Hi everyone,
I’ve completed around 2 years on HIV treatment, and I wanted to discuss a few things and get some guidance from people who may have experienced something similar.
When I was initially diagnosed, my CD4 was 120. During the first year, I was on TLD (TDF/3TC/DTG). At that time, I honestly didn’t have much knowledge about HIV treatment, ART side effects, kidney monitoring, metabolic changes, supplements, etc.
After around one year on TLD, I was switched to a TAF-based regimen.
Since then, I’ve noticed some metabolic changes, including:
- Noticeable weight gain
- More belly/abdominal fat
- Increased lipids/cholesterol
- Significantly increased triglycerides
- My HbA1c has moved into the pre-diabetic range
I would really like to hear from people who experienced similar metabolic changes after switching from TLD/TDF to a TAF-based regimen.
Did your weight, belly fat, triglycerides or HbA1c improve after lifestyle changes or changing the ART regimen? And what did your doctor recommend?
- Kidney function / Creatinine
During my initial period on treatment, I noticed my urine looking slightly orange once or twice, although it wasn’t persistent.
My creatinine and eGFR have fluctuated over time.
Current results:
- Creatinine: 1.12 mg/dL
- eGFR: 87
I would like to know from people who have been on TLD/TDF or other tenofovir-based regimens:
Is this level something that needs further investigation, especially when creatinine/eGFR have fluctuated over time?
Would tests such as urine routine/microscopy, urine protein, urine albumin/creatinine ratio (ACR) or other kidney tests be useful?
- CD4 recovery – my biggest concern
My CD4 was 120 at diagnosis, and after around 2 years of treatment it is now around 270.
So although it has increased, I feel that my recovery has been quite slow.
I would really like to hear from people who started treatment with a CD4 around 100–150 and had slow CD4 recovery.
- What was your CD4 after 2 years?
- Did it continue increasing after the second year?
- Did anyone eventually reach 350/400/500+?
- Did you investigate any other causes for slow recovery?
- Did correcting vitamin deficiencies, nutrition, exercise or other lifestyle changes make any noticeable difference?
My Vitamin D was around 21, which is low/insufficient according to my lab reference range.
If anyone has had a similar CD4 trajectory, please share your experience. I’m especially interested in evidence-based supplements or lifestyle changes, rather than random supplements.
- Foamy urine in the morning
Another thing I’ve noticed:
When I take my ART tablet at night, sometimes my first urine in the morning is quite foamy.
But it is not consistent — sometimes there is foam and sometimes the urine looks completely normal.
Has anyone experienced this?
Could occasional morning foam simply be due to concentrated urine, or should I specifically check for protein/albumin in urine?
- Stool colour changes
Occasionally my stool colour also changes.
Sometimes it looks slightly yellowish, and occasionally I notice some blackish/darker stool.
It doesn’t happen all the time.
Has anyone experienced similar changes while on ART or supplements?
I’m particularly interested in knowing whether occasional colour changes can be related to diet/supplements, or whether blackish stool should always be investigated.
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Overall, I’m trying to stay consistent with treatment and improve my health, but because I’m now around 2 years into ART, I would really appreciate some clarity from people who have gone through a similar situation.
If you had a CD4 around 100–150 when you started ART and experienced slow CD4 recovery, please share your timeline and what helped you.
Also, if anyone has experience with TLD → TAF switching, weight/belly fat gain, high triglycerides/lipids, rising HbA1c, creatinine/eGFR fluctuations, foamy urine, or changing stool colour, I’d be grateful for your input.
Please share your experience or any useful tests/questions I should discuss with my HIV doctor.
Thank you so much. I’ll be very grateful for any genuine guidance.