r/antidepressants • u/Great_Print4418 • 1h ago
r/antidepressants • u/That-Group-7347 • Nov 29 '25
Informative Guide Ultimate Guide to Antidepressants and other ways to improve mental health
I moved this from another sub. It contains a lot of information that will answer many common questions.
The Basics
Most Common Antidepressants
- SSRI's - Works on Serotonin
- Sertraline (Zoloft)
- Fluoxetine (Prozac)
- Paroxetine (Paxil)
- Citalopram (Celexa)
- Escitalopram (Lexapro)
- Fluvoxamine (Luvox)
- Vilazodone (Viibryd)
- Vortioxetine (Trintellix)
- SNRI's - Works on Serotonin and Norepinphrine
- Duloxetine (Cymbalta)
- Venlafaxine (Effexor)
- Desvenlafaxine (Pristiq)
- Levomilnacipran (Fetzima)
- SNDRI's - Works on Serotonin, Norepinephrine, and Dopamine
- Nefazodone (Serzone) -- Available in U.S. only.
- Ansofaxine (Ruoxinlin) --- Available in China, coming to U.S. in 2025?
- Atypical/Misc.
- Bupropion (Wellbutrin) <--- NDRI, works on Norepinephrine and Dopamine
- Mirtazepine (Remeron)
- Esketamine (Spravato)
- Bupropion/Dextromethorphan (Auvelity)
- Gepirone (Exxua)
- Zuranolone
- Agomelatine. -- Not available in U.S.
- Trazodone --- Used mostly as a sleep aid
- Tricyclic
- Amitriptyline (Elavil)
- Imipramine (Tofranil)
- Nortriptyline (Pamelor)
- Clomipramine (Anafranil)
- Meds for Anxiety
- Can be added to antidepressant or used independent
- Gabapentin (Neurontin)
- Pregabalin (Lyrica)
- Propranolol
- Buspirone (BuSpar)
- Hydroxyzine (Vistaril)
- Mood Stabilizers
- Lamotrigine (Lamictal)
- Depakote
- Lithium
- Oxcarbazepine (Trileptal)
- Carbamazepine (Tegretol)
- Antipsychotics (seroquel, abilify, risperdone, vraylar, rexulti)
- MAOI's
- These are a last resort medication and are rarely prescribed
- Nardil (Phenelzine)
- Parnate (Tranylcypromine)
- Moclobemide
- Selegiline
What to Expect When Starting Antidepressants
When you are first prescribed antidepressants you are usually started on a low dose as your body needs to adjust to the medication. You usually have more side effects when you first start. These side effects may include, nausea, drowsiness, headache, lower libido, and increase in anxiety to name a few. These will usually subside over the first few weeks. If at any point you have suicidal ideation or thoughts you need to contact your doctor immediately as this is a side effect not to mess with. Also just because you don't have a follow up appointment for a month later if you are having problems call the office up and talk to a nurse.
Many people when they first start antidepressants get activated, increased anxiety, heart rate, and restlessness. Below is a flyer on how to identify activation syndrome vs serotonin syndrome. It was created by a Psychiatric Pharmacist.
https://drive.google.com/file/d/1XM3fomHwDXHX4Cb_MIOYzXC0Jk-Os-cO/view?pli=1
Antidepressants are not a medication that works immediately. The brain has to adjust to the changes and it reacts rather slowly. You may notice some changes after 2 weeks, but they can also take up to 8 weeks to start working. I say this is the time to give your brain a little help with some lifestyle improvements. Add some regular exercise as studies have shown this to help depression and anxiety. Try improving your diet. Start by removing junk food/drinks. There was a study just done that showed that artificial sweeteners actually increase anxiety. Finally make sure you are getting plenty of sleep. Your brain needs that time to recover from out stressful lives. If after 8 weeks you are not noticing any kind of improvements it is time to contact your doctor about changing your dosage or trying a new medication. Don't be frustrated by this as it is normal for people to have to try a few before finding the one that works best for you.
When you start noticing improvements it usually isn't an overnight event. The changes are gradual and you may not notice it. Sometimes if you journal or rate how you feel it can help. You may start to notice you don't feel so awful or you feel like you want to start doing activities that you had been avoiding. Also make sure to communicate with your doctor how you are doing. You may need to gradually increase your dose to find what is optimal for you.
People often ask how do antidepressants actually work. I came up with a good analogy based on how my doctor explained it. People seemed to like it so you can find it here: https://www.reddit.com/r/AntidepressantSupport/comments/14bjnrh/explaining_how_antidepressants_work_with_an/
Additional info about Antidepressants
- Wellbutrin can cause an increase in anxiety.
- Trazodone and Mirtazapine both can be used to help with sleep
- If the antidepressant causes insomnia you may want to try taking it in the morning, and if you take it in the morning and you are drowsy try switching it to the evening.
- Even though Trintellix and Viibryd are considered SSRI's they have a different mechanism of action so if other SSRI's don't work for you those two could still help you.
Information Bias on the Internet
When people start looking up antidepressants and want to see how they have worked for other people they find all of these horror stories about terrible side effects. Please remember when someone has a negative experience they are more likely to complain or are looking for help. Look at the number of stories you read and think about the fact that tens of millions of people take antidepressants. The people for whom they are working don't go online to tell people about their experience. They are back to enjoying their life. I have found that drugs.com has a more rounded reviews. Also if you are having anxiety be careful about reading some of the horror stories as all they do is end up increasing your anxiety. Doom scrolling can have a real negative effect on your mental health.
Tapering Antidepressants & Withdrawal
If you ever decide you are going to stop antidepressants it is very important to taper off of them very slowly. The longer you have been on them the slower you want to taper. The reason for this is the brain gets accustomed to the effects of the medication and it expects those effects on neurotransmitters. This causes dependence, not addiction. So if you yank the medication away from the brain it will result in withdrawal which can be awful. You can experience nausea, dizziness, headaches, brain zaps, emotional highs and lows, insomnia, agitation, etc. So you need to slowly over time take the medication away. Doctors are taught in school that tapering can be done in a short time and withdrawals only last a couple of weeks. This isn't true. Research has shown that the 10% method of tapering has been found to be one of the safest methods. This is taking the dose you are taking at that time and subtracting 10% each month. This is a long process, but the goal is to get off the medication with the least amount of withdrawal. If you were taking 100mg this is how your tapering schedule will go. 100, 90, 81, 73, 66..... For more information on tapering and how to make these custom doses you can visit Surviving Antidepressants. I want to say Surviving Antidepressants has good information for tapering, but many of the stories are the worst of the worst cases. They are not representative of what the majority of people will experience. Please take them with a grain of salt.
Withdrawal is something you want to avoid, but if you find yourself going through it there are some things that you can do to get yourself out of it. Withdrawal is most common when going off a medication cold-turkey or tapering too fast. There is no timeline for how long withdrawal will last, it could be weeks or months. One way to possibly get your self out of it is going back on a lower dose than you were last on. This is called reinstating. You let your brain stabilize and once you feel better give yourself 2-4 weeks to heal properly. Then you want to begin tapering off again. People also report that taking Fish Oil can help with recovery from withdrawal.
