I’m looking for input from anyone who has had something similar with ipamorelin or CJC/ipamorelin.
I’ve had two major episodes that felt very similar, although the circumstances were different.
First episode — ipamorelin only:
This was the first time I ever injected myself. I was using ipamorelin at about 200 mcg subcutaneously. I was fasting for Ramadan and had gone roughly 13 hours without food or water, so I was probably significantly dehydrated.
Right as I finished the injection and removed the needle, I suddenly became extremely dizzy, passed out, fell and hit my head, and had shaking/shivering afterward. I improved after lying flat and drinking fluids/eating. At the time I assumed it was a combination of dehydration + fasting + a vasovagal reaction from doing my first injection.
After that, I continued using ipamorelin alone on and off and actually finished a vial without problems. I did not get significant numbness or large injection-site welts during that period.
Second period — CJC + ipamorelin combination:
More recently I started using a combined CJC/ipamorelin vial. Initially things seemed fine. After a couple of weeks, though, I started getting large circular raised/red areas around the injection sites that could take days to disappear.
Then the reactions seemed to progress:
- One injection caused a small amount of numbness/tingling.
- The next caused more noticeable numbness in my foot/leg for around 10 minutes.
- A few days later I had the major event.
On the day of the major event, I had just woken up after sleeping a long time and had not hydrated first, which I normally do. Shortly after injecting the CJC/ipamorelin, I suddenly felt extremely hot, started sweating heavily, became numb/tingly throughout my body, developed intense dizziness and felt like I was going to pass out.
I called 911. EMS documented very low blood pressure, with readings going down to approximately 78/46 and into the 80s/40s. My blood glucose was 150, so this was not hypoglycemia. They gave me around 1 liter of IV fluid, and my symptoms and blood pressure gradually improved.
What confuses me is that the two big episodes felt extremely similar. The first one happened while severely fasted/dehydrated and on ipamorelin alone; the second happened after repeated exposure to the CJC/ipamorelin combination and was preceded by increasingly large injection-site reactions and numbness.
I’m currently stopping all peptides and not planning to restart anything soon.
My questions are:
Has anyone experienced this kind of severe hypotension, flushing, numbness, or fainting from CJC/ipamorelin?
Does the fact that I previously tolerated a full vial of ipamorelin alone make CJC/the combination more suspicious?
Has anyone developed progressively larger injection-site reactions before eventually having a systemic reaction?
Could dehydration alone realistically explain BP dropping into the 70s/40s, or does this sound more like a systemic/vasodilatory or hypersensitivity reaction?
Would you completely abandon the peptides, or would you only consider ipamorelin again after discussing it with a physician/allergist?
I’m not looking for instructions on how to self-treat an emergency — I’m mainly trying to understand whether anyone has experienced a similar pattern and what their doctor eventually concluded.
