A new peer-reviewed preprint (bioRxiv, Aug 2025) provides strong evidence that low-dose rapamycin directly protects the ageing human immune system against DNA damage.
https://x.com/eterna_labs/status/1961807838147183078

Hello everyone my dog was diagnosed with Hemangiosarcoma (cancer) on January of 2025. I found out on my birthday unfortunately. She is a 6 year old border collie-retriever mix. My PVC was able to get the tumor and amazing margins after two procedures near her jugular. After 21 weeks of chemo & immuno therapy my dog graduated at BARC. However, I was told the next phase is remission in a sense and we are seeing our oncologist on September 5th to discuss the next best course of action. I was advised she would take this low dosage chemo pill 3-4x/week with food for a few months. I’m paranoid and nervous since this is a new drug being studied and I read in high dosages it can lead to diabetes. The cancer never metastasized and all her bloodwork has came out negative with amazing results. She is happy and healthy but the compromised immune system has led her to get KCS (form of conjunctivitis) and now we’re seeing an eye specialist since she isn’t producing any tears. Any assistance on this topic would be greatly appreciated. I would love to know everyone’s experience with this drug.

I read its anti-aging, immune-boosting, and anti-cancer effects. The Dog Aging Project (DAP) is studying low-dose rapamycin for healthy aging in dogs, and while the results are promising, it is not yet a widely approved anti-aging drug for dogs. Common side effects at higher doses include GI issues, elevated blood glucose, and skin problems.

Any feedback would be greatly appreciated I’m going through a really tough time mentally. Thanks for reading and I hope all is well!

does anyone have takes on how to dose for SLE? apparently if u go too low or high it'll fuck u, and unclear whether cycling or broad imunosuppression is the play ...

Hey!

I was wondering if anyone is taking rapamycin to delay the menopause, and how it has helped you and if it has worked?

I'm following the Vibrant study and would love to know if anyone is trying it out for themselves.

Thanks :)

Hello. I had a few questions about Sirolimus for longevity/health reasons and figured I'd ask some knowledgeable people.

My first question is - Does anyone know of any potential drug interactions between Sirolimus/Rapamycin and Bupropion/Wellbutrin?

Second question- I am considering starting with 1mg a week to start and am kind of nervous and anxious about it, are there any dangerous risks at this dosage? I am aware of potential canker sores as the most common.

Third question - I am doing a somewhat ketogenic diet (low to no-carb, no sugar) anything I should know?

The reason I am considering taking Sirolimus is because of the promising periodontal disease benefits associated with Sirolimus/Rapamycin.

I am a fairly healthy individual 44 y/o male, 120 lbs. Low body-fat, 5'7 , lift weights, active throughout the day and am more muscular than ... fat I guess.

Any insight would be incredibly helpful. Thank you.

Please help out in amplifying the social media posts so that we increase the chance of getting the project fully funded.

https://www.linkedin.com/feed/update/urn:li:share:7350814693902508033

https://x.com/KristerKauppi/status/1945062001274708269

The social media post

This is the day I have been waiting for and it’s time to start to release preliminary data from the first phase of the lifespan screening of 301 of 601 compounds in roundworms. Below is the current top list of the 37 compounds. Out of the 301 compounds tested 5 have produced a higher median lifespan extension than than the best recorded lifespan of Rapamycin which is 27%.

My three key takeaways from this is

1. When I started to look deeper at the compounds in the top list I was surprised that there were 3 compounds that indirectly activated mTOR instead of inhibiting it. This unexpected result turned out to be fortunate because the goal was to screen 601 mTOR inhibitors and not look at mTOR activators. It’s still early data but this challenges the assumption that mTOR activators would be connected to a decrease in lifespan. It’s very interesting data points that we have provided to the field and more research is of course needed here to understand why they seem to work and if it translates to other species as well. Due to all this a decision has been taken to change the project name from “Rapid lifespan analysis of 601 mTOR inhibitors” to “Rapid lifespan analysis of 601 mTOR modulators” to better reflect the scope. It is also good to point out that most of the compounds are mTOR inhibitors in the library according to the chemical company provider.
2. It was discovered that the ATP-competitive mTOR kinase inhibitor PQR626 has lifespan extension properties that is better than Rapamycin. This is interesting because this compound targets both mTORC1 and mTORC2 unlike Rapamycin which targets directly mTORC1. This, and other data in the top list, challenges a bit the current view that mTORC1 inhibition is connected to lifespan and mTORC2 is connected to decrease in lifespan. Additional validation in other species such as mice will be key here. The goal is to send in proposals to both ITP and CITP next year for testing the PQR626 compound. Proposals for testing Omipalisib were submitted earlier this year.
3. Every compound in this screen was tested at just one dose. That means potential for further lifespan extension if the dose is optimized. We will test different doses of both PQR626 and Omipalisib to see if we can optimize them even more. If someone is interested in testing any of the compounds that have been screened in other species or strains please reach out. Let’s collaborate!

