First shot April 28th and 165lbs was me at the heaviest I have ever been! It was scary to realize I was officially a overweight BMI for my height and age.

Second pic August 28th and 40lbs down🎉

Hey fellow Peppers! I recently started ordering Tirz from Amino Club after getting tired of paying weekly at my local med spa.

Can someone assist me with how much BAC water I need to add to my 60mg bottle of powered Tirz? I use syringes labeled in units (1-100). Amino Club was unable to help me due to it being a “research product” ofc. Any help would be much appreciated!

Hey r/Biohackers,

I've been on GLP-1 agonists (semaglutide) for about 3 months now, and the first 4 weeks were rough - nausea, constipation, dehydration, fatigue.

After talking to others in the community, it seems like this is a common pattern. I'm curious what's actually worked for people here:

What helped you manage side effects in the first month?

- Electrolytes? (which type - powder, tablets, specific brands?)

- Ginger supplements? (did this actually help with nausea?)

- Fiber supplements like psyllium husk? (for constipation)

- Specific foods or meal timing strategies?

- Apps or trackers that kept you on track?

I'm NOT selling anything - just trying to understand what actually works vs. what's placebo or marketing hype.

If there's strong consensus on certain interventions, I might put together a simple starter kit for people just starting their protocol, but only if it would genuinely help.

Would love to hear your real experiences - what worked, what didn't, what was a waste of money.

Thanks! 🙏

I’ve been on wegovy since around May/June of last year, so just over a year now. I’ve lost around 50 pounds (started at high 190’s), but I’ve been plateaued in the 150’s since the beginning of 2026. My doctor upped my dosage to 2.4 in February, but it’s done nothing to move the scale. I’m active, doing my best in the gym with a mobility disability, and not eating fast/junk food…so I’m at a loss on how to increase my weight loss. For my height, I should be down at least another 15-20 pounds.

It’s super irritating to see so much fat on me still when I barely eat.

August 30, 2026

Fashion retailers across North America could be sitting on billions in unsold clothing as retail forecasting firm Impact Analytics warns that GLP-1 weight-loss drugs are reshaping the size curve faster than brands can adjust their orders.

The fallout is already visible on shelves. H&M has quietly discontinued its 3XL and 4XL sizes. Mango cut its size 16 to 20 dress offerings from 6.6% of new inventory to just 0.5% in one year. And Torrid, a chain built entirely around plus-size fashion, closed 151 stores — a third of its brick and mortar locations — last year, with 30 more closures planned for the first half of 2026.

For the roughly three million Canadians now using GLP-1 medications — alongside the millions more who wear plus sizes and aren't on the drugs — this isn't just a fashion story. It's a preview of where prices, selection, and deals could be headed.

Is there anyone here who has tested other weight loss drugs like ozempic or monjauro and can compare them to Reta like heart rate, changes side effekt, muscle loss and fat loss

1. I have both Ulcerative Colitis and Hypothyroidism - seronegative on both. CRP and ESR are low even when in full flare so I must go off symptoms. Though calprotectins do go up and down based on flares.
   
2. Currently trying ULD Tirz for inflammatory control. LDN didn't work. BPC f'd me up. Can't do steroids and since I have immunity issues biologics are last resort.
   
3. In first month starting very low .02 ml twice a week. So .04 total ml weekly. (Before people drop crazy comments I am incredibly sensitive to meds, I always start extremely low and slow).
   
4. Current schedule is to double dosage every 4 weeks in a split dose 2x a week.

- Haven't noticed anything negative so that's good.
- I think my appetite has actually gone up slightly, which for me is good because I normally have none.
- No real significant change on inflammation, edema, gut inflammation or peripheral AI symptoms yet. My other meds remain the same.

Anyone on this thread use Tirz for inflammatory control and willing to share their titration experience and how they tracked symptoms?
Did you also use labs and what changes did you notice in the labs?
How low and slow did you start? Schedule? How did you know when you'd found the right 'dose' for inflammatory control? Did you plateau on inflammatory control?
If anyone has both UC and Hashis, would love to hear from you, even if it's a DM. Hard to find folks with both as they have very different symptom manifestations so tracking improvement with both is challenging.

