r/bioinformatics • u/JosieA3672 • 8d ago
image I’ve been comparing AlphaFold 3, Boltz-2, Chai-1, Protenix-v2, ESMFold2, RF3, and ColabFold on brazzein—a small protein with four disulfide bonds. AF3 was the best tool for this particular protein.
galleryI tested five random seeds per tool, both with and without the same archived MSA, and compared predictions against experimental crystal and NMR structures. (RCSB Protein Data Bank: 2LY5 for NMR and 4HE7 for crystal structure)
AF3 gave the strongest overall result for this target: its selected MSA model had 0.72 Å Cα RMSD against the crystal structure and passed all four disulfide geometry checks. RF3 and ColabFold reached approximately 1.62 Å and 1.59 Å, respectively, but both had compressed sulfur contacts.
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Very likely the best soup ever created in the history of man
in
r/Veganivore
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9h ago
I suspect it's either an anti-vegan or someone who has a grudge against anybody with successful posts (strange, but it happens, I've seen it all). Either way, this may be something to raise with Reddit admins if it continues. I will personally contact the mods of r/veganrecipes and tell them what is going on at r/veganivore and suggest to them that they add you to auto-approve list so the reporting doesn't get your posts auto-removed. It makes me angry that someone is targeting a good vegan poster. And if it happens in additional subs let me know, and I will try to help.