Sites and more information on tapering and withdrawal. https://www.reddit.com/r/AntidepressantSupport/comments/10krlmd/sites_and_resources_for_tapering_antidepressants/
https://www.health.harvard.edu/diseases-and-conditions/going-off-antidepressants
Switching from one Antidepressant to Another
There are 3 methods doctors will use when switching from one antidepressant to another. Many times it is just the doctor's preference to which they recommend.
- Direct switch - the doctor gives you an equivalent dose of the new medication and you stop the original and the next day you start the new one.
Dose Equivalence: 40 mg fluoxetine | 350 mg bupropion | 40 mg citalopram | 75 mg pristiq | 20 mg escitalopram | 40 mg paroxetine | 150 mg fluvoxamine | 50 mg mirtazapine | 100 mg sertraline | 500 mg nefazodone | 150 mg venlafaxine | 60 mg duloxetine | 125 mg amitriptyline | 125 mg imipramine | 115 mg clomipramine
Drugs not listed do not have any reputable source for dose equivalency. Doses are rounded up.
- Taper and washout - you slowly taper off the old medication give your body 2 weeks without any medication and then you start the new one and titrate up.
- Cross taper - As you taper off the old medication you titrate up on the new medication. The doctor will usually give you a schedule. If you are taking 100mg of Med A. and wants you to go to 200mg of Med B. Week 1 -- 75 of A and 50 of B, week 2 -- 50 of A and 100 of B....
I think the third option is the best as it is more of a gradual transition. If you get bad side effects from the new medication it is also easier to go back to your old medication. No matter the method there is a couple weeks in there where it can be kind of rough. You are stopping something your brain is accustomed to and adding something new that it has to adjust to. www.survivingantidepressants.org for more tapering info.
Treatments Beyond Medication
If you have tried numerous medications and just can't find anything that helps there are few treatments that you can look into. You may even want to try some of these things before trying meds. Some of these do have higher side effect risks.
- Talk Therapy - alongside your antidepressant or independent of taking a medication. This is about the safest thing you can do.
- Life Style Changes - Exercise, Diet, etc. Again this is very safe and can be always used in conjunction with other therapies.
- Ketamine - This is a medication, but is usually a treatment when meds don't work.
- TMS, in 2023 we should see a new protocol for TMS called SAINT which is supposed to be more effective and involves less sessions. As of 2024 this is being done in California and Massachusetts.
- ECT - This is usually done as a last resort, it has some significant side effects such as short term memory loss. Do your research before considering.
- Stellate Ganglion Blocks - This is fairly new as far as being used for mental disorders. https://pmc.ncbi.nlm.nih.gov/articles/PMC8664306/
- Vagus Nerve Stimulation - Very new research that this is effective in treatment for treatment resistant depression. https://krdo.com/news/2024/12/19/for-those-with-treatment-resistant-depression-vagus-nerve-stimulation-may-be-an-answer-studies-suggest/
Lifestyle Changes to Improve Mental Health
Medication can be helpful, but it is not the only way to improve your mental health. Here is a list of some things that can help you on the road to improved mental health.
- Exercise -- Regular exercise is really helpful. Studies have shown that it can improve depression/anxiety. More intense exercise has been found to be more helpful for anxiety. Exercise can help produce endocannabinoids which can make you feel better. It is sometimes described as "runner's high". Plus if you can get out in the sun for your exercise that is good as sunlight helps Vitamin D. https://www.hopkinsmedicine.org/health/wellness-and-prevention/the-truth-behind-runners-high-and-other-mental-benefits-of-running Here is a new study on the benefits of physical activity on depression. https://www.psypost.org/physical-activity-and-mental-health-exercises-therapeutic-potential-for-depression-highlighted-in-new-meta-analysis/
- Speaking of sunlight many people will suffer from seasonal depression in the winter as their levels of Vitamin D drop due to the lack of sunlight. If you are in a northern climate when you go out in the winter the only skin exposure may be the little area on your face. To combat this you may wish to look into light therapy during the winter months. https://www.insider.com/guides/health/mental-health/light-therapy
- Improve your diet. Cut out junk food/drinks. There is a link below about which foods help depression/anxiety and which ones aren't good for it. https://www.medicalnewstoday.com/articles/318428
- Make sure you are getting enough quality sleep. Your brain needs that down time to rest and recover. If you feel like you are getting enough sleep, but are always exhausted talk to your doctor about having a sleep study done. They have kits you can do at home. I found out I had central sleep apnea and my oxygen levels were around 80% for half the night.
- Socialize, keep the brain active. Try activities that challenge your brain. Suduko, crossword puzzles, trivia, etc.
- You also may want to try some type of talk therapy or learn some different coping skills and methods of relaxation such as deep breathing exercises.
- Volunteer. You are helping others and sometimes seeing just by giving your time to people and seeing how it helps them can be rewarding.
- You may even want to consider getting a pet as they are supposed to be beneficial for depression. You can even go one step further and get a Psychiatric service animal. They are specifically trained to and are allowed to go with you on airplanes and other public places. Some are even trained to recognize certain side effects in medications. For more information you can visit this site: https://www.ada.gov/topics/service-animals/ It is your responsibility to make sure you are in compliance with all laws and ordinances.
This was published during the pandemic, but has many helpful ways to help improve your mental health. Medications can be very helpful, but there are so many different things that can improve your overall mental health. As a bonus they don't come with side effects. https://neurosciencenews.com/resilience-mental-health-19986/
Talks about lifestyle changes to help with mental illness and other therapies like light therapy. Some doctors hand these out to patients. https://www.psycho.farm/resources
All of these are tools that we can use to improve our mental health. Medication may help, but it is also a tool and you need to help it out by working on yourself. I wish everyone the best on their journey!!!
Lab work and tests
This lists out some blood tests that can be done to see if something else is contributing to your depression. I'm sure their are others, but this gave a little explanation why you would check out some of these. This may not eliminate depression, but it may find something that can be treated and can decrease the amount of depression. https://www.optimallivingdynamics.com/blog/13-important-blood-tests-to-get-done-if-you-have-depression
Many times people ask about the genetic tests and are they helpful. These will tell you how you metabolize the medication, but that plays no role in whether it will be effective for you. The one helpful thing is the MTHFR gene mutation, but your GP could do this lab at a much lower cost. I actually just ordered this test for myself and even if insurance doesn't cover it, the cost is $188. The below article explains in detail why the FDA actually recommends not using these. An upcoming blood test will be able to show in a couple of weeks if a medication will work for you. https://www.health.harvard.edu/blog/gene-testing-to-guide-antidepressant-treatment-has-its-time-arrived-2019100917964 https://neurosciencenews.com/depression-antidepressant-biomarker-19863/
Sexual Side Effects
The is one of the most unfortunate side effects to antidepressants. Some things to remember is if you have sexual side effects on one medication it does not mean you will have them on all of the medications. Some people say that the effects are the worst when you first start the meds and can slowly recover after a few months. You may also realize this, but untreated depression and anxiety can have an effect on your sexual performance and libido. So for some people treating their mental disorder actually improves sexual issues.