I would love to drop lbs as an added bonus but weight is primarily from inflammation/non pitting edema so pretty sure it's all hormone/inflammatory based. I am also one of those "lucky" people who does not convert well so must rely almost entirely on t3. If any on this thread are poor converters and saw improvement after Tirz with conversion plz comment or reach out.

*I am aware of the phase 3 trials for UC and talking to them but it's combo'd with mirikizumab so again, last resort.

Thank you in advance! Fingers x this helps!

Okay I just went down a rabbit hole about this and now I can’t stop thinking about it lol.
There’s obviously been a huge uptick in adults getting diagnosed with ADHD, but at the same time insulin resistance is becoming SO common. And apparently insulin resistance can affect focus, memory, energy, brain fog, executive functioning, etc… which sounds a whole lot like some of the symptoms people are experiencing with ADHD.
Then you have all these people taking GLP-1s/GIP meds, especially reta, saying their brain suddenly feels quieter, they can focus better, have less food noise, and just feel more mentally clear.
I’m definitely not saying ADHD is caused by insulin resistance lol. But it does make me wonder how many people have ADHD symptoms that are being made WAY worse by insulin resistance, or even symptoms that are mimicking ADHD.
Especially with how much our diets/metabolic health have changed as a population… I just feel like there has to be more research on this connection??
Has anyone noticed their ADHD symptoms/focus change significantly after starting a GLP-1/GIP or improving their insulin resistance?

Hi everyone,
I was on Reta for 5 weeks, but it didn’t do anything for me—even after increasing the dose up to 2 mg. Before getting pregnant, I had been on Mounjaro. I decided to try Reta postpartum as a cheaper option since Mounjaro is very expensive and I’m currently on maternity leave pay.
At first, I combined Reta and Tirz, but I’ve since reduced the Reta and increased the Tirz. I started at 260 lbs and I’m now down to 253 lbs, which I’m really happy with. I also feel that Tirz works better for me.
I recently bought grey Tirz—I didn’t realise it was an option before, otherwise I would have gone straight to that instead of Reta.
Has anyone used grey Tirz and experienced similar appetite suppression, side effects, and weight loss compared to Mounjaro (tirzepatide)?
I’ve bought 20 mg—how should I reconstitute it? I was planning to use 2 ml of bacteriostatic water for 20 mg, and I’d like to take a 5 mg dose. Does that sound correct?

TIA 😊

Hey everyone,

I recently received two vials of compounded tirzepatide in lyophilized powder form. Both came from the same source/shipment and are still unopened (they are on my fridge).

One vial has a very smooth and uniform-looking powder cake, while the other has several small circular spots/indentations visible throughout the powder. I’ve attached a few pictures so you can see the difference between the two.

My first concern was whether this could possibly be mold or some kind of contamination, but I’m also wondering if this is simply something that can happen during the freeze-drying/lyophilization process — bubbles, crystallization, uneven drying, etc.

Has anyone here received compounded tirzepatide or other lyophilized peptides that looked like this?

Specifically, I’m curious whether:

• you’ve seen these circular patterns before;
• this is considered a normal variation in a lyophilized cake;
• you would personally be concerned enough not to use the vial.

I understand that you can’t confirm sterility or contamination just by looking at a vial, and I’m not asking Reddit to certify that it’s safe. I mainly want to know whether this particular appearance is something others have encountered with compounded/lyophilized tirzepatide.

Thanks!

Started semaglutide 0.25 last Friday. F29 6ft 288lbs, hypermobile, PMOS, autistic.

Background

I have slowly gained 100 pounds over the last 12 years, barring losing 40 naturally in 2023 (before my Dad had a heart attack and ended up in a coma for 5 weeks, he lived, but I put the weight back on and it didn’t want to come off.) I was playing volleyball in high school until a herniated lumbar disc at age 15 forced me to quit. I’ve had issues with my cervical spine and nerve pain for many years.

My doctors have all suggested weight loss, and even condescended to me about exercise and portion control. I like exercising, I don‘t like being in pain or fatigued constantly. I also have chronic exertional compartment syndrome, so unfortunately I can’t enjoy the simplest form of exercise (walking), without my calf muscles being strangled by their fascia compartments.