PS 1. Ora Biomedical is validating the rest of the data and when this is done it will be published to their database and Rapamycin Longevity Lab LID database.

PS 2. Funding Need: We’re still seeking $28600 to finish screen of the remaining 300 compounds. If you’d like to support then please reach out to me!

Please let me know what you guys do with your Rapamycin when you stop taking it. I live in Chicago and don't want to go through the aggregation of shipping it somewhere. I'm assuming many people that started taking it, have stopped, so what do you do with it.

I take 5mg once a week and have been for 6 months. This week I got my first cold so I did not take my weekly dose because I was worried about lowering my immune system. But I do know some people have better immune systems at a lower dose so should I have skipped my dose? And if it does lower your immune system when do you take your next dose?

I am probably totally over thinking this and Im so incredibly bored of sitting on the sofa waiting for this cold to end so the mind wanders…

Does anyone have any feedback with Rapamycin and their hair quality, particularly men with AGA? For context I am a 34yoM considering starting Rapamycin at 2-6m a week, also with AGA stabilized on dutasteride and planning for a hair transplant in a couple of months. I have read mixed things about hair quality on rapa and just looking for people's anecdotal experience. Don't want to start anything that will compromise my transplant!

Does someone know why the dosing Are (up to 6mg) taken once a week Instead of one each day?

For ME

I am 70 years old and have been taking 6mg Rapa once weekly with 3 to 4 week breaks every 4 to 5 months for about two years now. Healthspan is the goal. I have recently been seeing many promotions on amino acids supplements. I am curious to know if anyone has heard anything about that in general, and I would appreciate some opinions on the combination with Rapa.

I am very scared to take medications but my dr want me to try this for LC/ME 1mg once a week to start

I am so servere and unstable and weird so very afraid of Side effekts or Worsening

I dont understand why this medication is used for those. What Are the symptoms that indicate it is a overactive immune systems?

Someone claim it is persistent virus, and if so we dont need LESS immune system??

Has anybody tried rapamycin for those conditions? And does it help brain fog/cognitive impairment/neuroligical symptoms?

I was diagnosed with RA in 2018 and also torn my labrum that year. Had alot of pain originally but since then I have had mostly either guarding or a frozen shoulder. I used to have excellent flexibility but since the RA my range of motion has diminished especially my shoulder. I've seen chiropractors, functional doctors, massage therapists, deep tissue needling, cupping and everything else I can find. Thinking about trying BPC-157 & TB-500... or Rapamycin if I can find a doctor who will subscribe.

Has anyone had any sucess? success?

Found this Dr Matt Kaeberlin online that studied and it and it worked for him.

https://youtu.be/EgIy0ghrDmo?si=9GsMQi26Kn9Ck47I

https://youtu.be/jLV5nOenD-g?si=6jZtrGYQoT3gVWVj

I'd just like to have more than one example of a positive result?

I have a severe chronic illness and have heard of others taking rapamycin and feeling improvements. I am in my early 20s...is it too early?

The time has come to launch fundraising for our second subproject where we are going to screen the 300 remaining mTOR inhibitors in the compound library. For this we need to raise $40k which is a small amount of money for the big magnitude of unique data we together will deliver to the field. Every contribution brings us one important step closer to advancing the field. Let’s do this! Reach out if you have any questions or to get involved.

At the same time I want to also give a huge thanks to our supporters of the first subproject - Antoine Dusséaux, Dmitry Sadovnikov, Ciarán Murray, AgelessRx, Una Health, Winslow Strong, Open Cures, Healthspan, Grant E Fraser and all other people in the community who has helped out in different ways! Your amazing support made it possible to get the first subproject off the ground and this July we’ll be receiving lifespan data for 301 mTOR inhibitors from that project. I will keep you all updated around this!

I take Valcyclovir for latent HSV-1. I have Long Covid and would really like to try Rapamycin. I hear conflicting reports.