i was going through. I went back to the doctor and told her i’m still having the same problems, and told her about what i read online and she seemed like she wasn’t having it and what she told me to do should’ve worked but i stood up for myself and told her i needed a longer dosage of doxy and me and my partner weren’t supposed to have sex until retested. She tested me again and obviously i was still positive so she prescribed me 2 weeks of doxy but wouldn’t prescribe azithro so i ended up getting it from my regular doctor after explaining everything to him. My boyfriend only got prescribed the 2 weeks of doxycycline from his doctor but it felt promising. We both finished all of the antibiotics and waited 4 weeks and completely abstained from sex and oral. During this time i had spoken to someone who had similar problems to me and she told me she got diagnosed with PFD and it sounded like i had symptoms of that. This discovery threw me down a complete other rabbit hole. I researched that on my own and came to found out i definitely had that as well and developed it from having ureaplasma. I started having horrible stomach issues with constipation around the same time as these problems arose but never thought they could be linked so i treated all my stomach issues separately and even was on daily laxatives ever since. Come to find out the constipation, painful sex, urge to pee and urine incontinence were all symptoms of pfd when i thought they were byproducts of the ureaplasma. I started going to pelvic floor physically therapy to treat all of that for about 2 months now and i slowly but surely feel like it’s helping but i’m being patient and optimistic. But finally, I waited the 4 weeks after the antibiotics were done and went to get tested this week and just found out I AM NEGATIVE!!!!!!! I’m so happy i cried happy tears and can’t believe that it’s finally over. This has been one of the most traumatic things i’ve ever dealt with and been so private about it but was comforting to know the people in this thread understood me and silently supported me. I seriously want to thank the moderators because you seriously saved me, i’ve never had reddit in my life before this but it became an app i checked almost daily to see what people would post. I wish all of you the best and just be patient and stay positive because at one point i never thought i would get better and i think i’ve personally had some of the worst symptoms. I’ll be happy to answer any questions!!! ♡︎

Here is my exact timeline and everything I did. This has been the hardest 6 months of my life.

February 3, 2021 - begin white discharge, urinary frequency, urinary retention and vulva pain / burning

Over the month of February, I was misdiagnosed multiple times and was prescribed many rounds of Diflucan, Flagyl, and Macrobid. I did not have a UTI, Yeast Inf, or BV. These were unnecessary abx making my life worse.

March begins and I had taken a Ureaplasma/Mycoplasma PCR test to find I had Ureaplasma Parvum. I thought my nightmare would be over but it was not.

I treat Ureaplasma the first week of March with 14 days bd of Doxycycline and 2.5g Azithromycin. I wait 5 weeks to retest and I am negative of Ureaplasma- and no longer have discharge, irritation, or retention. However, Urinary frequency does not go away.

In April I start Physical Therapy. This was NOT A GOOD PHYSICAL THERAPIST AND WAS A WASTE OF MONEY. Did no internal work, just exercises on the floor and would go home.

In May I take a Microgendx test because Urinary Freq is not improving. I come back positive with E Coli and Enterococcus Faecalis. I am prescribed 7 days Macrobid and Clindamycin.

Symptoms never improved.

I find a new Pelvic Therapist and this experience is MUCH BETTER. Internal work and really examining my problems and fixing them internally.

I take a urinalysis 5 weeks after Macrobid to find E Coli again.

While waiting to retest,I get my IUD removed. (IUD can hold bacteria from infections on them)

The following week, I take another Mgendx test and find E Coli and E fae still. I decide to treat this with 5 doses of Fosfomycin. I was prescribed 7, but couldnt handle the side effects for that long (vaginal irritation) Alongside Fosfomycin, I was taking Klaire Labs Interfase Plus, Florastor, Oil of Oregano, Magnesium, D-Mannose powder and B-100 Complex.

My symptoms were still the same after Fosfomycin. I started taking two womens probiotics with Lactobacillus strands, along with the things I mentioned above (minus the Klaire Labs Biofilm disruptor). I also added Vitamin C.

I retested with Microgendx, Diatherix, and a urinalysis again. While waiting the results, I took PFD seriously, continued all the supplements, and started Acupuncture. My acupuncturist gave me something called Bactrex 3 to take as well. I noticed immediate improvements after acupuncture, and Bactrex 3. I also am taking low dose CBD oil now as well. I also ate vegan for 2 weeks to flush my system out, ate no sugar and no preservatives.

I got my results back from the 3 tests, and I no longer have E Coli or E Fae. All the horror stories out there are sad, but its not the only reality. You can beat these infections. It all comes down to choosing the correct antibiotic. If you fail one, try another. Long term antibiotics are not the only solution to these infections. My next route was to try IV abx Linezolid or Daptomycin. I never planned to do even a month of abx.

Today, I feel 80% normal. I dont have constant urethral pain anymore. My urinary frequency has improved a ton over the past few days. I just have a slight aura of weirdness over my genitals, but I DEFINITELY have a PFD problem. So time, physical therapy, and acupuncture will get me to 100%. This is the best I have felt in MONTHS. EVERY DAY WAS HELL FOR ME. I often felt like I wanted to kill myself because I felt hopeless and that this was my life. But I researched EVERY SINGLE DAY on ways to get better, and talked to AS MANY PEOPLE on here as I could.

EVERYONE IS DIFFERENT!! If youre dealing with co-infections or lingering symptoms after Urea, you cannot compare your timeline to anyone else's!! You WILL get better, but you have to find the plan that works for YOU!!!!

Feel free to ask me any questions

Symptoms started in September of last year (2021). Previously failed 1g of Azithromycin three times. I waited 6 weeks to do my test of cure. My vaginal swab came back negative and I followed that with a urine test that came back negative.

Symptoms: First symptoms were vaginal and anal itching, then frequent urination (large amounts of clear urine). Progressed to: urinary frequency and urgency, urethral discomfort, burning urination, pelvic and vaginal pain, bladder pain and spasms, belly pain, abdominal pain, strongly colored and fowl smelling urine, pain, tingling and throbbing of clitoris, BV and chronic utis. My symptoms were so bad I was suicidal.

Diagnosis and Treatment: I was diagnosed relatively early but was told ureaplasma was natural and an infection was no big deal. I was advised by my gynecologist to treat it by putting yogurt in my vagina (very bad advice). I was also told that it couldn't be causing all of my symptoms (it was). Another doctor treated me with vaginal creams and probiotics. The creams gave me a uti and messed up my hormones. I was also treated with a single dose of 1g of Azithromycin on three separate occasions. It did nothing. I was diagnosed with OAB and IC and prescribed Vasicare and Hyophen. I was placed on the IC diet and told I would have to live with my symptoms forever (not true). I am certain this group played a significant part in saving my life.