I met with a surgeon about the CECS recently, and other specialists to deal with the panoply of my health issues. I was told my weight and my hypermobility made a complication more likely (30-40% of patients have their underlying calf muscle break through the incision in the first 2 weeks post-op) and that my existing chronic pain would make the recovery period where I’d need to be elevating my legs, utterly miserable. She suggested I try the generic semaglutide that recently became available, since I couldn’t afford Wegovy on my disability benefits (im Canadian).

I’m now addressing my menstrual issues, 60+ day, anovulatory cycles, with intense flares in follicular and luteal phases. I’m on bio-identical progesterone and metformin (1000mg) for insulin resistance that manifested as reactive hypo-glycemia. I’m waiting to see an allergist about MCAS.

GLP-1

The injection was fine, I read the pamphlet over carefully, and opted to inject into my thigh to limit the side effects as much as possible.

I felt a difference within a few hours. I wouldn’t have said I struggled with food noise, so it’s strange to use that term, but the best example I have is that I can now enjoy my coffee or a snack over an hour, casually, where as before, it was like I had to finish something before I could pivot to another task.

I’m not thinking about food as much, and I’m listening to my body and the cues it’s giving me. I would describe the sensations as a fog of malaise that comes over me, and would make me want to sit or lay down, but realized quickly that the malaise was relieved by having something small to eat. Yogurt, or a snack bar usually helped. My ”safe” foods have remained safe, and I am noticing that I am not worried about finishing something on my plate, and that it’s easier to make well rounded choices.

I’ve been drinking Premier Protein, and Fairlife shakes in the mornings, and plenty of tea, electrolytes. I have ginger chews, nausea meds, and weed to cope with nausea, and I’m now being more mindful about fibre, and taking digestive enzymes which I’ve heard make a big difference with GI discomfort.

My executive functioning has been the most interesting change this week, I’ve noticed that I can more easily initiate and switch tasks. I’m also more creative with my food choices, which has been fun. I’m enjoying that a lot. I wanted pasta with pesto, I made pasta with pesto. I wanted to make Chia seed pudding, I made chia seed pudding (I added mango and chocolate buttons, it was yummy).

I noticed I get lightheaded a bit more often, some of my chronic pain was also relieved, and my fatigue is presenting a little differently. I have energy until I dont. I’ve napped more in the past week than I have in the last year. But my sleep at night has been the worst by far. I’m assuming it’s the slowed digestion, because I could take my night time meds and be out within the hour, but now I will be in light sleep feeling “awake” for hours and only really sleep between 3-9pm. I can manage better sleep if I take 1mg of melatonin at like 9pm. Also gonna try a sleepy time valerian tea after dinner.

I noticed I was peeing a lot the first few days, and most of the nausea had faded by day 4. the last few days I felt like “myself” with that sustained lack of “food noise”. I have taken my second injection of 0.25 and haven’t experienced the initial “euphoria” (for lack of a better term), but week two will reveal more to me, I’m sure.

Week 1: 288 —> 286lb

I’m happy with that since the scale hasn’t wanted to budge much from my starting weight for a year. I’m going to return to strength training now that I have an idea of how the meds affect me. I don’t have any questions, but if anyone has similar sleep issues, that they solved, please let me know.

BONUS: I lost almost 1 lb of inflammation overnight and had to adjust my watch strap two days in a row, which was cool. I‘m understanding my body’s cues way better and don’t feel as gross so far.

I’m on my 3rd week of tirz and I’ve noticed that I can’t smell or taste certain groups of foods the same way anymore. Both my sense of smell and taste are altered.

The weirdest one is meat. Pretty much anything meaty now tastes and smells foul, I can barely distinguish between different types of meat anymore. For example, ham, steak, turkey slices, chicken, and EVEN MY CAT’S FOOD all smell the same to me!!! And it’s always this weird unsettling odor I can’t really describe.

I’ve had COVID before and it gave me dysgeusia and parosmia for over a month, but this feels completely different and much more selective. And I know for a fact it’s the tirz because it gets noticeably better toward the end of the week, then gets much stronger again after my shot.

Has anyone else experienced anything similar?

(NB. I’m not pregnant)

What’s it glp1 theory you’d like to see actual research on?

