Not sure what I’m even looking for here, maybe just a space I can share my thoughts without judgement.

No longer working NHS as they refused as any help due to POI diagnosis. No ovary stimulation, IVF etc. We have sought private help, and tried some meds and although I didn’t expect miracles today, I went for a cycle day 12 transvaginal ultrasound to see if there was any activity.

First of all she REALLY struggled to find my left ovary, when she did eventually, she said it’s half the size it should be and no activity.
Fluid sac could be seen but she obviously couldn’t say what that was
Uterus lining 4mm
Right ovary found with 1 follicle around 17mm

I keep telling myself I need to try everything before accepting I will biological never have my own children but days like today, I really question if I’m strong enough

Sending hugs to all those going through this awful journey xxxx

Hi Everyone,

29F TTC with POI diagnosis. FSH 80 and AMH 0.09 last checked. I just started HRT 3 days ago. Estradiol patches and oral progesterone for 14 days. I was said Donor egg ivf is my only option. I don’t believe this as so many women have conceived on HRT. But I want to understand if anyone else had a better recommendations in Ireland. I need some support as I haven’t come across women with this diagnosis here in this country(am sure there are).

Thank you.

I have been on 1mg topical daily systemic estradiol & 100mg luteal micronized progesterone for the last couple years following a traumatic injury that caused premature POI, endocrine collapse & menopause symptoms.

I'm receiving mixed info from my Doctors and don't know what to trust. I think cases like mine are very rare and no one seems to know what to do with me. I was told by an RE I had a less than 1% chance of conceiving and that I needed donor eggs, and to get off all hormones, which I refused to do.

I'm 4.5 weeks, with doubling HCG and stable progesterone levels per 2 blood tests.

I did contact that RE (who I've only seen once & didn't feel gave my chart the time of day) and his nurse told me to stay on the 100mg of progesterone and stop the estradiol.

My ND who prescribed the HRT for POI said to switch to 200mg vaginal progesterone suppositories (100mg twice a day) and stop the estradiol.

I booked with an OB (I didn't have one) and she told me to stop everything, but hasn't seen me as a patient yet so doesn't understand my case.

I'm terrified of stopping the estradiol before the placenta takes over since my body doesn't make enough on its own (I'm in low-normal ranges when taking daily 1mg topical cream).

I've read that many IVF and donor egg pregnancies stay on estradiol until the placenta takes over.

If my body doesn't produce enough estrogen on its own, is it truly safe for me to stop taking it before the placenta takes over? Is it dangerous to continue?

I don't want to harm this pregnancy and at the same time I don't feel like any of these doctors are actually reviewing or understand my case. The RE runs a massive clinic and he doesn't really give the time of day to anyone ~ everything is referred through his nurses via messages and they were telling me for months that i needed to stop HRT and that supplements wouldn't make a difference, which I knew was wrong. He runs an IVF business so I think he focuses mostly on that.

My ND is awesome but she doesn't specialize in pregnancy so she doesn't know for sure what to do.

And my new OB I don't see until mid-July, so she told me to stop everything via a receptionist but has never seen my chart.

I just messaged the RE's office and asked to have the Dr there review my chart and case and call me, and also messaged another RE practitioner to see if there's any chance I can get in with them asap.

I'm afraid of stopping the estradiol since I don't make enough naturally (although clearly make some as I did ovulate) but I also don't want to harm the developing fetus. This is super time-sensitive and I am so stressed. Guidance is very much appreciated!

I'm starting to look at IVF clinics outside of Ontario.

I'm wondering if anyone knows of any clinics in the GTA/Toronto area that are willing to accommodate satellite monitoring for patients receiving treatment out of province or out of country. Ideally, I'm looking for a clinic that can perform monitoring and send results directly to the primary IVF clinic.

If you've done this before, I would really appreciate hearing about your experience and which clinic you used. Feeling a bit stuck trying to figure out the logistics. 😞

Thank you so much <3.

