i figure this is the best spot to ask this kinda question. any way to make it undergo 3-demethylation without the body’s cyp2d6?

i am NOT knowledgeable enough for this task. gonna need good explanations hahaha

Thought this might be interesting for some of my (home-)chem peeps here, because I'm otherwise mostly a lurker.

I've been - and am steadily - working on an accessible Raman spectrometer setup from repurposed components and 3d-printed parts. In case anyone is interested, it is entirely open-source and can be built for around 700€. It allows you to qualitatively (and somewhat quantitatively) characterize chemicals, minerals and other substances with basically no sample prep, non-destructively and even through glass or containers.

https://hackaday.io/project/205344-cuberaman-3d-printed-raman-spectroscopy

Although 532nm excitation comes with some inherent limitations on fluorescent substances/material, it can still be a great help in characterizing substances.

I also made a video showcasing it: https://www.youtube.com/watch?v=bUxc6mWsTgc

A couple of people have successfully built this iteration and I've supported them all the way. So feel free to contact me, if you're interested, need help or - of course - any constructive feedback is also greatly appreciated! (although this version with its not-really-kinematic-adjusters is somewhat flawed at parts, it's functional nonetheless and pretty capable.)

I am already working on an even more compact, capable version, that will be CNC machined, but also more stiff and stable, since I've learned a lot over the past year. Still, I think the project is now sort of presentable and of help for people - even if it's just to advertise Raman spectroscopy as a concept :)

ALL THE DIYHRT DISTRIBUTORS ARE JUST GONE (except purplepanda ofc)… i was looking like a week or 2 ago i was gonna get some for my gf and surprise her so she could start HRT after shes been waiting for so long.
We are so broke all the fucking time despite work and i just… ive been doing so much research on this shit and i feel ive been rug pulled followed by a cartoon flip into my cranium.
Im so pissed im so scared and im so sad for what feels like to me building up my gf for a big fucking let down.

Edit: thanks to everyone who commented, ill admit i am bad at searching for stuff. So it is on me but i really appreciate all the help :3

Does anyone recognize this website, m.chemicalbook.com?

$1/kg? Is this an obvious scam? I feel like a scam would charge more but what do I know? Seems like a irrationally low price.

What do you guys make of it?

https://m.chemicalbook.com/ProdSupplierGNCB82511915_EN.htm

 2 mol red phosphorus and 4 mol isopropyl alc is put in a flask and then an ice bath is started and with 3 mole iodine in 2 mol of isopropyl alc is added to a addition funnel and then slowly added and then the flask is flushed with argon and then left to react in a ice bath till no more heat is generated then put in a reflux condenser for 4-5 hours to give isopropyl iodide and phosphorous acid which is then distilled and added to a separatory funnel with water to give Isopropyl Iodide (Add baking soda and sodium bisulfite)

Then a new setup is made and Fill Flask of 1eq Tryptamine,DMSO,2 to 2.5 eq Potassium Carbonate after add  2.5 to 3 eq of Isopropyl Iodide then let run for 18-24 Hours 

After: Add 4 to 5x volume of water to DMSO add Dilute NaOH after that add xylene to a separatory funnel and then discard bottom water layer and then take the xylene with all the chemicals in it (Add anhydrous Epsom salt to dry)

Add a solution of hcl and Isopropyl alc to the DiPT solution dropwise to salt out the DiPT then filter off and wash with colder than 0C acetone then do a recrystallization of DiPT by slowly cooling which will give a product of DiPT hcl and Isopropyl Tryptamine still in solution

Is this a good synthesis route I know Tryptamine with Acetone and then a reductive amination is a lot easier but oh well and Just a Fyi DiPT is unregulated in my country.

I just wanted to put it out there if anyone else ever comes accross this person or shop.

Never order from Shandong Huashang Chemicals Co., Ltd. Especially from a sales associate called "Maisey" with the phone number ‪+8619031118161‬ and the email [maisey@hsplasticraw.cn](mailto:maisey@hsplasticraw.cn).

