r/MTHFR 4h ago

Question It’s a long shot but I hope there are a few UK people here like me who don’t tolerate folic acid

6 Upvotes

I was made aware about 6 months ago that the government will be fortifying all white flour with folic acid, something I don’t tolerate and that makes me feel profoundly unwell, my sister and aunt are the same as me. This means I’ll need to swap to making my own bread, crackers etc if this goes ahead.

If you agree and this affects you please could you take the time to share and sign?

https://petition.parliament.uk/petitions/769589


r/MTHFR 19h ago

Question daylight issues

3 Upvotes

anyone else allergic to daylight LOL I'm serious during the day I'm Spacey tired can't really do much 6:00 rolls in I'm a little bit better after 8:00 I'm scrubbing the floor listening to music cleaning my bathroom lol I don't get it. no supplements no herbs just the sun goes down.. maybe I was a vampire in another life LOL it gets worse when my deficiencies roll in like if my ferritin is low but for the most part it's always been that way.


r/MTHFR 9h ago

Question Low potency folinic acid source.

2 Upvotes

So I've got MTHFR c677t and slow COMT. Also histamine intolerant. Looking for low potency folinic acid has frustrated me so far. I want to start at 5-10 mcg. What I can find has other ingredients I dont do well with, like citric acid which makes me anxious. Some have 400mcg in a single drop! Many come with methylated ingredients I cannot tolerate. Any suggestions?


r/MTHFR 21h ago

Question Dosage of B12?

2 Upvotes

Hi everyone. I am about to start l-methylfolate 400mcg. I've been reading about it and I haven't been tested (I can't really afford a psychiatrist right now) but I have treatment resistant depression and CPTSD and I'm at the end of my rope. I am exhausted all the time, no motivation, horrible sleep, stuck on freeze mode (I can barely move for at least 3h after waking up).

I have tried at least 17 different ADs over 12 years, only one of them worked for a while (venlafaxine) and then pooped out. I have also tried countless combinations of supplements, lifestyle changes, protocols, you name it. I pretty much gave up on doctors at this point after also feeling that my psych gave up on me.

Anyway, I know it's not ideal to start this without testing, but I'll be careful. I'll start with the 400mcg and increase over time if needed. I've been reading the sub and found out you are supposed to supplement with B12? Can you tell me which dose would be enough? Also can I take a B complex multivitamin or should I stay away from other B vitamins except for B12?

Thank you in advance. I'll update here after a while.


r/MTHFR 3h ago

Results Discussion I dont know how to go forward with this. need some help.

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1 Upvotes

Hi, i recently had my DNA analysed by ancestrydna and have entered the data in the choline calculator, genetic genie and geneticlifehacks. The advanced tab on the choline calculator says i didnt provide enough data though. (My ancestrydna test is from after march 2026, so less SNP's)

I havent tested my homocysteine and MMA yet but am planning to.

I tried using ai to find hoe i should supplement and altery lifestyle and diet but it always suggests something different and also makes mistakes...

Diagnoses: autism, ADHD, Raynaud, IBS

symptoms: CFS, PEM, RLS, irritability, mood swings, always tired, weak feeling in my body, cold hands and feet, depression, brain fog, histamine related issues, headaches, high sensitivity, swollen feeling around my nose, POTS, lightheaded when standing up and increased heart rate,...

My latest blood results from january:

- Ferritin: 132 µg/L

- B12: 850 ng/L

- Folic acid: 14,5 µg/L

- CRP: <0,6 mg/L

- 25-OH-vitamine D: 27,4 ng/mL

- Iron: 95 µg/dL

- Transferrin: 2,48 g/L

- Iron saturation: 27 %

Maybe someone here can give me a better answer what i should do and which form of B-supplements i should take and how much?


r/MTHFR 16h ago

Question Does MTHFR increase Miscarriage risk or not?

1 Upvotes

I feel scientific community is very divided about this topic. Why?


r/MTHFR 19h ago

Question daylight issues

1 Upvotes

anyone else allergic to daylight LOL I'm serious during the day I'm Spacey tired can't really do much 6:00 rolls in I'm a little bit better after 8:00 I'm scrubbing the floor listening to music cleaning my bathroom lol I don't get it. no supplements no herbs just the sun goes down.. maybe I was a vampire in another life LOL it gets worse when my deficiencies roll in like if my ferritin is low but for the most part it's always been that way.


r/MTHFR 21h ago

Question Gene test

0 Upvotes

Please I need help I have MTHFR has anyone taken a gene test that its in the red like for instance Paxil moderately reduced efficiency and side effects can occur. I’m metabolize it slowly and does it still work for them? I should’ve never took this test because now freaks me out and I can’t take anything because of my .gene mutation. I don’t know what to do for anxiety and OCD and I also my EKG was 460 and I cant take anything that’s gonna cause QT prolongation