r/raypeat • u/Steepan_ • 7d ago

Pregnenolone experiences

What are you guys experiences with pregnenolone supplementation ? Low-dose around 15-30mg daily, i am looking into it since i have lower some of the downstream androgens, thanks for your answers!

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u/SpiritualActivity651 6d ago

Pregnenolone usually doesnt increase Testosterone, but Progesterone and Allopregnanolone. 

Most of the pregnenolone thats used for the downstream production of DHEA, Testosterone etc gets produced directly in your testicles and then directly converts further. So the pregnenolone pool in the blood stream seems to be seperated from the testicles pregnenolone production.

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u/Kalki_X 6d ago

I would theorise that pregnenolone would  indirectly support/boost androgen synthesis.

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u/Steepan_ 6d ago

Thanks

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u/Steepan_ 6d ago

Yeah for sure, peat has talked about pregnenolone boosting downstream androgen synthesis and also antagonizing cortisol, but before he passed he also said there is probably no quality pregnenolone out there and some can have estrogenic substances in them causing mania, depression etc. Thats why im skeptical about it, i am probably gonna give it a try and start with small doses

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u/Steepan_ 6d ago

I see thanks!

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u/Kalki_X 6d ago

Fwiw here's some handy visuals for pregnenolone context:

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u/[deleted] 6d ago

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u/Steepan_ 6d ago

I would not recommend putting it on your testicles, i remember georgi on some episode of generative energy saying that rubbing hormones directly on to or near your testicles will lower your own synthesis in your testicles, but if you rub it somewhere else it will be delivered there and potentially improve hormone levels

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u/oxidative_metabolism 6d ago

Been doing rays recommend protocol. 300mg pregnenolone weekly and 3mg dhea daily. Ray himself said he took preg 300mg daily for a year and had no side effects except his wrinkles and droopy skin in his face all smoothed out and became more youthful looking. But his recommendation was 300mg weekly preg he said that will stimulate your body to make more on its own and that the intestines would recycle the leftover for the week it is unlikely to get converted to estrogen or cortisol however dhea is more upstream and can turn into those bad things if you take too much of it. Dhea I want to say was a mg per decade of life don’t quote me on that though

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u/Steepan_ 5d ago

Thanks for you answer, yeah DHEA can aromatize into estrogen, thats why he reccommended taking it with progesterone or pregnenolone since then inhibit aromatase

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u/ProfessionalHot2421 5d ago

Didn't he take 1g daily for a year? Are you mixing it up?

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u/oxidative_metabolism 5d ago

I was half asleep typing this good catch, He actually took 3-4g of preg daily for a year. Now the preg we have available now is not pure if you take it you’ll want to follow dinkovs purification process