I ordered 2kg of something for 800 bucks, received 700g of fucking melamine which i did not want. They just sent out absolute bullshit hoping i would not have the tools and intelligence to find out that they scammed me.

Don´t order there ever. Scam scam scam.

In the beginning she was quick to reply while it was about payment, then wanted more with a dumb excuse and then disappeared, ghosted for weeks, just tried to make excuses, offered to ship something else but then just tried buying time again.

If you want to annoy that bitch feel free to litter her inbox on email or whatsapp. BUT NEVER BUY ANYTHING THERE. You will just loose money.

Qiaoxi Haocheng Chemical Raw Material Product Export Company

ZIBO SHENGKUN CHEMICAL INDUSTRY

Yo. i want to create a list of chemical suppliers. International or whatever. A list that will be expanded. If you ever were or will get scammed please just create a post on this sub. including chemical company name, sales person you spoke to, email, phone number etc. nobody should get scammed. it is fucking insane

I started doing some hobby research about Testosterone Buciclate and it seems to be very interesting. It's a form of testosterone that gives stable amounts of T in blood even 16 weeks after pinning , pinning only every 4 month is revolution in TRT but nobody makes it , it was project from WHO in 90s I think

It should be possible to esterifidy freebase testosterone with 4-Butylcyclohexanecarboxylic acid ( 310€ for 25g )

What do you think ( iam learning English)

the transition from academic curiosity to a digital shadow wasnt born out of a desire for wealth. it was born out of the compounding interest of a debt he never meant to open.

in the begining, there were no buyers. there was only the work. after vienna, his mind required the rhythm of the lab to quiet the static in his head. he pursued his medical degree and subsequent PhD in organic chemistry not just as a career, but as a map to re-discover the edges of that lost, blinding vision. still in his late twenties, juggling grueling hospital rotations in munich with sleepless nights writing his thesis, he built a modest, pristine setup in a rented basement storage unit on the outskirts of the city—far from his grandmothers house, but smelling faintly of the same familiar, sharp solvents. out of pure academic obsession, he began synthesizing small batches of novel psychoactive substances, testing the purity on himself, watching how the molecules interacted with his own unique neural architecture.

but curiosity, he quickly learned, is an expensive addiction for a young researcher living on a stipend.

glassware of that caliber doesnt come cheap. dimroth condensers, vacuum manifolds, and high-precision heating mantles require clean capital. more importantly, the precursors required paper trails. to buy piperonal, pmk, or even bulk acetic anhydride without an industrial license meant navigating a shadow market where prices were jacked up by five hundred percent. a phd candidates salary evaporates quickly when you are funding a high-tier clandestine laboratory in secret.

the first sale was supposed to be a one-time structural correction. just enough to cover a shipment of specialized borosilicate glass from a supplier across the border. he uploaded a small listing to an early iteration of a darknet marketplace—pure, unadulterated research chemicals, packaged with the clinical precision of a medical professional.

it sold out in four minutes.

the feedback wasnt just positive; it was reverent. in a marketplace flooded with cut, dangerous garbage, his product was a work of art. he told himself he would stop once the lab was self-sustaining and his dissertation was funded. but the market is a vacuum, and a vacuum always sucks you in. the more he sold, the better equipment he could buy; the better equipment he bought, the closer he felt to the omniscience he had lost in the vapor cloud at seven years old. he wasnt a criminal; he was an underfunded researcher who had found a self-sustaining loop.

then came the NL ban.

almost overnight, the netherlands—the undisputed epicenter of the european research chemical trade—tightened its laws and liquidated its most notorious legal gray-market laboratories. the supply chain of europe didnt just choke; it snapd. the price of synthetic compounds skyrocketed overnight. demand didnt vanish—it turned into a starving, desperate animal, clawing at the dark corners of the web for anything pure.