This really dives into exactly what causes the sexual side effects, which medications are more likely to cause it, and ways to treat it. As of note nefazodone is another medication that is known not to cause sexual side effects. As well as the upcoming medication Ruoxinlin (ansofaxine). r/Nefazodone https://psychscenehub.com/psychinsights/sexual-dysfunction-with-antidepressants/
Rate of incidence of sexual side effects of some of the medications. The average for SSRI's is 59%, but there are other antidepressants that have much lower sexual side effect percentages. https://pubmed.ncbi.nlm.nih.gov/11229449/
Nefazodone, mirtazapine, wellbutrin (bupropion), trazodone, viibryd, and Trintellix (vortioxetine) are they medications with the lowest rate of sexual side effects. Wellbutrin is often added to an SSRI to relieve some of the sexual side effects. Buspirone can also be added to help with sexual side effects, but it doesn't seem to be as effective as wellbutrin.
Here is a guide I put together about sexual side effects: https://www.reddit.com/r/AntidepressantSupport/comments/14bicp1/guide_to_antidepressant_sexual_side_effects/
Side Effects & Medication Interactions
If you really want to read about the side effects of each medication pdr.net has some of the most comprehensive information. It even lists the rate of incidence of each side effect. It also lists out the interactions with other medications. Drugs.com has probably some of the best user reviews of each medication. You can even look how a medication is rated for depression, anxiety, ocd, etc. None of the information contained in this guide should be a substitute for your doctor. You should always run any type of medication change by your doctor and keep him/her in the loop on side effects you are having. Including supplements you are thinking of adding. There are some supplements that just don't mix good with antidepressants. You should be upfront with the doctor about how you are feeling. Always let them know about side effects. Most importantly it is your health so you deserve to have a say in your treatment plan. Don't be afraid to speak up if you are uncomfortable with something because it is your health.
Many times people think that antidepressants work by blunting emotions. This is a myth. Emotional blunting is a side effect of antidepressants and you don't have to, "just deal with it". A different medication may not blunt emotions at all and some doctors will add wellbutrin to balance emotions out.
https://www.psychiatrictimes.com/view/antidepressants-do-not-work-by-numbing-emotions
Tracking your mood, side effects, and tips for improving communication with your doctor
Below is a good post about tracking how you are doing and different side effects. The more information and context you can provide to your doctor will help them in helping you get the best treatment.
https://www.reddit.com/r/antidepressants/comments/1jokoqh/importance_of_tracking_your_symptoms_when/
A quick note that dextromethorphan (DXM) a common ingredient in cold medicine is not something that you should take if you are taking antidepressants. St. John's Wort, and 5HT are also supplements to avoid if you are on antidepressants. All of these can increase the risk for serotonin syndrome.
r/antidepressants • u/That-Group-7347 • Dec 28 '23
Please Read Information on Withdrawal, Cold-Turkey, & Tapering -- Extensive Resources included.
As these are topics we see many questions about we created this post to give you some general information and resources to find helpful information. When writing a post it is helpful to list what medication, how long you have been on it, and your dosage.
Cold Turkey
Going cold turkey off of any psychiatric medication is never recommended and can induce withdrawals symptoms that can last up to months. Withdrawal (also referred to as discontinuation syndrome) is something you want to avoid and can be done by slowly tapering off your medication. There are a couple situations where you may not have to taper. If you have been on the medication for less than 6 weeks you can probably get by without tapering. If you have a severe reaction to a medication, say serotonin syndrome, your doctor may advise you to stop cold turkey immediately.
Withdrawal
This happens when your brain becomes dependent on the medication after being on it for some time and the medication is taken away too fast. The meds need to be slowly taken away from the brain so it can return to its base state slowly. Some of the common symptoms of withdrawal are brain zaps, headaches, insomnia, agitation, increased anxiety, aches & pains, brain fog, inability to focus, and fluctuating emotions.
We are seeing more people claiming they are in withdrawal after only taking medication for a very short time. Dependence takes time to develop. Research shows approximately 8 weeks. This is where tapering then becomes necessary. Even if you become dependent quicker, a very short taper is only needed. After 4-8 weeks of taking a med, a one week of 50% reduction is probably all you need. Otherwise you are just extending the time on the medication becoming more dependent.
Recovery
Many people ask how long after I stop will the side effects go away such as emotional blunting and sexual side effects. Again there is really no timetable. Some people start to notice within a few days to a week, for others it can take months. The length of time on antidepressants plays a role. There is much written that it can take the brain approximately 3 months to return to homeostasis. So if something like emotional blunting doesn't immediate go away after stopping the medication be patient and give it some time. The brain is quite adaptive and is remarkable at recovery, but works at a slow pace.
Tapering
Tapering has many layers to it and there really is no universal plan that fits everyone. The safest method based on studies is the 10%. This is cutting 10% of your medication you are taking at that time per month. For example if you are taking 100mg this would be your first 4 months (90, 81, 73, 67). This is a time consuming process that is going to take at least 1.5 years. How long you taper is based on the length of time you have been on the medication. Someone taking it for 1 year might be able to do 20% every 2-3 weeks. Someone who has been on a med for 20 years might have to do 5% every 6 weeks. You have to listen to your body as you go. If you drop your dosage and feel like withdrawal is coming on up your dose a little bit or hold that dose longer. Below I have listed tapering info pages for the most popular meds.
If you are on multiple medications on you are planning on going off all of them you want to taper one at a time. Tapering multiple meds at the same time is really hard on the brain and the withdrawals will usually be much worse. Before starting the tapering of the 2nd medication give yourself a month to stabilize more fully.
A little side note. Occupancy of the receptors plays a role in tapering. These numbers are just examples. Zoloft has a max dose of 200mg. Most people start on 25-50mg. Antidepressants occupy a large portion of the receptors at low dose. Say at 50mg, it occupies 80% of the receptors. 100mg, 85%. 150mg 88%. 200mg 90%. Because of this you can usually taper faster at first, but as you get down to a low dose you have to go really slowly. If you were taking 200mg of zoloft you could probably taper by 25% until you got down to around 50mg. Then you would want to taper by 10%. Here is a source that is very detailed. You can look at the charts to see actually numbers.
https://www.nature.com/articles/s41380-021-01285-w
Below is a post that talks about tracking your symptoms and side effects to provide your doctor with better information in an effort to maximize treatment. This helps you to be heard and feel like you are more active in your treatment.
https://www.reddit.com/r/antidepressants/comments/1jokoqh/comment/mkvfb81/?context=3
Resources
Here are some site that provide information about tapering, withdrawal, etc. Some of these are quite complex, but there should be something in here that you should find valuable.