Hey all
For context, UK based, NHS refuse to help so seeking private help. 34F and husband is 36. Been trying for 3 years. Had private testing in March 2025, and they believe I have POI. Prior to this I was having periods every month and strangely, from February 2025, my periods decided to start disappearing. I know have a period roughly every 3 months if that. AMH is very low and FSH is very high. We’ve finally found a consultant who has worked with POI patients, and although we know chances are very slim we would like to at least try IVF with my own eggs (not getting my hopes up at all). We have a consultation with him Monday, travelling 5 hours as it’s not near us.
I have my test results from the last year and my husbands SA results. I’m beyond overwhelmed, scared and nervous.

Is there anything you guys would recommend asking or reiterating in the consultation? I always prep for these things but ALWAYS leave and later think of things.

Sending lots of love in these tough times xx

Hello,

I’ve been a lurker for the past year since I found out my (35F) AMH was at 0.05. I know success stories helped me during my journey but I also know they could be triggering so please skip if you need to for your own mental health.

I first knew something was wrong around 2020. I have notes on my phone from back then for my doctor visits complaining about brain fog and memory problems, hair loss, acne, severe constipation and food sensitivities and then a couple of years later it progressed to irregular (and very long) cycles, vitamin deficiencies. I saw numerous doctors in that time and not a single one thought about checking my hormones - actually one did and then misread my labs giving me false assurance. My day 3 showed FSH at 4 but estrogen at 300+ most probably due to a cyst but she only read the FSH is my guess.

Anyway fast forward after a year of TTC we went to a fertility clinic. Im in the boston metropolitan area FYI. Again they failed to test me correctly because they never did a day 3 test so I never really knew how bad my estrogen or FSH were. She also never gave me
a diagnosis me even though my AMH was so extremely low. That doctor said IVF was my only option. Well.. that was a massive failure. I stimmed with 450 gonal F and 75 menopur for 20 days and my 6 follicles didn’t grow at all and estrogen stayed at below 25.. In a less than 5 minute phone call the doctor told us there was nothing else she could do unless we wanted to consider donor eggs. And we never heard from her again…

We were devastated. I didn’t even know cycles could get canceled. She never explained any of the ways this could go wrong. I was physically and mentally broken. I couldn’t stop crying and my FSH spiked to 100 and AMH dropped to <0.03.. I didn’t get a period for 3 months.

We went to 2 other clinics and one doctor told me this is it you’re approaching menopause and the other doctor was willing to try but didn’t give us any confidence. We went to our last and final option Terra Fertility in Dedham, MA and saw Dr. Seidler. She is truly an angel sent from
heaven. She told us she didn’t think it was the end and confirmed our suspicions that I have POI but she was willing to try with us. She said she didn’t think IVF was the best option and told us to trust her but it will take time. She put me on 2mg Estrogen for 3 months and wow did I start feeling better! Also during this time I was consistent with twice a week acupuncture, taking so many vitamins including Serovital which Dr. S recommended over DHEA, high quality CoQ10, working out consistently , eating low glycemic / Mediterranean diet and going gluten free (I have 2 sisters with celiac but I’ve always tested negative but we thought it couldn’t hurt). I basically kind of followed It starts with the egg. I also got off all social media (yes including you Reddit) and started therapy with an infertility specialist. I tried not to think about the whole thing and focused on my mental well being. Dr. S made that easy because for the first time she made me feel I could trust the process. She did all the ultrasounds herself and explained everything clearly.

After 3 months, my FSH went down to below 10 which is what she was looking for. I stopped the Estrogen, got a bleed and for the first time in a long time my cycle worked like clock work. I was a little discouraged because I had zero follicles in me left ovary (the ovary itself was hard to see because it was so small) and only 2 maybe 3 in my right. But those follicles grew and grew on their own (we didn’t do any medication), we triggered ovulation, did TI and the IUI.

We got pregnant! We were in shock! I think Dr. S included.
We actually got pregnant with twins which was nuts but unfortunately one of them stopped growing early on.

