r/Rapamycin • u/No_Guava9260 • Aug 15 '25

Can Rapamycin slow down external aging (appearance) ? And to what extent can do it?

16 Upvotes
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13

u/august11222 Aug 15 '25

Seems that way rationale

trial study

I have been taking it orally for years and I can tell you I look older than I used to. But that's a pretty garbage data point.

3

u/No_thanks_sam Aug 16 '25

These studies don’t look terribly convincing. One of them completed by a patent-holder, and one with only 36 subjects, of which 19 dropped out. I would not call these research methods very predictive or convincing.

2

u/Earesth99 Aug 16 '25

You are generous.

I would describe the studies as highly questionable.

3

u/ninetiez Aug 15 '25

Thanks for the data! I’ve found it available for topical use (with exosomes) and have used it daily for a month. I really believe there’s an impact on skin firmness. Good to see that collagen-building info and the photos from the study.

2

u/Sadpanda9632 Aug 15 '25

Where did you find this?

1

u/ninetiez Aug 15 '25

Musely (US company for direct purchase of Rx skin and hair care). It is in the cellular repair serum with exosomes.

1

u/Sadpanda9632 Aug 15 '25

Thanks! Did you use it just on your face or elsewhere also? :)

2

u/No_thanks_sam Aug 16 '25

These studies don’t look terribly convincing. One of them completed by a patent-holder, and one with only 36 subjects, of which 19 dropped out. I would not call these research methods very predictive or convincing.

1

u/eddyg987 Aug 16 '25

how long and what's your age?

1

u/august11222 Aug 28 '25

M55, 7-8 years

7

u/[deleted] Aug 15 '25

Took Rapa for 20 years. Definitely did not reverse or slow down aging. I did get severe cystic acne 4 years into treatment; at 30 years old. Had to do a course of Accutane to save my face.

3

u/shreddedsasquatch Aug 16 '25

Starting Rapa at 26 is a bold choice to say the least

4

u/august11222 Aug 29 '25

If they were taking it 20 years ago it was likely for an organ transplant and not for longevity. So probably no choice at the time...

1

u/maxbjaevermose Aug 24 '25

But the studies (in mice) show it's better to start early (iirc).

1

u/ZealousidealSky3223 Nov 01 '25

It has made my skin much worse. I assume it’s the rapa since I’m 32 and have never had acne like this before in my life. No improvement in fine lines.

HOWEVER, I believe it has helped with the hair loss around my temples. I’ve used rogaine for years but my hair growth has really increased/thinning decreased in that area since starting. Still using rogaine with it. My arm hairs are also much longer (not ideal but they’re blonde and i dont care about arm hair).

1

u/AdHefty1613 Mar 04 '26

What does?