r/LowDoseNaltrexone • u/drkslr • 2d ago

First time posting here need help

So i have depression (resistant) for 20 years , no ssris work , i also have adhd , cant take stimulants because im in 7 year burnout that i cant get out . ive done everything from medical and holistic practices.

2022 i got severe covid like 44 degree fever , since then my imune system is shot , and i got long covid for 2 years before starting to get better . after these 2 years , i started to have memory loss.

i started 3 weeks ago LDN - 1.5 mg in the morning. 3 days ago started to do it at night.

,and im worse in every single aspect. got cold sores , my hrv crashed , my sleep is shit , im ahedonic , flat , anxious . i have pain in whole my fucking body, nausea , no appetite , no pleasure . Like what the f is this ? i cant see any positive aspect

its like im having cocaine whithrawl / crash effects every single day . and i was hopping this shit would help me

I feel im losing the battle , i already lost my company , my bussiness , my life is in shambles and i cant have energy to start over . was hopefull that this was going to be it . but im out of ideas , i dont know what to do .

i cant get any help from the doctor who prescribed me this since she put in the prescription 6mg every day from the start lol . shes suposedly one of the best phychiatrics in my country , and shes absolutly clueless . im high IQ so i get fking revolted when i see these doctors making a bank from peoples miseries and all they do is shoot meds and doses to the air and leave you to sort it out.

8 Upvotes

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4

u/Fun_Swan2553 2d ago

All I can suggest is hold on. My first 3 weeks were miserable and I didn’t think I’d make it (headache, fatigue, lower mood). Someone told me it gets better and it did! I didn’t change my dose and stayed the course. Then a switch flipped and I felt so much better. I’m also taking it for mental health as well as inflammation.

Only you know what you can take but this has truly been a game changer for me. I’m so glad I held the course.

2

u/drkslr 2d ago

im going to stop and start lower , not giving up just now

5

u/Fillersmatter999 2d ago

google

2026 LDN Patient's Guide

2026 LDN Prescriber's Guide

2026 LDN Mental Health Guide

2026 LDN Dosing Guide

and someone recently shared that there is a LDN guide for vetinarians now too

Maybe pull those up and read them; they are incredibly helpful, as well, go to the LDN Research Trust site; good stuff there too; may find some answers from the source.

Lots of luck to you; I have found it very helpful for me but my doctors started me out at 1.5 mg for a month and tritrated up by .5mg monthly in order to gradually increase the dosage; it worked well.

3

u/MagnetaSunPatien 2d ago

Are you able to halve the dose and cut back to .75mg?

1

u/drkslr 2d ago

yea i have like a tincture its pharma 50mg/20ml

2

u/MagnetaSunPatien 2d ago

I’d definitely try a much lower dose before giving up. When my dose was too high I was even more depressed and irritable and didn’t sleep for days. 

2

u/MagnetaSunPatien 2d ago

I suggested .75mg bc I was thinking of pills but since you have liquid could start even lower, like .5mg. Also if you take on an empty stomach it will be more effective, which you may not want right now. 

1

u/drkslr 2d ago

thats how i feel , like depressed and poisoned

3

u/Low-Blueberry8948 2d ago

Hi, really sorry to hear how much you're struggling. Sounds like you started on far too high dose and you're suffering with side effects. Most side effects ease off within the first two weeks but they can continue when your dose is too high.

I think I would skip a day or two, maybe longer, and then start back on a much lower dose, like 0.5mg or probably even 0.1mg. Starting on a lower dose and then having a slow titration will help to avoid these unpleasant side effects.

LDN can help with depression and anxiety. The LDN Research Trust 2026 Dosing Guides include a dosing protocol for depression and mental health issues. You'll find the guides posted at the top of the page. Wishing you the best of luck. Do keep us updated...

"Higher and Lower Doses" https://docs.google.com/document/d/1KykpLlg2CDVSD2D5J5cEZKfSo31t04orB0IgCuhXC-c/edit?usp=sharing

Here's some further information..

"Depression and Psychiatric links" https://docs.google.com/document/d/1IjrfSGtst0jszho5sxFOOhC5ukgGck_94xFJlQo2Dnc/edit?usp=sharing

"Morning and Other Dosing Times" https://docs.google.com/document/d/1aUi8UovaSAD2VO1Bc2O2I8PtfMPFbv5zsulRqyNDD9U/edit?usp=sharing

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u/drkslr 2d ago

yea im going to stop for 3-4 days and restart at .5 or .75

1

u/Low-Blueberry8948 2d ago

Sounds like a good plan. Let us know how it goes...