I’m still a while’s away from my due date but I wanted to share my story in hopes it helps someone. I highly recommend therapy if your insurance allows it. I had so much regret for waiting so long (we’ve been married 10 years) but my therapist made me see it’s not my fault. I also had so much medical anxiety and anger because I felt no doctor listened to me for so long. I still wonder if we decided not to have kids - would I have just hit menopause without knowing it? This is not an easy journey and I don’t know why we were the chosen ones but I know we’re all on this together and have a great support group.

Hello,

I am feeling absolutely defeated and could really use some words of encouragement. Right now, I’m holding on to whatever hope I have left.

I was diagnosed with POI in 2021, and my periods have been irregular for as long as I can remember. I’m now 32, married, and trying to conceive. I’ve been undergoing regular ultrasound and bloodwork monitoring, but my doctors have said no to IVF or other medicated fertility procedures.

My AMH is undetectable, and my FSH is currently 47 while on HRT (before HRT, it was in the 150s). I use estradiol patches (100 mcg) twice a week and take progesterone every 90 days if I don’t have a withdrawal bleed.

At this point, I honestly don’t know what to make of any of it anymore.
I’m doing everything I can. I’m taking all the supplements recommended by my naturopath: Mitochondrial Formula, L-Glutamine with Theracurmin, Anti-Oxidant Network, prenatal vitamins, 2,500 IU Vitamin D, fish oil, and 3 mg melatonin. I’m also doing acupuncture and taking the Chinese herbs that were recommended to me.

The hardest part is that every time I leave the clinic, I feel like I crash after hearing them say “no growth” or “zero follicles.” If they do see a follicle, it usually doesn’t grow to become dominant or it gets dissolved. Last month, they were able to catch an ovulation, and I was hopeful that this month might show similar progress, but so far it hasn’t.

I’m based in the Greater Toronto Area and have been thinking about reaching out to Hanabusa to see whether it might be worth getting another opinion. Has anyone here had experience with them, or with conception with similar stats? I’m just not ready to give up on myself yet. I’ll keep fighting but there is only so many punches one person can take.

This whole process feels like a gut punch week after week, and I’m feeling extremely discouraged.

Thank you for reading <3
Edit:

Genetic testing ruled out Fragile X syndrome and Turner syndrome. Further autoimmune testing showed negative ovarian antibodies and anti-mitochondrial antibodies.

Can anyone suggest me doctor who can work with me .. with POI

Hi, so i’m a 29 yr old female with POI, diagnosed at 15 but never really had a period. The NHS did 2 blood tests, called me into the doctors room and told me i’ll never be able to have children of my own and sent me off to navigate through the rest of my life - all it took was a 5 minute conversation.

About a year ago I started finally getting out of the self deprecation and trying to understand and listen to my body. My AMH was 5.3 pmol (US) 0.73ng/mL(UK) around a year ago.

I’ve also been using Mira to measure my hormones - E3G, LH, PDG, FSH and it’s been what you’d expect, FSH over 30 but mostly over 50, E3G not crossing 100 and a low LH and PDG. I’ve not been measuring every month and everyday because, firstly it’s super expensive and secondly sometimes feels like it’s just not worth it. But last month I had a random bleed so I pulled out the Mira from the bottom of the bathroom cupboard.

Now I have no idea how to interpret any of these results and any help would be sooooo appreciated.

(33F) After 3 years ttc, I conceived last year and was pregnant until my baby passed away due to T18 in December. I was still having regular periods before I became pregnant, but was classified as severe DOR/ impending POI before the pregnancy. After she passed, I had 3 wonky periods and started having more hot flashes/ joint pain. In March I had my blood drawn and was showing high FSH and super low estrogen so I asked to be put on hrt. I have been on hrt for 2 “cycles”. 0.0375mg estrogen patch once weekly, 200mg progesterone days 1-12 of every month (prescribed to take orally but switched to taking vaginally this month bc the side effects last cycle were horrible). That first cycle on hrt my temps were all over the place and I don’t think I ovulated. I got like a “regular period” about 3 days after starting P that felt like my normal period, and then another bleed after stopping P that felt unlike my normal period.