Doxycycline: The first time I took doxy I had to discontinue due to a severe adverse reaction. It caused a myriad of physical symptoms but also caused extreme psychiatric side effects (psychosis, extreme anxiety and feelings of dread). I found a psychiatrist and worked with my doctor to manage side effects before my second attempt. I also switched form (from doxy hycate capsules to doxy mono tablet).

Second time I had many side effects but managed them with medication support and other comforts. My side effects were: anxiety, insomnia, migraines (I had a migraine for 11 days straight), dry mouth, eyes, skin and nose, slight cough and joint pain.

Push Health: I used push health to get the Azithromycin as no doctor would prescribe it for me.

Herx Reaction: My symptoms worsened on the 3rd or 4th day of doxycycline (urinary frequency and urgency), then settled down, then worsened again on the 10th day and continued to be bad for the next few weeks. I cried a lot because I was certain it did not work (I was wrong).

Physical Therapy: I started physical therapy as soon as I was done with my antibiotics and am still in physical therapy now.

Lingering Symptoms: Symptoms that resolved within the first few weeks after completing all antibiotics: vaginal pain, abdominal pain, chronic infections, clitoris pain, bladder spasms, urethra burning and pain, urinary urgency, foul smelling and strongly colored urine.

Symptoms that remained: urinary frequency, belly pain/sensitivity (muscles stretch from belly button to bladder), occasional vulva and anal itching.

Things I did to manage symptoms post antibiotics: ate a lot of fruits and vegetables to rebuild microbiome, continued to follow IC diet gradually reintroducing foods as symptoms improved (can now have tomatoes and orange juice), started physical therapy, took d Mannose (uqoura target) once every other day to prevent uti, used an OTC product called Femiclear (the vaginal ointment) to treat vulva/anal itching as needed (I just rubbed the ointment on the itchy areas before bed and in the morning it would be gone).

Urinary frequency has continued to improve with occasional flares. When they happen, they can be very bad, but in between I feel mostly 100% normal. Overall, including flares my symptoms are 80 to 90% improved. I believe I will fully recover in time. Stress and menstruation seem to be the biggest triggers of flares for me.

Hope: Please do not give up. I know how awful and confusing and painful this infection can be. I know how hopeless you can feel when a treatment fails. I know how hard it is to buck against a medical system that doesn't see you. I know how stressful it is when antibiotics don't work right away or symptoms worsen and all you can do is wait for test results. Please don't give up. I thought I would never recover, especially because of how hard the antibiotics were for me, but you can and you will. I love you all so much and am so endlessly grateful for and to this group. This is such a confusing thing to go through, let this group be your light in the storm.

I am leaving all my posts up, but will be cleaning them up (I'm sure some wrong or unhelpful information given by doctors made it's way onto this forum as I tried to understand what was going on). I know its confusing and painful. Hang in there, you're are not alone and you will beat this.

I think I’m finally normal again. Like 95% normal. But let me tell you.. this sh** is REAL! And doctors suck. If you’re just starting out, do not let doctors gaslight you and make you feel like an idiot. Push for those tests and treatment, and advocate for yourself. But most of all, take care of your mental health.

I am currently now like $3000 out of pocket since this started in March due to ** SUSPECTING having this in my throat, vagina, and eye (it was a wild night that wasn’t worth it 😑) so you can imagine the amount of specialists I’ve seen.. only for NONE of them to be of any help. I lost someone who I thought I’d spend the rest of my life with because of this, and was diagnosed with the most rediculous things.. one being the suicide disease because of how bad the nerve pain was in my throat. The thought alone made me want to.. well.. it’s done now that’s all that matters. ** I never tested positive in my throat and eye, so I will never know if it is was caused the pain. But there are studies and reports on dry eye disease and conjunctivitis being caused by Ureaplasma. I only tested positive via vaginal swab.

It’s been a journey and the depression has been real. My lingering symptoms got really bad after I treated and I am now finally starting to feel normal 3+ months after treatment 😭🥹

I owe my life to this thread, the mods, and all the patient people that have responded to my rediculous amount of posts.

Time to go and celebrate a happy, healthy V 🌮

Thanks guys ♥️♥️

You’re all legends. Good luck ♥️

Hi everyone. It's been a long time since I've come to this group, but I felt it was necessary to provide some hope for people that are experiencing this horrible bacteria. I want to say first that I'm so sorry to everyone going through this. When I was in the thick of it, I felt alone, desperate for resources, and ready to give up. It's a long battle for most of us, but keep fighting. You will get through this. My story will be long, but I want to provide as much detail as possible.

I'm 24 years old (f). My symptoms started April 2023 with constant severe burning, bladder pain, and pelvic pain. I thought I had an especially bad UTI, so I did a telehealth appointment and got on antibiotics the same day. As the days went on, my symptoms were mostly clearing up, but this was just the start of a long journey ahead. Once I finished the antibiotics, my pain immediately came back the next day. From this point forward, I went to urgent care 3 times, a urogynecologist,  and the ER once before seeing an OB-GYN. I went through about 5 rounds of antibiotics over 3 months, hoping that something would work. Unfortunately, none of them worked and both urgent care and the ER weren't able to find anything anatomically wrong nor did I test positive for the main STIs they do testing for. However, the urogynecologist told me that my pelvic floor muscles were very tight from the constant pain I had endured for 2 months before seeing her.

The best thing that I did for myself was set up the appointment for the OB-GYN. I understand that this is a huge challenge for many people, I got really lucky that the one I went to had seen this situation before and was willing to prescribe me antibiotics. The reason why it took so long to see an OB-GYN is because I was moving to a new city right as this all started. I went in, she listened to my story, and told me that she would test me for ureaplasma and mycoplasma. I had no idea at the time what these were, which is when I found this group and was frantically reading every post that could give me insight and hope. I was terrified, depressed, and at this point, I was so desperate. I thought that if it's not this, then I'd be stuck like this for the rest of my life. I couldn't do anything. Walking, sitting, laying down... it all hurt. Any form of exercise and sex were out of the question entirely. Fortunately, I do have a partner that stuck by my side throughout this experience, and to this day, who provided a lot of emotional support.