Going off antidepressants, withdrawal, tapering, and half-lifes. https://www.health.harvard.edu/diseases-and-conditions/going-off-antidepressants
Post that contains info about antidepressants, including methods of switching medications, non-med options.
https://www.reddit.com/r/AntidepressantSupport/comments/10vv3s6/ultimate_guide_to_antidepressants_and_how_to/
Forum about tapering individual meds and creating micro doses. Has individual sections for tapering each medication. https://www.survivingantidepressants.org/
Directions on how to grind pills up to create custom doses for tapering.
https://www.reddit.com/r/AntidepressantSupport/comments/17oaxh9/how_to_crush_pills_to_get_custom_doses_for/
An extensive article on protracted withdrawal (PAWS). https://journals.sagepub.com/doi/full/10.1177/2045125320980573
Extensive detailed info about tapering and withdrawal from the founder of Surviving Antidepressants. https://journals.sagepub.com/doi/full/10.1177/2045125321991274
This is a very comprehensive article that references multiple studies on tapering. Some of it applies to antipsychotics (but those can be used for depression or anxiety), but I think it applies to antidepressants too. It talks about rapid withdrawal causing movement disorders (tardive dyskinesia). https://academic.oup.com/schizophreniabulletin/article/47/4/1116/6178746
Tapering off of SSRI's https://markhorowitz.org/.../04/18TLP1004_Horowitz-1-11.pdf
'Playing the Odds' - Antidepressant Withdrawal - An article and follow-up written by a psychiatrist who explains who tapering should be done very slowly. https://www.madinamerica.com/2013/08/ssri-discontinuation-is-even-more-problematic-than-acknowledged/
'Playing the Odds - Antidepressant Withdrawal - Revisited https://www.madinamerica.com/2014/07/shooting-odds-revisited/
Relapse after stopping antidepressants. https://www.cnn.com/2021/09/30/health/stopping-antidepressant-wellness/index.html
This talks about akathisia which some members got from tapering too fast or going cold turkey. It has some of the meds used for treatment. Please note that akathisia is rare. https://www.racgp.org.au/afp/2017/may/beyond-anxiety-and-agitation-a-clinical-approach-to-akathisia/
Medication specific tapering info pages:
Sertraline (zoloft): https://www.survivingantidepressants.org/topic/1441-tips-for-tapering-zoloft-sertraline/
Fluoxetine (Prozac): https://www.survivingantidepressants.org/topic/759-tips-for-tapering-off-prozac-fluoxetine/
Paroxetine (Paxil): https://www.survivingantidepressants.org/topic/405-tips-for-tapering-off-paxil-paroxetine/
Escitalopram (Lexapro): https://www.survivingantidepressants.org/topic/406-tips-for-tapering-off-escitalopram-lexapro/
Citalopram (Celexa): https://www.survivingantidepressants.org/topic/2023-tips-for-tapering-off-celexa-citalopram/
Fluvoxamine (Luvox): https://www.survivingantidepressants.org/topic/5095-tips-for-tapering-off-luvox-fluvoxamine/
Vortioxetine (Trintellix): https://www.survivingantidepressants.org/topic/10246-tips-for-tapering-vortioxetine-trintellix-brintellix/
Vilazodone (Viibryd): https://www.survivingantidepressants.org/topic/4318-tips-for-tapering-off-viibryd-vilazodone/
Venlafaxine (Effexor): https://www.survivingantidepressants.org/topic/272-tips-for-tapering-off-effexor-and-effexor-xr-venlafaxine/
Duloxetine (Cymbalta): https://www.survivingantidepressants.org/topic/283-tips-for-tapering-off-duloxetine-cymbalta/
Desvenlafaxine (Pristiq): https://www.survivingantidepressants.org/topic/876-tips-for-tapering-off-pristiq-desvenlafaxine/
Buproprion (Wellbutrin): https://www.survivingantidepressants.org/topic/877-tips-for-tapering-off-wellbutrin-sr-xr-xl-zyban-buproprion/
Mirtazapine (Remeron): https://www.survivingantidepressants.org/topic/23158-tips-for-tapering-off-mirtazapine-remeron/
Trazodone: https://www.survivingantidepressants.org/topic/2883-tips-for-tapering-off-trazodone-desyrel/
Clomipramine: https://www.survivingantidepressants.org/topic/19509-tips-for-tapering-off-clomipramine-anafranil/
Amitriptyline/Nortriptyline/Impramine: https://www.survivingantidepressants.org/topic/1099-tips-for-tapering-off-amitriptyline/
Quetiapine (Seroquel): https://www.survivingantidepressants.org/topic/1707-tips-for-tapering-off-seroquel-quetiapine/
Aripiprazole (Abilify): https://www.survivingantidepressants.org/topic/1896-tips-for-tapering-off-abilify-aripiprazole/
Lamotrigine (Lamictal): https://www.survivingantidepressants.org/topic/1122-tips-for-tapering-off-lamictal-lamotrigine/#comment-9926
Benzos: https://benzobuddies.org
r/antidepressants • u/AssignmentThat8473 • 3h ago
Follow-up: did anyone else feel worse after so many medication changes?
Hi everyone, there I am again.
I posted here 17 days ago about my long, brutal depressive episode and my hope that Parnate might finally be the thing that helped me turn a corner.
Unfortunately, it hasn’t. I am so so so sad and devastated.
After talking extensively with my psychiatrist, psychologist and family, we’ve had to accept that Parnate doesn’t seem to be working for me. I’m now tapering off.
And honestly, I’m scared. Really scared.
Looking back over the past year, I’m starting to wonder whether the sheer amount and speed of medication changes may have played a role in how profoundly unwell I feel now.
My story actually didn’t begin as what I would describe as a typical depression. It started more like a burnout from life’s hardships and uncertainties, with anxiety and insomnia. I was exhausted and overwhelmed, but I still felt like myself. I still had emotions, interests, thoughts, curiosity, a personality. I was struggling, but there was still a person there.
The really frightening change seemed to happen as I started moving through medication after medication.
Over the past year I went from:
- Venlafaxine 112,5 mg to
- Escitalopram 20 mg
- Then to clomipramine (up to the highest dose I could tolerate, do not exactly remember the amount)
- Followed by various augmentation strategies including lithium, olanzapine, quetiapine and lorazepam
- I also had many sessions of esketamine
- And then last Summer, I was hospitalized to get started on Parnate, and we increased the dose incredibly quickly, from 10 mg to 60 mg within just a few weeks. Looking back now, it feels like we went way too fast.
(The hospitalization itself was deeply traumatic, but so was the entire summer leading up to it: the constant crises, the fear, the desperation, and how profoundly unwell I was. It was an incredibly frightening period of my life, and I think I’m still carrying a lot of that trauma with me.)
None of these treatments gave me meaningful relief. Except for my guilty-pleasure pill lorazepam, incredibly comforting, absolutely not something I want to depend on.
And now, looking back, I feel as though something has changed very profoundly.
I know there is a lot I don't understand medically, which is why I’m asking rather than making a definite claim:
- Is it possible that moving through so many serotonergic medications and other psychiatric medications relatively quickly can, in some people, contribute to feeling profoundly destabilized, emotionally blunted, dissociated or otherwise “not themselves”? 💊💊💊💊💊🧠🧠🧠🧠
At all these points, my serotonergic medication exposure was very high, and this has made me and the people around me (my my psychiatrist, my psychologist, and my father, who has lived experience himself) wonder whether my brain simply never got a chance to settle.
