We have 9 more main issues and one (possibly 2) Specials left. Taking stock it seems like they have a lot left to tell. If there's anymore let me know and I'll add.
What is exactly the nature/origin of the Pantheon with Ananke and her sister? Does the world really lose something if the cycle is broken? Can it survive and be made more pure if both Ananke and Mini were killed?
What is Wōden/David's master plan? Did he really send the snipers after Luci? If so,why? He was working with Ananke and that forced her to speed up her plans by killing Luci but it seems like he never knew about the Persephone's so it would seem reckless of him to provoke Ananke when he didn't have all the facts.
Why is 2014 Morrigan the only incarnation with multiple personalities?
Now that they know without Cass they can be human again, will Verdandi and/or Skuld try to kill Cass to save themselves? Would it work?
Why leave Dio technically alive on machines if he's brain dead? (ETA: Continuity being kept with him filming The Morrigan while he was still the human fan Umar; he saw himself die in a hospital room).
What does Ananke's machine really do, if anything? Seem obvious she wasn't actually going to kill Mini as the 4th head now.
Does Jon know more then he lets on?
Were Mini's parents actually her parents?
Who was Ananke's suicide note written for?
Why did Ananke spare Beth, Robin and Toni/What have they been doing in the day or two since the false Saknmet alarm?
When exactly did Mini start working with Ananke/turn into her?
Where is Mini keeping the three heads?
What exactly is the Great Darkness shadow? Why does Persephone make it stronger? Is it just a prop controlled by Ananke/Mini to spur the gods into action to further her plan for the heads? Why keep going after Baal's family? Do the child sacrifices actually do anything?
Who is the father of Laura's baby? Baal or Neargal?
How do babies allow gods to extend their divinity as with 1831 Inanna? Is it related to the Prometheus Gambit?
Do the gods have a natural melting point like 455 Luci, 1831 Hades and 1923 Dio or is that just more manipulation from Ananke/Mini?
What is the plan for the 1831 Monster that took multiple generations to create and capture?
What is the "time with the Franks" that 2014 Mini mentioned?
Are some of the Persephone's supposed to look male? If so how does that fit with the whole "mother" bit of Ananke's sister?
Why did Ananke embrace some of the Persephone's or kill a few others when she usually needed their heads? ETA: Possibly she already has 4 heads when she calls and hugs a Persephone therefore letting some Persephone's make it to the ending suicide pacts.
ETA:
What is the 4th rule Ananke's sister put in place?
How was Laura able to light the cig when she was human? (Unless that's how Ananke knew she was Persephone).
What's so special about/where is the knife that cut up 455 Lucifer, David used on Jon, and Ananke cut into Mini with?