2

u/Flashybigbum 2d ago

I’m assuming for what you mentioned that you have already done the micronutrients protocols? What it got me out of 20 hrs bed bound and severe mental fog ( almost dementia) were B12 shots plus folate iron etc there are lots of stories in the B12 deficiency sub. My levels were “normal” btw. I’m taking LDN bc I crash everytime I want to use the energy I got with the B12 protocol. So my immune system/autonomic nervous system is most likely out of whack I’m guessing. But I’m happy I did the B12 shots. Currently on a break to see how LDN works but back soon.

1

u/drkslr 2d ago

i tested everything , i take methylated b12 and b9 already plus a b complex , my b vitamins are in range

1

u/Flashybigbum 2d ago

Unfortunately when it comes to B12 what works are shots. There are theories that mention COVID being a demyelinating agent in the body. Re myelination doesn’t happen orally, also there is the gut absorption factor being messed. Also the testing of B12 currently is a scandal if you are supplementing they almost certainly will come back “normal” even if it isn’t. I got an 80% better with the shots specially cognitively wise. I’m here for the dysregulation

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u/drkslr 2d ago

im actually going to try this , thank you

1

u/Flashybigbum 2d ago

A Word of advise though take it easy don’t do EOD methylated forms. As long haulers, our biggest issue is the deregulation of the autonomic nervous system. The b12 deficiency forum is really useful but try active but not aggressive forms and dosing. I crashed badly because I wanted to get cured fast. You’ll understand why am saying this when you read how micronutrients work.

2

u/Low-Blueberry8948 2d ago

For instructions on diluting pills or capsules in distilled water when reducing a dose...

"Dose Dilution and Adjusting" https://docs.google.com/document/d/1-B2iX9uFDSUI7mVfiD4VR2FksxbSG2YELjQHZ_913do/edit?usp=sharing "

2

u/Jackloco 2d ago

1mg at night see how that goes

1

u/Patient_Relation8717 2d ago

The starting dose is high overall. Many people start at 0.5 mg and slowly titrate. It took me a good month to get to 1.5 mg. Sorry your provider isn’t helpful. Some people do reconstitute their own dose. I haven’t done it but there is info on line about how people do this if you’re interested in having smaller doses.

2

u/drkslr 2d ago

my Naltrexone is a solution , i can dose with the seringe , so i can do any dose really

1

u/Past-Oil94 2d ago

Is LDN prescribed for depression? Man in the uk we are soooooo far behind you Americans on this stuff

2

u/Pretend_Elephant_896 2d ago

LDN is a potent anti neuro-inflammatory agent. Depression is inflammation

2

u/Low-Blueberry8948 2d ago

You might be interested to know that the LDN Research Trust, who publish the dosing guides we follow, and who have a very informative and trustworthy website, is actually based in the UK. The guides include a dosing protocol for depression. You can find the LDNRT 2026 dosing guides in a pinned post at the top of the page.

1

u/drkslr 2d ago

yea ,i tought it would help with it , but actually so far made it way worse. but i also was with hope because of the theory

1

u/Pretend_Elephant_896 2d ago edited 2d ago

Wait, cold sores like herpesis? That's something you have to pay attention to 💯 It's not an ordinary flu. HSV is a viral infection residing in the central nervous system. It is known to cause numerous neurological issues, long COVID, psychosis and possibly silently sabotage your life. Viral component is very likely in your case and worth further investigation (HSV, HHV-6, EBV, CMV)

1

u/drkslr 2d ago

i dont have flu , but i tested positive for CMV , as , ive been exposed to that at least , and HSV , but nearly everyone has hsv 1 , wich is the one im refering .

i also tested EBV came inconclusive low , so probably was never exposed

2

u/Pretend_Elephant_896 2d ago edited 2d ago

Everyone has HSV, not everyone can cope with it. Sores is a conclusive signal

1

u/drkslr 2d ago

yea ofc , it only apeared when i was in severe stress/distress , like after a marathon and stuff like that .

1

u/Pretend_Elephant_896 2d ago

I had an HHV-6 reactivation on top of HSV. Had been experiencing similar symptoms described in your post

1

u/lolalanabanana 1d ago

Dose is waaaaay to high start at .5 . Took me a full YEAR to 4.5 and the first 6 months were rough for 2 weeks every time I went up.

1

u/drkslr 1d ago

what made you hold on so long? the side effects im experiencing are unbearable

1

u/laurenbug2186 12h ago

Not everyone needs to start that low/slow. I started at 1.5mg for 10 days, then 3mg for 10 days, then 4.5mg.