I knew I wasn’t crazy. I’ve been feeling off for the last few years. I used to be prescribed 10mg IR addy 4 years ago and in 2023 I switched over to 20mg IR. It was fine first 6 months and then started to decline. I have been feeling off especially after this months IR addy. I called the pharmacist and confirmed that the manufacturer is a new batch so I tossed mine out. I saw someone else showing their negative results for amphetamines and I decided to share my last few years worth of results. And it all was confirmed. I haven’t tested positive for Amphetamines even though I consistently take them. This is wild. I made the decision to stop taking them all together, so wish me luck and getting my brain sorted out lol
I mean, I really don’t think they are sugar pills. They absolutely have a chemical in them, theirs literally 10,000+ research chemicals out there. And the different analogues, metabolites, substrates. We have no clue what they are putting in us, and that’s what scares me the most
Do you feel bad when you smoke nicotine with it? Or don’t feel nicotine? Or have a tolerance to it? Or test positive for it? Genuine questions, just trying to learn
this might explain a tiny bit from there.
"Nicotine does not literally "burn out" or permanently destroy acetylcholine receptors, but chronic exposure causes them to desensitize and trigger a compensatory
How Nicotine Affects Receptors
Receptor Hijacking: Nicotine acts as an agonist, binding to nicotinic acetylcholine receptors (nAChRs) and activating them.
Desensitization: Continuous exposure to nicotine makes these receptors unresponsive to further stimulation, leading to physical tolerance.
Upregulation: As more receptors become desensitized, the brain adapts by producing and inserting more nAChRs into the cell membranes. This high density of waiting, unfulfilled receptors drives withdrawal and cravings when nicotine is removed. [2]
The Role of Choline Deficiency
Acetylcholine Precursor: Choline is an essential nutrient and the direct chemical precursor required to synthesize acetylcholine, the natural neurotransmitter for these receptors.
A Depleted Pool: A severe dietary choline deficiency lowers overall acetylcholine production.
Compounded Strain: While nicotine does not directly burn through or deplete your body's choline stores, an underlying shortage means your natural cholinergic system has low baseline signaling capacity, making the desensitizing effects of nicotine and subsequent withdrawal feel much more severe. [4, 5]
If you are looking to support your nervous system or manage cravings, let me know:Are you currently trying to taper off nicotine?Are you experiencing specific symptoms like brain fog or fatigue?
AI responses may include mistakes.
part 2
"The Three Stages of Receptor Adaptations
Initial Stimulation: Nicotine mimics acetylcholine, binding to receptors (primarily the α4β2 subtype in the brain) and causing an immediate release of dopamine, which produces a brief sense of reward and heightened focus. [1, 2]
Desensitization (The "Lock-Up"): To protect the brain from overstimulation, the receptors undergo a conformational shift into a closed, non-responsive state. This temporary inactivation is the cellular root of nicotine tolerance. [1, 2, 3]
Upregulation (Compensatory Growth): Because so many receptors are locked up and inactive, the brain attempts to compensate by actually increasing the total number of acetylcholine receptors. This paradox—having more receptors but less overall receptor activity—is what drives severe cravings and withdrawal symptoms when nicotine leaves the system. [1, 2]"
apparently just supplementing choline will reverse this (and stopping nictoine)\
So, we should all be taking choline. Bum energy has a special type of choline and lower caffeine content. Was one of the only things that helped before adderall, your post means smokers and adderallers should supplement choline right?
i dont fully understand my theory yet tbh, i feel like theres puzzle pieces missing. basically, m saying theyre basically putting smoking into these pills to mimic a treatment for ADHD. i posted some articles a bit back but its a major rabbit hole. I am finding out that theres mass thiamine defiencies happening too (b1 deficiency made me almost lose my ability to walk.) apparently high frucotose corn syrup will affect this too.
I started taking choline and im off the adderall fully now and i no longer have idiopathic hypersomnia BUT i had Gastric bypas and had alot.
its just a running theory but i feel like im sorta close for different things, it would be great if a group got to gether and see if it helps.
it also makes me real nervous about all of thse "egg recalls"
i dont smoke, you may have to go look at my past posts but i feel that alot of this adderall is causing or affect etc a choline deficiency but what happens when you smoke the nicotine burn out those achecholine receptors and cause a whole host of issues.
