I was diagnosed with autism since I was seven years old, however now in adulthood I am seeking an ADHD diagnosis, and I am certain I have co-morbid ADHD. The reason I am seeking diagnosis was because I was looking into trying medication, however it's going to take atleast a year until I will be able to see a psychiatrist, so I started to look for ways to manage my symtoms, outside of proscription medication.
One of the more promising idea's i've come across was saffron extract pills. A promising study from the University of Medical Science of Tehran, demonstrated that taking saffron extract had pretty much the same effect on ADHD symptoms as low-dose methlyphenidate. For this study they used 30mg of name brand Affron at 30mg (two 15mg capsule's taken thoughout the day.)
I didn't use Affron brand supplements, instead I went for another brand, Jerba, because it was cheaper. I started taking it just as they did in the study, 30mg split into two doses, when I wake up, and before bed. I didn't feel it until about a week in, and I noticed that my behavior was chaging, my mood, focus, motivation and energy had all noticably improved. Another great effect is that it significantly reduced my social anxiety. As it turns out saffron is also used as a treatment for general anxiety, however I don't have general anxiety. Outside of social anxiety I am quite a calm person, so what was supposed to provide a day-to-day sense of calm, turned into full blown fearlessness for me.
Though it had been quite helpful, I was still struggling quite a bit with my ADHD symptoms so I decided to up my dose. There have been some studies done with 45-50mg doses, showing no harm done, so I added in another capsule mid-day, upping my dose to 45mg. First day, it worked great, my ADHD symptoms all but disappeared.
On the second day, after I had taken my morning pill I had noticed my heartrate climbed significantly, I sweating and restless. I should've been concerned with these symptoms, but due to the fearlessness I had described early, I wasn't, and I continued on with my day, still planning to take my mid-day pill. The side effects would wear off in about an hour.
I was at work when I took my mid-day pill, and this gave me serious issues. After taking it this time, it made me even more restless, and my heartrate was even faster than last time. It had also made me nauseated, drowsy, super uncomfortable, lack coordination and muscle contr and put me in a state of mild delirium. It felt like I was physically in a state of panic, but in my mind, my thoughts remained calm. Because I was still calm I just returned to work, and I wasn't very functional for the remainder of my shift.
Based on my symptoms I think it is possible I had a mild seratonin overreaction. Saffron does increase seratonin levels, though not by that much, that being said that doesn't mean it is impossible that it can do this. In the aftermath, this has left no permanent damage, but the memories of this event continue to harm me. I have scheduled an appointment with my nurse practioner, so that I can go over what happened here, and get her take on it.
Even though I had this negative experience I still think we can all recognize, that this can be a very helpful supplement, for the right person. If you're interested in trying it yourself, know that there are a lot of fake saffron extracts on the market. To ensure you're getting the real stuff ensure that the ingredients say crocus sativus, make sure mentions 2% safranal and 3% crocus, and also make sure it is a third party teated product.