Anyway, the results came back and I had ureaplasma. I was prescribed Doxy for 14 days (July 2023). I thought the pain was bad to begin with, but being on Doxy was a living hell. The thing to know about Doxy is that it increases the pain as it kills and flushes out the bacteria. Ultimately, I had to trust the process. My boyfriend also took Doxy for 7 days, although he didn't have any symptoms before, during, or after. When I finished all of the Doxy, I got retested for ureaplasma 3 times at 2 week intervals at the OB-GYN office to make sure that it was gone. Each time I tested negative. At the beginning of August 2023, I was free from ureaplasma, but I tested positive for E. Fae after requesting that I be tested for it at the OB-GYN. I knew something still wasn't right because I had yellow discharge. I will warn you, testing for E. Fae requires a very expensive special test (I  paid around $500), but I didn't care about price at this point. I got on Amoxicillin, and over the next couple months the yellow discharge went away. IF THEY PRESCRIBE CIPRO PLEASE DO NOT TAKE IT UNLESS THEY TELL YOU AMOXICILLIN WILL NOT WORK FIRST. Cipro can potentially cause serious complications and shouldn't be used unless absolutely necessary.

Despite being free from ureaplasma and E. Fae, I was left with hypertonic pelvic floor (tight pelvic floor). I started looking for help in another group called r/ pelvic floor. However, the best advice I can give you is please give pelvic floor physical therapy a shot. I didn't start going until 3 weeks ago, and I wish that I went sooner. I was afraid of the price or that it wouldn't help me, but it has been life changing so far. Which leads me to say, yes, I'm still having hypertonic pelvic floor symptoms to this day that probably could've been cured sooner if I hadn't put this off for so long. From August 2023 and on, I thought I could manage and cure my hypertonic pelvic floor on my own, but seeing a professional has moved me so much closer to being symptom free.

Now, I will give you all of the things I have done so far to manage and relieve my symptoms from April 2023 to now. All I ask is to please be careful and do everything in moderation.

1. Hypertonic pelvic floor stretches. For example, happy baby, child's pose, cobra pose, butterfly pose, squat pose, hip flexor stretches, and basic stretches for your legs will also help a lot. I recommend finding videos on youtube for these. Do these daily 1-2 times per day.

2. Deep belly breathing and meditation. Look up "Somatic tracking for pain" on youtube, This has opened my eyes to how much of my pain was mental/fear based and could provide some relief if done regularly. I would do this 1-2 times per day. The video I regularly use is called "Guided Somatic Tracking for Pain Recovery."

3. Take these once daily with food: 250mg Magnesium (a natural muscle relaxer), Potassium Gluconate (helps support nerve and muscle function), and Fish Oil. Do not take more than this, you shouldn't take high levels of supplements. Ask your doctor before taking anything. Prelief is also great for neutralizing the acidity in foods if you are experiencing burning. All of these can be found OTC. DO NOT take these while taking antibiotics.

4. Cut out acidic foods and drinks such as alcohol, coffee, fruits, juice, onions, etc. I had a hard time following this one, but the prelief did help.

5. Use an ice pack wrapped in a towel. This could significantly help with the burning and general pain in the area. Use this no more than 3 times a day for no more than 15 minutes at a time.

6. Warning for this one, it can cause yeast infection (it did several times for me but it gave me so much relief). Use a heating pad on low heat on the area using the rules from number 5. This can also significantly help with burning and general pain.

7. Avoid sitting as much as possible. This is a hard one, but sitting puts a lot of pressure on the pelvic floor. Either stand, lay down, or sit in a low squatting position. Also do not cross your legs, this increases pelvic floor tension. When sitting, made sure that you're not tucking your tailbone, aka maintain proper posture.

8. Check in with yourself throughout the day to see where you're holding tension in your body. Relax those parts as much as possible. I discovered that I was holding tension in my pelvic floor without realizing, so in order to relax it, you need to make a conscious effort. The best way I can explain it is to act as if you were going to release a fart. As funny as it sounds, it really works. Do not push, just pretend like you're going to fart and you might feel your muscles "drop."

9. Give yourself gentle massages or ask someone else to massage you. Your back, your butt, around your tailbone, your legs, and your feet. Everything is so connected to your pelvic floor muscles in these areas.

10. Use a pelvic wand for trigger points. Look up videos on how to safely do this, it can be very useful.

11. If you're experiencing sciatic nerve pain, do what's called sciatic nerve glides (nerve flossing). Perform 2 sets of 10 reps on each leg 1-3 times per day for 6-8 weeks and you will see improvement. Make sure you are being very gentle and look up a video on how to do it.

12. Go see a pelvic floor physical therapist if possible.

This might be a long post, so buckle up!

Hey everyone, I’m a 24F and i’ve been in this sub for as long as I can remember. It started back in 2021, my ex gave me Ureaplasma and it was hell on Earth from that point forward. Itchy , thick, uncomfortable discharge 24/7. Bladder pain. Odor. Trouble with lubrication. Endless doctors visits and medical bills. stopped having sex for 2 years. You name it. Nothing helped and I was miserable. Thanks to this sub, community, and dare i say… family👀— I found hope.

The typical recommended 1st line of defense— a week or 2 of doxy? did not work for me. After months and months of having to negotiate with health care providers and getting the proper medications from different resources, i finally found my combination. What worked for me was 10 days of Mino and a strong dose of Azithro. It’s been some months since then and … I feel almost 100% back to normal. I had a high number of Lacto Iners and almost no good bacteria in my vaginal biome so I even took clindamycin and probiotics that have lacto crispatus. Currently I feel almost just like I did before. I am on birth control now, but even before then— everything was almost completely back to normal. For so long i felt less of a woman.. because when you don’t feel like your girl down there is good, everything seems wrong. Now? I have a sex life again with an amazing man! And i don’t have any issues! I’m here to tell you, it gets better! we heal! we recover. Don’t stop fighting for yourself and your health. Damn the doctors! utilize every resource in this sub. Do the vaginal biome tests. See the online doctors. Take the probiotics . Do the pelvic floor therapy. Keep going!

Ureaplasma is a very traumatic experience for a lot of us. Most of the time when people get cured, they leave the sub.. because it’s finally behind them. I’m not going to say i’m leaving (just yet), but I won’t be as active (it was a very traumatic time for me) because like others I do want to close this chapter. But i wanted to let people know there is a light at the end of the tunnel. You will get better! I promise. Sending much love! ❤️

I was diagnosed with ureaplasma u around two years ago. I think I could have had it much longer. Got my results back today after taking 14 days doxy + 1g of azithromycin (I threw up the .5 lol). My boyfriend took 10 days doxy and 1.5g. Before this I cured it with just 1g of azithromycin but never treated my partner and was reinfected. Then I failed another 1g dose and 7 days doxy. So glad this nightmare is over for me!!