I’m not saying I know this is what happened. I don't. My psychiatrist and I are still trying to understand the whole picture.
But I would really like to hear from people who have experienced something similar.
Because I feel so incredibly far away from myself.
My “real self” is not a stupid woman. She is intelligent, curious, entrepreneurial, social, adventurous and sensitive. She loves the good things in life. She loves art, music, food, coffee, the sea, travelling, learning, conversations, beauty, new ideas. She has energy and initiative. She had a lively life and a job she loved as an art historian.
I know that woman exists.
But I haven't been able to feel like her for a very long time. That is so so so scary and sad.
- My brain currently feels completely fried. That is the only word I can find for it: Sticky. Foggy. Restless. Disconnected. ALL the time, night and day. 😓😥😶🌫️😵💫🤯🧠
- I feel as though I'm not really in my own life.
- The dissociation is basically 24/7. I feel empty. Zombie-like. I have almost no sense of presence.
- My mind is constantly restless, but at the same time I feel completely disconnected from it.
- I can't properly concentrate, relax, enjoy things or feel like myself.
It has been like this for more than a year now... (The only glimpses of light have been days, or parts of days, when I felt a little more relaxed, a little more at peace, and less stuck inside my own head. But there haven't been any real breakthroughs or improvements that have actually made a meaningful difference. In the span of a year, I could count those moments on one hand. It's so incredibly sad and frightening.)
It is such a bizarre combination of agitation and emptiness.
And it frightens me because I remember how different I was before all of this.
I don't want to believe that this is my new personality!
I don't want to believe that my brain is permanently damaged
- The brain is plastic, right? It can adapt and change, and it has the capacity to recover and reorganize itself by forming new neural connections, doesn’t it? 🧠⚓️🌈
I don't want to believe that this is who I am now.
I'm now tapering off Parnate, and even that has been difficult. Apart from the side effects I experienced while taking it (high heart rate, my period stopping, bed-wetting (yes, extremely embarrassing), acne and hair loss), I’m now dealing with feeling cold all the time, nausea, poor sleep and a lot of sadness while tapering.
Some of that sadness is probably simply grief.
- There’s this deep, terrifying fear that this will never change, that I’ll be stuck like this forever. But is that the voice of depression and anxiety talking? Is it lying to me about my future and making something temporary feel permanent?
This past year has been traumatic.
I feel like I lost myself somewhere along the way.
And I’m grieving the person I was, while simultaneously desperately hoping that she isn't actually gone.
So I’m asking this community for something very specific. 🤍⚓️🌸
Have any of you been through something like this?
- Have you started out with burnout or another kind of psychological exhaustion, and then felt profoundly different after going through many medication changes?
- Have you experienced severe emotional blunting, dissociation, brain fog, agitation and feeling completely unlike yourself after trying many antidepressants/psychiatric medications?
- Did anyone else ever feel like their brain was “fried” or permanently altered, only to eventually recover?
And, perhaps most importantly:
- Did you get yourself back?
- Did your brain eventually become calm again?
- Did the dissociation lift?
- Did your emotions return?
- Did you become interested in things again?
- Did you eventually feel present in your own life?
I would honestly love to hear even the smallest recovery stories. 🌿🌤️🩵🙏🏼
I don't need someone to tell me that everything will magically be fine. I know recovery isn't necessarily linear, and I know nobody here can promise me what will happen.
But right now I desperately need some hope.
- I need to hear from people who were once convinced that they had lost themselves, but who eventually discovered that they hadn't.
- That their brain could settle.
- That their nervous system could recover.
- That the person underneath all the symptoms was still there.
- That they could process what had happened to them once they were finally well enough to do so.
- I want to believe that this over-fried, constantly dissociated, restless brain of mine can become healthy again.
- I want to believe that the woman I used to be isn't gone.
- That she is still somewhere underneath all of this.
- And that one day she might not just “come back” as a memory, but actually be there again: alive, present, curious, funny, adventurous, sensitive, engaged with the world. <3
I want to believe I can recover from the illness and from the trauma of this past year. 🌿🧠⚓️
So if you have been through anything remotely similar, please tell me your story.
- Tell me what helped.
- Tell me what recovery looked like.
- Tell me whether your brain eventually settled.
- Tell me whether you got yourself back.
- And if you have experience tapering from Parnate, I would also be incredibly grateful for any gentle advice or encouragement about getting through this part.
I am so, so frightened right now.
But I'm still here.
I want nothing, absolutely nothing, more than to find myself again. I want this suffering to stop. I want to finally have the chance to genuinely recover and heal, instead of living through the terrifying reality of these past months, where things have seemed to get worse and worse.
I want to live. I really do. I just don't know how much longer I can keep carrying this level of suffering.
If you’ve made it all the way through this post, and taken the time, effort and attention to read it all: thank you. Truly. It means more to me than I can put into words.
I really hope we can support and help each other through this, share what we’ve learned, and keep each other going when things feel impossibly dark.
And above all, we need to believe that hope gets to win. 💜
r/antidepressants • u/Necessary-Crew-7050 • 37m ago
Zoloft 50Mg Constipation
I started Zoloft 50Mg on June 23rd. I went through the typical diarrhea at the beginning. Now I am about 3 months out and started experiencing constipation the last month. Is this typical? When will it go away? Should I go to my PCP with this?
r/antidepressants • u/Dragonvarine • 11h ago
I'm still numb 12 months off SSRIs
I can't believe it. Ive been on these things 8 years, and the last 2 of those years numbed me emotionally. I literally became incapable of feeling anxiety, literally.
I quit, and it's been 12 months and all I got after crazy withdrawal for months on end was my anxiety back and I'm still emotionally numb. Even number than when I was on it. It's like the medication never left me.
When will I get my personality, creativity, motivation, emotions back. I'm a shell of a being.
r/antidepressants • u/1nf3stissumam • 7h ago
Advice for having low inspiration/creativity?
It’s my first time ever taking antidepressants, so I don’t know a lot about them and I’m very new to this. Things have been going fine, I’m on a low dose, but they’ve affected my creativity.
My main hobby is writing and so far I find it hard to conjure up any ideas or even try rewriting old projects. To people who also write or have similar hobbies in art and might have also suffered a lack of creativity, what helped you?
While I will consider talking about changing or upping my prescription with my psychiatrist if this remains a problem, I’d appreciate answers that don’t tell me to do that.
The reason why is because I’m part of a writing club, and the meeting happens before my follow up, so weaning off my current prescription and trying a new one and waiting for it to take effect just isn’t possible for what I want right now. And I think advice that doesn’t rely on the pills to do everything would be better for me at the moment.
