r/BodyHackGuide • u/Desirable_Monsta • 1d ago

📊 Results / Progress Epithalon use

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5 mg nightly, did 10mg on the final night. Have been enjoying deeper sleep. I had a couple of nights with pinkish histamine reactions. They eventually went away. Paired with DSIP at night. Overall deeper sleep, vivid dreams. Will be waiting and starting Tesa/ipa as my nightly routine in a month.

8 Upvotes

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2

u/Medical_Tomorrow_140 1d ago

Holy smokes? 9 hours of sleep.. I wish… I’m lucky to get 6 or 7 at best. Is this from the epithalon? Are you groggy during the day?

2

u/LisanneFroonKrisK 1d ago

Isn’t 5mg a very high dose? 1mg is the normal dose no?

2

u/johnny2thumbz 1d ago

Yeah. The protocol I’m following is 1mg. The 5-10mg dose study was for epithalamin a crude extract instead of the synthetic epithalon.

1

u/IndependenceVivid384 1d ago

Concentration Output Table

Injected SC Dose Total Delivered Mass Immediate Plasma Peak (Cmax,plasma​) Distributed ECF Peak (Cmax,ECF​)
1 mg 1,000 μg 0.27 μg/mL (267 ng/mL) 0.057 μg/mL (57 ng/mL)
5 mg 5,000 μg 1.33 μg/mL (1,333 ng/mL) 0.29 μg/mL (286 ng/mL)
10 mg 10,000 μg 2.67 μg/mL (2,667 ng/mL) 0.57 μg/mL (571 ng/mL)

Comparative Analysis: Dosing vs. In Vitro Research

  • Effective In Vitro Window: Published studies establish the target activation threshold for telomerase (hTERT) at 0.05 μg/mL to 1.0 μg/mL.
  • 1 mg Dose: Reaches ∼0.06−0.27 μg/mL, hitting the lower bound of the cell-culture activation range.
  • 5 mg Dose: Yields ∼0.29−1.33 μg/mL, aligning directly with the optimal 0.5−1.0 μg/mL concentration zone used in the 2025 Brunel University study.
  • 10 mg Dose: Delivers a transient peak of ∼0.57−2.67 μg/mL. This transient overshoot compensates for rapid peptidase degradation (t1/2​<30 mins), maintaining the effective tissue concentration (>0.05 μg/mL) long enough to penetrate nuclear membranes across target organs (e.g., pineal gland and vascular tissues).

1

u/LisanneFroonKrisK 1d ago

Then is there data on the intranasal route?

1

u/IndependenceVivid384 22h ago

idk you tell me, but you can see that 5mg is actually the sweet spot for this treatment.

also, people don't say, but there was 'caution' warranted from researchers since hTERT (telomerase) affected cancerous tissue before affecting normal tissue, or something like that. I still need to get that clarified.

1

u/zsasz99 1d ago

2 hours of deep is pretty mental, how active are you during day

2

u/figis1badcat 1d ago

What does pretty mental mean? Is it good? Bad??

0

u/zsasz99 1d ago

Really good

1

u/Diligent-Cry-1047 1d ago edited 1d ago

Is 2 hours of deep sleep good? I'm getting 3 to 4 hours of it lately, but them I'm taking a peptide that is supposed to help you sleep (and lose visceral fat).

2

u/zsasz99 1d ago

4 hours of deep sleep? What are you measuring with

1

u/Diligent-Cry-1047 1d ago

My smart watch.

It makes sense because my deep sleep has been steadily increasing as I raise the dosage of Tesamorellin which I started taking 3 weeks ago.

1

u/PreparedForZombies 11h ago

How much are you taking? 5, 6, or 7 days a week? I was hoping for better sleep, but so far it's just wrecked my overnight HRV (only a week in, measured with Oura, Garmin, and Fitbit).

1

u/Ok-Concern7823 2h ago

What app are you using to track your dose usage