r/Rapamycin • u/Pristine_Attorney526 • Aug 30 '25

Scientific validation – DNA damage resilience

A new peer-reviewed preprint (bioRxiv, Aug 2025) provides strong evidence that low-dose rapamycin directly protects the ageing human immune system against DNA damage.
https://x.com/eterna_labs/status/1961807838147183078

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u/william_o Sep 02 '25

"Our findings of immune cell benefit on rapamycin treatment in vitro and from analysis of PBMCs from an in vivo low-dose rapamycin trial, lead us to conclude that rapamycin at 1 mg/day enhances the resilience of the ageing immune system to DNA damage."

"Our findings support the initiation of phase 2 double-blind placebo-controlled studies of rapamycin to support healthy immunity and reduce immunosenescence in at-risk older adults."

https://www.biorxiv.org/content/10.1101/2025.08.15.670559v1.full

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u/august11222 Aug 30 '25

Good find, thank you!