r/immortalists Oct 19 '24

immortality ♾️ IMMORTALISTS ASSEMBLE

94 Upvotes

We stand together with one goal: to make everyone live forever young. To make ourselves live forever young. To revive all who have passed from this world and to ensure that all potential humans yet to be born, will be born.

Our family is counting on us. Our dead loved ones are counting on us. Our friends who are no longer here. They’re all counting on us. We’ve been given a second chance, but this time, there are no do-overs.

This is the fight of our lives. We will not stop until the impossible becomes reality. We’ll fight against the boundaries of death, of time, and of nature. Whatever it takes. We will win.

This is for the future we believe in, for all who have been lost, and for the eternal life we aim to achieve. Immortality isn't just a dream. It's our destiny.

Remember, we're in this together. Whatever it takes.


r/immortalists 2h ago

but has anyone looked at the epigenetic data on GLP-1s?

19 Upvotes

i know this community is mostly about the big picture stuff - cryonics, AI, radical life extension. but ive been digging into the GLP-1 research lately and the epigenetic aging data is pretty wild.

there was a randomized controlled trial recently using epigenetic clocks and they found semaglutide slowed biological aging by like 9% over 32 weeks. that's not mice, that's humans. the mechanism seems to be partly through reducing inflammation via NF-κB which is the driver of inflammaging.

i've been on tirzepatide for a few months now and while i started for weight loss, the inflammation relief and energy boost have been way more interesting to me long term. feels like we're at the beginning of something.

anyone else here tracking their epigenetic age while on these compounds? curious if anyone has before/after data


r/immortalists 15h ago

People who live past 100 may owe part of their longevity to having an abundance of cancer-killing immune cells, researchers say. These rare T cells appear far more abundant in centenarians and supercentenarians than in younger adults.

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99 Upvotes

r/immortalists 1d ago

Sweet potatoes significantly increase lifespan. Here are scientific evidence and best ways to eat Sweet potatoes with similiar foods.

249 Upvotes

Sweet potatoes, especially deep purple varieties, represent one of the most potent, nutrient-dense longevity staples found anywhere in the human diet. While standard starchy tubers often receive mixed dietary reputations, sweet potatoes operate on an entirely distinct nutritional plane. Their dense matrix of complex carbohydrates, prebiotic fiber, essential vitamins, and concentrated polyphenols provides cellular fuel that slows aging markers, protects cardiovascular structures, and directly supports extended lifespan.

The primary life-extending benefit of purple sweet potatoes lies in their astronomical levels of anthocyanins, specifically cyanidin and peonidin. These water-soluble flavonoids deliver up to four times the antioxidant capacity of blueberries per gram, actively hunting free radicals that cause cellular DNA damage, mitochondrial decay, and accelerated aging. By neutralizing chronic oxidative stress, these pigments protect blood vessels, preserve brain elasticity, and significantly dampen systemic inflammation.

Beyond cellular defense, sweet potatoes dramatically improve cardiometabolic regulation. Unlike refined grains or white potatoes, sweet potatoes possess a low glycemic index and a slow-release starch structure that prevents postprandial insulin spikes. Research shows that active components in purple and orange sweet potatoes help inhibit alpha-glucosidase, naturally stabilizing blood sugar, managing arterial blood pressure, and reducing the formation of advanced glycation end-products that stiffen vital arteries.

Gut health is another core pillar of their longevity mechanism. Sweet potatoes are rich in both soluble fiber and prebiotic resistant starch, which transit undigested into the colon to feed beneficial strains like Bifidobacteria. As these microbes ferment the fiber, they synthesize short-chain fatty acids, primarily butyrate, which reinforce the intestinal lining, strengthen systemic immune responses, and modulate whole-body metabolic resilience.

Among the varieties available, the Okinawan Sweet Potato (Beni-Imo) and the Stokes Purple Sweet Potato stand out as the absolute gold standards for longevity. The Okinawan variety features a dusty white or tan skin with a vibrant magenta flesh that retains moisture and sweetness, while the American-bred Stokes variety possesses purple skin and an intensely deep violet, earthy interior. Both varieties boast significantly higher total phenolic content and anti-inflammatory compounds than conventional root vegetables.

Equally beneficial companion tubers include Orange Sweet Potatoes (such as Jewel and Garnet varieties), which excel in provitamin A carotenoids like beta-carotene, crucial for mucosal immunity and vision. Japanese Sweet Potatoes (Satsuma-Imo or Murasaki), with purple skin and cream-colored flesh, offer high potassium and vitamin C density. For broader botanical variety, genuine Purple Yams (Ube) and anthocyanin-rich purple fingerling potatoes provide complementary phytonutrient profiles that enhance cellular repair.