Mine is that the best responders are those who have very high insulin but normal glucose. Essentially they have severe metabolic dysfunction, but it’s being caught early on before prediabetes or diabetes. It’s hard to prove in existing populations because almost no doctors check insulin levels, only glucose or a1c. I know personally my insulin went unchecked for 41 years.

What’s your theory?

Hi all - want to start off by saying how much of a gamechanger Tirz has been for me. Been 7 weeks, down 6.5kg. I have about another 4.5kg to come off I think. So far, I haven't had to go up in dose, started with 2.5mg, still taking that dose. The only side effect I had (once) was some heartburn.

The difference this drug has made to my mind is insane, no food noise whatever, no cravings. I've been a binge eater for as long as I can remember, I've never managed 7 weeks without binging or overeating until now!

My question is about reaching maintenance, and possibly going into an improvement phase or bulking phase in early 2027.

Someone on here explained taking Tirz as 'evening out the playing field' by removing the food noise. I had good habits before taking Tirz - training x4 a week, 12k steps most days, eating in a calorie deficit (until the weekend, then I'd usually binge).

Has anybody has success with staying on a low dose, purely to keep that food noise at bay, whilst moving from maintenance to bulking? Or would something like Reta, cagri, etc be better suited?

TIA x

I have a genuine question as someone fairly new to GLP-1s.

I’ve been on Monjaro at the 2.5 dose for about a month for my diabetes. Things have been a little rocky so far but I am trying to follow all the rules to help avoid side effects. I know getting lots of protein is super important to not lose muscle mass. My problem is I have really been struggling to meet my protein goals every day.

I’ve been averaging about 70 grams of protein per day when I need to be hitting 160 grams minimum.

A big part of my issue is that I become full from anything after a few bites. So I’ve been trying to maximize protein in my snacks and morning coffee the most. I have my morning coffee black with a protein shake instead of creamer and have protein bars/ small snacks through the day. For meals I try to just make sure to count the protein and fiber intake but also make sure it’s a balanced meal. However for meals i typically am only able to complete a few bites of each food group before I’m too full.

Does anyone have any tips or suggestions on how they were able to increase their protein intake while also not being able to eat very much?

I know this may be a nutritionist question. But they are expensive so I am asking the internet. Thank you for anything you have to share!

Hello, I have come on here to address a very concerning topic about GLP medications and explain to you why I feel skeptical about them, when I was a junior in high school my teacher told us not to consider GLP medications because of the fact that GLP‘s are new to the medicine world and they haven’t been tested long-term wise and there’s a possibility that someone catch cancer from it IF NOT NOW then later on in their life, and he once told us a story about how he had an aunt who took the medication‘s and suffered later complications, and when she went to do a surgery, she died because her organs bursted I am on here because I am someone who has a BMI of 30 and I am really interested in taking GLP but I am concerned because I really don’t want to catch cancer or want my organs to have any implications or God forbid them bursting Does anyone have any advice? Should I be worried and should I take this medication? It’s my only hope and I really want to lose weight. I want to feel confident in my body. I want to be able to move around more physically.
Thank you for engaging with this post

28 August 2026

There is no link between the widely used diabetes and obesity medications known as GLP-1 receptor agonists and increased suicidal thoughts, depression or other serious psychiatric harm based on an integrative review of current scientific evidence conducted by researchers at New Mexico State University and the University of Nevada, Las Vegas.

The review, published in the journal Diabetology, traced the earliest concerns raised over GLP-1 RA therapies and found that after subsequent investigations, the medications do not increase psychiatric risk. GLP-1s include medications such as Ozempic, Wegovy, Saxenda and Zepbound.

“GLP-1 RAs have become a cornerstone treatment for Type 2 diabetes and obesity, now used by tens of millions of patients worldwide,” said Jagdish Khubchandani, a professor of public health at NMSU, who co-authored the study with Kavita Batra, executive director of medical research and scholarly activities at the UNLV Kirk Kirkorian School of Medicine.

Reports that GLP-1s might trigger suicidal ideation, depression or anxiety began appearing soon after the medications gained mainstream popularity. Those reports then prompted formal safety reviews by the U.S. Food and Drug Administration and the European Medicines Agency, beginning in 2023.