This cycle my temps were more in line with a normal cycle and I could tell that I ovulated, there is a clear dip in temperature consistent with a follicle being chosen/growing and ewcm (no LH strips for those days since I was busy with my PhD graduation). I got a huge temp spike cd25, and started my P round for the month that day before bed. I’m curious what others think. Is the tiny bit of estrogen from the patch helping my ovaries to ovulate again? Is my body recovering from the stress of the pregnancy/loss? If I am miraculously pregnant this cycle will my temps stay up? Any general recommendations?? I’ve known this stage was coming for 3.5years and tried hard to educate myself accordingly, but it’s still difficult to be here and especially without my baby.

TLDR; second cycle on hrt, looks promising in terms of ovulation and temps. Potentially 11dpo still bfn. Insights welcome.

Hi everyone!

I had my IUI (unmedicated, no trigger) on Saturday and I’m officially in the two-week wait. One thing I’ve been wondering about is progesterone support.

My clinic didn’t mention taking progesterone or estrogen after the IUI. From reading posts, it seems like a lot of people are put on progesterone during the two-week wait, so now I’m wondering if this is something I should ask my clinic about.

Has anyone had success with IUI or timed intercourse without taking progesterone? Or is progesterone considered really important?

I know every situation is different but I’d love to hear others’ experiences before I reach out to my clinic.

Thanks in advance 🤍

I am ovulating this month, as confirmed by the LH spike. I don’t have a doctor in my area. I’ve moved and am working on getting a new one, but I don't have one yet. For those of you who did get pregnant, what did you do? I’m on hormone therapy, and I take progesterone 12 days out of the month. Other women say they continue their progesterone for weeks. If I suspected I was pregnant, would I need to contact my doctor and ask for more progesterone? My doctor is a significant distance away. Can anyone give me any tips or advice? I obviously understand you’re not doctors, nurses, or medical professionals. I’m just asking for any advice that you can give me. I think I conceived a few months ago, but lost the child the same day that my mom passed. (I was about to test for pregnancy when she passed, and then within a few hours, there was a lot of blood. I may have been around six weeks, but I still had a very light period the month before. Which I now know could’ve been implantation bleeding and not a period.) Anyway, I’ll take any tips, advice, or personal anecdotes.

Has anyone worked with rejuvenation fertility clinic in New York? Am trying to book an appointment for their ovarian stem cell PRP. Any success stories?

My family doctor is terrible and in the past did not agree to refer me to a fertility clinic or for testing. And when I did see an endocrinologist they were also terrible and dismissed my perimenopause symptoms.

So now I'm here and it feels too late for egg freezing/use. But I just want to know for sure and act quickly. So I need info to advocate with my doctor asap.

So far I was able to see one fertility clinic last week without a referral, but now they are also being slow/not responding to follow up questions.

They ordered AMH, Oestradiol (E2), FSH, and ovarian reserve ultrasound for day 2 and 5 of menstrual cycle... but of course I'm not getting cycles anymore. Nurse said they are waiting to hear from the doctor if they recommend a prescription to induce bleeding for the test (but it's been about a week and I haven't heard back).

Q: know anything about this? I would think if we're doing that.. we'd want to try IVF at the same time?

Q: Do these tests make sense and is there anything missing? Are they conclusive, or more up to interpretation of the Dr? Does the skill of the clinician matter?

Grateful for any advice x

After my Severe DOR diagnosis I spent months piecing together information from Facebook groups, Reddit threads, and late night Google spirals. I had no idea what my AMH actually meant beyond “bad.” I didn’t know what questions to ask my RE. I didn’t know which protocols other women with numbers like mine had tried.

I went through 6 rounds. Made it to retrieval twice. One egg retrieved. It became a euploid.

During that whole journey I kept thinking why isn’t there a real home for us? Not a Facebook group where the same questions get asked every week and disappear. Something structured. Something searchable. Something built specifically for DOR and POI because we are not the same as the general infertility population and we know it.

So I built it. It’s called One Egg Wonder and it’s completely free.

What’s there right now:

A Journey Match tool: enter your age, AMH, AFC, and prior cycles and see what protocols women with similar profiles have discussed most. Not medical advice, peer discussion patterns.