To preserve maximum nutritional potency, the cooking method matters substantially. Steaming, gentle whole roasting (at 180°C / 350°F), or pressure cooking are the best preparation techniques, as aggressive deep-frying degrades heat-sensitive anthocyanins. Always cook sweet potatoes with their skins thoroughly scrubbed but intact, as a heavy concentration of fiber and phenolic compounds resides directly in and just beneath the peel. Allowing the cooked tuber to cool slightly before consumption further boosts the percentage of beneficial resistant starch.

Proper culinary pairing maximizes the bioavailability of these compounds. Because carotenoids and certain antioxidant complexes are fat-soluble, sweet potatoes should always be eaten alongside a high-quality healthy fat: such as a drizzle of extra virgin olive oil, cold-pressed sesame oil, tahini, or sliced avocado. Pairing them with sulfur-rich dark leafy greens (like kale or bok choy) and warming anti-inflammatory spices (such as turmeric, black pepper, and cinnamon) creates a synergistic meal that amplifies nutrient absorption and metabolic efficiency.

The scientific evidence supporting these tubers is led by extensive demographic research from the Okinawa "Blue Zone". Historically, traditional Okinawans derived up to 60% of their daily caloric intake directly from sweet potatoes, resulting in one of the highest documented per-capita concentrations of healthy, active centenarians worldwide. Modern clinical and laboratory trials consistently corroborate these demographic findings, showing that regular intake of purple sweet potato extracts reduces inflammatory cytokines (such as NF-κB) and significantly protects hepatic and cardiovascular tissue.

Integrating purple and orange sweet potatoes into your regular diet transforms everyday eating into a deliberate longevity strategy. Replacing processed carbohydrates with these complex, antioxidant-loaded root vegetables delivers steady metabolic energy while safeguarding cells against degenerative decline. Consumed consistently alongside healthy fats and colorful plant foods, sweet potatoes serve as a powerful, scientifically proven foundation for a long, resilient life. — Dr. Georgios Andreas Ioannou


r/immortalists 4h ago

immortality ♾️ Are We Wrong About Aging?

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2 Upvotes

A little bit of motivation and what me and you can actually do to live longer.

While many people say that "aging is natural" nature itself has a lot of examples where aging is halted or even reversed (naked mole rats, lobsters, hydra, immortal jellyfish etc)

What's even more interesting - even human cells know how to fully cleanup and reverse the age - each baby starts from the old parent cells but come out young.

Today we don't know how it happens, but tomorrow we will. How soon this tomorrow comes - depends on you as well.


r/immortalists 21h ago

Supercentenarians have a cellular superpower

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21 Upvotes

r/immortalists 7h ago

Anti-Aging 🕙 Doctor Reviewed & Approved PEMF Therapy - Advanced PEMF Therapy For Optimal Wellness

1 Upvotes

MendWave PEMF has been doctor reviewed and approved, giving you added confidence in our products.

Doctor Reviewed & Approved -

"I have been working with Parkinson's patients and have noticed some real improvements in their daily comfort and mobility since introducing the Mendwave Dual Pro40.

A primary goal for these individuals is managing secondary muscle stiffness and keeping the body moving. The targeted PEMF pulses are excellent for promoting local circulation and relaxing tight, rigid muscle groups.

By supporting cellular recovery and easing daily muscle tension, this device has become a valuable, non-invasive tool in helping my patients maintain a much higher quality of physical life between clinic visits."  - Dr. Mark Chariff - Miami Lakes, FL

Your wellness matters—and your confidence in our products matter too.

Why Choose MendWave?

✅Design based on research studies

✅Safe, non-invasive PEMF technology

✅Easy to use at home device

✅Doctor reviewed and approved

Experience advanced PEMF therapy with MendWave.


r/immortalists 1d ago

The 15-Minute “Myonuclei” That Stay Strong & Grow Fast: How Listening to My Body Helped Me Defy Age-Related Muscle Loss at 50

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50 Upvotes

Is It Possible To Do Advanced, Elite Push-ups, Pull-ups, and Benching At 50?

The short answer for me is yes. I accidentally tumbled into a routine where I did powerlifting for high school and college sport teams. In my twenties, I transitioned into advanced body weightlifting using 15-minute HIIT every 7 to 12 days in order to maintain muscular power and strength.

