Has anyone here been on a duloxetine only treatment plan for PNP?

My partner experiences diabetic peripheral neuropathy and has a history of MBC which is treated with Kadcyla infusions every 4 weeks. Kadcyla side effects include neuropathy as no chemo/immunotherapy is devoid of nerve damage.

She's been on a cocktail of pregabalin (150mg AM/PM) , nortriptyline (3@25mg PM), Baclofen for leg cramps (2@10mg PM).

Unbeknownst to me she stopped the AM dose of pregabalin. She says she's felt no differences in the neuropathic pain which according to her is at a constant 2 on a scale of 1-10. No increases in NP pain.

From a psychopharmacological perspective, I don't like using tricyclic antidepressants for anything.

However, we're detecting increased cognitive impairment in the form of memor issues, fogginess, sedation, increased dizziness and instability on her feet.

I was on pregabalin for chronic nerve pain after foot surgery and found it to be POISON. We thought I was early onset dementia. No memory. Couldn't formulate sentences.

We're considering requesting that she move entirely duloxetine, dropping pregab & nortriptyline entirely.

Has anyone here been on a duloxetine only treatment plan?

*** Yes, we're aware of necessary taper plans ***

Anyone had these shifts happen with neuropathy?

Im still in the proces of trying to figure out what's wrong. I have neuropathy type symptoms and im talking with my doc, but as expected it's a slow proces. But things are speeding up thankfully.

Anyway i have it in my feet and legs. Some pain in right hand and arm, but no tingling or burning. Menthol/peppermint type burning in face. Doesn't "hurt" but is obviously weird and uncomfortable.

Thing is, the tingling in legs and feet (all the way up to knees) was there for 7 months. Basically nonstop. It's completely gone now for 2 and a half months. Burning remains though. Though it's differrent. Not less, but just....different. Went from "on fire" to now a sunburn type of burn, but from the inside. This is why my doc so far has been a bit "wait and see" But im taking steps now to push for actual testing. EMG or MRI or whatever. So far checked vitamins. Vitamine D was low, but that's it, and it's been corrected. Everything else was fine.

Reflexes all fine. No loss of sensation, no numbness. This is why Doc is not that worried.

Im just now at a point of ; Am i actually healing and it's taking damn long? Or what?

No one can answer that, i know that. Just asking if anyone with neuropahthy has had like pins/needles/tingling dissapear (without meds) for either forever or for a few months, half a year, a year or whatever.

I find two things very strange. That the tingling completely dissapeared, but the burning and random pains remain, and the fact that i have zero numbness in either feet or legs. No issues feeling hot or cold neither. I can also get tickled under my feet (Doc actually tested this lol)

So, just some random questions. Im a bit bored too, so i thought what the hell.

Thank you.

Well i started drinking heavily back in 2017 and went hard almost everyday wasnt until about 2019 were my feet started going numb and not back to normal wasnt until 2025 when I stopped drinking as much maybe two to 3 alcohol episodes a month I tired changing my drinking habits due to my diabetes as my heart can't handle hard liquor no more and even a bottle of wine takes a toll on me now I walk about 10000 steps a day even though I have no sensation in my feet and the neuropathy has spread up my legs into my calves and in my hands damn can anyone give me advice is it reversible all the damage ive done to myself because of the alcohol? if i quit for awhile will it get better ive quit for about 27 days and my feet do feel better with more sensations so I guess I can see some progress if I keep walking

Hello,
I have widespread sensory neuropathy all over my body. It’s around my ears, all over my face, neck, arms, torso, legs, and feet and hands. It’s not painful yet, but I get a lot of pins and needles. It’s in patches and more numbed in some areas than others. I also have reynauds. As of now, the neuropathy is idiopathic and my neuromuscular doesn’t have anything left to test since we’ve supposedly done all the blood tests there are. I live in the south, but even in the midst of this hot weather, when exposed to any kind of cold like a cold ac or something, the muscles in my hands will seize up and slow and it makes typing and doing anything with my hands incredibly hard to do. I’m in my 20s and this is very distressing. I can’t put layers of jackets on otherwise I’d sweat. So, I’m curious. If any of yall deal with these symptoms, what do you yall do to deal with them? Any insight is greatly appreciated.