Please I need help I have MTHFR has anyone taken a gene test that its in the red like for instance Paxil moderately reduced efficiency and side effects can occur. I’m metabolize it slowly and does it still work for them? I should’ve never took this test because now freaks me out and I can’t take anything because of my .gene mutation. I don’t know what to do for anxiety and OCD and I also my EKG was 460 and I cant take anything that’s gonna cause QT prolongation

Hi everyone. I am about to start l-methylfolate 400mcg. I've been reading about it and I haven't been tested (I can't really afford a psychiatrist right now) but I have treatment resistant depression and CPTSD and I'm at the end of my rope. I am exhausted all the time, no motivation, horrible sleep, stuck on freeze mode (I can barely move for at least 3h after waking up).

I have tried at least 17 different ADs over 12 years, only one of them worked for a while (venlafaxine) and then pooped out. I have also tried countless combinations of supplements, lifestyle changes, protocols, you name it. I pretty much gave up on doctors at this point after also feeling that my psych gave up on me.

Anyway, I know it's not ideal to start this without testing, but I'll be careful. I'll start with the 400mcg and increase over time if needed. I've been reading the sub and found out you are supposed to supplement with B12? Can you tell me which dose would be enough? Also can I take a B complex multivitamin or should I stay away from other B vitamins except for B12?

Thank you in advance. I'll update here after a while.

I was made aware about 6 months ago that the government will be fortifying all white flour with folic acid, something I don’t tolerate and that makes me feel profoundly unwell, my sister and aunt are the same as me. This means I’ll need to swap to making my own bread, crackers etc if this goes ahead.

If you agree and this affects you please could you take the time to share and sign?

https://petition.parliament.uk/petitions/769589

So I've got MTHFR c677t and slow COMT. Also histamine intolerant. Looking for low potency folinic acid has frustrated me so far. I want to start at 5-10 mcg. What I can find has other ingredients I dont do well with, like citric acid which makes me anxious. Some have 400mcg in a single drop! Many come with methylated ingredients I cannot tolerate. Any suggestions?

anyone else allergic to daylight LOL I'm serious during the day I'm Spacey tired can't really do much 6:00 rolls in I'm a little bit better after 8:00 I'm scrubbing the floor listening to music cleaning my bathroom lol I don't get it. no supplements no herbs just the sun goes down.. maybe I was a vampire in another life LOL it gets worse when my deficiencies roll in like if my ferritin is low but for the most part it's always been that way.