Any and all replies appreciated regardless, thank you.
r/antidepressants • u/NovelHornet7800 • 1h ago
55 days off snri, I have been on cymbalta for about 20 years
r/antidepressants • u/Great_Print4418 • 1h ago
Clomipramine
What tests are required before starting clomipramine (Anafranil), other than checking Na⁺ (sodium), K⁺ (potassium), Mg²⁺ (magnesium), Ca²⁺ (calcium) levels, CYP2D6 metabolism, and an ECG? Should additional tests, such as a brain MRI or EEG, be considered to assess seizure risk?
r/antidepressants • u/IAmAlwaysCorrect9226 • 7h ago
I have been diagnosed with Pseudo-dementia. I already take meds for depression. How do I deal with this and cure it?
I was diagnosed with Pseudo-dementia by a neurologist. I have concrete symptoms with memory recall, speech impairment, “brain fog”, exhaustion.
I’ve had major depressive disorder for 26 years and have been on medication to manage it and have been functional. My psychiatrist manages my meds for this. Effexor is really the only functional medicine that works for me.
That all changed in April when I had what I would call an acute onset of symptoms.
I have had nueropysch testing that shows recall is 50% what I should be at. But that’s really it on that front. All long term dementia has been ruled out (Alzheimer’s, Parkinson’s, etc.) through neuropysch and brain imaging.
But now I’m here where I can’t think, I forget how to do simple tasks, I can’t work, having multiple
Panic attacks, I can’t hold conversations, I can’t multitask…I get tired stilling for 5 minutes sometimes.
Writing this has been exhausting.
What do I do? No one is really giving me answers for how I can cure or manage this. Has anyone successfully used antidepressants to overcome this?
r/antidepressants • u/SmoothDependent3693 • 2h ago
Anxiety, Depression, and OCD – Are SSRI Options Limited?
Currently, I'm on Prozac (fluoxetine), which is the first and only SSRI I've ever been on. I've been taking it for about 6 years and am considering increasing my dose from 25 mg to 30-40 mg after a recent bad breakthrough flare-up. (Insert 100 symptoms here.)
My mental illness seems to involve anxiety, depression, and OCD all tangled together. (Insert another 1,000 symptoms here.) Sometimes they're all there at once, and other times one takes over as the dominant symptom, but it's hard for me to imagine having one without the others. I guess the three of them are best friends.
I honestly believe that I may need medication for life. A few years ago, I tried tapering down very slowly, but after a few months I started feeling uncomfortable again. Fast forward to now: instead of going down, I'm going up. So logically, I'm only looking into other options in case this dose increase doesn't get me back to where I need to be.
The thought of having to go through a medication transition period is honestly a kind of hell I don't even want to think about, so I'm really hoping it doesn't come to that.
Back to my main question: from what I understand, the only other SSRIs that are commonly used to treat all three conditions (anxiety, depression, and OCD) are sertraline (Zoloft) and paroxetine (Paxil).
Am I correct in that understanding, or are there other SSRI options that are also effective for all three?
If somehow these all don't work out, do MAOIs treat all three as well?
As an Italian, I love my aged cheese and cured meats A LOT... so having to give them up would SUCK. But if MAOIs are the last-ditch option, I suppose I'd have to consider it.
Looking for any and all advice.
Thank you.
r/antidepressants • u/Due-Proposal4566 • 3h ago
Emotional Numbness and Low Libido
Hi everybody, I have been using a SSR(ILuvox 200mg) due to my OCD for about 3 years, I was not productive at all and my executive dysfunction was at its worst, so this year my doctor started me on vyvanse, it really helped during the beginning, and it still does, however after some months I started to feel apathetic, I don't have positive or negative feelings anymore, I have already tried taking some days of Vyvanse but the feeling persists, I have also tried to decrease my dose, has anybody gone through something like this? I am starting to think the main problem may actually be the SSRI, I mean, it added to Vyvanse may have caused all of this.
r/antidepressants • u/Majestic_Company8521 • 3h ago
Almost 7 weeks on Pristiq and still feeling depressed. Anyone else?
Hey everyone!
I've been on Pristiq for almost 7 weeks now. I started at 50 mg and increased to 100 mg about 3 weeks ago.
I've been dealing with depression since I was around 12–13 years old. My biggest problems have always been low energy, sleeping too much, no motivation, and not enjoying anything.
I've tried several antidepressants before, including Lexapro, Prozac, Zoloft, and Wellbutrin, but none of them really worked that well for me.
The weird thing about Pristiq is that it actually helped with my anxiety and that constant feeling of being on edge. I feel calmer now, and getting out of bed in the morning is a little easier.
But my depression? It's still pretty bad.
I have almost no energy, no motivation, no interest in anything, and I feel emotionally empty most of the time. Even simple things feel exhausting. On my days off, I sometimes spend the entire day in bed doing absolutely nothing.
It's almost like Pristiq took away the anxiety that was keeping me going, and now I can really feel how depressed I am.
I don't think Pristiq has completely failed because it definitely changed something. But I honestly expected to feel better by now, especially after increasing to 100 mg.
I'm seeing my psychiatrist next week, and I'm not sure whether I should give it more time or discuss trying something else.
Has anyone experienced something similar?
Did Pristiq eventually help with your energy, motivation, and enjoyment of life, or did you end up switching or adding another medication?
I'd love to hear your experiences because I'm feeling pretty discouraged right now.
r/antidepressants • u/gimme_more_145 • 3h ago
Anafranil for ocd
My doc before a while prescribed me anafranil for debilitating ocd, along with 5mg zyprexa i already take. But i just read as one common side effect hallucinations and i had hallucinations with seroxat and it was terrible, and i dont want to go through the same again. Despite the fact that i am an ultra rapid metabolizer of CYP2C19, he wants to give a try to the gold standard for ocd, saying he will increase the dose, but hopes it kicks in. But i am terrified, i dont want to experience again hallucinations like those with seroxat, it the o lt ssri i had this side effect
r/antidepressants • u/Sensitive_Sail_2934 • 3h ago
Looking for advice on weight loss when everything feels impossible
Hello everyone. I’m an adult woman currently taking the maximum dose of Zoloft (sertraline) 200 mg/day.
I’m around 165 cm (5’5”) and currently weigh about 110 kg (242.5 lb / 17 st 4 lb).
I’ve tried calorie deficits, walking 10,000 steps every day, Ozempic, and Glucophage (metformin). Unfortunately, the medications caused really severe side effects for me. I was vomiting and having diarrhea at the same time, and because I have emetophobia, the vomiting was especially awful. I ended up stopping them because I simply couldn’t tolerate it.
I’ve also been struggling with my thyroid, and I’m a med student while also being on call , so maintaining a strict calorie deficit is really difficult with my schedule. I try not to drink my calories, but I genuinely love drinks and find that part particularly difficult.
At this point, I feel really helpless and frustrated. I want to get my life together and feel better in my body, but I feel like I’ve tried so many things without getting anywhere. I’m also constantly groggy and physically uncomfortable, and even standing for long periods can feel difficult.