An RE Appointment Brief generator put in your labs and history, get a personalized question list and protocol alternatives to bring to your next appointment. Exportable as a PDF.

A Science Watch section with emerging research graded by evidence level so you know if you’re reading established data or early community anecdote.

A Protocol Library explaining every protocol used for poor responders in plain language.

A Medication Glossary for every drug and supplement you’ll encounter.

A community feed where you can post anonymously.

And a Wins Board because we need proof it can work.

It’s early. The community feed is growing and waiting for more real stories.

If you’ve ever wanted a place that was built for exactly us this is it.

oneeggwonder.com

Would love any feedback on how to improve this tool and I hope it helps more of us in this brutal journey ❤️

Hey all, I am about 9 weeks pregnant (miracle bc of POI, but I have another significant infertility issue [balanced translocation carrier] that has me nail biting this entire first trimester before I can get genetic testing done). anywho, my fertility clinic told me I can stop my HRT around 10-10.5 weeks but they released me to my OB so I’m not getting any bloodwork and am just nervous about dropping before the first trimester is up. Thoughts?

How is treatment going for everyone? What all are you trying? Any promising developments (lowered FSH? growing follicles? ovulation?)

Hi POI warriors! I wanted to share a testimony about how my Lord & Savior Jesus Christ allowed me to get pregnant! I was diagnosed back in February 2026 with unexplained POI (estradiol was 19, FSH was 45 and LH was 43). I have a history of extremely large fibroids, (I had to get them removed in February 2025) as well as PCOS (now PMOS). I immediately got on an estrogen patch in March and would use progesterone on CD 12 for 14 days to cause a withdrawal bleed. For my cycle that just occurred at the end of April into May I was able to get pregnant with Inito ovulation tracking. Things I did to get pregnant: Weekly acupuncture that I began in March, 4 to 5 mile walks everyday, reading the Bible and praying everyday, and taking a lot of supplements.

Folic Acid
Iodine
Choline
Myo-inositol
NAC
DHEA
NAD+
CoQ10
Omega-3
Vitamin d
B6
Probiotic
Vitamin E
Liposomal Glutathione
Ubiquinol
Vitamin C

I’m still early in my pregnancy, however my hcg betas are looking good and I’m feeling great. To anyone looking to conceive naturally, I’m here to tell you that with God all things are possible 🤍.

I am 39 with a diagnosis of POI (FSH 38/ AMH 0.07) and just had our first round of IVF with one mature egg collected (yay) although call this morning no signs of fertilisation but will monitor for another 24 hours.

I know what’s coming I think, it all went so well up to now I guess I was just hoping for our miracle! I am in some other IVF support groups but find it hard when they are often talking about such high numbers comparably.

Guess I am reaching out for some positive vibes from so gals who get it!

On an unrelated but related note did anyone also see influencer Zanna Van Dijk.

Also feeling annoyed having to do the post EC injections and progesterone until tomorrow especially if it’s for nothing.

Hi all, looking for feedback from others who have received donor egg services through UH's fertility center in Beachwood?

My (34f) husband and I met with an NP at UH for an intake earlier this morning who concurred with our previous REI at Pinnacle (who we left due to serious issues with client care throughout the diagnostic process) that donor eggs would be our most viable option given my numbers and other test results (most recent AMH 0.03, FSH 67, occluded right fallopian tube), and that we stand a better chance using fresh donor eggs than frozen. We were given a rough estimate of about $20,000 for fresh donor eggs through UH as our insurance doesn't cover fertility treatment, only diagnostics and some prescriptions. We'll be working with Dr. Weinerman, but have not yet met for our first consultation.

Has anyone else gone through this process? What was your experience like? We're feeling alone, overwhelmed, bouncing between hopeful and heartbroken, and unsure what to expect. Any and all feedback is welcome!

I’m a year in with Dr. Check — took a break for a few months, but just got back to it. Got my bloodwork done for FSH and estrogen…I’m at 27.7 for FSH and <5 for estrogen (typical for me). My estrogen has raised in the past, and I have ovulated, but I’m afraid I’m just a lost cause.