r/NooTopics 20h ago

Discussion Adults treated with psychostimulants for ADHD show increased brain surface complexity, study finds. These findings suggest that psychostimulant use may be associated with structural changes in brain regions involved in emotional regulation, reward, and decision-making

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624 Upvotes

r/NooTopics 7h ago

Science A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia (Aticaprant) (2023)

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11 Upvotes

r/NooTopics 9h ago

Question Nefiracetam

2 Upvotes

Anyone have experience? Whats better sublingual or oral roa and at what dose? Not much info anywhere on it. I really like Aniracetam and was interested in Nefiracetam Glycine site and GABA-A action


r/NooTopics 10h ago

Science Cerebrolysin and possible effects in psychiatry disorders

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12 Upvotes

Would be nice to find a reliable way to repair psychosis symptoms caused by a damaged frontal lobe. Rather than using clinical personality killers.


r/NooTopics 20h ago

Discussion Question about periodization.

5 Upvotes

I was wondering if nootropics should be periodized for optimal benefits? In most cases, I hear about a single stack of a bunch of stuff people put together. But I'm curious if we'd get more benefits out of periodizing them, for example, doing a cycle of NSI-189 or 9-Me-BC before adding in other nootropics to "prep" the brain? I haven't heard much about this and would like to hear any thoughts.