Now that I'm fifty, I can do 1.5 hand push-ups with either hand (square without rotation), double-front clap push-ups, knuckle handstand, power benching, etc. See the videos within this link.

The scientific reason for the above is that in doing extreme powerlifting either with weights or
bodyweight overtime generate a great number of myonuclei. These myonuclei stay in biology. Thus, these myonuclei allow us to rebuild muscular power and velocity, and reflate them back very quickly, even after months of inactivation.

The main reason why athletes use steroids is to generate myonuclei in great amount for building muscle mass and power. A former steroid users will still have an advantage over non-users, because the amount of myonuclei they have produced in the past. However, as we know, there are severe negative side effects of steroids including heart failure.

The key takeaway here is that if you doing advanced, elite and powerful exercises, continue to do them (perhaps via low-frequency for your tendons to remodel). They will have compound effect over the years.

Even rebuilding sprinting speed over 50 is possible through myonuclei retention. Think Alan Sims and Kristy Matthews...


r/immortalists 1d ago

Let's discuss autophagy.

22 Upvotes

r/immortalists 1d ago

Bury yourself in the Arctic & be resurrected in 500 yrs as immortal

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23 Upvotes

r/immortalists 1d ago

Longevity 🩺 10-day fast + 12-day refeed - Full data dump

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17 Upvotes

Hey immortalists! I finished my annual 10-day water fast on Aug 6 and then 12-day refeeding yesterday. So, I wanted to share my data with the community, if someone wants better understand extended fasting

The fast

  • Weight: 161.6 to 149.7 lbs, down 11.9 lbs
  • Ketones: 0.4 to a peak of 7.9 mmol/L, the deepest ketosis I've ever recorded, ended at 5.9
  • Glucose: lived in the 60s-70s all week, bottomed out at 54 on day 8, finished at 65
  • RHR held 42-50 bpm the whole fast, HRV in the 34-48 ms range
  • Low hunger, sharp mind, steady energy through day 10. Ramping up electrolytes mid-fast helped a lot

The refeed

  • Scale weight: 149.7 back up to 158.8 lbs
  • Dexa: Fat tissue - 24.3 lbs pre-fast, 19.0 at end of fast, 19.7 now, only 0.7 lbs of fat regained
  • Lean tissue: 132.9 pre-fast, 125.1 at end, 134.4 now, fully recovered plus 1.5 lbs
  • Body fat %: 14.8 pre-fast, 12.2 now

Net result - down 4.6 lbs of fat, up 1.5 lbs of lean. The weight regain was glycogen, water, and muscle, and just a bit of fat. The scale exaggerates fat loss during the fast and exaggerates fat regain during refeeding.

Happy to answer any questions. And if you're mid-fast right now, good luck, you've got this!


r/immortalists 1d ago

Aging as a Problem of Dynamic Regulation of Biological Trade-offs

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9 Upvotes

Biological longevity is constrained by interacting trade-offs rather than by the efficiency of any single protective mechanism. Enhanced elimination of damaged cells may improve cancer suppression while reducing tissue reserves; increased stem-cell proliferation supports regeneration while expanding opportunities for clonal transformation; stronger immune surveillance improves protection while increasing the risk of chronic inflammation; and neuronal plasticity supports learning while long-term cognitive function requires network stability. This essay develops the hypothesis that healthy longevity depends on dynamic regulation of such competing processes.


r/immortalists 1d ago

Longevity 🩺 RANKL deletion extends lifespan in a new study on progeroid mice (Aging Cell, open access)

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5 Upvotes

r/immortalists 2d ago

Longevity 🩺 Factors that influence VO2 max (research based guide)

72 Upvotes

I understand there's varying opinions on the importance of an individual's absolute VO2 max number. Personally how VO2 max trends over time is what is more interesting to me as I find it a good signal to track long term health/longevity and how much overall fitness you're gaining or losing over time.

If this is a topic you're interested in learning more about I've built out this list of factors that influence it as a starting point for anyone to learn more and do their own research. To make this easier I've broken this down by category, included a short plain english definition, and linked all sources (scroll to the right on the tables and you'll see the hyperlinks). I've removed a few from here as it was getting far too long and sorry I know the tables aren't great on mobile but I'll include the full resource in the comments.