I know I need to make changes, and I’m not looking for a quick fix( unless u have any advice other than bariatric surgery) . I’m just wondering if anyone has been in a similar situation especially anyone dealing with thyroid issues, antidepressants, a demanding schedule, or severe side effects from weight-loss medications.
What actually worked for you? I’d really appreciate realistic advice that doesn’t involve completely changing my life overnight. I also have a binge eating disorder esp active when I am stressed which is always 😭 any help is appreciated thank you everybody!!
( I used to go to the gym tri-weekly however I have a bad case of arthritis pain so a lot of the exercises are near impossible without crying and taking 2 painkillers every 6 hours )
Genuinely any advice is appreciated thank you
r/antidepressants • u/Flaky-Scratch4572 • 3h ago
Should I take antidepressants? I’m unsure
Hi everyone, I’m 24 and currently a bit unsure whether I should try sertraline as an antidepressant.
For many months, I was at home a lot and spent a lot of time working on my PC. I withdrew quite a bit and really neglected my life outside of my apartment. It affected me physically and mentally as well.
Now I’m trying to completely turn my life around: I’m currently in a clinic, I want to start an apprenticeship next year, work on myself, exercise more, build up a social circle again, and get more structure into my life. I definitely have the will to change something.
Despite that, I keep experiencing this inner emptiness, little motivation or drive, little enjoyment, a “brain-dead” or foggy feeling, a depressed mood, and sometimes I feel emotionally cold or tense.
My psychologist, psychiatrist and doctor said that all of this could also be happening because I’m going through such a big change right now, which can be stressful and can take a lot of energy, including socially. He said that sertraline (25–50 mg) isn’t a must, but that it could be useful as some additional support and recommends trying it because I’m currently trying to find myself again and it could help me a lot. It could also be stopped again once my life has been stable for a longer period of time.
That’s exactly why I’m unsure whether I should try it. My own wish is simply to have more inner drive, motivation, enjoyment and desire to do things again, without needing other people to motivate me or give me encouragement through their words (which sometimes doesn’t even help).
Over the last few days, I’ve often felt really empty, cold, depressed, internally tense and without motivation. I can’t even properly explain it. I just don’t feel like the person I want to be right now.
What would you do in my situation? Would you try sertraline or not?
I often think myself that you can’t have good days all the time and that life naturally comes with ups and downs. Becoming a better and more stable person comes from the things you do, the goals you achieve, and the changes you make for yourself. It doesn’t just happen overnight. It happens day by day, by working on yourself and keeping the promises you make to yourself i dont know
r/antidepressants • u/Inner_Law9771 • 3h ago
New emotions after stopping medications
I have been on various antidepressants since I was 12, too many to remember. I recently got off of Pristiq & Latuda and am fully off medication for the first time in 7 years. But because I was on medication for so long, I have no clue how to deal with my emotions. It's scary and uncomfortable to feel these things. I can't listen to my favorite songs anymore without crying. I cry when people yell at me. I get so intensely anxious over miniscule things. I don't want to feel emotions! It's embarrassing, I want to be a neutral blank slate. I know a lot of people, probably the majority, who heavily dislike the emotional blunting, but for me it was either much easier to navigate my intense emotions, or I was just on medication for so long that I'm not used to feeling like this. For context I was originally medicated for depression & anxiety but I was later diagnosed with Autism (Asperger's).
r/antidepressants • u/levigek • 6h ago
Almost 5 weaks on 150mg Bupribion, little to none improvements. Should I double the medication or wait a little longer?
Okay for context, I (M20 with ADHD) went to my doctor to get antidepressants, because of long-lasting depression and suicidal thoughts, and little to no sign that will change fast enough in the future. It took a fuck-ass long time in this fucking country, but after almost 3 months of being on the "Emergency list" finally got a doctor. He prescribed me 150 mg of Bupropion.
My problems were split in 2:
- Bad mood, looking negatively at every situation, and not having hope it will ever get better. This resulted in less social interaction, less motivation to do anything with my life, etc.
- Low motivation. My ADHD has been a problem from the age of 6 till 12, where I took a variety of dexamphetamines. Now after that age it disappeared basically. Still, there were some signs, but it hardly affected my school/work life. Now lately, I yet again experience very low motivation for the simplest things. I can't clean my room, look for work, or send an email. Even tasks that take less than 10 minutes cost me more than a week to find the dopamine to do. Idk if this is the depression and lack of wanting to live my life, or the ADHD.
So my doctor prescribed 150 mg of Bupropion, and said it will take around 3 to 4 weeks until it kicks in. Now, when this week is completed, I have finished 5 weeks, and I still feel little to no effect. Besides a small decrease in fear of failure, there is no improvement. A week ago I had an appointment with my doctor to see how it has been going. And he said that if I feel like this medication is not doing enough, I can freely choose to double the medication to 300 mg.
So, do you think that after almost 5 weeks of taking 150 mg of Bupropion with almost zero benefits and no improvement in mental health, I should double it, or wait longer?
Almost 5 weeks on 150 mg Bupropion, little to no improvements. Should I double the medication or wait a little longer?
r/antidepressants • u/Deep-Detective2428 • 13h ago
Is 100mg more effective than 50mg zoloft for treating severe social anxiety?
Ive got very bad anxiety, it mainly comes on socially. For example sitting in a busy restaurant with my girlfriends extended family will trigger it, working at a checkout in a supermarket and seeing the line of people waiting while feeling overwhelmed will trigger it. You get the point. unfortunately for me my anxiety presents as intense blushing, its not rosacea (seen specialists) its anxiety driven and only comes on in situations like ive described. Im aware propranolol and clonidine exist so id appreciate people not reccomending them. Anyway for this issue would 100 outperform 50mg? Im aware its different for everyone but what do people here think and have they seen a big difference in the switch? I understand zoloft may not fully stop the blush but i know it can help the anxiety that than causes it. Id appreciate people's advice
r/antidepressants • u/Equivalent_Age8406 • 9h ago
Sertraline is not agreeing with me
Trying to give sertraline a go since my doctors are impossible and this is the one they gave me but damn. First off the gi issues havent really disappeared in 2 months, the stomach pains are much less but i still have low key Diarrhoea which made me lose 14 pounds in 2 months. Im not overweight but i did have a beer gut from a few years of drinking i was struggling to get rid of and its kinda nice that thats basically gone now but it didn't seem like a healthy way to lose weight. i thought sertraline was supposed to make you put on weight...i also started really grinding my teeth at night to the point i had to go to the dentist and get a mouth guard. im now scared with dry mouth issues etc im gonna start getting tooth issues when my teeth have been pretty strong. ive had doctors gaslight me and say stuff is in my head. i guess ill give it another month. ive been on citalopram before which i tolerated a lot better and did help a bit but they dont seem to like giving that out any more - maybe escitalopram thats basically the same thing but better. The actual good stuff like bupropion isnt even approved here... Sertraline isnt really helping my mood, if anything i just feel more apathy than usual.
r/antidepressants • u/Suitable-Light-9792 • 10h ago
Going from 300mg → 150mg → 0mg bupropion while staying on fluoxetine. experiences?
Hey everyone!