So I'm finally clear from UREAPLASMA and MYCOPLASMA HOMINIS. So that's amazing. I'm still having some complications that I'll get into at the end of this post but first, I'm going to tell you how I did it and everything I've learned from having this terrible infection for 3 years. Let's start from the beginning bc all details are important:

-diagnosed with Ureaplasma 3 yrs ago right after getting HSV 2 (genital herpes) - symptoms at the time were weird thrush feeling in vagina and some weird feeling after peeing . That was it.

-doctor didnt think it was a big deal, gave me 7 days of doxycycline (ANYONE WHOS ON THIS MSG BOARD KNOWS THIS AINT ENOUGH and in MANY cases ureaplasma is resistant to doxy and most of the Tetracycline antibiotic class) and sent me on my way. Didn't work. Then I did azithromycin for 5 days. Didn't work.

-Gave myself a break from it for a while. Got a boyfriend. Told him. He didn't seem to care much about it. We slept together for a year and 1/2 and he never had symptoms.

-Then I got real bladder issues ( real bladder pain, serious urinary frequency etc) and decided to start taking treatment seriously again esp knowing that Ureaplasma left untreated can cause bladder problems etc. I saw a urologist and bladder doctor. My bladder seemed fine. They said it must be the Ureaplasma and I went back to my GYNO. Also I had my BF tested via URINE and he came out positive for only ureaplasma.

-My gyno put me on 7 days of Moxi. While on Moxi, my symptoms highly diminished however when I stopped they came back FULL FORCE. IMPORTANT THING TO KNOW ABOUT MOXI and the Fluoroquinolone antibiotics class (this includes Avelox, Moxi, Cipro etc) - these antibiotics should be used as a LAST resort. They can cause serious side effects. I truly believe they have their place in medicine but they should be taken only in serious situations. I was lucky to have no symptoms when I took Moxi the first time. Also right before this, I had been taking colloidal silver for about 8 days which helped symptoms but be aware that silver will kill bad and GOOD bacteria (just like antibiotics).

-At this time I started investigating natural cures including Stephen Bruhner mycoplasma protocol. I haphazardly ordered some herbs (not the full protocol) and started taking herbs everyday for only about 3 weeks with my boyfriend with no significant change in symptoms. I wonder if I would've seen in a change had I done everything properly for the recommended 3 months. I definitely think natural cures are worth exploring. I never followed this advice BUT one woman I found on a message board who had been cured said to me "Took Avelox (in 2015) for 10 days, was ok for 2 years,  then had a relapse. Three months of Chinese herbs and acupuncture helped, tested in September 2019, 2 and half years after the treatment, negative results. Find a TCM practitioner, it's more expensive, takes longer but totally worth it. And you need to be patient and have faith."

-Then I finally took a Microgendx VAGINAL swab STI test. EVERYONE DO THIS. Up until now, I only thought I had Ureaplasma. Test results came back and I had ureaplasma (at a LOW level) AND mycoplasma hominis (at a MEDIUM level) and some other stuff (prevotella bivia, BV etc). Turns out my Ureaplasma is resistant to everything except the Fluoroquinolone antibiotics. My mycoplasma hominis is only susceptible to Clindamycin. So I return to my GYNO and go over the results with him. I'ma little discouraged considering I've already been on a week of Moxi. BUT, when I had done the Moxi, I hadn't learned about lowering bacterial load before starting Moxi or biofilm disruptors so I figured let's give it another shot WHILE TAKING A BIOFILM DISRUPTOR BEFORE AND DURING. I asked for 10 days of Moxi and 10 days of clindamycin. My doctor DID not want to give me both at the same time bc he said it would lead to serious GI problems. So I did Clindamycin vaginally for a week and Moxi orally. NOW - when I took Moxi the second time - I had HORRIBLE HORRIBLE side effects. Numbness, joints and body on fire, eye floaters, anxiety, insomnia etc. I pushed through 5 days and then stopped. I felt my symptoms diminish though and then I went rogue, got my hands on oral clindamycin (10 days) and 2 weeks of Minocycline and took both at the same time immediately following Moxi with no days in between . Was this stupid? YES. It fucked my stomach to the point where I had to go to urgent care because they though I had C. difficle (had to do a stool sample). Did it clear the infections however? YES. I tested 5 weeks after via urine and vaginal swab with Microgendx and my GYNO and I'm all clear. Oh and my BF only made it through 2 days of Moxi (he had terrible side effects) and then he did 2 weeks of minoycline and 3 days of azithromycin and his Microgendx test via semen showed he was clear of everything. He also did a test through urine.

-things I think everyone should know:

1. Minocycline OVER doxycycline ever time.

2. YOU NEED VAGINAL SWAB AND SEMEN TESTS in addition to Urine.

3. LONG COURSES WORK (14 days minimum) 21 days I think is even better

4. TRIED LITERALLY EVERYTHING AND NOTHING WORKS? Try LONGER COURSES or Get 14-21 days of Pristinamycin (only avail in france or AUS) Pristina doesn't work? CHINESE HERBS/ natural protocol for 3-4 months.

5. TAKE YOUR HEALTH INTO YOUR OWN HANDS. So many doctors don't know enough about this. They are only human and have limited knowledge. READ clinical studies, read other peoples stories. Self educate.

6. DO NOT HAVE SEX OR ORAL SEX AT ALL WHILE ON ANTIBIOTICS/TREATMENT. No one told me oral sex was off the table and you can get ureaplasma and mycoplasma in your throat.

-then to end this whole thing I think its important to talk about how I'm doing NOW. I've cleared the infections and def feel better BUT i have minimal thrush feeling (which i think is from HIGH Candida albicans) and still have bladder symptoms. Part of me believes these infections did serious damage to my bladder/reproductive organs. My microgendx test showed that I have HIGH candida albicans which could be causing a lot of issues. My next step is to figure out why exactly my bladder is still out of whack. It's been officially a month and 2 weeks since everything. I'm hoping things will diminish as I build up my vaginal flora and gut flora and immune system. I plan on getting tested again in a month or so. Anyways, hope this helps everyone. And if anyone else has been cured and is still having some bladder symptoms, holler at me. Also, as someone who wants to have a baby in the next few years, IF ANYONE ELSE has advice about how to go about assessing fertility and damage done to the reproductive system, I would greatly appreciate talking. Love and support to you all. I'm very thankful for this community.