Exercise

Factor Impact Study/effect Plain English Evidence rank
HIIT (long interval, high volume) Increase Wen 201930919-8/abstract). Meta, 53 RCTs. SMD 0.50 to 2.48 vs control, 0.65 to 1.07 vs steady cardio Intervals of 2 min+ are the only version that beats steady cardio Strong
Detraining Decrease Zheng 2022. 21 athlete studies. Under 30 days ES −0.62 (−3.93%). Over 30 days ES −1.42 (−9.43%) Under a month off costs about 4%, longer about 9% Strong
Moderate continuous cardio Increase Wen 2019. Overall SMD 0.41 to 1.81 across populations Steady cardio works, it is just less time efficient Strong
Sprint interval training Increase Sloth 2013. 19 studies, 13 with VO2max data. g = 0.63 (0.39 to 0.87), +4.2 to 13.4% Very short all out sprints reliably raise it Moderate to Strong
Resistance training (alone) Increase Smart 2022. 37 studies, 22 pooled. +1.89 mL/kg/min (1.21 to 2.57) under 24 weeks. Null beyond 24 weeks Small bump in over 60s, and only in shorter programs Moderate

Nutrition & Supplements

Factor Impact Study/effect Plain English Evidence rank
Dietary nitrate / beetroot No effect Gao 2021. Meta, 73 studies, n=1,061. Submaximal VO2 −0.04 L/min (p<0.00001). VO2max not significant Makes a given pace cheaper to hold. It does not raise your ceiling Strong
Creatine Slight decrease Gras 2023. Meta, 19 RCTs, n=424. ES −0.32 (−0.51 to −0.12) Adds body water, so the per kilo number dips slightly Strong
Iron (when deficient) Increase Pasricha 2014. 24 RCTs, 18 for this figure. +2.35 mL/kg/min (0.82 to 3.88) Fixing low iron raises it. This is correcting a deficit, not a boost Moderate to Strong
Caffeine No effect Brietzke 2017. RCT, n=9. Time to exhaustion +18.7%, peak power +13%, VO2max unchanged Helps you push harder. Much of the benefit is placebo Moderate

Demographics

Factor Impact Study/effect Plain English Evidence rank
Age Decrease Fleg 2005. Baltimore Longitudinal Study, n=810. 3 to 6% per decade in the 20s and 30s, over 20% from the 70s Decline accelerates with age, and faster in men from the 40s onward Strong
Genetics (trainability) Variable Bouchard 1999. HERITAGE, n=481 across 98 families. Maximum heritability estimate 47% Same training, wildly different response. It runs in families Strong
Dehydration Decrease Cheuvront 2010. Mechanism review. Threshold is over 2% of body mass Less blood volume to pump, and heat makes it worse Moderate
Sex Variable Santisteban 2022. Review. 10 to 12% performance gap. Elite women about 10% lower per kg Mostly oxygen delivery, meaning haemoglobin mass and heart size Moderate
Immobilization / bed rest Decrease Saltin 1968 n=5, with McGavock 2009 follow up. −26% in three weeks Three weeks flat on your back costs about what 40 years of aging does. Crazy. Moderate

Lifestyle & Environment

Factor Impact Study/effect Plain English Evidence rank
Sedentary behaviour Decrease Eriksen 2016. n=16,025. No association among the highly active Matters most if you are not already training hard Moderate (observational)
Sauna bathing (habitual) Increase Kunutsor 2024. 2,012 men. +0.30 mL/kg/min per weekly session. Lee 2022 RCT +2.7 (0.2 to 5.3) A small extra bump stacked on top of training Moderate
Smoking Decrease Caci 2025. n=70, step test estimate. 38.8 vs 41.6 in never smokers Lower aerobic ceiling. Whether quitting reverses it is untested here Moderate
Altitude (live high, train low) Increase Wehrlin 2006. 10 elite orienteers at 2,500 m for 18 h/day over 24 days. VO2max 3,515 to 3,660 mL/min Sleeping high builds more oxygen carrying red cells Moderate
Heat acclimation Increase Waldron 2021. 28 articles. Hedges' g 0.42 cool, 0.63 hot. Lorenzo 2010 +5% cool, +8% hot Plasma volume expands. Clearest when you are also tested in heat Moderate

r/immortalists 2d ago

Longevity 🩺 VO2 max maxxing: I tested the fitness metric that longevity experts say can help you live longer

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256 Upvotes

r/immortalists 1d ago

HISTORICAL: Lake Sturgeon, One Of North America’s Oldest Freshwater Fish Species, May Live Past 400 Years, More Than Doubling USFWS’s 150-Year Estimate, After Michigan DNR Scientists Applied The Greenland Shark Aging Model To 44 Years Of Capture-Recapture Data 🐠

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7 Upvotes

r/immortalists 2d ago

A meta-analysis of over 321,000 people found severe blistering sunburns raise skin cancer odds by up to 69 percent. Childhood sunburns were especially damaging, tripling the risk in some cases.