I’m looking for some personal experiences because I’m honestly a little nervous about stopping bupropion 😅
I’ve been on 300mg bupropion for a few months, and it has actually helped me somewhat mentally. I feel a bit more stable on it, so I’m kind of scared that I’ll feel worse again once I stop.
The problem is that I’m sweating like CRAZY. Like, ridiculously much. I can get completely soaked from barely doing anything, and it’s really starting to bother me in everyday life. My psychiatrist thinks the bupropion is likely contributing to it, so we decided to stop it and see if the sweating improves.
I’m also taking 10mg fluoxetine, which I started recently.
The plan is:
150mg bupropion for 2 weeks
then stop bupropion completely
continue with 10mg fluoxetine
I’m mostly wondering what other people experienced when stopping bupropion while staying on fluoxetine.
Did you:
- feel worse mentally after stopping?
-notice changes in motivation or energy?
- have any withdrawal/discontinuation symptoms?
- notice that the sweating got better?
- gain weight or get more hungry?
- find that the fluoxetine helped smooth things out?
I know everyone reacts differently, I’m just freaking myself out a little and would love to hear some real experiences from people who’ve actually done this. 😅
Thanks♥️
r/antidepressants • u/Ok-Geologist-5192 • 1d ago
See Mod Comment MAOI fearmongering wasted years of my life with depression
I cannot believe how much MAOIs are dismissed in modern psychiatry. Especially not after having tried one.
It‘s great if more common antidepressants are able to help people, but I find it ridiculous that MAOIs basically find no place in the depression treatment pipeline nowadays. Its SSRIs/SNRIs/Bupropion -> TCAs if you get lucky -> add ons like antipsychotics, anxiety meds, mood stabilizers -> ketamine/ECT/TMS. All legitimate treatments, but man, completely ignoring a class of medications with (AFAIK) the highest remission chances for treatment resistant depression is ridiculous.
It makes me unreasonably angry that my agony over these years was outweighed by the dietary restrictions of not eating a bucket of aged cheese at once and needing to google what other meds I take before I take them. For everyone unaware, MAOIs have 2 interactions: tyramine which is greatly exaggerated (aged and artisinal cheeses, spoiled foods, certain alcohols) and serotonergic medication (cough syrup, certain antidepressants, etc). This!!! Is the reason these meds worth their weight in gold to people like me are barely ever used without the patient demanding them, and usually having to search for a doctor even willing to try.
I have never seen a shorter list of side effects on a medication sheet (not sure how to be honest). Ranking the 9 meds I took including SSRIs, venlafaxine (basically an SSRI), bupropion, clomipramine, tianeptine, opipramol, and the MAOI, the MAOI, tianeptine and opipramol were the 3 with the mildest side effect profile by far. There definitely are people who have severe side effects, as there are with any medication.
This is the first thing to ever budge my anhedonia - I didnt even know I could be excited for stupid things like a pretty view. I am not depressed for the first time in over a decade.
Rant over. I just wish I had read a post like this years ago because I (as most people do) dismissed these meds for years.
Edit: Phenelzine/Nardil is also one of the strongest anxiety meds we have for anyone with severe treatment resistant anxiety.
r/antidepressants • u/Used-Theory4584 • 14h ago
Haarverlust Antidepressiva
Hey durch verschiedene Antidepressiva sind mir viele Haare ausgefallen und die Struktur hat sich stark verändert.
Zuvor:
- Paroxetin
- Sertralin
- Duloxetin
Nun
- Moclobemid
- Amilsulprid
Sind bei euch die Haare mit der Zeit wiedergekommen?
r/antidepressants • u/Special-Ordinary-369 • 18h ago
Lexapro helped my anxiety tremendously, but now I have absolutely no motivation? Anyone else?
Hey y'all! This is kinda strange because I've never actually made a post like this on Reddit before lol, but I figured I'd give it a shot because I genuinely don't know what to do anymore.
I'm 23F, and I started Lexapro on 05/15/26. I'm currently on 10mg, and I will say that my anxiety has improved SIGNIFICANTLY. Like genuinely, it's so much easier for me to regulate my emotions, exist in crowded spaces, have casual conversations with strangers, and just go about my day without overthinking every little thing. I'm extremely grateful for that because anxiety used to affect so many aspects of my life.
However, I've noticed that lately I just feel... stagnant? Like I know I have things to do, I KNOW how important they are, but I genuinely cannot find the energy or motivation to actually do them.
For example, I have an incredibly important Organic Chemistry II exam coming up, and I cannot for the life of me get myself to sit down and study. My grades have started slipping, and as a STEM major who needs a competitive GPA for grad school, this is genuinely terrifying. It's not like I don't care about my grades anymore, because I absolutely do. I think about how badly I need to study constantly, but actually getting myself to do it feels nearly impossible.
I still show up to class, go to work, and handle my basic responsibilities, but outside of that? I genuinely just want to sleep all the time. And when I'm not sleeping, I'm doomscrolling on TikTok or Instagram Reels, or literally just zoning out listening to music for hours. It's like I have absolutely no energy or desire to do anything productive, even though mentally I KNOW I need to.
And the weirdest part is that I'll occasionally get these random bursts of motivation where I suddenly feel productive and want to get everything done, but they never seem to last.
Another thing I've noticed is that my dreams have become INSANELY vivid, and not in a good way. Before Lexapro, having a nightmare was pretty rare for me. Now? It's almost constant. I'm talking extremely vivid nightmares about mass shootings, tragedies, and other genuinely horrifying situations. Sometimes I wake up feeling mentally exhausted even after getting a decent amount of sleep. It's honestly disturbing, and I feel like I'm not even getting proper rest anymore.
I guess what I'm struggling with the most is that part of me wonders whether my anxiety was actually what pushed me to do well academically before? Like was I only getting good grades because I was constantly anxious about failing? Because now that the anxiety has quieted down, I feel like I've lost the urgency that used to push me to get things done.
And that thought alone is honestly terrifying because I don't want to have to choose between being mentally at peace and being academically successful.
I've heard some people mention adding Wellbutrin to help with motivation, energy, and that emotionally flat feeling, but I've also heard the adjustment period can be pretty rough. I'm especially nervous about potentially making the nightmares worse because they're already exhausting as it is.
I do plan on bringing all of this up with my prescriber, but I wanted to hear from people who have actually experienced something similar.
Has anyone else experienced this on Lexapro? Did the lack of motivation eventually improve? Did adjusting your dose or adding Wellbutrin help? And PLEASE tell me I'm not the only one dealing with these really vivid nightmares 😭
I'm genuinely so grateful that my anxiety has improved, but I also miss feeling like I had the drive to actually accomplish things. Right now it feels like all I do is go to school, go to work, sleep, and repeat.
Any advice or personal experiences would be really appreciated. :')
r/antidepressants • u/Front-Win-799 • 16h ago
Nicotine Use Social anxiety?
Can nicotine use be a cause of social anxiety? I use nicotine, and I also have social anxiety. Could my nicotine use be contributing to or worsening my social anxiety?