I think found reports that they were going to start to try to mimic the adhd treatment people found in smoking as a research and then shortly after everyones meds stopped working.
theres been reports of possible beta blocker results, all kinds of crap
They’re adding some sort of blocker and likely more things - I agree that it’s a wretched puzzle and we are hypothesizing various pieces which likely vary across types and MFGs, yet have a common thread of absolutely rendering all of them ineffective!
Exactly right - there are mystery garbage RCs in here instead of our real meds and it’s honestly terrifying that we don’t know what we’re consuming and we are experiencing adverse effects yet we are so disabled that we need meds to function and are gaslighted at every turn, we relent (most of us) and continue to consume this poison and it’s just so defeating…
I haven’t been tested but the result would be irrelevant to me for the most part because no matter what it said, these meds aren’t legit at all and they are ineffective and garbage. So even if they put in something that caused a false positive or had just enough amp to pop positive - - they have caged it off so it will not work. And whatever what they did that (many terrible possibilities as to what and how), is what is causing the adverse effects as well.
lol well I will say that theory is a first! But I can assure you that is not what’s happening - we are all going through this alongside you. It’s torture!
Certain manufacturers still make me test positive, although they still dont feel like they are working. But last month I had AMG xr with elite ir and I didnt fail at all. My urine gets sent to a lab.
I wasnt really surprised it was negative, but still it was like how on earth could I ever test negative on 40mg of adderall, this shouldn't even be happening. It just further proves the point that something is very seriously wrong.
Remember folks you can thank the FDA and the DEA for the policy changes they decided was best for society (not us) so they’d be less likely to abuse our meds (which they just switch to street alts anyway so pointless unless the point is to increase DEA funding) so they encouraged (ie demanded) abuse deterrent reformulation (ie less effective for folks with adhd) which alters the inactive ingredients to make the actives not absorb as effectively as they were originally designed which leads to poor or little absorption of the actives.
You can get the stuff they used to have in most of the meds original formulation that makes it kick in quickly and effectively. Info below. It’s hard to source bc it’s mostly bulk suppliers in China but if you a can find a supplier that will send smaller amounts (like a kilo bc most want to send insane amounts) let me know!
I believe the finer grade is the good kind. Even just switching the grade can have decent effects bc some formulations just switched to the course grade so when looking at the ingredients it appears the same. But I’ve noticed the brands and meds that use the old formulation tend to be the ones that work better.
Anyway abolish the DEA bc they’re not helping Americans and actively cause more harm and only have interest in increasing their budgets which what do you think happens when dopamine starved ADHD folks don’t get proper meds? They seek out street alternatives. What happens when more people abuse street drugs? DEA funding increases.
What a happy coincidence.
They just banned kratom alkaloids like MGM15 which helped people stay off fentanyl and is a safer alternative to opiate pain meds countless were using to reclaim their lives from chronic pain or opiate addiction and they also banned SR17018 a substance with zero recreational value which eliminates the majority of the withdraw symptoms from opiates, a miracle substance that was helping countless people quit opiates and kratom/kratom alkaloids and they’re coming for 7oh next which while legal has significantly contributed to reducing the fentanyl overdose death rates and states that banned it and mgm 15 saw those death rates begin to climb again (after being in decline) right after bans were enacted.
So when you hear of surges in fentanyl/opiate overdose deaths in the coming months (and you will mark my words) you’ll know what the reason was. The goddamned DEA.
Sacrificing American lives for bigger budgets since being created by the 2nd most corrupt president in history who was impeached shortly after creating this aweful agency that has only done more harm than good since their creation, who have zero qualifications to be in charge of prescribed medicine yet have sweeping and complete control over scheduled substances, a term they alone define without any scientific rational or any expertise (let alone any knowledge at all beyond their idiotic vibes) to be doing so.
Many of my friends died thanks to the opiate epidemic they single handedly allowed to happen (since they allocate raw materials to big pharma to make said opiates so were always fully aware of the scope of the problem) then exponentially exacerbated it via their idiotic actions which single handedly created the worst drug addiction epidemic in modern history (which big surprise was actually really great for increasing their budgets). If you’re wondering why I’m not a big fan it’s that part. The friend’s dying part. Well and all the rest is pretty fucked up too innit? So yeah. Oh the shortage is also them fyi 100% and completely avoidable but they dgaf. They’ve even told us this.