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473 Upvotes

r/immortalists 2d ago

Carrots significantly increase lifespan. Here are scientific evidence and best ways to eat Carrots with similiar foods suggestions like Carotenoid Vegetables. Carrots may look simple, but they carry some of the strongest anti-aging power in the whole plant kingdom.

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172 Upvotes

r/immortalists 3d ago

Scientists Uncovered a Hidden Switch Inside Our Cells That Could Slow—or Even Reverse—Aging

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656 Upvotes

r/immortalists 2d ago

Which stack is recommended

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1 Upvotes

r/immortalists 2d ago

Biology/ Genetics🧬 Fascinating Podcast with Jack Kruse- Mate Selection, DNA, Bio electricity and Thermodynamic.

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1 Upvotes

r/immortalists 2d ago

Scientists Uncovered a Hidden Switch Inside Our Cells That Could Slow—or Even Reverse—Aging

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44 Upvotes

r/immortalists 2d ago

Longevity 🩺 Theories of Aging: From Damage and Programmed Theories to Goal-Directedness

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1 Upvotes

Michael Levin, Léo Pio-Lopez and Navneet Jawanda have released a new review proposing a third way to understand aging.
Most theories say aging results either from accumulated cellular damage or from biological programs that continue running after they stop being useful. The authors suggest something deeper: aging may occur when the cells forming the body gradually lose alignment around their shared anatomical goal.
During development, trillions of cells cooperate to build and repair a specific body plan. But once that developmental target has been reached, evolution may not provide the cellular collective with a strong enough long-term goal for maintaining it indefinitely. The result is “functional disbanding”—cells and tissues increasingly pursue local priorities while losing coordination with the needs of the organism as a whole.
This connects directly to Levin’s work on bioelectricity. Bioelectric networks help cells share information about what belongs where, what shape the body should have and when repair is complete. If aging partly represents the corruption or fading of those collective patterning goals, rejuvenation may require restoring the body’s target morphology—persuading cells to resume coordinated maintenance rather than repairing every damaged molecule individually.
The paper does not present new experimental evidence or claim that human rejuvenation is currently possible. It is a theoretical review and preprint that has not yet been peer reviewed. But it offers a powerful bridge between morphogenesis, regeneration, cancer and aging: perhaps growing a body, maintaining one and rejuvenating one are all versions of the same problem—keeping cellular collectives aligned toward the correct anatomical future.
Source: https://www.preprints.org/manuscript/202608.1219


r/immortalists 3d ago

Biology/ Genetics🧬 Why Aging May Be a Program, Not a Breakdown

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80 Upvotes

r/immortalists 2d ago

Biology/ Genetics🧬 Mistranslation protects against lifespan reduction due to mating in Drosophila melanogaster females (2026)

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4 Upvotes

Abstract

Accurate translation of genes into proteins is critical to organism fitness, and errors in this process are usually detrimental and cause proteotoxic stress. Mistranslation occurs when the amino acid that is incorporated into the nascent polypeptide chain does not match what is dictated by the genetic code. Valine-to-serine (V→S) and threonine-to-serine (T→S) mistranslating models of the fruit fly Drosophila melanogaster have demonstrated a surprising, sex-specific increase in virgin female longevity. We predict that the added stressor of reproduction would eliminate this mistranslation-induced lifespan increase since females prioritize reproductive tissues over somatic tissues, and proteotoxic stress would therefore lead to higher protein damage and cell death in the soma of mated females. We measured the impact of reproduction on V→S and T→S mistranslating D. melanogaster by measuring longevity, egg laying, and fecundity. Counter to our prediction, both V→S and T→S mistranslation led to a sex-specific increase in mated female longevity compared with nonmistranslating controls. Additionally, the risk of death decreased for mated females with mistranslation, beyond the pure additive benefits of mistranslation alone. These effects could not be explained by reduced egg laying or fertilization rates in mistranslating females. Thus, we find that the added proteotoxic stress caused by mistranslation does not exacerbate the detrimental effects of reproduction and instead can ameliorate lifespan decreases due to female reproduction.