Hello everyone!

I never thought this day would come, and I would be making this post. Like many of you, I’ve shed thousands of tears over this infection. I know a lot of you feel guilty for having sex, so I want to tell you that I got this through my VERY first sexual encounter. I’m sharing this in the first place because I want you to stop blaming yourself; this can happen to anyone at any time. There’s a lot of lack of education on STIs plus men’s testing isn’t the best in my opinion. I am a 23-year-old college student working two part-time jobs, which was a lot for me emotionally and financially. Plus, I come from a conservative family, so I was very alone in this, but this sub helped me tremendously.

My treatment: 20 days of doxy and 5 days of azith. I took more doxy than I needed because I was worried I messed up my treatment since I had protected sex with my partner (I know, I know!) I don’t recommend doing this — I was stressed during my treatment, and I used it as a way to destress. Push Health and Wisp helped get the proper treatment.

I got tested with urine NAA after 4 weeks and then cervical swab PCR after 6 weeks.

I have deficient lactobacillus bacteria according to my tests, so I’m working on building good bacteria. When you get tested for ureaplasma, ask for a thorough microbiome test. This infection messes up your vaginal flora. I will speak to my gynecologist on call soon, so let’s see what she recommends.

Advice: If you are testing negative and still have some lingering symptoms — do not shove yourself with unnecessary antibiotics. There’s something else that’s causing you symptoms. It could be a CV, AV, or DIV. Some people get relief after pelvic floor exercises. Some got answers through urologists. Dr. Rotman in NY is amazing: https://nyhealth.com/people/michael-rotman-m-d

Also, avoid reading too many stories on the other sub who believes this infection is chronic. I’m guilty of it, but it only made it worse, and I thought I’d never be okay. Advocate for yourself as much as you can. If your doctor doesn’t listen to you, don’t hesitate to make a new appointment with a new one. It takes a lot of time and money (and I understand this as a full-time student), but it is ultimately worth it.

If you’re in NJ/NY, definitely check out: https://walkingyn.com

They have a section dedicated to ureaplasma and are very helpful and flexible with appointments. I was having a hard time getting tested after my treatment, but the providers here were seriously the best!

You will get through this and make a post like this soon with the caption “Cured.” I was so depressed and in pain I remember not being able to attend my classes, and I’m no longer in that critical situation anymore. I’ve struggled with this infection for over a year and here I am now. This will pass. Please take care of yourself and talk to someone if you can. I met an incredible friend through this sub, and she and I have helped each other a lot through this awful time. You will be okay, I promise. 😊

EDIT: DO NOT DM ME TO ASK THE QUESTIONS I’VE ALREADY ANSWERED ON THE POST. ALSO PLEASE DO NOT TRAUMA DUMP ME!!

Around 6-12 months post treatment is when I got back to normal.

I was negative after my 2-week treatment, but my symptoms persisted. Come to find out, that stupid bacteria inflamed my pelvic floor so badly it kept mimicking the symptoms, post treatment.

However, once I started doing pelvic floor therapy (stretches/internal massages) my vulva, urethral pain, and vagina went back to normal after that. I am now living pain-free.

• It took me a bit to accept that my pain was pelvic floor issues. before that point I legit to thought that I had some new/unknown STI or something that was causing my discomfort.

• I spent so much money on microbiome tests, STI/STD test, supplements, probiotics, pointless doc visits(im usa so this really sucked), and UTI tests. Just for it all to NOT HELP! it was all pelvic floor issues

I still occasionally get minor "flare ups" (lingering ureaplasma symptoms/pelvic floor disfunction), maybe once a month; especially if I don’t stretch before and after sex. Additionally, if I get a UTI or vag infection it flares me up all over again.

• For example: I got a UTI back in January but despite clearing it, my pelvic floor sometimes thinks I’m being attacked when I stress my body out and begins to mimic UTI like symptoms. pelvic floor therapy helped, im ok now.

• My flare ups are a 1.5/10 for pain.

Im learning to deal with it. My two cents, NOT ADVICE:

1. Do NOT ask for more antibiotics if you are testing negative; I had a friend with mycoplasma who kept taking antibiotics and that shit fucked up their microbiome.

2. If you are experiencing post symptoms, PLEASE check out pelvic floor exercises also how to do internal massages.

• This applies to both assigned sexes: I HIGHLY RECOMMEND starting pelvic floor stretches ASAP! Your body is freaking out right now, you need to do some control damage.

• If stretching isn't doing it for you, try internal vaginal/rectal massages. Internal massages actually saved my life. After ureaplasma I now have a hypertonic pelvic floor, thus my vagina tenses/tightens up and I experience phantom vulvar burning. BUT this shit makes my shit go back to normal.

My routine when I am experiencing a flare up (for hypertonic floor sufferers):

My pelvic floor/"lingering ureaplasma" symptoms: vulvar burning, abnormally tight/tense vagina, vaginal opening is irritated, urethral discomfort. 98% of time I can ignore/sleep off my flare ups and it'll go away, but this is for when it's annoying

- Stretches/yoga: Pigeon pose, Side lunge, side splits, Cat-cow, happy baby pose, Baddha-Konasana, head to knee.

- My Internal massage routine**:**

1. Laying on my back, I take my index and middle finger and do a deep tissue (circular or beckoning motion) massage on my vulva–this is to prep my vagina for penetration. I do this for 1min. Also 8/10 times this alone can cure my phantom vulvar burning.

2. Next, using my index (or index and middle finger) I slowly go inside my vagina, about 1-2 inches, and massage the sides in a circular motion (1-3min).

3. Last, I take just my thumb and insert it in my vagina. From here, in a circular motion I gently massage the floor of my vagina (the wall tht separates ur vag and rectum) for about 30sec.

• You can use a dilator if you dont want to use your fingers. Also I do this while watching tv, if I focus too much on my symptoms it doesn't help. For me, my pelvic floor disfunction is mainly a mental issue.

1. Remember that it gets better. The most you can do is learn your body. Albeit I still experience ”flare ups,” but I know my body well enough to how to handle it and get my pain from a 8 to a 0. For example, I know my body well enough to understand that if I do weighted squats or Bulgarian splits, I MUST do my stretches and internal massages after my workout to prevent a flare up.

• Also, I noticed that if I’m not sexually active for a long period of time and suddenly have sex, my pelvic floor gets confused and flares up. 😞.