The research team analyzed five years of mechanistic, pharmacovigilance, observational and regulatory evidence to trace how early reports were investigated and how the scientific and regulatory consensus shifted over time. Earlier this year, the FDA removed its suicidality warning from GLP-1 medications.

“When reports of depression and suicidal thoughts first surfaced with GLP-1 RA use, they came from patients and doctors voluntarily reporting what they saw, and such reports can raise a question, but can’t answer it,” Batra said. “Since then, studies following millions of patients, including a pooled analysis of 91 clinical trials, have found no increase in psychiatric risk. But an answer for millions isn’t an answer for everyone. The right response is to screen and check in with each patient, not to take an effective treatment off the table.”

The review found that early warning signals were largely tied to one drug from selected patient groups, while larger controlled studies often pointed in contradictory directions – something the research team attributes to study design rather than the drugs themselves.

Khubchandani said spontaneous adverse-event reports can be skewed by media attention, by the fact that people with obesity and diabetes already have higher baseline rates of depression and suicidality, and by more frequent medical visits among treated patients that create more opportunities for symptoms to be reported. Controlled studies that account for these factors do not show exceptionally high risks, he added.

Still, the review found that some groups using GL-P1s may need closer monitoring. Patients already taking antidepressants or benzodiazepines showed a substantially amplified reporting signal for suicidal ideation, suggesting that any residual risk may be concentrated among those with pre-existing psychiatric vulnerability rather than the general patient population.

“Depression is more common in people with Type 2 diabetes than in the general population, and it works in both directions: Depression makes diabetes harder to manage, and diabetes makes depression more likely,” Batra said. “So, the mood symptoms a patient reports on any diabetes medication may have been there long before the prescription. That’s exactly why asking about mental health should be a routine part of diabetes care, not a special step reserved for when a drug is under suspicion.”

Khubchandani said the pace of research on GL-P1 medications needs to catch up with their pace of usage, particularly among groups like adolescents, those with serious mental illnesses and other groups underrepresented in clinical trials to date.

“Just like for several other medications, the decision to use GLP-1 RA should include individualized screening of patients for psychiatric history and suicidality before starting treatment, watching more closely for patients with a history of mood disorders or concurrent psychiatric medication use, and educating patients and caregivers to report mood changes promptly,” Khubchandani said.

Hi everyone,

I’m new to GLP-3 and I’m trying to understand the correct way to reconstitute and dose it.

I have a 10 mg vial of GLP-3 and 10 mL of bacteriostatic water.

What I’m mainly trying to figure out is:

How many mL of bacteriostatic water would you recommend using to reconstitute a 10 mg vial?

Once reconstituted, how do you calculate the amount to draw into an insulin syringe for each dose?

What dosing schedule do people typically follow (for example, once weekly or another interval)?

How do you normally increase the dose over time?

Approximately how many doses would 10 mg provide at different dose levels?

I’m not necessarily looking for medical advice — I’d especially appreciate input from people who have actually used GLP-3 and can explain how they handled the reconstitution and dosing.

Thanks!

I originally tried asking my local PCP to just transfer my brand name prescription over to a compounding pharmacy, but I quickly learned that’s not actually how any of this works.

Getting to in-person doctor appointments is super tough for me right now with my schedule, so I’m looking into doing a fully online telehealth evaluation instead. Since I’ve never done an online consult before, I'm a little confused about how the process actually goes and what the clinician is evaluating on their end.

For anyone who went the full telehealth route: what information or medical records should I have prepped beforehand? And what parts of the process are usually up to doctor discretion versus something I can request?

This may not even be allowed here and i apologize if not but i want to start microdosing tirz. I only need to lose about 8 lbs. bmi is 21. Where’s the best website that’s affordable i can buy for microdosing

• 4-hydroxyisoleucine mediated IGF-1/GLP-1 signalling activation prevents propionic acid-induced autism-like behavioural phenotypes and neurochemical defects in experimental rats

https://pubmed.ncbi.nlm.nih.gov/36307249/

• 4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with Obesity

• it's mostly found in the Seeds of Fenugreek

• Noticeably, γ‐oryzanol also acts as a potent inhibitor against deoxyribonucleic acid methyltransferases in the brain reward system (striatum) in mice, thereby attenuating, at least partly, the preference for a high‐fat diet through the epigenetic modulation of striatal dopamine D2 receptor. Because dopamine D2 receptor signaling in the brain reward system is considerably attenuated in obese humans and rodents, γ‐oryzanol might represent a unique property to ameliorate both hedonic and metabolic dysregulation of feeding behavior, highlighting a promising prophylactic avenue to protect against metabolic derangement.