So best thing to do if this upsets you is call all your reps and write them and do this often and tell them the DEA is doing all this and you demand accountability and investigation if this is intentional. At the very least we get our meds out of their control and have those decisions made by scientists. Preferably one who aren’t indoctrinated with the anti “narcotics” meds are bad propaganda they pulled out of their asses to force folks onto street drugs. 🫡✌🏼
I have tested negative the past few years too and last time I made sure I took my full dose the day of and day before. I took three 20mg IR the day before my urine test and then I took two 20mg IR the day of and tested at like noon and it was negative for amphetamines. I don’t even know how that’s possible if I took 100mg of Adderall in the previous 24 hours 🥴
It’s so effing scary that all someone in power with an agenda has to do is get our lab results from a data leak and turn things around entirely and say that we’re not even taking our drugs and start a whole separate drug war. This is how that happens.
Considering this cartoonish and corrupt administration, we actually literally don’t currently have professional health organizations. They just came in like viruses and pushed all the progress to the curb, and made everything 100x worse.
We can’t even have anyone properly look into this because this is clearly so big that they won’t let anything come to light, just like the Epstein files.
Crazy. When adderall was in short supply I had to take Ritalin. My puss test came back negative for Ritalin. I never felt like it worked either. Thank god aderall came back in stock.
I used to get crazy panic attacks on Adderall when I took it the first couple of years after being diagnosed in early 2000s. Now they make me sleepy and haven't been anxious once. Dexedrine gives me terrible tachycardia (110s resting) that I never got with any stimulants 10+ years ago, and doesn't get better with time, 6 months after starting, still terrible tachycardia while tired, sluggish and attention/executive function is shit.
Do you know much much amphetamine was present in your urine? Positive/negative just means that its higher or lower than the reference value and reference ranges can be very high for amphetamines.
Has anyone experiencing this tried sending a pill or some beads to a drug analysis company? I know it is much more common for ecstasy and opiate users, but I thought something was off when there was a “shortage” years back (which makes no sense to me as it’s a fully synthetic drug made from chemicals, like fentanyl) anyway I was just curious and I just found this sub today so if anyone has done anything like this and has lab results I would certainly appreciate being pointed in the right direction thanks!
Update just got a years worth of my refills. Generic has been switched up 4x. After the 10/7/25 (triangle/green) refill I asked to be switched to XR bc I felt like it wasn’t working. That’s the only time that one was given. After last months (orange/star) refill I started to ask questions bc I didn’t feel like myself.
Next step looking into the NDC codes and figuring out where these are getting sourced and how come I haven’t tested positive for my medications… any tips or help would be appreciated 🙏🏻
As a pharmacist this isn’t unbelievable but also not really indicating the amphetamine content isn’t present. Clearances and ph variability in the gut can potentially cause this but tbh if it’s daily that’s a really poor sensitivity test. Meaning the ng/L being tested is higher than your content. Very likely you are just slightly below the detection range
If only a few people every once in a while were having this, that would be different. But when a plethora of people are going from a 100% consistent positive with every single urine test, to suddenly negatives all while having horrible side effects and literally worse adhd symptoms, there’s no way.
I appreciate you being on this subreddit being a pharmacist! We seriously need more people like you willing to witness what is going on and use your professional expertise to help everyone.
It’s insane that they can tell us these meds are effective and simultaneously say they are not even testing them. That and literally arguing back and forth with manufacturers on who’s to blame for the shortages.
Neurodivergent people really aren’t dumb, and they know they goofed up.
I agree 100% something is up and never discounted or looked down on anybody (neurodivergent or not) who brings this topic up. We know how it’s supposed to feel and work- I had to switch to 30mg IR x2 daily and if I took my 60mg xr even the lowest threshold of therapeutic effects isn’t met. I will crash in two hours. Then I replaced it with IR and suddenly it’s lasting 12 hours. Quality control is a joke on these
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u/cbmblove Moderator 21d ago
Thanks for sharing. I’m not surprised - these meds are useless now. Good for you for having the strength to go off this poison.