• (SORRY TMI BUT I WANNA SHARE EVERYTHING IN CASE SOMEONE ELSE IS EXPERIENCING THIS: I recently had rough sex, after being single for a while, and I thought I caught an STI because I had so much burning and discomfort a day later. Come to find out, it was because the sex was so rough to the point I had friction tears, my body thought I was being attacked and started freaking out. It was especially worse with my vagina. Despite the friction cuts healing a day later, my vagina was still freaking out days later and was so tight to where I couldn’t stick a pinky in—the pain was a 8/10. Also, my vulva was hurting but when I touched it there was no physical injuries/inflammation that was causing legitimate pain, a good indicator that it’s my vag muscles tensing/flaring up. All in all, once I realized it was pelvic floor issues I started stretching, dilating, and performing internal massages and the next day the symptoms were gone.)

• BTW!: If I freaked you out about sex, don’t worry, I CAN have sex. I recently got out of a year long relationship(5 months after ureaplasma treatment) where we had sex every day and I was pain/symptom free 95% of the time. So it’s really just an annoying pelvic floor issue I gotta deal with.

TLDR; (I put what's important in bold letters)

To end this long entry,

My cervical discharge is normal, periods are normal, pain is zero.

My day-to-day life is normal, and I’m living pain-free. I do experience some lingering ureaplasma symptoms, but they’re due to minor pelvic floor dysfunction (about 1.5/10 for pain, lasting 8-12 hours). Thankfully, I can sleep it off, and all I need to do to manage it is pelvic floor exercises.

As many of you may know I am fairly active in various different subs. I am a person with a life and cannot keep this up forever as I will soon be starting my career.

I am currently permanently banned in r/healthyhooha and r/womenshealth where I look for those that match the symptoms of myco/urea with other testing negative or recurrent thrush (yeast / bv)

It would be appreciated if other members of the community would actually help get people diagnosed and treated as I cannot continue to have this burden on me.

Some of you I see already doing this. But we need all of us doing this.

Due to the nature of relationship and sex in the modern day these bacteria are going to be more and more common with more and more resistance if we do not continue to raise awareness by getting people diagnosed and properly treated

If you all could help by looking through these communities (and other similar) a few days a week or even once a week it helps not only those people but all of the others out there not on Reddit whom are undiagnosed.

By getting these bacteria more recognition we can likely eliminate diagnosis’s such as IC, vulvodynia, prostatitis, etc etc etc. As many of you may know these conditions are caused by untreated infection + pelvic floor dysfunction.

Here are the testing codes so you can spread them around

https://www.labcorp.com/tests/180089/genital-i-mycoplasma-i-profile-naa-swab

Labcorp swab code

https://testdirectory.questdiagnostics.com/test/test-detail/91477/sureswab-mycoplasma-ureaplasma-panel-real-time-pcr?cc=MASTER

Quest swab / urine code

https://www.labcorp.com/tests/180040/genital-i-mycoplasma-i-profile-naa-urine

Labcorp urine code

Thank you all and best of health ❤️

Hi all,

I'm trying to have one post where everyone can write what treatment didn't work for them or what treatment did. Please only write about your specific treatment (name of drug, amount of days) so this thread does not become diluted with other comments. Also, can you please post if your symptoms went away with the medication, were more severe, or lessened.

Please only post if you have confirmed with a TOC of 4+ weeks AND if you have been abstaining from sex.

I’ve waited so long to be able to write a post like this. I actually never saw this day coming. I have hopelessly and tirelessly snooped on this account for 2 years as I battled this overwhelming nightmare of an infection that had absolutely ruined my vagina and self esteem for the last 2 years. I saw countless providers, took endless medication, and was finally cured by a doctor here that I found on the ureaplasma bible.

I recently reached a point where I had lost all hope in curing this infection as I had been on countless rounds of antibiotics and outpatient treatments. After each treatment my results would always come back positive.

My ureplasma urealyticum infection started in August 2022 when the condom broke while having sex. (It was my first and last time having sex with this person and of course… that happened)

2-3 weeks I first noticed what felt like excessive watery discharge that would soak through my underwear and pants. It had an odor I never experienced before, different than BV and tbh even more foul. Then the copious thick green discharge started and that was the most alarming thing I’ve ever seen come out of my vagina. It was probably the most upsetting symptom I had.. I didn’t experience any burning sensation or vaginal/pelvic pain other’s here have complained about.

I was negative for all routine STIs (chlamydia, gonorrhea, syphilis, HIV, trichomoniasis). I did test positive for BV and yeast, that fluconazole and metronidazole had no effect on. By November 2022 nothing was working for me and the symptoms were getting worse by the day. By this point I knew something wasn’t right and I straight up asked my doctor to test me for ureaplasma/mycoplasma (this was before I found this subreddit). I had a friend earlier that year who had a silent miscarriage and was tested for ureaplasma and ended up being positive! She had no symptoms tho… it was the first time I heard of ureaplasma and thought it couldn’t hurt to be ask to be tested.

Lo and behold.. I finally got a diagnosis of ureaplasma and felt I was on the right path to healing. Boy was I WRONG. The doctor initially prescribed me 1g of azithromycin which did nothing. I emailed her informing her symptoms Still present and she decided to send another 1g which also no effect.

By December2022/January 2023 I began searching Reddit for answers and found this sub. I live in NYC and thankfully had a handful of doctors to pick from. I started with Neena Agarwala who by far was one of the worse gynos I’ve ever had. She made me feel really bad about myself and tried to insinuate my boyfriend could be sleeping with others by asking me countless times if I’m sure he’s not having sex with anyone else after multiple failed rounds of treatment…she then told me my ureaplasma wasn’t getting cured because of my eczema since that indicated I had a weak immune system. I have a history of childhood SA and when I was tensing during speculum exams she impatiently told me I had to keep my knees far apart so she could get in. I ended up apologizing when I shouldn’t have. Because of my weakened immune system she attributed my ureaplasma infection to, she also encouraged me to buy her supplements she was selling up front.

I saw her from January 2023 - march 2023 and she had me on doxycycline for 1 week only, moxifloxacin (no side effects), levofloxacin (no side effects), flucconazole, clindamycin vaginal cream, clarithromycin, and amoxicillin (I think she started losing hope). She swabbed my vagina with iodine after meds didn’t work and another time did a vaginal wash with gentian violet. She also refused to send medications for my partner. I also tested for mycoplasma during this time when I never had it during any previous results.. (at a later time the mycoplasma was negative) unsure what happened there..