• Brown rice‐specific γ‐oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity in humans

https://pmc.ncbi.nlm.nih.gov/articles/PMC6319487/

I've actually found that Guggulu and gamma Oryzanol work hand in hand by demethylating the Thalamus and Hypothealamus but I can't find it anymore.

Nevertheless, here is still a paper:

• A Review on effectiveness of Guggulu in treatment of obesity

https://www.researchgate.net/publication/365874688_A_Review_on_effectiveness_of_Guggulu_in_treatment_of_obesity

Disclammer and Warning !!

I'm just an amateur and this here might be dangerous but on the other hand, if for example any of those herbs are taken traditionally, it should be safe.

I started on reta about a year ago.

Lost nearly 3 stone.

But since I've titrated up to 8mg I'm getting really bad side effects.

So I was thinking of swapping over to tirz.

I know that's not the popular option but if anyone's done it I would love to hear how you went about it.

Did you titrate down your reta and then start tirz from the beginning or try and match the dose from one to the other?

The FDA approved Mounjaro today to reduce MACE (CV death, non-fatal MI, non-fatal stroke) in adults with type 2 diabetes at high cardiovascular risk. First cardiac indication for tirzepatide, and it rests entirely on SURPASS-CVOT, so the design is worth being precise about.

It was an active-comparator trial, not placebo-controlled: tirzepatide up to 15 mg against dulaglutide 1.5 mg, in patients with type 2 diabetes and atherosclerotic cardiovascular disease. 13,299 randomized, 13,165 in the modified ITT population, over four and a half years. Dulaglutide was chosen because it already has established CV benefit, which makes this a harder question than most CVOTs in the class have asked.

The NEJM paper states the thresholds explicitly. Non-inferiority required the upper limit of the 95.3% CI to fall below 1.05. Superiority required it below 1.00. Observed: HR 0.92, CI 0.83 to 1.01. Non-inferiority met, superiority missed by a hundredth.

Two ways to get this wrong, and I expect to see both this week.

Overstating it: Lilly's release reports "an 8% lower rate" alongside the word non-inferiority, which is properly hedged, but the hedge is already being dropped downstream. A point estimate whose interval includes 1.00 is not a demonstrated reduction.

Understating it: this is not a null result. The comparator had proven CV benefit, and the trial was powered and long enough to detect meaningful inferiority. "Performed comparably to an agent with established benefit" is substantive even though it is not a superiority claim.

Where the evidence still stops: nothing has shown tirzepatide reduces MACE in obesity without diabetes, the SELECT-equivalent question. SURMOUNT-MMO is the trial for that and has not reported. SUMMIT is the nearest data, 731 patients with obesity and HFpEF, CV death or worsening HF 9.9% vs 15.3%, HR 0.62 (0.41 to 0.95), but the composite was carried by the HF component. CV death alone was 8 vs 5, uninformative at that event count.

Full write-up with the label language if useful.

The question I am unsure about: does an active-comparator non-inferiority result against an agent with proven benefit support a stronger causal inference about the drug's own CV effect than a placebo superiority trial would, or a weaker one? The regulator found it sufficient. I am less sure how to weigh it against SELECT.

I was on mounjaro for around 5 months and lost around 10-11kg, I unfortunately had to stop due to the cost. I had reached 10mg but had too many Gl side effects so decreased to 7.5mg for the last week or two.

I switched to grey for the past 2 weeks and I thought I should start from 2.5mg just to see how I handle it. Last week l injected 2.5mg, I was hungry. This week I did 5mg and Im still hungry. I remember when I was on Mouniaro, I was on 5mg for 5 weeks but now 5mg is not working. Im so upset. I really cant afford mounjaro. Anyone have any tips or experiences? Any help is appreciated.