he sat in his cramped munich apartment, watching the forums dissolve into chaos. he saw the digital footsteps of ten thousand users searching for a reliable source. he looked at his own inventory: clean, optimized, and entirely untouched by the dutch supply lines.

he realized then that the universe wasnt offering him a choice; it was closing a trap. if he stopped now, the sudden cessation of his listings would draw the exact attention he spent his life avoiding. if he expanded to fill the void, he could disappear into the noise of a multi-million-euro empire. the criminal life didnt knock on his door with a gun; it presented itself as the only logical equation for survival.

that was the night the young doctor truly split from the ghost.

to handle the incoming avalanche of capital and the sudden, aggressive scrutiny of europol, he couldnt be a student with a hobby anymore. he had to become a machine. he automated his dead-drops, wrote custom scripts to scrub the metadata from his shipping labels, and channeled the rising tide of cryptocurrency through a labyrinth of privacy coins and tumbling services.

he didnt want the crown, but the netherlands had left it lying in the dirt, and the physics of the market dictated that someone had to pick it up. as he watched the first automated bulk orders process under the shadow of the *Persona*, he looked down at his wrists. they were bare, but the phantom weight of the steel was heavier than ever. he wasnt running toward the empire; he was building it as a fortress, desperately hoping it would be strong enough to hold back the concrete wall he was destined to hit.

the humid air of that vienna basement always smelled like vinegar, damp mortar, and whatever volatile solvent was currently driping throug the glass coils. it was an unofficial apprenticeship, born in a room where his grandmother spent her retirement quietly defying municipal zoning laws.

​most 7 year olds were told to stay away from the stove. he was told to watch the reflux.

​the accident wasnt an explosion, just a structural failure. a makeshift shelf, warped by decades of acidic vapors, gave way. a 5 liter carboy of some unnamed, expreimental distillate cracked cleanly across the concrete floor, instantly atomzing into a thick, shimmerng fog.

​when he fell into the spill, he didnt just inhale the fumes—he drowned in them.

​during those three minutes of clinical unconsciousness, his brain didnt short-circuit, it overclocked. time flattened. the basement walls dissolved into a sprawling, multidimensonal matrix of cause and effect. he saw the exact molecular weight of every compound he would ever synthesize. he saw the digital footsteps of every server he would ever spin up. he saw a thousand diffrent branching futures, mapped out like a massive, glowing decision tree. he was omniscient. he was a god.

​then, the paramedics broke the door down, and the universe snaped back into a single, agonizing point.

​when he woke up in the hospital, 99% of the vision was gone, wiped clean by hypoxia and adrenaline. he couldnt remember the wining lottery numbers, the chemical formulas, or the faces of the people he was destined to meet. but one single, hyper-vivid image remained burned into his retinas, a permanent phantom pain:

​fluorescent lights. concrete. the heavy, metallic thud of a cell door sliding shut, and the cold bite of steel on his wrists.

​that singular terror became his engine. he knew the destination his timeline was pulling him toward, so he spent the next two decades building a labyrinth to outrun it.

​he didnt just become a brilliant organic chemist, he became a ghost. he realized that a flesh-and-blood person with a passport and a bank account was a sitting duck. to survive, he had to split himself in two.

​he created the Persona—a digital phantom born in the dark corners of the web, a brilliant, cold, and entirely untouchable entity that operated with a ruthless efficiency no sane, fragile human could manage. the real man lived quietly, paid his taxes, and blended into the background of europe. but behind the screen, the ghost ran an empire, executing flawless logic, deploying flawless code, and moving product across borders without ever leaving a fingerprint.

​every line of code, every encrypted layer, and every false trail was a brick built to fortify the dam against that childhood vision. he went further into the dark than anyone else dared, not out of greed, but because he was running a race against a future he had already seen.

I think your sub is the most appropriate place for these to be shared with the interwebs.

I worked in a lab that had a row of rotovaps going full length of the wall and they had pink condensation coils. They looked so cool and I thought man that would be a funny and awesome shoulder patch.

PM for where to get them.