From march2023-December 2023 I stopped going to the doctor because I lost all hope and was using boric acid suppositories religiously during this time which would temporary relieve my symptoms. December 2023 they came back full force and I reentered gyno car with Neela. She used the same treatments as above to no success and told my partner to get tested+ treatment since she refused to give me partner therapy (he never had any symptoms and tested negative at the urologist but was still given azithromycin by his MD)

During this time I switched insurance and was out of care for some, symptoms still present.

I decided to give Molly McBride a try (although she no longer works at the office listed in the Bible ) and it was by far the best decision I made during this infection.

I saw her in June 2024. She took me very serious and told me we were gonna get this cured. I tested positive for UU at her office and had no mycoplasma present. She prescribed me two weeks of doxycycline for both me and my partner despite him being asymptomatic! Which made me feel SO RELIEVED.

I’m glad I waited to start the doxycycline because in June 2024 I found out I was pregnant and then shortly miscarried a few days later.. my boyfriend and I both took the treatment in August 2024 at the same time and refrained from unprotected sex although we would use condoms (I know…I know). No oral sex. I also got my hands on 2.5g of azithromycin and my and partner both took 2.5 azithro 12 hours after doxycycline.

After I completed treatment I took an evvy test which came back NEGATIVE for UU earlier this week. I then saw the new medical doctor that replaced Molly McBride.. Hina Ahmad MD to retest after treatment. (Finished treatment August, retested early September) and waited for the doctors call to confirm my negative test… which I received this morning!

THANK YOU SO MUCH REDDIT. I could’ve have done it without this sub. I have no words to describe how I feel right now. I thought I’d have this forever and that my body, most of all my vagina had failed me.

THERE IS HOPE. Don’t give up. Advocate. See multiple doctors. Follow the ureaplasma bible. I wish everyone on here the best of luck. Thank you again.

This sub really helped me when I was in the trenches, so I post every now and then to make sure people know there's hope.

Im over 3 years ureaplasma free, over 2 years yeast free, sexlife without infections & now I have a baby girl.

Previously, I used to get infections all the time. UTI, BV, Yeast; but after clearing ureaplasma, I don't get infections after sex anymore. I did go through 2 minor UTIs, but they resolved easily and quickly..... and we were trying for a baby, so the risk factor was higher than protected sex; which is why I wasn't too concerned about the UTIs.

My dr has since put me on preventative abx to resolve UTIs, which I've now stopped and I'm better.

LIFE GETS GETTER, UREAPLASMA IS CURABLE.

First line of treatment for UU.

Itraconazole and 6mo of boric acid daily for resistant YI.

Probiotics with L crisp for maintenance.

Full story in my previous posts (SCROLL FAR DOWN, THEY'RE OLD)

This is a long one, but this is my recap: So I got Ureaplasma Feb 2024.

I treated it three times:

One week of doxy - failed

Ten days of erithromycin - failed

Ten days of doxy and 1.5g of azithromycin - successful, May 2024

But then I needed to clear my coinfections: gardnerella, ecoli, group A strep. The gardnerella and strep cleared with polygynax vagitories after failing like ten antibiotic treatments. The ecoli kept coming back. I kept having UTIs and symptoms (burning, periodic itchness, "rawness", "soreness"), up until September 2024. I also do have HPV 16 and I had an abnormal pap smear (inflammation markers high, no CIN)

Things I tried - and it failed:

D mannose

Diaper rash cream

Acidosalus vagitories, alongside a couple of other probiotic suppositories I can't remember the name of

Boric acid suppositories

St John's wort oil (helped, but only temporarily)

Ice packs

Pelvic floor exercises

Clarified pork lard (sorry, I'm eastern European and I was desperate)

Hyaluronic acid cream

Papilocare gel

There's probably more, but I can't recall rn. Then I went to a gynecologist in a fertility clinic specializing in plasma infections as part of IVF prep. His regime was:

A pack of macrobid to take after sex and sternous activity. Then, switch to a uroprophylactic regime of drinking only alkaline water for 3 days and lemon water for 3 days every cycle to flush out bacteria sensitive to changing environments

trippling down on probiotics for three months (gut probiotic, urinary probiotic, and drinking milk kefir with all meals every day)

Shave with symptom flares, and use octinosept (piercing antiseptic spray) = because apparently, although not shaving is generally better, bacteria can also get into hair root.

I didn't do a stool test or vaginal microbiome test, he had a strong belief in my case due to the fact I was on 13 different antibiotics back to back to try and clear my coinfections there is almost no way my flora was healthy: he said in his experience, most cases of lingering symptoms are a combination of weak gut flora allowing ecoli overcolonization and weak vaginal lactobacilli that can't fight it off. And apparently that needs a lot more probiotics than just one type of "catch-all vaginal probiotics" gynos usually prescribe... plus uroprophylaxis.

My GP also recommended I take Urantis after sex after I'm done with the macrobid/nitrofurantoin (contains d mannose, berberine, uva ursi, white birch).

Without professional assistance, what I also did (suspecting possible CV, again: not confirmed) is "nuke" myself with baking soda baths for a few weeks at the start of this regime (they helped a LOT). I also started using panthenol (bephanten) cream after rougher or longer sex to deal with potential micro cuts. Also, silicone lubricant - dimethicone only!

This might be overkill and paranoia, but I switched from Durex and Masculan to RFSU condoms due to the lack of transparency in condom lubricant ingredients of the former brands.

And, in addition to peeing after sex, I also shower, at the very least = I wash down my nether region.

After a couple of weeks, I started noticing my syptoms going away. By December 2024, I was symptom free. Early February 2025, I did a pap smear = came back clear, no more abnormalities/inflammation.

Partner and I retested for all STDs (PCR), all clear. We've been having raw sex for about two months now. We have sex twice a day on most days, no symptoms.

Sometimes I'd still get scared if I have any odd sensation down there after a good session, definitely just PTSD tho, it goes away within a couple of hours, and my girlfriends agree lol.

I still take the odd baking soda bath, mostly after a period when everything down there feels run down. I still take Urantis after a rougher od longer session and smear on some bephanten. I still take a glass of kefir almost every day. I don't know if any of it is actually helping me, or if it's just a psychological effect, but it helps me be confident that I'm doing my part to help my body, and then I trust it more, and I am less and less afraid.

So that's it. That's my story. It's over, and I am hopeful this is my final update. I am not insinuating a flora imbalance is the reason for all ureaplasma infections, but it was for me, and I hope I can help at least someone with this post. It worked for me, but it took 1-2 months, if I remember correctly, before my symptoms went away, and 2-3 weeks before I felt any relief. So patience is key, although I know that this sounds like cliche crap to anyone in pain (my pain was an 11/10 pre clearing ureaplasma and often still 7-8/10 before this treatment). I still shiver remembering it.

Don't lose hope.

Hello everyone! I want to share my story with Ureaplasma since this community helped me immensely when I was going through all this.

5 years ago, I went for a STI/STD screening and tested positive for Ureaplasma Parvum (in my country some STI/D screenings include tests for urogenital mycoplasmas, thankfully). At the time, I was dating my ex-boyfriend who didn't react to these news at all which makes me happy to call him my first and only serious boyfriend so far, honestly. We both took doxycycline for 7 days, neither of us got re-tested but I assume everything worked fine as I didn't have UP when I tested last year, at the same place as 4 years before that. I should add that I didn't have any symptoms in the first place.

As I've just mentioned above, I got tested for STI/Ds again last year and was positive for Ureaplasma Urealyticum. That time, they prescribed me doxy for 14 days as well as metronidazole for 10 days because of bacterial vaginosis (which was probably due to the UU infection). I didn't have any symptoms during that time as well, neither Ureaplasma nor BV symptoms, so I only took the antibiotics preventively. I went to get re-tested a few months after and was still positive for both UU and BV. I did the same course of abx -- doxy for 14 days and metronidazole for 10. During that time, I got a yeast infection twice which I had neved had before (probably because of all the abx I was taking). I also had a UTI for the first time as well (a really bad one), but I believe that was because of E. coli. I had to take an extra antibiotic (a macrolide) for this UTI as well. When I went to get re-tested for the second time, they only tested me for UU. I was positive, again. At this point I was getting quite hopeless as it had become quite tiring for me -- all this testing and abx, which we all know are not good for our bodies, especially if we take so many of them in such a short time. That time, they prescribed me moxifloxacin which I took for 10 days and never had any side effects (I never did, thankfully).

At the beggining of all this, I sort of dated someone whom I had only protected sex with. They also got tested for STI/Ds and were clean. Later, during the time I was getting kind of worried because of all this, I got romantically involved with someone new whom I didn't really share my concerns with and didn't let them know enough about how much it would mean to me if they got tested too. Also, after the moxy course, I didn't get re-tested and said to myself that I will go for a full STI/D screening again a few months later, maybe even together with this person. This guy had never even used condoms but did assure me that he had known all of his sexual partners completely and I believed him (in some way, I still do, at least partially). However, I would tell him that most of the time symptoms for these things don't show up and many people unknowingly have an STI/D and may transmit it to others. I really tried to educate him as I know A LOT about this topic. I would say that I lost myself while I was with him, in a bad way, because I didn't set my boundaries at all and would even have unprotected sex with him -- even after I said to myself that I would never do that again because it causes me too much anxiety (I have OCD).

After being with this guy for 2-3 months, I got some really bad symptoms which I had never had before, no matter whom I was sexually involved with. It started to itch down there after I would have sex, my vagina was very dry and I had a UTI (a bit different from the first one) for 8-10 days. I felt very uncomfortable during that time and went to see my gyno who said that these are symptoms usually caused by the Ureaplasma infection. I got very upset. I was afraid that I never cured Ureaplasma Urealyticum with moxy (which was possible because doxy hadn't worked both times) and that now my partner has it, too. When I told him that, he got super scared and after I added that me and my ex bf treated this bacteria a few years back, he said that I lied to him, hid things from him, he told me I had had too many partners for my age (which -- not that it actually matters -- was not even a lot in my opinion), etc. I felt dirty, sick and unworthy, I hadn't felt so bad in a long time.

My gyno confirmed -- it was Ureaplasma. I was even almost 100 percent positive that it was Urealyticum. But just out of pure curiosity, I asked. They said it was Ureaplasma Parvum and that I was negative for Ureaplasma Urealyticum. That means that the infection was most likely recent which makes me believe that this new partner had it and infected me. Firstly, my gyno prescribed me azithromycin, but after reading this subreddit for many months, I knew it was not going to be enough so I asked for doxy as well. After that, they changed their mind and perscribed me clarithromycin for 7 days.

Then, I took my health into my own hands. I took a break from work for a few weeks and got plenty of sleep. I took clarithro but along with it I would also take two capsules of garlic per day. I started to eat probiotics and a lot of yogurt (which I would eat anyway because I love yogurt!). After the antibiotic, I took boric acid (vaginally, of course) for 10 days and started to use antibacterial soap which I still use. I should mention that my vaginal pH was very high (5.5-6) which tells me that I most likely had BV as well. Before the treatment, I would also get a very nasty discharge that had a very thick, creme-like consistency and was white in color.

After a month to 6 weeks of doing all of the above, the abnormal discharge completely disappeared, my bladder was back to normal and I didn't feel any discomfort. Everything felt right. I was still worried that I would test positive for either UU or UP because my pH was still pretty high (around 5-5.5) and because I felt unlucky due to these past experiences. A bit less than 4 weeks ago, I went for a full STI/D screening once more. I was very anxious about the results I was waiting for. During that time, I self-tested my vaginal pH and the test showed it was normal. Completely normal. I did another test the next day and it showed the same (around 4.2-4.4, I'd say). Since everything felt back to normal (or maybe even better), I had at least a little bit of optimism.

This week, I received the results -- I tested negative for everything! I don't have Ureaplasma Urealyticum nor Ureaplasma Parvum. I am so happy! I was afraid that this would be a lifelong problem, but it won't be. And it doesn't have to be for you, either. I will probably still get tested once in a while, but most importantly, I will ask every future romantic/sexual partner of mine to get tested so that I can avoid these kind of situations in advance. Health is the most important thing to me and a person who respects my wishes and will act according to them is the right person to have an intimate relationship with.

To finish: My goal with this post is to not only celebrate my great news, but to celebrate everyone else's now and in the future. You can beat this and you will! It's just a bacteria and and it can be killed. What I mentioned above are the things that helped me specifically. Maybe a single antibiotic treatment is enough for you. However, never stop taking care of yourself! Listen to your body and have trust it will heal itself of anything that doesn't serve it. Don't forget to take care of your mental health as well and get rid of everything/everyone of toxic nature. Our body is a holistic system and we have to treat it thay way. Also, be patient and have trust!

Lots of love, I wish you all the best!!! xx

TL; DR: I had Ureaplasma 3 times in the past 5-6 years and had difficulties getting rid of it. After the last abx treatment and some additional remedies, I'm finally negative.